Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

Journal of Medicinal Chemistry

Volumn 48, Issue 3, 2005, Pages 888-892

  Araújo, Maria João ^a   Bom, Joana ^b   Capela, Rita ^c   Casimiro, Catarina ^b   Chambel, Paula ^c   Gomes, Paula ^a   Iley, Jim ^d   Lopes, Francisca ^c   Morais, José ^c   Moreira, Rui ^c   De Oliveira, Eliandre ^e   Do Rosário, Virgílio ^b   Vale, Nuno ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^c UNIVERSITY OF LISBON   (Portugal)

^d OPEN UNIVERSITY   (United Kingdom)

^e Proteomics Platform   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; IMIDAZOLIDINE DERIVATIVE; PRIMAQUINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HUMAN; MALARIA; MOSQUITO; MOUSE; NONHUMAN; OOCYST; PH; PLASMA; PLASMODIUM BERGHEI; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANOPHELES; ANTIMALARIALS; DRUG STABILITY; HUMANS; IMIDAZOLIDINES; MALARIA; MICE; MICE, INBRED BALB C; PLASMODIUM BERGHEI; PRIMAQUINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 13444269006     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0494624     Document Type: Article

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24. a value for the derivative 4f, kinetically determined from a pH-rate profile, is 3.5 (data not shown).