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Volumn 160, Issue 3, 2013, Pages 303-320

Genetic profiling in acute myeloid leukaemia {box drawings light horizontal} where are we and what is its role in patient management

Author keywords

Acute myeloid leukaemia; Acute myeloid leukaemia classification; Genetic interaction; Genetic profile

Indexed keywords

ANTHRACYCLINE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CD135 ANTIGEN; DAUNORUBICIN; DNA METHYLTRANSFERASE 3A; INTERLEUKIN 2 RECEPTOR ALPHA; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; MICRORNA; NUCLEOPHOSMIN;

EID: 84872597896     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12135     Document Type: Review
Times cited : (44)

References (127)
  • 1
  • 2
    • 81255158158 scopus 로고    scopus 로고
    • The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine
    • Ahmad, E.I., Gawish, H.H., Al Azizi, N.M. & Elhefni, A.M. (2011) The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine. OncoTargets and Therapy, 4, 115-121.
    • (2011) OncoTargets and Therapy , vol.4 , pp. 115-121
    • Ahmad, E.I.1    Gawish, H.H.2    Al Azizi, N.M.3    Elhefni, A.M.4
  • 3
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel, D.P. (2009) MicroRNAs: target recognition and regulatory functions. Cell, 136, 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 14
    • 67651024980 scopus 로고    scopus 로고
    • C/EBPα initiates primitive myelopoiesis in pluripotent embryonic cells
    • Chen, Y., Costa, R.M.B., Love, N.R., Soto, X., Roth, M., Paredes, R. & Amaya, E. (2009) C/EBPα initiates primitive myelopoiesis in pluripotent embryonic cells. Blood, 114, 40-48.
    • (2009) Blood , vol.114 , pp. 40-48
    • Chen, Y.1    Costa, R.M.B.2    Love, N.R.3    Soto, X.4    Roth, M.5    Paredes, R.6    Amaya, E.7
  • 22
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
    • Dohner, K., Schlenk, R.F., Habdank, M., Scholl, C., Rucker, F.G., Corbacioglu, A., Bullinger, L., Frohling, S. & Dohner, H. (2005) Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood, 106, 3740-3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Dohner, K.1    Schlenk, R.F.2    Habdank, M.3    Scholl, C.4    Rucker, F.G.5    Corbacioglu, A.6    Bullinger, L.7    Frohling, S.8    Dohner, H.9
  • 24
    • 84865838761 scopus 로고    scopus 로고
    • EuroFlow: resetting leukemia and lymphoma immunophenotyping. Basis for companion diagnostics and personalized medicine
    • van Dongen, J.J. & Orfao, A. (2012) EuroFlow: resetting leukemia and lymphoma immunophenotyping. Basis for companion diagnostics and personalized medicine. Leukemia, 26, 1899-1907.
    • (2012) Leukemia , vol.26 , pp. 1899-1907
    • van Dongen, J.J.1    Orfao, A.2
  • 26
    • 79958025809 scopus 로고    scopus 로고
    • Treatment of acute myeloid leukemia in the elderly
    • Estey, E.H. (2011) Treatment of acute myeloid leukemia in the elderly. Haematologica, 96, 795-798.
    • (2011) Haematologica , vol.96 , pp. 795-798
    • Estey, E.H.1
  • 28
    • 80053545678 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy
    • Fathi, A.T. & Abdel-Wahab, O. (2012) Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy. Advances in Hematology, 2012, 469592.
    • (2012) Advances in Hematology , vol.2012 , pp. 469592
    • Fathi, A.T.1    Abdel-Wahab, O.2
  • 34
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale, R.E., Green, C., Allen, C., Mead, A.J., Burnett, A.K., Hills, R.K. & Linch, D.C. (2008) The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood, 111, 2776-2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3    Mead, A.J.4    Burnett, A.K.5    Hills, R.K.6    Linch, D.C.7
  • 35
    • 78650444882 scopus 로고    scopus 로고
    • Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    • Gentles, A.J., Plevritis, S.K., Majeti, R. & Alizadeh, A.A. (2010) Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA, 304, 2706-2715.
    • (2010) JAMA , vol.304 , pp. 2706-2715
    • Gentles, A.J.1    Plevritis, S.K.2    Majeti, R.3    Alizadeh, A.A.4
  • 37
    • 77957759961 scopus 로고    scopus 로고
    • The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    • Green, C.L., Evans, C.M., Hills, R.K., Burnett, A.K., Linch, D.C. & Gale, R.E. (2010) The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. Blood, 116, 2779-2782.
