-
1
-
-
1342325381
-
-
Amat di San Filippo C and Longo N (2004) Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter. J Biol Chem 279:7247-7253.
-
Amat di San Filippo C and Longo N (2004) Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter. J Biol Chem 279:7247-7253.
-
-
-
-
2
-
-
0013904716
-
Subacute toxicity of cephaloridine to various species
-
Atkinson RM, Caisey JD, Currie JP, Middleton TR, Pratt DA, Sharpe HM, and Tomich EG (1966) Subacute toxicity of cephaloridine to various species. Toxicol Appl Pharmacol 8:407-428.
-
(1966)
Toxicol Appl Pharmacol
, vol.8
, pp. 407-428
-
-
Atkinson, R.M.1
Caisey, J.D.2
Currie, J.P.3
Middleton, T.R.4
Pratt, D.A.5
Sharpe, H.M.6
Tomich, E.G.7
-
3
-
-
0018191874
-
The nephrotoxicity of cephalosporins: An overview
-
Barza M (1978) The nephrotoxicity of cephalosporins: an overview. J Infect Dis 137 (Suppl):S60-S73.
-
(1978)
J Infect Dis
, vol.137
, Issue.SUPPL.
-
-
Barza, M.1
-
4
-
-
16044374493
-
Immunologic distribution of an organic anion transport protein in rat liver and kidney
-
Bergwerk AJ, Shi X, Ford AC, Kanai N, Jacquemin E, Burk RD, Bai S, Novikoff PM, Stieger B, MeierPJ, et al. (1996) Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol 271:G231-G238.
-
(1996)
Am J Physiol
, vol.271
-
-
Bergwerk, A.J.1
Shi, X.2
Ford, A.C.3
Kanai, N.4
Jacquemin, E.5
Burk, R.D.6
Bai, S.7
Novikoff, P.M.8
Stieger, B.9
MeierPJ10
-
5
-
-
0025101871
-
Carnitine deficiency syndromes
-
Breningstall GN (1990) Carnitine deficiency syndromes. Pediatr Neurol 6:75-81.
-
(1990)
Pediatr Neurol
, vol.6
, pp. 75-81
-
-
Breningstall, G.N.1
-
6
-
-
33748919292
-
Endocrine rgulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression
-
Cheng X, Maher J, Lu H, and Klaassen CD (2006) Endocrine rgulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Mol Pharmacol 70:1291-1297.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1291-1297
-
-
Cheng, X.1
Maher, J.2
Lu, H.3
Klaassen, C.D.4
-
7
-
-
0037161834
-
Molecular identification of a renal urate-anion exchanger that regulates blood urate levels
-
Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, et al. (2002) Molecular identification of a renal urate-anion exchanger that regulates blood urate levels. Nature 417:447-452.
-
(2002)
Nature
, vol.417
, pp. 447-452
-
-
Enomoto, A.1
Kimura, H.2
Chairoungdua, A.3
Shigeta, Y.4
Jutabha, P.5
Cha, S.H.6
Hosoyamada, M.7
Takeda, M.8
Sekine, T.9
Igarashi, T.10
-
8
-
-
0034695673
-
3-Lactam antibiotics as substrates for OCTN2, an organic cation/ carnitine transporter
-
Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, and Ganapathy V (2000) /3-Lactam antibiotics as substrates for OCTN2, an organic cation/ carnitine transporter. J Biol Chem 275:1699-1707.
