PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice

Drug Metabolism and Disposition

Volumn 36, Issue 6, 2008, Pages 1181-1188

  Sugiura, Tomoko ^a   Kato, Yukio ^a   Wakayama, Tomohiko ^a   Silver, David L ^b   Kubo, Yoshiyuki ^a   Iseki, Shoichi ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; CEFALEXIN; ORGANIC CATION TRANSPORTER 2; PDZ PROTEIN; PEPTIDE TRANSPORTER 1; PHENAZONE; POSTSYNAPTIC DENSITY PROTEIN 95;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SMALL INTESTINE MUCOSA;

ANIMALS; ANTI-BACTERIAL AGENTS; CARNITINE; CELL LINE; CEPHALEXIN; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, KNOCKOUT; ORGANIC CATION TRANSPORT PROTEINS; RNA, MESSENGER; SYMPORTERS;

MUS;

EID: 44149117976     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.020321     Document Type: Article

References (40)

1. Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, et al. (2004) The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J Biol Chem 279:45942-45950.
2. Chu XY, Sanchez-Castano GP, Higaki K, Oh DM, Hsu CP, and Amidon GL (2001) Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter. J Pharmacol Exp Ther 299:575-582.
3. Frieman DI and Amidon GL (1990) Passive and carrier-mediated intestinal absorption components of two ACE-inhibitor prodrugs in rats; enalapril and fosinopril. Pharm Res 6:1043-1047.
4. Ganapathy V and Leibach FH (1985) Is intestinal peptide transport energized by a proton gradient? Am J Physiol 249:G153-G160.
5. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao Z, Manser E, Biber J, et al. (2003) PDZK1. I. A major scaffolder in brush borders of proximal tubular cells. Kidney Int 64:1733-1745.
6. Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, Yun C, Kocher O, and Seidler U (2007) Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice. Pflugers Arch 454:575-586.
7. Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, and Lim WA (1999) Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 284:812-815.
8. Hu M and Amidon GL (1988) Intestinal absorption of captopril in rats. J Pharm Sci 77:1007-1011.
9. Kato Y, Sai Y, Yoshida K, Watanabe C, Hirata T, and Tsuji A (2005) PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Mol Pharmacol 67:734-743.
10. Kato Y, Sugiura M, Sugiura T, Wakayama T, Kubo Y, Kobayashi D, Sai Y, Tamai I, Iseki S, and Tsuji A (2006) Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Mol Pharmacol 70:1-9.
11. Kato Y, Yoshida K, Watanabe C, Sai Y, and Tsuji A (2004) Screening of the interaction between xenobiotic transporters and PDZ proteins. Pharm Res 21:1886-1894.
12. + exchange activity. Pflügers Arch 445:139-146.
13. Kocher O, Pal R, Roberts M, Cirovic C, and Gilchrist A (2003) Targeted disruption of the PDZK1 gene by homologous recombination. Mol Cell Biol 23:1175-1180.
14. Kramer W, Girbig F, Gutjahr U, Kleemann HW, Leipe I, Urbach H, and Wagner A (1990) Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics. Biochim Biophys Acta 1027:25-30.
15. Lan D and Silver DL (2005) Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1. J Biol Chem 280:23390-23396.
16. Miyazaki H, Anzai N, Ekaratanawong S, Sakata T, Shin HJ, Jutabha P, Hirata T, He X, Nonoguchi H, Tomita K, et al. (2005) Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J Am Soc Nephrol 16:3498-3506.
17. Nakanishi T, Tamai I, Sai Y, Sasaki T, and Tsuji A (1997) Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080. Cancer Res 57:4118-4122.
18. Naruhashi K, Sai Y, Tamai I, Suzuki N, and Tsuji A (2002) PepT1 mRNA expression is induced by starvation and its level correlates with absorption transport of cefadroxil longitudinally in the rat intestine. Pharm Res 19:1417-1423.
19. Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, et al. (1999) Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet 21:91-94.
20. Ohashi R, Tamai I, Nezu J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, and Tsuji A (2001) Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol 59:358-366.
21. Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, and Murer H (2003) Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells. Am J Physiol 285:F784-F791.
22. Rebouche CJ and Paulson DJ (1986) Carnitine metabolism and function in humans. Annu Rev Nutr 6:41-66.
23. Rossmann H, Jacob P, Baisch S, Hassoun R, Meier J, Natour D, Yahya K, Yun C, Biber J, Lackner KJ, et al. (2005) The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa. Biochemistry 44:4477-4487.
24. Sai Y, Tamai I, Sumikawa H, Hayashi K, Nakanishi T, Amano O, Numata M, Iseki S, and Tsuji A (1996) Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of beta-lactam antibiotics. FEBS Lett 392:25-29.
25. Saito H, Ishii T, and Inui K (1993) Expression of human intestinal dipeptide transporter in Xenopus laevis oocytes. Biochem Pharmacol 45:776-779.
26. Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, et al. (2007) The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature 448:366-369.
27. Silver DL, Wang N, and Vogel S (2003) Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. J Biol Chem 278:28528-28532.
28. Sugiura T, Kato Y, Kubo Y, and Tsuji A (2006) Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2. Drug Metab Pharmacokinet 21:375-383.
29. Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, Shiraga T, Miyamoto K, Takeda E, Higashida H, and Tsuji A (1997) The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of β-lactam antibiotics in the rat small intestine. J Pharm Pharmacol 49:796-801.
30. Tamai I, Ohashi R, Nezu J, Sai Y, Kobayashi D, Oku A, Shimane M, and Tsuji A (2000) Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem 275:40064-40072.
31. + exchanger. Gastroenterology 122:1322-1333.
32. Tsuji A, Nakashima E, Asano T, Nakashima R, and Yamana T (1979) Saturable absorption of amino-cephalosporins by the rat intestine. J Pharm Pharmacol 31:718-720.
33. Tsuji A, Nakashima E, Kagami I, and Yamana T (1981) Intestinal absorption mechanism of amphoteric beta-lactam antibiotics I: comparative antibiotics by in situ rat small intestine. J Pharm Sci 70:768-772.
34. Tsuji A and Tamai I (1996) Carrier-mediated intestinal transport of drugs. Pharm Res 13:963-977.
35. + gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. J Pharmacol Exp Ther 241:594-601.
36. Wakayama T, Koami H, Yamamoto M, and Iseki S (2004) Expression of the adhesion molecule spermatogenic immunoglobulin superfamily (SgIGSF) in mouse tissues. Acta Histochem Cytochem 37:365-371.
37. Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, and Wolkoff AW (2005) Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem 280:30143-30149.
38. Wang S, Yue H, Derin RB, Guggino WB, and Li M (2000) Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell 103:169-179.
39. +/oligopeptide transporter 1. Drug Metab Pharmacokinet 20:443-451.
40. Yokogawa K, Higashi Y, Tamai I, Nomura M, Hashimoto N, Nikaido H, Hayakawa J, Miyamoto K, and Tsuji A (1999) Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice. J Pharmacol Exp Ther 289:224-230.