Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1303-1310

  Barazarte, Arthur ^a   Lobo, Gricela ^a   Gamboa, Neira ^b   Rodrigues, Juan R ^b   Capparelli, Mario V ^c   Álvarez Larena, Ángel ^d   López, Simón E ^e   Charris, Jaime E ^a  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c FACULTAD DE CIENCIAS   (Venezuela)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e UNIVERSIDAD SIMÓN BOLÍVAR   (Venezuela)

Author keywords

Hematin; Benzothiazines; Hemoglobin; Plasmodium berghei; Pyrazol; Pyrimidine

Indexed keywords

2,4 DIAMINO 7 CHLORO 10H (2' METHYLPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 7 CHLORO 10H (2',5' DIMETHYLPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 7 CHLORO 10H (4' METHYLPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 7 CHLORO 10H PHENYLPYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (2' METHYLPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (2',5' DIMETHYLPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (3' CHLOROPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (3' METHOXYPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (3',4' DICHLOROPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (4' BROMOPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (4' CHLOROPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (4' METHOXYPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H (4' METHYLPHENYL)PYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 2,4 DIAMINO 8 CHLORO 10H PHENYLPYRIMIDO[5,4 B]BENZOTHIAZINE 5,5 DIOXIDE; 3 AMINO 6 CHLORO 9 (2' METHYLPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 6 CHLORO 9 (2',5' DIMETHYLPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 6 CHLORO 9 (3' METHOXYPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 6 CHLORO 9 (4' METHYLPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 6 CHLORO 9 PHENYL 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (2' METHYLPHEYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (2',5' DIMETHYLPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (3' CHLOROPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (3' METHOXYPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (3',4' DICHLOROPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (4' BROMOPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (4' CHLOROPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 (4' METHYLPHENYL) 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; 3 AMINO 7 CHLORO 9 PHENYL 1,9 DIHYDRO PYRAZOLO[4,3 B]BENZOTHIAZINE 4,4 DIOXIDE; ANTIMALARIAL AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MALE; MOUSE; NONHUMAN; PLASMODIUM BERGHEI;

ANIMALS; ANTIMALARIALS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PLASMODIUM BERGHEI; SPECTROPHOTOMETRY, INFRARED; THIAZINES;

EID: 60549090588     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.08.005     Document Type: Article

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