Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa

Reproduction

Volumn 134, Issue 5, 2007, Pages 651-658

  Kobayashi, Daisuke ^a   Tamai, Ikumi ^b   Sai, Yoshimichi ^a   Yoshida, Kazuhiro ^a   Wakayama, Tomohiko ^a   Kido, Yasuto ^a   Nezu, Jun Ichi ^c   Iseki, Shoichi ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; CARNITINE; CARNITINE ORGANIC CATION TRANSPORTER 2; CARNITINE ORGANIC CATION TRANSPORTER 3; ORGANIC CATION TRANSPORTER; SODIUM ION; TRITIUM; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPIDIDYMIS; IMMUNOFLUORESCENCE TEST; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; TRANSPORT KINETICS;

ACETYLCARNITINE; ANIMALS; BETAINE; BIOLOGICAL TRANSPORT, ACTIVE; CARNITINE; EPIDIDYMIS; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MEMBRANE PROTEINS; MICE; ORGANIC CATION TRANSPORT PROTEINS; PYRILAMINE; SPERM MATURATION; SPERM MOTILITY; SPERMATOZOA;

MUS;

EID: 36348965914     PISSN: 14701626     EISSN: None     Source Type: Journal    
DOI: 10.1530/REP-06-0173     Document Type: Article

References (42)