    • (2010) Blood , vol.116 , pp. 2779-2782
    • Green, C.L.1    Evans, C.M.2    Hills, R.K.3    Burnett, A.K.4    Linch, D.C.5    Gale, R.E.6
  • 38
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    • Green, C.L., Evans, C.M., Zhao, L., Hills, R.K., Burnett, A.K., Linch, D.C. & Gale, R.E. (2011) The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood, 118, 409-412.
    • (2011) Blood , vol.118 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3    Hills, R.K.4    Burnett, A.K.5    Linch, D.C.6    Gale, R.E.7
  • 39
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade, D., Walker, H., Oliver, F., Wheatley, K., Harrison, C., Harrison, G., Rees, J., Hann, I., Stevens, R., Burnett, A. & Goldstone, A. (1998) The importance of diagnostic cytogenetics on outcome in AML: analysis of 1, 612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood, 92, 2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3    Wheatley, K.4    Harrison, C.5    Harrison, G.6    Rees, J.7    Hann, I.8    Stevens, R.9    Burnett, A.10    Goldstone, A.11
  • 40
    • 0035469883 scopus 로고    scopus 로고
    • The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade, D., Walker, H., Harrison, G., Oliver, F., Chatters, S., Harrison, C.J., Wheatley, K., Burnett, A.K. & Goldstone, A.H. (2001) The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood, 98, 1312-1320.
    • (2001) Blood , vol.98 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3    Oliver, F.4    Chatters, S.5    Harrison, C.J.6    Wheatley, K.7    Burnett, A.K.8    Goldstone, A.H.9
  • 41
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
    • Grimwade, D., Hills, R.K., Moorman, A.V., Walker, H., Chatters, S., Goldstone, A.H., Wheatley, K., Harrison, C.J. & Burnett, A.K. (2010a) Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood, 116, 354-365.
    • (2010) Blood , vol.116 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3    Walker, H.4    Chatters, S.5    Goldstone, A.H.6    Wheatley, K.7    Harrison, C.J.8    Burnett, A.K.9
  • 42
    • 77958468721 scopus 로고    scopus 로고
    • Assessment of minimal residual disease in acute myeloid leukemia
    • Grimwade, D., Vyas, P. & Freeman, S. (2010b) Assessment of minimal residual disease in acute myeloid leukemia. Current Opinion in Oncology, 22, 656-663.
    • (2010) Current Opinion in Oncology , vol.22 , pp. 656-663
    • Grimwade, D.1    Vyas, P.2    Freeman, S.3
  • 46
    • 84857711160 scopus 로고    scopus 로고
    • Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotype
    • Haferlach, C., Alpermann, T., Schnittger, S., Kern, W., Chromik, J., Schmid, C., Pielken, H.J., Kreuzer, K.A., Hoffkes, H.G. & Haferlach, T. (2012a) Prognostic value of monosomal karyotype in comparison to complex aberrant karyotype in acute myeloid leukemia: a study on 824 cases with aberrant karyotype. Blood, 119, 2122-2125.
    • (2012) Blood , vol.119 , pp. 2122-2125
    • Haferlach, C.1    Alpermann, T.2    Schnittger, S.3    Kern, W.4    Chromik, J.5    Schmid, C.6    Pielken, H.J.7    Kreuzer, K.A.8    Hoffkes, H.G.9    Haferlach, T.10
  • 47
    • 84855473821 scopus 로고    scopus 로고
    • Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia
    • Haferlach, C., Kern, W., Schindela, S., Kohlmann, A., Alpermann, T., Schnittger, S. & Haferlach, T. (2012b) Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia. Genes Chromosomes Cancer, 51, 257-265.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 257-265
    • Haferlach, C.1    Kern, W.2    Schindela, S.3    Kohlmann, A.4    Alpermann, T.5    Schnittger, S.6    Haferlach, T.7
  • 48
    • 80053903465 scopus 로고    scopus 로고
    • Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling
    • Havelange, V., Stauffer, N., Heaphy, C.C., Volinia, S., Andreeff, M., Marcucci, G., Croce, C.M. & Garzon, R. (2011) Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling. Cancer, 117, 4696-4706.