-
(2000)
J Biol Chem
, vol.275
, pp. 1699-1707
-
-
Ganapathy, M.E.1
Huang, W.2
Rajan, D.P.3
Carter, A.L.4
Sugawara, M.5
Iseki, K.6
Leibach, F.H.7
Ganapathy, V.8
-
9
-
-
0036081327
-
Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17/3-D-glucuronide in rats
-
Gotoh Y, Kato Y, Stieger B, Meier PJ, and Sugiyama Y (2002) Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17/3-D-glucuronide in rats. Am J Physiol Endocrinol Metab 282:E1245-E1254.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
-
-
Gotoh, Y.1
Kato, Y.2
Stieger, B.3
Meier, P.J.4
Sugiyama, Y.5
-
10
-
-
59649127836
-
The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate
-
Grigat S, Fork C, Bach M, Golz S, Geerts A, Schomig E, and Grundemann D (2009) The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. Drug Metab Dispos 37:330-337.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 330-337
-
-
Grigat, S.1
Fork, C.2
Bach, M.3
Golz, S.4
Geerts, A.5
Schomig, E.6
Grundemann, D.7
-
11
-
-
11144281351
-
Expression, localization, and function of the carnitine transporter OCTN2 (SLC22A5) in human placenta
-
Grube M, Schwabedissen HM, Draber K, Prager D, Moritz KU, Linnemann K, Fusch C, Jedlitschky G, and Kroemer HK (2005) Expression, localization, and function of the carnitine transporter OCTN2 (SLC22A5) in human placenta. Drug Metab Dispos 33:31-37.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 31-37
-
-
Grube, M.1
Schwabedissen, H.M.2
Draber, K.3
Prager, D.4
Moritz, K.U.5
Linnemann, K.6
Fusch, C.7
Jedlitschky, G.8
Kroemer, H.K.9
-
12
-
-
0242624720
-
Acetyl-L- carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2
-
Inano A, Sai Y, Nikaido H, Hasimoto N, Asano M, Tsuji A, and Tamai I (2003) Acetyl-L- carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos 24:357-365.
-
(2003)
Biopharm Drug Dispos
, vol.24
, pp. 357-365
-
-
Inano, A.1
Sai, Y.2
Nikaido, H.3
Hasimoto, N.4
Asano, M.5
Tsuji, A.6
Tamai, I.7
-
13
-
-
36049039871
-
Involvement of organic anion transport system in transdermal absorption of flurbiprofen
-
Ito K, Kato Y, Tsuji H, Nguyen HT, Kubo Y, and Tsuji A (2007) Involvement of organic anion transport system in transdermal absorption of flurbiprofen. J Control Release 124:60-68.
-
(2007)
J Control Release
, vol.124
, pp. 60-68
-
-
Ito, K.1
Kato, Y.2
Tsuji, H.3
Nguyen, H.T.4
Kubo, Y.5
Tsuji, A.6
-
14
-
-
48849091224
-
Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carni- tine to the heart
-
Iwata D, Kato Y, Wakayama T, Sai Y, Kubo Y, Iseki S, and Tsuji A (2008) Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carni- tine to the heart. Drug Metab Pharmacokinet 23:207-215.
-
(2008)
Drug Metab Pharmacokinet
, vol.23
, pp. 207-215
-
-
Iwata, D.1
Kato, Y.2
Wakayama, T.3
Sai, Y.4
Kubo, Y.5
Iseki, S.6
Tsuji, A.7
-
15
-
-
18344371636
-
Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: In comparison with rOAT1
-
Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim DK, Chairoungdua A, Choi BK, Kusuhara H, Sugiyama Y, et al. (2002) Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci 70:1861-1874.
-
(2002)
Life Sci
, vol.70
, pp. 1861-1874
-
-
Jung, K.Y.1
Takeda, M.2
Shimoda, M.3
Narikawa, S.4
Tojo, A.5
Kim, D.K.6
Chairoungdua, A.7
Choi, B.K.8
Kusuhara, H.9
Sugiyama, Y.10
-
16
-
-
0036073213
-
Gender difference in the urinary excretion of organic anions in rats
-
Kato Y, Kuge K, Kusuhara H, Meier PJ, and Sugiyama Y (2002) Gender difference in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther 302:483-489.
-
(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 483-489
-
-
Kato, Y.1
Kuge, K.2
Kusuhara, H.3
Meier, P.J.4
Sugiyama, Y.5
-
17
-
-
33747618018
-
Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse
-
Kato Y, Sugiura M, Sugiura T, Wakayama T, Kubo Y, Kobayashi D, Sai Y, Tamai I, Iseki S, and Tsuji A (2006) Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Mol Pharmacol 70:829-837.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 829-837
-
-
Kato, Y.1
Sugiura, M.2
Sugiura, T.3
Wakayama, T.4
Kubo, Y.5
Kobayashi, D.6
Sai, Y.7
Tamai, I.8
Iseki, S.9
Tsuji, A.10
-
18
-
-
0035209172
-
Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier
-
Kido Y, Tamai I, Ohnari A, Sai Y, Kagami T, Nezu J, Nikaido H, Hashimoto N, Asano M, and Tsuji A (2001) Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. J Neurochem 79:959-969.