1. Angulo C, Rauch MC, Droppelmann A, Reyes AM, Slebe JC, Delgado-Lopez F, Guaiquil VH, Vera JC & Concha II 1998 Hexose transporter expression and function in mammalian spermatozoa: cellular localization. Journal of Cellular Biochemistry 71 189-203.
2. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 248-254.
3. Casillas ER 1972 The distribution of carnitine in male reproductive tissues and its effect on palmitate oxidation by spermatozoal particles. Biochimica et Biophysica Acta 280 545-551.
4. Casillas ER 1973 Accumulation of carnitine by bovine spermatozoa during maturation in the epididymis. Journal of Biological Chemistry 248 8227-8232.
5. Casillas ER & Chaipayungpan S 1979 The distribution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit spermatozoa during maturation. Journal of Reproduction and Fertility 56 439-444.
6. Casillas ER, Villalobos P & Gonzales R 1984 Distribution of carnitine and acetylcarnitine in the hamster epididymis and in epididymal spermatozoa during maturation. Journal of Reproduction and Ferlility 72 197-201.
7. Cooper TG, Gudermann TW & Yeung CH 1986 Characteristics of the transport of carnitine into the cauda epididymidis of the rat as ascertained by luminal perfusion in vitro. International Journal of Andrology 9 348-358.
8. Dacheux JL & Paquingnon M 1980 Relations between the fertilizing ability, motility and metabolism of epididymal spermatozoa. Reproduction, Nutrition, Development 20 1085-1099.
9. Deana R, Rigoni F, Francesconi M, Cavallini L, Arslan P & Siliprandi N 1989 Effect of L-carnitine and L-aminocarnitine on calcium transport, motility, and enzyme release from ejaculated bovine spermatozoa. Biology of Reproduction 41 949-955.
10. Enornoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y et al. 2002 Molecular identification of a novel carnitine transporter specific to human testis. Journal of Biological Chemistry 277 36262-36271.
11. Grundemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A & Schomig E 2005 Discovery of the ergothioneine transporter. PNAS 102 5256-5261.
12. Hinton BT, Snoswell AM & Setchell BP 1979 The concentration of carnitine in the luminal fluid of the testis and epididymis of the rat and some other mammals. Journal of Reproduction and Fertility 56 105-111.
13. Hinton BT, Brooks DE, Dott HM & Setchell BP 1981 Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis. Journal of Reproduction and Fertility 61 59-64.
14. Jenkins AD, Lechene CP & Howards SS 1980 Concentrations of seven elements in the intraluminal fluids of the rat seminiferous tubules, rete testis, and epididymis. Biology of Reproduction 23 981-987.
15. Jeulin C & Lewin LM 1996 Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Human Reproduction Update 2 87-102.
16. Jeulin C, Soufir JC, Marson J, Paquignon M & Dacheux JL 1987 The distribution of carnitine and acetylcarnitine in the epididymis and epididymal spermatozoa of the boar. Journal of Reproduction and Fertility 79 523-529.
17. Jeulin C, Dacheux JL & Soufir JC 1994 Uptake and release of free L-carnitine by boar epididymal spermatozoa in vitro and subsequent acetylation rate. Journal of Reproduction and Fertility 100 263-271.
18. Johansen L & Bohmer T 1979 Motility related to the presence of carnitine/acetylcarnitine in human spermatozoa. International Journal of Andrology 2 202-210.
19. Kobayashi D, Irokawa M, Maeda T, Tsuji A & Tamai I 2005 Carnitine/organic Tam cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. Reproduction 130 931-937.
20. Levine N & Marsh DJ 1971 Micropuncture studies of the electrolyte transport in individual seminiferous tubules, the epididymis and the vas deferens in rats. Journal of Physiology 213 557-570.
21. Marquis NR & Fritz IB 1965 Effects of testosterone on the distribution of carnitine, acetyl carnitine and carnitine acetyltransferase in tissues of the reproductive system of the male rat. Journal of Biological Chemistry 240 2197-2200.
22. 0,+ from mouse colon expressed in a HRPE cells and Xenopus oocytes. Journal of Physiology 532 297-304.
23. Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N et al. 1999 Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nature Genetics 21 91-94.
24. +-dependent carnitine transport by organic cation transporter d (OCTN2): its pharmacological and toxicological relevance. Journal of Pharmacology and Experimental Therapeutics 291 778-784.
25. Radigue C, Es-Slami S & Soufir JC 1996 Relationship of carnitine transport across the epididymis to blood carnitine and androgens in rats. Archives of Andrology 37 27-31.
26. Sekine T, Kusuhara H, Utsunomiya-Tate N, Tsuda M, Sugiyama Y, Kanai Y & Endou H 1998 Molecular cloning and characterization of high-affinity a carnitine transporter from rat intestine. Biochemical and Biophysical Research Communications 251 586-591.
27. Soler C, Yeung CH & Cooper TG 1994 Development of sperm motility patterns inthe murineepididymis. International Journal of Andrology 17 271-278.
28. Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M & Tsuji A 1997 Cloning and characterization of a novel human pH-dependent organic cation transporter. FEBS Letter 419 107-111.
29. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y & Tsuji A 1998 Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. Journal of Biological Chemistry 273 20378-20382.
30. Tamai I, Ohashi R, Nezu J, Sai Y, Kobayashi D, Oku A, Shimane M & Tsuji A 2000 Molecular and functional characterization of organic cation/carnitine transporter family in mice. Journal of Biological Chemistry 275 40064-40072.
31. +-coupled transport Of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochimica et Biophysica Acta 1512 273-284.
32. Tamai I, Nakanishi T, Kobayashi D, China K, Kosugi Y, Nezu J, Sai Y & Tsuji A 2004 Functional characterization nd renal apical membrane ocalization of organic cation transporter OCTN1 (SLC22A4). Molecular Pharmaceutics 1 57-66.
33. Toshimori K, Kuwajima M, Yoshinaga K, Wakayama T & Shima K 1999 Dysfunctions of epididymis as a result of primary carnitine deficiency in uvenile visceral steatosis mice. FEBS Letters 446 323-326.
34. Turner TT, Hartmann PK & Howards SS 1977 In vivo sodium, and perm concentrations in the rat epididymis. Fertility and Sterility 28 91-194.
35. Wakayama T, Koami H, Ariga H, Kobayashi D, Sai Y, Tsuji A, Yamamoto M & Iseki S 2003 Expression and functional characterization of the dhesion molecule spermatogenic immunnoglobulin superfamily in the mouse testis. Biology of Reproduction 68 1755-1763.
36. Wu X, Prasad PD, Leibach FH & Ganapathy V 1998 cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochemical and Biophysical Research Communications 246 589-595.
37. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ & Ganapathy V 1999 Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. Journal of Pharmacology and Experimental Therapeutics 290 1482-1492.
38. Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH & Ganapathy V 2000 Structural and functional characteristics and tissue distribution pattern f rat OCTN1, an organic cation transporter, cloned from placenta. Biochimica et Biophysica Acta 1466 315-327.
39. Kuan W, Lamhonwah AM, Librach C, Jarvi K & Tein I 2003 Characterization of organic cation/carnitine transporter family in human sperm. Biochemical and Biophysical Research Communications 306 121-128.
40. Yabuuchi K, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y & Tsuji A 1999 Novel membrane transporter OCTN1 mediates multispecific, bi-directional, and pH-dependent transport of organic cations. Journal of Pharmacology and Experimental Therapeutics 289 768-773.
41. Yamaoka K, Tanigawara Y, Nakagawa T & Uno T 1981 A pharmacokinetic nalysis program (MULTI) for microcomputer. Journal of Pharmacobio-Dynamics 4 879-885.
42. Yeung CH, Cooper TG & Waites GMH 1980 Carnitine transport into the perfused epididymis of the rat: regional differences, stereospecificity, timulation by choline, and the effect of other luminal factors. Biology of Reproduction 23 294-304.