    • (2011) Cancer , vol.117 , pp. 4696-4706
    • Havelange, V.1    Stauffer, N.2    Heaphy, C.C.3    Volinia, S.4    Andreeff, M.5    Marcucci, G.6    Croce, C.M.7    Garzon, R.8
  • 50
    • 33845512736 scopus 로고    scopus 로고
    • Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a prospective clinical trial
    • van der Holt, B., Breems, D.A., Berna Beverloo, H., van den Berg, E., Burnett, A.K., Sonneveld, P. & Lowenberg, B. (2007) Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a prospective clinical trial. British Journal of Haematology, 136, 96-105.
    • (2007) British Journal of Haematology , vol.136 , pp. 96-105
    • van der Holt, B.1    Breems, D.A.2    Berna Beverloo, H.3    Van Den Berg, E.4    Burnett, A.K.5    Sonneveld, P.6    Lowenberg, B.7
  • 51
  • 54
    • 0025780876 scopus 로고
    • Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML
    • Kakizuka, A., Miller, W.H. Jr, Umesono, K., Warrell, R.P. Jr, Frankel, S.R., Murty, V.V., Dmitrovsky, E. & Evans, R.M. (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell, 66, 663-674.
    • (1991) Cell , vol.66 , pp. 663-674
    • Kakizuka, A.1    Miller Jr., W.H.2    Umesono, K.3    Warrell Jr., R.P.4    Frankel, S.R.5    Murty, V.V.6    Dmitrovsky, E.7    Evans, R.M.8
  • 57
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis, P.D., Gale, R.E., Frew, M.E., Harrison, G., Langabeer, S.E., Belton, A.A., Walker, H., Wheatley, K., Bowen, D.T., Burnett, A.K., Goldstone, A.H. & Linch, D.C. (2001) The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood, 98, 1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5    Belton, A.A.6    Walker, H.7    Wheatley, K.8    Bowen, D.T.9    Burnett, A.K.10    Goldstone, A.H.11    Linch, D.C.12
  • 58
    • 0036785393 scopus 로고    scopus 로고
    • Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
    • Kottaridis, P.D., Gale, R.E., Langabeer, S.E., Frew, M.E., Bowen, D.T. & Linch, D.C. (2002) Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood, 100, 2393-2398.
    • (2002) Blood , vol.100 , pp. 2393-2398
    • Kottaridis, P.D.1    Gale, R.E.2    Langabeer, S.E.3    Frew, M.E.4    Bowen, D.T.5    Linch, D.C.6
  • 59
    • 70449711157 scopus 로고    scopus 로고
    • Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts
    • Le Dieu, R., Taussig, D.C., Ramsay, A.G., Mitter, R., Miraki-Moud, F., Fatah, R., Lee, A.M., Lister, T.A. & Gribben, J.G. (2009) Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts. Blood, 114, 3909-3916.
    • (2009) Blood , vol.114 , pp. 3909-3916
    • Le Dieu, R.1    Taussig, D.C.2    Ramsay, A.G.3    Mitter, R.4    Miraki-Moud, F.5    Fatah, R.6    Lee, A.M.7    Lister, T.A.8    Gribben, J.G.9
  • 62
    • 84872612953 scopus 로고    scopus 로고
    • CR-UK biomarker roadmaps. In: AACR Meeting Abstracts, Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development- Sep 27-30, 2010; Denver, CO, 2010: B33a.
    • Lioumi, M. & Newell, D. (2010) CR-UK biomarker roadmaps. In: AACR Meeting Abstracts, Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development- Sep 27-30, 2010; Denver, CO, 2010: B33a. http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2010/1_Molecular_Diagnostics_Meeting/B33.
    • (2010)
    • Lioumi, M.1    Newell, D.2
  • 67
    • 79251585937 scopus 로고    scopus 로고
    • The prognostic and functional role of microRNAs in acute myeloid leukemia
    • Marcucci, G., Mrozek, K., Radmacher, M.D., Garzon, R. & Bloomfield, C.D. (2011) The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood, 117, 1121-1129.
    • (2011) Blood , vol.117 , pp. 1121-1129
    • Marcucci, G.1    Mrozek, K.2    Radmacher, M.D.3    Garzon, R.4    Bloomfield, C.D.5
  • 71
    • 84856366956 scopus 로고    scopus 로고
    • Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies
    • McDevitt, M.A. (2012) Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies. Seminars in Oncology, 39, 109-122.