-
(2001)
J Neurochem
, vol.79
, pp. 959-969
-
-
Kido, Y.1
Tamai, I.2
Ohnari, A.3
Sai, Y.4
Kagami, T.5
Nezu, J.6
Nikaido, H.7
Hashimoto, N.8
Asano, M.9
Tsuji, A.10
-
19
-
-
0032746479
-
Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency
-
Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, et al. (1999) Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency. Hum Mol Genet 8:2247-2254.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 2247-2254
-
-
Koizumi, A.1
Nozaki, J.2
Ohura, T.3
Kayo, T.4
Wada, Y.5
Nezu, J.6
Ohashi, R.7
Tamai, I.8
Shoji, Y.9
Takada, G.10
-
20
-
-
0023837255
-
Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2° strain of mouse with similarities to Reye's syndrome
-
Koizumi T, Nikaido H, Hayakawa J, Nonomura A, and Yoneda T (1988) Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2° strain of mouse with similarities to Reye's syndrome. Lab Anim 22:83-87.
-
(1988)
Lab Anim
, vol.22
, pp. 83-87
-
-
Koizumi, T.1
Nikaido, H.2
Hayakawa, J.3
Nonomura, A.4
Yoneda, T.5
-
21
-
-
0036205460
-
Gene expression levels and immunolocalization of organic ion transporters in the human kidney
-
Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, and Inui K (2002) Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13:866-874.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 866-874
-
-
Motohashi, H.1
Sakurai, Y.2
Saito, H.3
Masuda, S.4
Urakami, Y.5
Goto, M.6
Fukatsu, A.7
Ogawa, O.8
Inui, K.9
-
22
-
-
0032953645
-
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
-
Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, et al. (1999) Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 21:91-94.
-
(1999)
Nat Genet
, vol.21
, pp. 91-94
-
-
Nezu, J.1
Tamai, I.2
Oku, A.3
Ohashi, R.4
Yabuuchi, H.5
Hashimoto, N.6
Nikaido, H.7
Sai, Y.8
Koizumi, A.9
Shoji, Y.10
-
23
-
-
0035132434
-
Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2
-
Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, and Tsuji A (2001) Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol 59:358-366.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 358-366
-
-
Ohashi, R.1
Tamai, I.2
Nezu Ji, J.3
Nikaido, H.4
Hashimoto, N.5
Oku, A.6
Sai, Y.7
Shimane, M.8
Tsuji, A.9
-
24
-
-
0032696186
-
+-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
-
+-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther 291:778 -784.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 778-784
-
-
Ohashi, R.1
Tamai, I.2
Yabuuchi, H.3
Nezu, J.I.4
Oku, A.5
Sai, Y.6
Shimane, M.7
Tsuji, A.8
-
26
-
-
4344611974
-
Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 null (OCTN2(-/-)) mice
-
Shekhawat PS, Yang HS, Bennett MJ, Carter AL, Matern D, Tamai I, and Ganapathy V (2004) Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 null (OCTN2(-/-)) mice. Pediatr Res 56:323-328.
-
(2004)
Pediatr Res
, vol.56
, pp. 323-328
-
-
Shekhawat, P.S.1
Yang, H.S.2
Bennett, M.J.3
Carter, A.L.4
Matern, D.5
Tamai, I.6
Ganapathy, V.7
-
27
-
-
0033458777
-
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity
-
Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, and Endou H (1999) Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int 56:2128 -2136.
-
(1999)
Kidney Int
, vol.56
, pp. 2128-2136
-
-
Takeda, M.1
Tojo, A.2
Sekine, T.3
Hosoyamada, M.4
Kanai, Y.5
Endou, H.6
-
28
-
-
0035815991
-
Na+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
-
Tamai I, China K, Sai Y, Kobayashi D, Nezu J, Kawahara E, and Tsuji A (2001) Na+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta 1512:273-284.
