Experimental conditions for testing the inhibitory activity of chloroquine on the formation of β-hematin

Experimental Parasitology

Volumn 96, Issue 4, 2000, Pages 243-248

  Baelmans, R ^a   Deharo, E ^b   Muoz, V ^a   Sauvain, M ^c   Ginsburg, H ^d  

^a Instituto Boliviano de Biologia de Altura   (Bolivia)

^b Institut de Recherche Pour le Developpement   (Bolivia)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; HEMATIN; HEMOGLOBIN;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SCREENING; DRUG SOLUBILITY; FOURIER ANALYSIS; INFRARED RADIATION; POLYMERIZATION; PRIORITY JOURNAL;

EID: 0034475070     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.2000.4558     Document Type: Article

References (7)

1. Investigations of B- and β-hematin
2. A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs
3. A comparison and analysis of several ways to promote hematin (Haem) polymerization and an assessment of its initiation in vitro
4. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerization by quinoline antimalarials
5. Quinoline antimalarial drugs inhibit spontaneous formation of B-haematin (malaria pigment)
6. The role of haem in the activity of chloroquine and related antimalarial drugs
7. Formation of haemozoin/haematin under physiological conditions is not spontaneous