    • (2012) Seminars in Oncology , vol.39 , pp. 109-122
    • McDevitt, M.A.1
  • 72
    • 77957715843 scopus 로고    scopus 로고
    • Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience
    • Medeiros, B.C., Othus, M., Fang, M., Roulston, D. & Appelbaum, F.R. (2010) Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood, 116, 2224-2228.
    • (2010) Blood , vol.116 , pp. 2224-2228
    • Medeiros, B.C.1    Othus, M.2    Fang, M.3    Roulston, D.4    Appelbaum, F.R.5
  • 77
    • 84862150331 scopus 로고    scopus 로고
    • Acute myeloid leukemia and myelodysplastic syndromes after radiation therapy are similar to de novo disease and differ from other therapy-related myeloid neoplasms
    • Nardi, V., Winkfield, K.M., Ok, C.Y., Niemierko, A., Kluk, M.J., Attar, E.C., Garcia-Manero, G., Wang, S.A. & Hasserjian, R.P. (2012) Acute myeloid leukemia and myelodysplastic syndromes after radiation therapy are similar to de novo disease and differ from other therapy-related myeloid neoplasms. Journal of Clinical Oncology, 30, 2340-2347.
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 2340-2347
    • Nardi, V.1    Winkfield, K.M.2    Ok, C.Y.3    Niemierko, A.4    Kluk, M.J.5    Attar, E.C.6    Garcia-Manero, G.7    Wang, S.A.8    Hasserjian, R.P.9
  • 81
    • 77950990572 scopus 로고    scopus 로고
    • Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies
    • O'Keefe, C., McDevitt, M.A. & Maciejewski, J.P. (2010) Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies. Blood, 115, 2731-2739.
    • (2010) Blood , vol.115 , pp. 2731-2739
    • O'Keefe, C.1    McDevitt, M.A.2    Maciejewski, J.P.3
  • 83
    • 80052097088 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia
    • Park, S.H., Chi, H.S., Min, S.K., Park, B.G., Jang, S. & Park, C.J. (2011) Prognostic impact of c-KIT mutations in core binding factor acute myeloid leukemia. Leukemia Research, 35, 1376-1383.
    • (2011) Leukemia Research , vol.35 , pp. 1376-1383
    • Park, S.H.1    Chi, H.S.2    Min, S.K.3    Park, B.G.4    Jang, S.5    Park, C.J.6
  • 85
  • 93
    • 79952366279 scopus 로고    scopus 로고
    • Metabolism unhinged: IDH mutations in cancer
    • Prensner, J.R. & Chinnaiyan, A.M. (2011) Metabolism unhinged: IDH mutations in cancer. Nature Medicine, 17, 291-293.
    • (2011) Nature Medicine , vol.17 , pp. 291-293
    • Prensner, J.R.1    Chinnaiyan, A.M.2
  • 96
    • 68549132617 scopus 로고    scopus 로고
    • Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association
    • Renneville, A., Boissel, N., Zurawski, V., Llopis, L., Biggio, V., Nibourel, O., Philippe, N., Thomas, X., Dombret, H. & Preudhomme, C. (2009b) Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association. Cancer, 115, 3719-3727.
    • (2009) Cancer , vol.115 , pp. 3719-3727
    • Renneville, A.1    Boissel, N.2    Zurawski, V.3    Llopis, L.4    Biggio, V.5    Nibourel, O.6    Philippe, N.7    Thomas, X.8    Dombret, H.9    Preudhomme, C.10
  • 103
    • 0032170594 scopus 로고    scopus 로고
    • Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors
    • Schnittger, S., Wormann, B., Hiddemann, W. & Griesinger, F. (1998) Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors. Blood, 92, 1728-1734.
    • (1998) Blood , vol.92 , pp. 1728-1734
    • Schnittger, S.1    Wormann, B.2    Hiddemann, W.3    Griesinger, F.4
  • 104
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger, S., Schoch, C., Kern, W., Mecucci, C., Tschulik, C., Martelli, M.F., Haferlach, T., Hiddemann, W. & Falini, B. (2005) Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood, 106, 3733-3739.
    • (2005) Blood , vol.106 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3    Mecucci, C.4    Tschulik, C.5    Martelli, M.F.6    Haferlach, T.7    Hiddemann, W.8    Falini, B.9
  • 105
    • 33344465478 scopus 로고    scopus 로고
    • KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
    • Schnittger, S., Kohl, T.M., Haferlach, T., Kern, W., Hiddemann, W., Spiekermann, K. & Schoch, C. (2006) KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival. Blood, 107, 1791-1799.
    • (2006) Blood , vol.107 , pp. 1791-1799
    • Schnittger, S.1    Kohl, T.M.2    Haferlach, T.3    Kern, W.4    Hiddemann, W.5    Spiekermann, K.6    Schoch, C.7
  • 106
    • 0141816710 scopus 로고    scopus 로고
    • AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases
    • Schoch, C., Schnittger, S., Klaus, M., Kern, W., Hiddemann, W. & Haferlach, T. (2003) AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood, 102, 2395-2402.
    • (2003) Blood , vol.102 , pp. 2395-2402
    • Schoch, C.1    Schnittger, S.2    Klaus, M.3    Kern, W.4    Hiddemann, W.5    Haferlach, T.6
  • 112
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede, C., Steudel, C., Mohr, B., Schaich, M., Schakel, U., Platzbecker, U., Wermke, M., Bornhauser, M., Ritter, M., Neubauer, A., Ehninger, G. & Illmer, T. (2002) Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood, 99, 4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schakel, U.5    Platzbecker, U.6    Wermke, M.7    Bornhauser, M.8    Ritter, M.9    Neubauer, A.10    Ehninger, G.11    Illmer, T.12
  • 113
    • 33646557337 scopus 로고    scopus 로고
    • Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    • Thiede, C., Koch, S., Creutzig, E., Steudel, C., Illmer, T., Schaich, M. & Ehninger, G. (2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood, 107, 4011-4020.
    • (2006) Blood , vol.107 , pp. 4011-4020
    • Thiede, C.1    Koch, S.2    Creutzig, E.3    Steudel, C.4    Illmer, T.5    Schaich, M.6    Ehninger, G.7
  • 115
    • 84555191728 scopus 로고    scopus 로고
    • Dnmt3a silences hematopoietic stem cell self-renewal
    • Trowbridge, J.J. & Orkin, S.H. (2012) Dnmt3a silences hematopoietic stem cell self-renewal. Nature Genetics, 44, 13-14.
    • (2012) Nature Genetics , vol.44 , pp. 13-14
    • Trowbridge, J.J.1    Orkin, S.H.2
  • 119
    • 80052493235 scopus 로고    scopus 로고
    • Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia
    • Wakita, S., Yamaguchi, H., Miyake, K., Mitamura, Y., Kosaka, F., Dan, K. & Inokuchi, K. (2011) Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia. Leukemia, 25, 1423-1432.
    • (2011) Leukemia , vol.25 , pp. 1423-1432
    • Wakita, S.1    Yamaguchi, H.2    Miyake, K.3    Mitamura, Y.4    Kosaka, F.5    Dan, K.6    Inokuchi, K.7
  • 122
    • 58849167390 scopus 로고    scopus 로고
    • A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects
    • Wouters, B.J., Lowenberg, B. & Delwel, R. (2009a) A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects. Blood, 113, 291-298.
    • (2009) Blood , vol.113 , pp. 291-298
    • Wouters, B.J.1    Lowenberg, B.2    Delwel, R.3
  • 123
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters, B.J., Lowenberg, B., Erpelinck- Verschueren, C.A., van Putten, W.L., Valk, P.J. & Delwel, R. (2009b) Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood, 113, 3088-3091.
    • (2009) Blood , vol.113 , pp. 3088-3091
    • Wouters, B.J.1    Lowenberg, B.2    Erpelinck-Verschueren, C.A.3    van Putten, W.L.4    Valk, P.J.5    Delwel, R.6
  • 126
    • 84867297401 scopus 로고    scopus 로고
    • Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial
    • Yin, J.A., O' Brien, M.A., Hills, R.K., Daly, S.B., Wheatley, K. & Burnett, A.K. (2012) Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial. Blood, 120, 2826-2835.
    • (2012) Blood , vol.120 , pp. 2826-2835
    • Yin, J.A.1    O'Brien, M.A.2    Hills, R.K.3    Daly, S.B.4    Wheatley, K.5    Burnett, A.K.6


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