-
(2001)
Biochim Biophys Acta
, vol.1512
, pp. 273-284
-
-
Tamai, I.1
China, K.2
Sai, Y.3
Kobayashi, D.4
Nezu, J.5
Kawahara, E.6
Tsuji, A.7
-
29
-
-
0032493741
-
Molecular and functional identification of sodium ion-dependent, high affinity human carni- tine transporter OCTN2
-
Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, and Tsuji A (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carni- tine transporter OCTN2. J Biol Chem 273:20378-20382.
-
(1998)
J Biol Chem
, vol.273
, pp. 20378-20382
-
-
Tamai, I.1
Ohashi, R.2
Nezu, J.3
Yabuuchi, H.4
Oku, A.5
Shimane, M.6
Sai, Y.7
Tsuji, A.8
-
30
-
-
0034704135
-
Molecular and functional characterization of organic cation/carnitine transporter family in mice
-
Tamai I, Ohashi R, Nezu JI, Sai Y, Kobayashi D, Oku A, Shimane M, and Tsuji A (2000) Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem 275:40064-40072.
-
(2000)
J Biol Chem
, vol.275
, pp. 40064-40072
-
-
Tamai, I.1
Ohashi, R.2
Nezu, J.I.3
Sai, Y.4
Kobayashi, D.5
Oku, A.6
Shimane, M.7
Tsuji, A.8
-
31
-
-
0024246260
-
Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle and fibroblasts
-
Treem WR, Stanley CA, Finegold DN, Hale DE, and Coates PM (1988) Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle and fibroblasts. N Engl J Med 319:1331-1336.
-
(1988)
N Engl J Med
, vol.319
, pp. 1331-1336
-
-
Treem, W.R.1
Stanley, C.A.2
Finegold, D.N.3
Hale, D.E.4
Coates, P.M.5
-
32
-
-
0033996647
-
Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Nptl
-
Uchino H, Tamai I, Yabuuchi H, China K, Miyamoto K, Takeda E, and Tsuji A (2000) Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Nptl. Antimicrob Agents Chemother 44:574-577.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 574-577
-
-
Uchino, H.1
Tamai, I.2
Yabuuchi, H.3
China, K.4
Miyamoto, K.5
Takeda, E.6
Tsuji, A.7
-
33
-
-
24344461838
-
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOATl
-
Ueo H, Motohashi H, Katsura T, and Inui K (2005) Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOATl. Biochem Pharmacol 70:1104-1113.
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 1104-1113
-
-
Ueo, H.1
Motohashi, H.2
Katsura, T.3
Inui, K.4
-
34
-
-
33751178828
-
Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5)
-
Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, et al. (2006) Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Mol Pharmacol 70:1602-1611.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 1602-1611
-
-
Urban, T.J.1
Gallagher, R.C.2
Brown, C.3
Castro, R.A.4
Lagpacan, L.L.5
Brett, C.M.6
Taylor, T.R.7
Carlson, E.J.8
Ferrin, T.E.9
Burchard, E.G.10
-
35
-
-
0032767691
-
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
-
Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, and Ganapathy V (1999) Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther 290:1482-1492.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 1482-1492
-
-
Wu, X.1
Huang, W.2
Prasad, P.D.3
Seth, P.4
Rajan, D.P.5
Leibach, F.H.6
Chen, J.7
Conway, S.J.8
Ganapathy, V.9
-
37
-
-
0032952772
-
Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice
-
andTsujiA
-
Yokogawa K, Higashi Y, Tamai I, Nomura M, Hashimoto N, Nikaido H, Hayakawa J, Miyamoto K, andTsujiA(1999) Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice. J Pharmacol Exp Ther 289:224-230.
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 224-230
-
-
Yokogawa, K.1
Higashi, Y.2
Tamai, I.3
Nomura, M.4
Hashimoto, N.5
Nikaido, H.6
Hayakawa, J.7
Miyamoto, K.8
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