Synthesis, transport and mechanism of a type i prodrug: L-carnitine ester of prednisolone

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1629-1640

  Mo, Jing Xin ^a   Shi, San Jun ^a   Zhang, Qin ^a   Gong, Tao ^a   Sun, Xun ^a   Zhang, Zhi Rong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

BEAS 2B cells; ELISA; IL 6; L carnitine; OCTN2 transporter; prednisolone; prodrug; pulmonary absorption

Indexed keywords

CARNITINE; CARNITINE TRANSPORTER OCTN1; CARNITINE TRANSPORTER OCTN2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; ORGANIC ANION TRANSPORTER; PREDNISOLONE; PRODRUG; SODIUM ION; SUCCINIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CELL FREE SYSTEM; CYTOKINE PRODUCTION; DRUG ABSORPTION; DRUG ACTIVITY; DRUG RELEASE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; LUNG LAVAGE; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEMPERATURE MEASUREMENT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL TRANSPORT; BIOTRANSFORMATION; BRONCHI; CARNITINE; CELL LINE; DRUG STABILITY; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HEK293 CELLS; HUMANS; INTERLEUKIN-6; MICE; ORGANIC CATION TRANSPORT PROTEINS; PREDNISOLONE; PRODRUGS; RESPIRATORY MUCOSA; RNA, MESSENGER; SUBSTRATE SPECIFICITY; SUCCINATES;

EID: 80053474357     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100412z     Document Type: Article

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