-
1
-
-
85047690606
-
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease
-
Chan IT, Kato JL, Williams IR, et al. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest. 2004;113(4):528-538.
-
(2004)
J Clin Invest
, vol.113
, Issue.4
, pp. 528-538
-
-
Chan, I.T.1
Kato, J.L.2
Williams, I.R.3
-
2
-
-
0037264633
-
Targeting RAS signaling pathways in cancer therapy
-
Downward J. Targeting RAS signaling pathways in cancer therapy. Nat Rev Cancer. 2003;3(1):11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.1
, pp. 11-22
-
-
Downward, J.1
-
3
-
-
64849100299
-
Molecular genetic pathways as therapeutic targets in acute myeloid leukemia
-
Haferlach T. Molecular genetic pathways as therapeutic targets in acute myeloid leukemia. Hematology Am Soc Hematol Educ Program. 2008:400-411.
-
(2008)
Hematology Am Soc Hematol Educ Program
, pp. 400-411
-
-
Haferlach, T.1
-
4
-
-
0037810249
-
Signal transduction mediated by the Ras/Raf, MEK, and ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
-
Chang F, Steelman LS, Lee JT, et al. Signal transduction mediated by the Ras/Raf, MEK, and ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia. 2003;17(7):1263-1293.
-
(2003)
Leukemia
, vol.17
, Issue.7
, pp. 1263-1293
-
-
Chang, F.1
Steelman, L.S.2
Lee, J.T.3
-
5
-
-
18244383283
-
Activation of the RAS pathway for a chemosensitive phenotype of acute myelogenous leukemia blasts
-
Illmer T, Thiede C, Fredersdorf A, et al. Activation of the RAS pathway for a chemosensitive phenotype of acute myelogenous leukemia blasts. Clin Cancer Res. 2005;11(9):3217-3224.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.9
, pp. 3217-3224
-
-
Illmer, T.1
Thiede, C.2
Fredersdorf, A.3
-
6
-
-
2442521341
-
RAS gene mutations in patients with acute myeloid leukemia and exposure to chemical agents
-
Barletta E, Gorini G, Vineis P, et al. RAS gene mutations in patients with acute myeloid leukemia and exposure to chemical agents. Carcinogenesis. 2004;25(5):749-755.
-
(2004)
Carcinogenesis
, vol.25
, Issue.5
, pp. 749-755
-
-
Barletta, E.1
Gorini, G.2
Vineis, P.3
-
7
-
-
11244357067
-
The normal response to RAS: Senescence or transformation?
-
Benanti JA, Galloway DA. The normal response to RAS: senescence or transformation? Cell Cycle. 2004;3(6):715-717.
-
(2004)
Cell Cycle
, vol.3
, Issue.6
, pp. 715-717
-
-
Benanti, J.A.1
Galloway, D.A.2
-
8
-
-
0034823632
-
Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
-
Milella M, Komblau SM, Estrov Z, et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest. 2001;108(6):851-859.
-
(2001)
J Clin Invest
, vol.108
, Issue.6
, pp. 851-859
-
-
Milella, M.1
Komblau, S.M.2
Estrov, Z.3
-
9
-
-
0031023137
-
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: A prospective study
-
Rodenhuis S, Boerrigter L, Top B, et al. Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study. J Clin Oncol. 1997;15(1):285-291.
-
(1997)
J Clin Oncol
, vol.15
, Issue.1
, pp. 285-291
-
-
Rodenhuis, S.1
Boerrigter, L.2
Top, B.3
-
10
-
-
0033134792
-
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
-
Kiyoi H, Naoe T, Nakano Y, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93(9):3074-3080.
-
(1999)
Blood
, vol.93
, Issue.9
, pp. 3074-3080
-
-
Kiyoi, H.1
Naoe, T.2
Nakano, Y.3
-
11
-
-
0035383768
-
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
-
Stirewalt DL, Kopecky KJ, Meshinchi S, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood. 2001;97(11):3589-3595.
-
(2001)
Blood
, vol.97
, Issue.11
, pp. 3589-3595
-
-
Stirewalt, D.L.1
Kopecky, K.J.2
Meshinchi, S.3
-
12
-
-
0015246254
-
A rapid banding technique for human chromosomes
-
Seabright M. A rapid banding technique for human chromosomes. Lancet. 1971;2(7731):971-972.
-
(1971)
Lancet
, vol.2
, Issue.7731
, pp. 971-972
-
-
Seabright, M.1
-
13
-
-
0028114788
-
The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia
-
Coghlan DW, Morley AA, Matthews JP, Bishop JF. The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia. Leukemia. 1994;8(10):1682-1687.
-
(1994)
Leukemia
, vol.8
, Issue.10
, pp. 1682-1687
-
-
Coghlan, D.W.1
Morley, A.A.2
Matthews, J.P.3
Bishop, J.F.4
-
14
-
-
61849150985
-
High-throughput sequencing screen reveals novel transforming RAS mutations in myeloid leukemia patients
-
Tyner JW, Erichson H, Deininger MW, et al. High-throughput sequencing screen reveals novel transforming RAS mutations in myeloid leukemia patients. Blood. 2009;113(8):1749-1755.
-
(2009)
Blood
, vol.113
, Issue.8
, pp. 1749-1755
-
-
Tyner, J.W.1
Erichson, H.2
Deininger, M.W.3
-
15
-
-
9144253166
-
Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia
-
Ritter M, Kim TD, Lisske P, Thiede C, Schaich M, Neubauer A. Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia. Haematologica. 2004;89(11):1397-1399.
-
(2004)
Haematologica
, vol.89
, Issue.11
, pp. 1397-1399
-
-
Ritter, M.1
Kim, T.D.2
Lisske, P.3
Thiede, C.4
Schaich, M.5
Neubauer, A.6
-
16
-
-
0028214608
-
Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia
-
Neubauer A, Dodge RK, George SL, et al. Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia. Blood. 1994;83(6):1603-1611.
-
(1994)
Blood
, vol.83
, Issue.6
, pp. 1603-1611
-
-
Neubauer, A.1
Dodge, R.K.2
George, S.L.3
-
17
-
-
24744449132
-
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
-
Bowen DT, Frew ME, Hills R, et al. RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years. Blood. 2005;106(6):2113-2119.
-
(2005)
Blood
, vol.106
, Issue.6
, pp. 2113-2119
-
-
Bowen, D.T.1
Frew, M.E.2
Hills, R.3
-
18
-
-
0842328518
-
Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16)
-
Valk PJ, Bowen DT, Frew ME, Goodeve AC, Lowenberg B, Reilly JT. Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16). Haematologica. 2004;89(1):106.
-
(2004)
Haematologica
, vol.89
, Issue.1
, pp. 106
-
-
Valk, P.J.1
Bowen, D.T.2
Frew, M.E.3
Goodeve, A.C.4
Lowenberg, B.5
Reilly, J.T.6
-
19
-
-
0035127543
-
Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukemia
-
Schaich M, Ritter M, Illmer T, et al. Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukemia. Br J Haematol. 2001;112(2):300-307.
-
(2001)
Br J Haematol
, vol.112
, Issue.2
, pp. 300-307
-
-
Schaich, M.1
Ritter, M.2
Illmer, T.3
-
20
-
-
0041737454
-
Activating mutations of RTK/RAS signal transduction pathway in pediatric acute myeloid leukemia
-
Meshinchi S, Stirewalt DL, Alonzo TA, et al. Activating mutations of RTK/RAS signal transduction pathway in pediatric acute myeloid leukemia. Blood. 2003;102(4):1474-1479.
-
(2003)
Blood
, vol.102
, Issue.4
, pp. 1474-1479
-
-
Meshinchi, S.1
Stirewalt, D.L.2
Alonzo, T.A.3
-
21
-
-
0345743699
-
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
-
Braun BS, Tuveson DA, Kong N, et al. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004;101(2):597-602.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.2
, pp. 597-602
-
-
Braun, B.S.1
Tuveson, D.A.2
Kong, N.3
-
22
-
-
33646575624
-
Implications of NRAS mutations in AML: A study of 2502 patients
-
Bacher U, Haferlach T, Schoch C, Kern W, Schnittger S. Implications of NRAS mutations in AML: a study of 2502 patients. Blood. 2006;107(10):3847-3853.
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 3847-3853
-
-
Bacher, U.1
Haferlach, T.2
Schoch, C.3
Kern, W.4
Schnittger, S.5
-
23
-
-
10544253077
-
Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes
-
Koo HM, Monks A, Mikheev A, et al. Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes. Cancer Res. 1996;56(22):5211-5216.
-
(1996)
Cancer Res
, vol.56
, Issue.22
, pp. 5211-5216
-
-
Koo, H.M.1
Monks, A.2
Mikheev, A.3
-
24
-
-
0033572310
-
RAS oncogene-induced sensitization to 1-beta-D-arabinofuranosylcytosine
-
Koo HM, McWilliams MJ, Alvord WG, Vande Woude GF. RAS oncogene-induced sensitization to 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1999;59(24):6057-6062.
-
(1999)
Cancer Res
, vol.59
, Issue.24
, pp. 6057-6062
-
-
Koo, H.M.1
McWilliams, M.J.2
Alvord, W.G.3
van de Woude, G.F.4
-
25
-
-
33845269825
-
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco R, Fumagalli M, Cicalese A, et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature. 2006;444(7119):638-642.
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
-
26
-
-
33645213890
-
Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints
-
Knauf JA, Ouyang B, Knudsen ES, Fukasawa K, Babcock G, Fagin JA. Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. J Biol Chem. 2006:281(7):3800-3809.
-
(2006)
J Biol Chem
, vol.281
, Issue.7
, pp. 3800-3809
-
-
Knauf, J.A.1
Ouyang, B.2
Knudsen, E.S.3
Fukasawa, K.4
Babcock, G.5
Fagin, J.A.6
-
27
-
-
33846020950
-
Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling
-
Fikaris AJ, Lewis AE, Abulaiti A, Tsygankova OM, Meinkoth JL. Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling. J Biol Chem. 2006;281(46):34759-34767.
-
(2006)
J Biol Chem
, vol.281
, Issue.46
, pp. 34759-34767
-
-
Fikaris, A.J.1
Lewis, A.E.2
Abulaiti, A.3
Tsygankova, O.M.4
Meinkoth, J.L.5
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