Functional relevance of carnitine transporter OCTN2 to brain distribution of L-camitine and acetyl-L-carnitine across the blood-brain barrier

Journal of Neurochemistry

Volumn 79, Issue 5, 2001, Pages 959-969

  Kido, Yasuto ^a   Tamai, Ikumi ^a,b   Ohnari, Aki ^a   Sai, Yoshimichi ^a,b   Kagami, Toru ^a   Nezu, Jun Ichi ^c   Nikaido, Hiroko ^a   Hashimoto, Noriyoshi ^a   Asano, Masahide ^a   Tsuji, Akira ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Acetyl L carnitine; Blood brain barrier; Jvs mice; L carnitine; octn2; Transport

Indexed keywords

CARNITINE; CARRIER PROTEIN; LEVACECARNINE; PROTEIN OCTN2; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CAPILLARY ENDOTHELIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITAMIN METABOLISM;

ACETYLCARNITINE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN CHEMISTRY; CAPILLARIES; CARNITINE; CARRIER PROTEINS; CELLS, CULTURED; CEREBROVASCULAR CIRCULATION; ENDOTHELIUM, VASCULAR; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION;

ANIMALIA; BOVINAE; SUIDAE;

EID: 0035209172     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00621.x     Document Type: Article

References (32)

1. Uptake of acetyl-L-carnitine in the brain
2. The uptake of carnitine by slices of rat cerebral cortex
3. Functional clarification of MCTI-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI Studies
4. Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier
5. Kinetic analysis of L-camitine by the choriod plexus
6. Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2 (0) strain of mouse with similarities to Reye's syndrome
7. Protein measurement with the Folin phenol reagent
8. Carnitine in Alzheimer's disease fibroblast and patients
9. Evidence for an asymmetrical uptake of L-carnitine in the blood-brain barrier in vitro
10. Blood-brain barrier controls carnitine level in the brain: A study on a model system with RBE4 cells
11. Carnitine: A known compound, a novel function in neural cells
12. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
13. +-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
14. Molecular and physiological evidence for multifunctionality of carnitine/organic cation Transporter OCTN2
15. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
16. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: Relevance for its mode of action in Alzheimer's disease and geriatric depression
17. Double-blind, placebo controlled study of acetyl-L-carnitine in patients with Alzheimer's dementia
18. Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine
19. An in situ, brain perfusion technique to study cerebrovascular transport in the rat
20. Transporter-mediated permeation of drugs across the blood-brain barrier
21. - dependent transport of taurine at the blood-brain barrier
22. Cloning and characterization of novel human pH-dependent organic cation transporter, OCTN1
23. Molecular and functiional identification of sodium ion-dependent, high afinity human cartinine transporter OCTN2
24. Molecular and functional characterization of organic cation/carnitine transporter family in mice
25. Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier
26. + -coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
27. Transport of monocarboxylic acids at the blood-brain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells
28. Transport of L-carnitine in isolated cerebral cortex neurons
29. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
30. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
31. Novel membrane transporter OCTNI mediates, multispecific, bidirectional, and pH-dependent transport of organic cations
32. Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice