-
1
-
-
70350654370
-
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
-
A.M. Brske, L. Vockentanz, S. Kharazi DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction Nat Genet 41 2009 1207 1215
-
(2009)
Nat Genet
, vol.41
, pp. 1207-1215
-
-
Brske, A.M.1
Vockentanz, L.2
Kharazi, S.3
-
2
-
-
70349469788
-
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
-
J.J. Trowbridge, J.W. Snow, J. Kim, S.H. Orkin DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells Cell Stem Cell 5 2009 442 449
-
(2009)
Cell Stem Cell
, vol.5
, pp. 442-449
-
-
Trowbridge, J.J.1
Snow, J.W.2
Kim, J.3
Orkin, S.H.4
-
3
-
-
77956902023
-
Comprehensive methylome map of lineage commitment from haematopoietic progenitors
-
H. Ji, L.I. Ehrlich, J. Seita Comprehensive methylome map of lineage commitment from haematopoietic progenitors Nature 467 2010 338 342
-
(2010)
Nature
, vol.467
, pp. 338-342
-
-
Ji, H.1
Ehrlich, L.I.2
Seita, J.3
-
4
-
-
0035839136
-
Translating the histone code
-
DOI 10.1126/science.1063127
-
T. Jenuwein, C.D. Allis Translating the histone code Science 293 2001 1074 1080 (Pubitemid 32758077)
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
5
-
-
78649812261
-
Interplay between microRNAs and the epigenetic machinery: An intricate network
-
M.V. Iorio, C. Piovan, C.M. Croce Interplay between microRNAs and the epigenetic machinery: an intricate network Biochim Biophys Acta 1799 2010 694 701
-
(2010)
Biochim Biophys Acta
, vol.1799
, pp. 694-701
-
-
Iorio, M.V.1
Piovan, C.2
Croce, C.M.3
-
6
-
-
78649881517
-
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
-
A. Lujambio, A. Portela, J. Liz CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer Oncogene 29 2010 6390 6401
-
(2010)
Oncogene
, vol.29
, pp. 6390-6401
-
-
Lujambio, A.1
Portela, A.2
Liz, J.3
-
8
-
-
51649103380
-
Whole genome scanning as a cytogenetic tool in hematologic malignancies
-
J.P. Maciejewski, G.J. Mufti Whole genome scanning as a cytogenetic tool in hematologic malignancies Blood 112 2008 965 974
-
(2008)
Blood
, vol.112
, pp. 965-974
-
-
MacIejewski, J.P.1
Mufti, G.J.2
-
9
-
-
77950990572
-
Copy neutral loss of heterozygosity: A novel chromosomal lesion in myeloid malignancies
-
C. O'Keefe, M.A. McDevitt, J.P. Maciejewski Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies Blood 115 2010 2731 2739
-
(2010)
Blood
, vol.115
, pp. 2731-2739
-
-
O'Keefe, C.1
McDevitt, M.A.2
MacIejewski, J.P.3
-
10
-
-
70449715477
-
New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia
-
R.V. Tiu, L.P. Gondek, C.L. O'Keefe New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia J Clin Oncol 27 2009 5219 5226
-
(2009)
J Clin Oncol
, vol.27
, pp. 5219-5226
-
-
Tiu, R.V.1
Gondek, L.P.2
O'Keefe, C.L.3
-
11
-
-
79955945973
-
Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies
-
R.V. Tiu, L.P. Gondek, C.L. O'Keefe Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies Blood 2011 Feb 1 www.blood.org
-
(2011)
Blood
-
-
Tiu, R.V.1
Gondek, L.P.2
O'Keefe, C.L.3
-
12
-
-
67650588639
-
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
-
A.M. Jankowska, H. Szpurka, R.V. Tiu Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms Blood 113 2009 6403 6410
-
(2009)
Blood
, vol.113
, pp. 6403-6410
-
-
Jankowska, A.M.1
Szpurka, H.2
Tiu, R.V.3
-
13
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
T. Ernst, A.J. Chase, J. Score Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders Nat Genet 42 2010 722 726
-
(2010)
Nat Genet
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
-
14
-
-
77957987676
-
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
-
H. Makishima, A.M. Jankowska, R.V. Tiu Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies Leukemia 24 2010 1799 1804
-
(2010)
Leukemia
, vol.24
, pp. 1799-1804
-
-
Makishima, H.1
Jankowska, A.M.2
Tiu, R.V.3
-
15
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
H. Yan, D.W. Parsons, G. Jin IDH1 and IDH2 mutations in gliomas N Engl J Med 360 2009 765 773
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
16
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
E.R. Mardis, L. Ding, D.J. Dooling Recurring mutations found by sequencing an acute myeloid leukemia genome N Engl J Med 361 2009 1058 1066
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
-
17
-
-
79952164235
-
Unraveling the molecular pathophysiology of myelodysplastic syndromes
-
R. Bejar, R. Levine, B.L. Ebert Unraveling the molecular pathophysiology of myelodysplastic syndromes J Clin Oncol 29 2011 504 515
-
(2011)
J Clin Oncol
, vol.29
, pp. 504-515
-
-
Bejar, R.1
Levine, R.2
Ebert, B.L.3
-
18
-
-
79952092487
-
Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
-
G. Marcucci, T. Haferlach, H. Dhner Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications J Clin Oncol 29 2011 475 486
-
(2011)
J Clin Oncol
, vol.29
, pp. 475-486
-
-
Marcucci, G.1
Haferlach, T.2
Dhner, H.3
-
19
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
S. Jones, X. Zhang, D.W. Parsons, J.C. Lin, R.J. Leary, P. Angenendt Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 2008 1801 1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
20
-
-
77955602596
-
Visualizing the landscape of selection biomarkers in current phase III oncology clinical trials
-
R. Sikorski, B. Yao Visualizing the landscape of selection biomarkers in current phase III oncology clinical trials Sci Transl Med 2 2010 34ps27
-
(2010)
Sci Transl Med
, vol.2
-
-
Sikorski, R.1
Yao, B.2
-
21
-
-
0023270085
-
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies
-
S.B. Baylin, E.R. Fearon, B. Vogelstein Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies Blood 70 1987 412 417 (Pubitemid 17142924)
-
(1987)
Blood
, vol.70
, Issue.2
, pp. 412-417
-
-
Baylin, S.B.1
Fearon, E.R.2
Vogelstein, B.3
De Bustros, A.4
Sharkis, S.J.5
Burke, P.J.6
Staal, S.P.7
Nelkin, B.D.8
-
22
-
-
0029843950
-
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
-
DOI 10.1073/pnas.93.18.9821
-
J.G. Herman, J.R. Graff, S. Myhnen, B.D. Nelkin, S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc Natl Acad Sci U S A 93 1996 9821 9826 (Pubitemid 26296693)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.18
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
23
-
-
0036371904
-
Combined bisulfite restriction analysis (COBRA)
-
C.A. Eads, P.W. Laird Combined bisulfite restriction analysis (COBRA) Methods Mol Biol 200 2002 71 85
-
(2002)
Methods Mol Biol
, vol.200
, pp. 71-85
-
-
Eads, C.A.1
Laird, P.W.2
-
24
-
-
33746407333
-
The emerging science of epigenomics
-
P.A. Callinan, A.P. Feinberg The emerging science of epigenomics Hum Mol Genet 15 Spec No 1 2006 R95 R101
-
(2006)
Hum Mol Genet
, vol.151 SPEC NO
-
-
Callinan, P.A.1
Feinberg, A.P.2
-
25
-
-
34548188589
-
Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation
-
DOI 10.1038/nprot.2007.271, PII NPROT.2007.271
-
M.L. Gonzalgo, G. Liang Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation Nat Protoc 2 2007 1931 1936 (Pubitemid 47308131)
-
(2007)
Nature Protocols
, vol.2
, Issue.8
, pp. 1931-1936
-
-
Gonzalgo, M.L.1
Liang, G.2
-
26
-
-
78049425259
-
DNA methylation detection using MS-qFRET, a quantum dot-based nanoassay
-
V.J. Bailey, B.P. Keeley, C.R. Razavi, E. Griffiths, H.E. Carraway, T.H. Wang DNA methylation detection using MS-qFRET, a quantum dot-based nanoassay Methods 52 2010 237 241
-
(2010)
Methods
, vol.52
, pp. 237-241
-
-
Bailey, V.J.1
Keeley, B.P.2
Razavi, C.R.3
Griffiths, E.4
Carraway, H.E.5
Wang, T.H.6
-
27
-
-
0030046322
-
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
-
J.G. Herman, J. Jen, A. Merlo, S.B. Baylin Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B Cancer Res 56 1996 722 727
-
(1996)
Cancer Res
, vol.56
, pp. 722-727
-
-
Herman, J.G.1
Jen, J.2
Merlo, A.3
Baylin, S.B.4
-
28
-
-
77956163003
-
Epigenetic mechanisms in AMLa target for therapy
-
Y. Oki, J.P. Issa Epigenetic mechanisms in AMLa target for therapy Cancer Treat Res 145 2010 19 40
-
(2010)
Cancer Treat Res
, vol.145
, pp. 19-40
-
-
Oki, Y.1
Issa, J.P.2
-
29
-
-
0034654269
-
Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications
-
I.H. Wong, M.H. Ng, D.P. Huang, J.C. Lee Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications Blood 95 2000 1942 1949 (Pubitemid 30151630)
-
(2000)
Blood
, vol.95
, Issue.6
, pp. 1942-1949
-
-
Wong, I.H.N.1
Ng, M.H.L.2
Huang, D.P.3
Lee, J.C.K.4
-
30
-
-
0032523011
-
Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
-
B. Quesnel, G. Guillerm, R. Vereecque Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression Blood 91 1998 2985 2990 (Pubitemid 28227550)
-
(1998)
Blood
, vol.91
, Issue.8
, pp. 2985-2990
-
-
Quesnel, B.1
Guillerm, G.2
Vereecque, R.3
Wattel, E.4
Preudhomme, C.5
Bauters, F.6
Vanrumbeke, M.7
Fenaux, P.8
-
31
-
-
0141502199
-
INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia
-
DOI 10.1038/sj.leu.2403054
-
D.H. Christiansen, M.K. Andersen, J. Pedersen-Bjergaard Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia Leukemia 17 2003 1813 1819 (Pubitemid 37185257)
-
(2003)
Leukemia
, vol.17
, Issue.9
, pp. 1813-1819
-
-
Christiansen, D.H.1
Anderson, M.K.2
Pedersen-Bjergaard, J.3
-
32
-
-
77957741934
-
Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome
-
E.F. Rodrigues, C.B. Santos-Rebouas, M.M. Gonalves Pimentel Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome Leuk Lymphoma 51 2010 1887 1894
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 1887-1894
-
-
Rodrigues, E.F.1
Santos-Rebouas, C.B.2
Gonalves Pimentel, M.M.3
-
33
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer
-
DOI 10.1038/5047
-
E.E. Cameron, K.E. Bachman, S. Myhnen, J.G. Herman, S.B. Baylin Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nat Genet 21 1999 103 107 (Pubitemid 29036293)
-
(1999)
Nature Genetics
, vol.21
, Issue.1
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
34
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
S.D. Gore, S. Baylin, E. Sugar Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms Cancer Res 66 2006 6361 6369
-
(2006)
Cancer Res
, vol.66
, pp. 6361-6369
-
-
Gore, S.D.1
Baylin, S.2
Sugar, E.3
-
35
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment
-
M. Daskalakis, T.T. Nguyen, C. Nguyen Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′- deoxycytidine (decitabine) treatment Blood 100 2002 2957 2964
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
-
36
-
-
70350506791
-
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
-
T.E. Fandy, J.G. Herman, P. Kerns Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies Blood 114 2009 2764 2773
-
(2009)
Blood
, vol.114
, pp. 2764-2773
-
-
Fandy, T.E.1
Herman, J.G.2
Kerns, P.3
-
37
-
-
0033215453
-
P15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
-
E.E. Cameron, S.B. Baylin, J.G. Herman p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing Blood 94 1999 2445 2451 (Pubitemid 29467693)
-
(1999)
Blood
, vol.94
, Issue.7
, pp. 2445-2451
-
-
Cameron, E.E.1
Baylin, S.B.2
Herman, J.G.3
-
38
-
-
77956497376
-
Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia
-
J. Bies, M. Sramko, J. Fares Myeloid-specific inactivation of p15Ink4b results in monocytosis and predisposition to myeloid leukemia Blood 116 2010 979 987
-
(2010)
Blood
, vol.116
, pp. 979-987
-
-
Bies, J.1
Sramko, M.2
Fares, J.3
-
39
-
-
0038528151
-
INK4b cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML)
-
DOI 10.1038/sj.leu.2402891
-
M. Tessema, F. Lnger, J. Dingemann, A. Ganser, H. Kreipe, U. Lehmann Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML) Leukemia 17 2003 910 918 (Pubitemid 36626319)
-
(2003)
Leukemia
, vol.17
, Issue.5
, pp. 910-918
-
-
Tessema, M.1
Langer, F.2
Dingemann, J.3
Ganser, A.4
Kreipe, H.5
Lehmann, U.6
-
40
-
-
66249109644
-
Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence
-
H. Agherbi, A. Gaussmann-Wenger, C. Verthuy, L. Chasson, M. Serrano, M. Djabali Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence PLoS One 4 2009 e5622
-
(2009)
PLoS One
, vol.4
, pp. 5622
-
-
Agherbi, H.1
Gaussmann-Wenger, A.2
Verthuy, C.3
Chasson, L.4
Serrano, M.5
Djabali, M.6
-
41
-
-
69349103956
-
The Ink4/Arf locus is a barrier for iPS cell reprogramming
-
H. Li, M. Collado, A. Villasante The Ink4/Arf locus is a barrier for iPS cell reprogramming Nature 460 2009 1136 1139
-
(2009)
Nature
, vol.460
, pp. 1136-1139
-
-
Li, H.1
Collado, M.2
Villasante, A.3
-
42
-
-
77951045228
-
Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML
-
T.A. Paul, J. Bies, D. Small, L. Wolff Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML Blood 115 2010 3098 3108
-
(2010)
Blood
, vol.115
, pp. 3098-3108
-
-
Paul, T.A.1
Bies, J.2
Small, D.3
Wolff, L.4
-
43
-
-
38049155825
-
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
-
W. Yu, D. Gius, P. Onyango Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA Nature 451 2008 202 206
-
(2008)
Nature
, vol.451
, pp. 202-206
-
-
Yu, W.1
Gius, D.2
Onyango, P.3
-
44
-
-
78449243068
-
Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health
-
N. Popov, J. Gil Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health Epigenetics 5 2010 685 690
-
(2010)
Epigenetics
, vol.5
, pp. 685-690
-
-
Popov, N.1
Gil, J.2
-
45
-
-
77953096072
-
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
-
K.L. Yap, S. Li, A.M. Muoz-Cabello Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a Mol Cell 38 2010 662 674
-
(2010)
Mol Cell
, vol.38
, pp. 662-674
-
-
Yap, K.L.1
Li, S.2
Muoz-Cabello, A.M.3
-
46
-
-
78449266144
-
Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia
-
C.R. Geyer Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia Epigenetics 5 2010 696 703
-
(2010)
Epigenetics
, vol.5
, pp. 696-703
-
-
Geyer, C.R.1
-
47
-
-
0033740401
-
E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia
-
P.G. Corn, B.D. Smith, E.S. Ruckdeschel, D. Douglas, S.B. Baylin, J.G. Herman E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia Clin Cancer Res 6 2000 4243 4248
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4243-4248
-
-
Corn, P.G.1
Smith, B.D.2
Ruckdeschel, E.S.3
Douglas, D.4
Baylin, S.B.5
Herman, J.G.6
-
48
-
-
70350539558
-
Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies
-
Y. Ye, M.A. McDevitt, M. Guo Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies Cancer Res 69 2009 8482 8490
-
(2009)
Cancer Res
, vol.69
, pp. 8482-8490
-
-
Ye, Y.1
McDevitt, M.A.2
Guo, M.3
-
49
-
-
78449247471
-
Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia
-
E.A. Griffiths, S.D. Gore, C.M. Hooker Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia Epigenetics 5 2010 590 600
-
(2010)
Epigenetics
, vol.5
, pp. 590-600
-
-
Griffiths, E.A.1
Gore, S.D.2
Hooker, C.M.3
-
50
-
-
34247579710
-
Discovery of epigenetically silenced genes in acute myeloid leukemias
-
DOI 10.1038/sj.leu.2404611, PII 2404611
-
J.C. Desmond, S. Raynaud, E. Tung, W.K. Hofmann, T. Haferlach, H.P. Koeffler Discovery of epigenetically silenced genes in acute myeloid leukemias Leukemia 21 2007 1026 1034 (Pubitemid 46672080)
-
(2007)
Leukemia
, vol.21
, Issue.5
, pp. 1026-1034
-
-
Desmond, J.C.1
Raynaud, S.2
Tung, E.3
Hofmann, W.-K.4
Haferlach, T.5
Koeffler, H.P.6
-
51
-
-
33846113924
-
Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin (CTNNA1) in myeloid cell transformation
-
DOI 10.1038/nm1512, PII NM1512
-
T.X. Liu, M.W. Becker, J. Jelinek Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation Nat Med 13 2007 78 83 (Pubitemid 46067389)
-
(2007)
Nature Medicine
, vol.13
, Issue.1
, pp. 78-83
-
-
Liu, T.X.1
Becker, M.W.2
Jelinek, J.3
Wu, W.-S.4
Deng, M.5
Mikhalkevich, N.6
Hsu, K.7
Bloomfield, C.D.8
Stone, R.M.9
DeAngelo, D.J.10
Galinsky, I.A.11
Issa, J.-P.12
Clarke, M.F.13
Look, A.T.14
-
52
-
-
0345357773
-
Gene Silencing in Cancer in Association with Promoter Hypermethylation
-
DOI 10.1056/NEJMra023075
-
J.G. Herman, S.B. Baylin Gene silencing in cancer in association with promoter hypermethylation N Engl J Med 349 2003 2042 2054 (Pubitemid 37448928)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.21
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
53
-
-
0034883005
-
Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2′- deoxycytidine
-
DOI 10.1046/j.1365-2141.2001.02933.x
-
M. Lbbert, P. Wijermans, R. Kunzmann, G. Verhoef, A. Bosly, C. Ravoet Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine Br J Haematol 114 2001 349 357 (Pubitemid 32762234)
-
(2001)
British Journal of Haematology
, vol.114
, Issue.2
, pp. 349-357
-
-
Lubbert, M.1
Wijermans, P.2
Kunzmann, R.3
Verhoef, G.4
Bosly, A.5
Ravoet, C.6
Andre, M.7
Ferrant, A.8
-
54
-
-
34548131144
-
CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
-
DOI 10.1038/sj.leu.2404796, PII 2404796
-
K. Raj, A. John, A. Ho CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine Leukemia 21 2007 1937 1944 (Pubitemid 47299967)
-
(2007)
Leukemia
, vol.21
, Issue.9
, pp. 1937-1944
-
-
Raj, K.1
John, A.2
Ho, A.3
Chronis, C.4
Khan, S.5
Samuel, J.6
Pomplun, S.7
Thomas, N.S.B.8
Mufti, G.J.9
-
55
-
-
73149099172
-
Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities
-
F. Ravandi, J.P. Issa, G. Garcia-Manero Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities Cancer 115 2009 5746 5751
-
(2009)
Cancer
, vol.115
, pp. 5746-5751
-
-
Ravandi, F.1
Issa, J.P.2
Garcia-Manero, G.3
-
56
-
-
0035042611
-
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
-
DOI 10.1038/88225
-
H. Yoshikawa, K. Matsubara, G.S. Qian SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity Nat Genet 28 2001 29 35 (Pubitemid 32405812)
-
(2001)
Nature Genetics
, vol.28
, Issue.1
, pp. 29-35
-
-
Yoshikawa, H.1
Matsubara, K.2
Qian, G.-S.3
Jackson, P.4
Groopman, J.D.5
Manning, J.E.6
Harris, C.C.7
Herman, J.G.8
-
57
-
-
24944476696
-
Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome
-
DOI 10.1111/j.1365-2141.2005.05590.x
-
K. Brakensiek, F. Lnger, B. Schlegelberger, H. Kreipe, U. Lehmann Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome Br J Haematol 130 2005 209 217 (Pubitemid 41602521)
-
(2005)
British Journal of Haematology
, vol.130
, Issue.2
, pp. 209-217
-
-
Brakensiek, K.1
Langer, F.2
Schlegelberger, B.3
Kreipe, H.4
Lehmann, U.5
-
58
-
-
33847223121
-
Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
-
E. Jost, O.N. do, E. Dahl Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders Leukemia 21 2007 505 510
-
(2007)
Leukemia
, vol.21
, pp. 505-510
-
-
Jost, E.1
Do, O.N.2
Dahl, E.3
-
59
-
-
50549085051
-
Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases
-
L. Teofili, M. Martini, T. Cenci Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases Int J Cancer 123 2008 1586 1592
-
(2008)
Int J Cancer
, vol.123
, pp. 1586-1592
-
-
Teofili, L.1
Martini, M.2
Cenci, T.3
-
60
-
-
55549126446
-
Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders
-
N. Fourouclas, J. Li, D.C. Gilby Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders Haematologica 93 2008 1635 1644
-
(2008)
Haematologica
, vol.93
, pp. 1635-1644
-
-
Fourouclas, N.1
Li, J.2
Gilby, D.C.3
-
61
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
-
S. Verstovsek, H. Kantarjian, R.A. Mesa Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis N Engl J Med 363 2010 1117 1127
-
(2010)
N Engl J Med
, vol.363
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
-
62
-
-
34548613972
-
Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways
-
DOI 10.1038/cr.2007.69, PII CR200769
-
M.J. Nemeth, D.M. Bodine Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways Cell Res 17 2007 746 758 (Pubitemid 47409701)
-
(2007)
Cell Research
, vol.17
, Issue.9
, pp. 746-758
-
-
Nemeth, M.J.1
Bodine, D.M.2
-
63
-
-
0038783316
-
Secreted antagonists of the Wnt signalling pathway
-
DOI 10.1242/jcs.00623
-
Y. Kawano, R. Kypta Secreted antagonists of the Wnt signalling pathway J Cell Sci 116 2003 2627 2634 (Pubitemid 36857216)
-
(2003)
Journal of Cell Science
, vol.116
, Issue.13
, pp. 2627-2634
-
-
Kawano, Y.1
Kypta, R.2
-
64
-
-
77950287628
-
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
-
Y. Wang, A.V. Krivtsov, A.U. Sinha The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML Science 327 2010 1650 1653
-
(2010)
Science
, vol.327
, pp. 1650-1653
-
-
Wang, Y.1
Krivtsov, A.V.2
Sinha, A.U.3
-
65
-
-
12144291274
-
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
-
DOI 10.1038/ng1330
-
H. Suzuki, D.N. Watkins, K.W. Jair Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer Nat Genet 36 2004 417 422 (Pubitemid 38437267)
-
(2004)
Nature Genetics
, vol.36
, Issue.4
, pp. 417-422
-
-
Suzuki, H.1
Watkins, D.N.2
Jair, K.-W.3
Schuebel, K.E.4
Markowitz, S.D.5
Chen, W.D.6
Pretlow, T.P.7
Yang, B.8
Akiyama, Y.9
Van Engeland, M.10
Toyota, M.11
Tokino, T.12
Hinoda, Y.13
Imai, K.14
Herman, J.G.15
Baylin, S.B.16
-
66
-
-
48749092367
-
Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia
-
E. Jost, J. Schmid, S. Wilop Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia Br J Haematol 142 2008 745 753
-
(2008)
Br J Haematol
, vol.142
, pp. 745-753
-
-
Jost, E.1
Schmid, J.2
Wilop, S.3
-
67
-
-
70349311852
-
Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia
-
A. Valencia, J. Roman-Gomez, J. Cervera Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia Leukemia 23 2009 1658 1666
-
(2009)
Leukemia
, vol.23
, pp. 1658-1666
-
-
Valencia, A.1
Roman-Gomez, J.2
Cervera, J.3
-
68
-
-
77956303152
-
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation
-
E.A. Griffiths, S.D. Gore, C. Hooker Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation Leuk Lymphoma 51 2010 1711 1719
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 1711-1719
-
-
Griffiths, E.A.1
Gore, S.D.2
Hooker, C.3
-
69
-
-
75149166496
-
MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
-
M. Weller, R. Stupp, G. Reifenberger MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 6 2010 39 51
-
(2010)
Nat Rev Neurol
, vol.6
, pp. 39-51
-
-
Weller, M.1
Stupp, R.2
Reifenberger, G.3
-
70
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
DOI 10.1056/NEJMoa043331
-
M.E. Hegi, A.C. Diserens, T. Gorlia MGMT gene silencing and benefit from temozolomide in glioblastoma N Engl J Med 352 2005 997 1003 (Pubitemid 40349502)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.10
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.-C.2
Gorlia, T.3
Hamou, M.-F.4
De Tribolet, N.5
Weller, M.6
Kros, J.M.7
Hainfellner, J.A.8
Mason, W.9
Mariani, L.10
Bromberg, J.E.C.11
Hau, P.12
Mirimanoff, R.O.13
Cairncross, J.G.14
Janzer, R.C.15
Stupp, R.16
-
71
-
-
0035874892
-
6- methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis
-
M. Esteller, R.A. Risques, M. Toyota Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis Cancer Res 61 2001 4689 4692 (Pubitemid 32691877)
-
(2001)
Cancer Research
, vol.61
, Issue.12
, pp. 4689-4692
-
-
Esteller, M.1
Risques, R.-A.2
Toyota, M.3
Capella, G.4
Moreno, V.5
Peinado, M.A.6
Baylin, S.B.7
Herman, J.G.8
-
72
-
-
0033179375
-
Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
-
J.R. Melki, P.C. Vincent, S.J. Clark Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia Cancer Res 59 1999 3730 3740 (Pubitemid 29381880)
-
(1999)
Cancer Research
, vol.59
, Issue.15
, pp. 3730-3740
-
-
Melki, J.R.1
Vincent, P.C.2
Clark, S.J.3
-
73
-
-
0035353188
-
Methylation profiling in acute myeloid leukemia
-
M. Toyota, K.J. Kopecky, M.O. Toyota, K.W. Jair, C.L. Willman, J.P. Issa Methylation profiling in acute myeloid leukemia Blood 97 2001 2823 2829
-
(2001)
Blood
, vol.97
, pp. 2823-2829
-
-
Toyota, M.1
Kopecky, K.J.2
Toyota, M.O.3
Jair, K.W.4
Willman, C.L.5
Issa, J.P.6
-
74
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
H. Noushmehr, D.J. Weisenberger, K. Diefes Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell 17 2010 510 522
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
75
-
-
29144469286
-
Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia
-
O. Galm, S. Wilop, C. Lders Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia Ann Hematol 84 Suppl 1 2005 39 46
-
(2005)
Ann Hematol
, vol.84
, Issue.SUPPL. 1
, pp. 39-46
-
-
Galm, O.1
Wilop, S.2
Lders, C.3
-
76
-
-
77449149371
-
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
-
L. Shen, H. Kantarjian, Y. Guo DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes J Clin Oncol 28 2010 605 613
-
(2010)
J Clin Oncol
, vol.28
, pp. 605-613
-
-
Shen, L.1
Kantarjian, H.2
Guo, Y.3
-
77
-
-
40849124009
-
DNA methylation markers and early recurrence in stage I lung cancer
-
DOI 10.1056/NEJMoa0706550
-
M.V. Brock, C.M. Hooker, E. Ota-Machida DNA methylation markers and early recurrence in stage I lung cancer N Engl J Med 358 2008 1118 1128 (Pubitemid 351398486)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.11
, pp. 1118-1128
-
-
Brock, M.V.1
Hooker, C.M.2
Ota-Machida, E.3
Han, Y.4
Guo, M.5
Ames, S.6
Glockner, S.7
Piantadosi, S.8
Gabrielson, E.9
Pridham, G.10
Pelosky, K.11
Belinsky, S.A.12
Yang, S.C.13
Baylin, S.B.14
Herman, J.G.15
-
78
-
-
51649122312
-
Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
-
H. Kroeger, J. Jelinek, M.R. Estcio Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse Blood 112 2008 1366 1373
-
(2008)
Blood
, vol.112
, pp. 1366-1373
-
-
Kroeger, H.1
Jelinek, J.2
Estcio, M.R.3
-
79
-
-
33847082188
-
DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia
-
S. Agrawal, M. Unterberg, S. Koschmieder DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia Cancer Res 67 2007 1370 1377
-
(2007)
Cancer Res
, vol.67
, pp. 1370-1377
-
-
Agrawal, S.1
Unterberg, M.2
Koschmieder, S.3
-
80
-
-
0035874532
-
Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci
-
L.J. Rush, Z. Dai, D.J. Smiraglia Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci Blood 97 2001 3226 3233
-
(2001)
Blood
, vol.97
, pp. 3226-3233
-
-
Rush, L.J.1
Dai, Z.2
Smiraglia, D.J.3
-
81
-
-
0036561649
-
Altered methylation patterns in cancer cell genomes: Cause or consequence?
-
DOI 10.1016/S1535-6108(02)00061-2
-
S. Baylin, T.H. Bestor Altered methylation patterns in cancer cell genomes: cause or consequence? Cancer Cell 1 2002 299 305 (Pubitemid 41039130)
-
(2002)
Cancer Cell
, vol.1
, Issue.4
, pp. 299-305
-
-
Baylin, S.1
Bestor, T.H.2
-
82
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
P.A. Jones, S.B. Baylin The fundamental role of epigenetic events in cancer Nat Rev Genet 3 2002 415 428 (Pubitemid 34587077)
-
(2002)
Nature Reviews Genetics
, vol.3
, Issue.6
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
83
-
-
78649274945
-
Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer
-
M.R. Estcio, J. Gallegos, C. Vallot Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer Genome Res 20 2010 1369 1382
-
(2010)
Genome Res
, vol.20
, pp. 1369-1382
-
-
Estcio, M.R.1
Gallegos, J.2
Vallot, C.3
-
84
-
-
77953892366
-
Mobile interspersed repeats are major structural variants in the human genome
-
C.R. Huang, A.M. Schneider, Y. Lu Mobile interspersed repeats are major structural variants in the human genome Cell 141 2010 1171 1182
-
(2010)
Cell
, vol.141
, pp. 1171-1182
-
-
Huang, C.R.1
Schneider, A.M.2
Lu, Y.3
-
85
-
-
48649100069
-
Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells
-
K.M. McGarvey, L. Van Neste, L. Cope Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells Cancer Res 68 2008 5753 5759
-
(2008)
Cancer Res
, vol.68
, pp. 5753-5759
-
-
McGarvey, K.M.1
Van Neste, L.2
Cope, L.3
-
86
-
-
34247579710
-
Discovery of epigenetically silenced genes in acute myeloid leukemias
-
DOI 10.1038/sj.leu.2404611, PII 2404611
-
J.C. Desmond, S. Raynaud, E. Tung, W.K. Hofmann, T. Haferlach, H.P. Koeffler Discovery of epigenetically silenced genes in acute myeloid leukemias Leukemia 21 2007 1026 1034 (Pubitemid 46672080)
-
(2007)
Leukemia
, vol.21
, Issue.5
, pp. 1026-1034
-
-
Desmond, J.C.1
Raynaud, S.2
Tung, E.3
Hofmann, W.-K.4
Haferlach, T.5
Koeffler, H.P.6
-
87
-
-
34247348182
-
The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemia
-
DOI 10.1182/blood-2006-08-040147
-
S. Agrawal, W.K. Hofmann, N. Tidow The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia Blood 109 2007 3895 3905 (Pubitemid 46641742)
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 3895-3905
-
-
Agrawal, S.1
Hofmann, W.-K.2
Tidow, N.3
Ehrich, M.4
Van Den Boom, D.5
Koschmieder, S.6
Berdel, W.E.7
Serve, H.8
Muller-Tidow, C.9
-
88
-
-
37049001640
-
Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
-
DOI 10.1158/0008-5472.CAN-07-1502
-
L. Shen, Y. Kondo, S. Ahmed Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel Cancer Res 67 2007 11335 11343 (Pubitemid 350248560)
-
(2007)
Cancer Research
, vol.67
, Issue.23
, pp. 11335-11343
-
-
Shen, L.1
Kondo, Y.2
Ahmed, S.3
Boumber, Y.4
Konishi, K.5
Guo, Y.6
Chen, X.7
Vilaythong, J.N.8
Issa, J.-P.J.9
-
89
-
-
0035875049
-
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
-
D.J. Smiraglia, L.J. Rush, M.C. Frhwald Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies Hum Mol Genet 10 2001 1413 1419 (Pubitemid 32640670)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.13
, pp. 1413-1419
-
-
Smiraglia, D.J.1
Rush, L.J.2
Fruhwald, M.C.3
Dai, Z.4
Held, W.A.5
Costello, J.F.6
Lang, J.C.7
Eng, C.8
Li, B.9
Wright, F.A.10
Caligiuri, M.A.11
Plass, C.12
-
90
-
-
60849089645
-
Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
-
Y. Jiang, A. Dunbar, L.P. Gondek Aberrant DNA methylation is a dominant mechanism in MDS progression to AML Blood 113 2009 1315 1325
-
(2009)
Blood
, vol.113
, pp. 1315-1325
-
-
Jiang, Y.1
Dunbar, A.2
Gondek, L.P.3
-
91
-
-
70350720044
-
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
-
M.E. Figueroa, L. Skrabanek, Y. Li MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation Blood 114 2009 3448 3458
-
(2009)
Blood
, vol.114
, pp. 3448-3458
-
-
Figueroa, M.E.1
Skrabanek, L.2
Li, Y.3
-
92
-
-
73649110641
-
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
-
M.E. Figueroa, S. Lugthart, Y. Li DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia Cancer Cell 17 2010 13 27
-
(2010)
Cancer Cell
, vol.17
, pp. 13-27
-
-
Figueroa, M.E.1
Lugthart, S.2
Li, Y.3
-
93
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
M.E. Figueroa, O. Abdel-Wahab, C. Lu Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 18 2010 553 567
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
94
-
-
77449157068
-
Quantitative DNA methylation predicts survival in adult acute myeloid leukemia
-
L. Bullinger, M. Ehrich, K. Dhner Quantitative DNA methylation predicts survival in adult acute myeloid leukemia Blood 115 2010 636 642
-
(2010)
Blood
, vol.115
, pp. 636-642
-
-
Bullinger, L.1
Ehrich, M.2
Dhner, K.3
-
95
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
T. Ernst, A.J. Chase, J. Score Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders Nat Genet 42 2010 722 726
-
(2010)
Nat Genet
, vol.42
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
-
96
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
G. Nikoloski, S.M. Langemeijer, R.P. Kuiper Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes Nat Genet 42 2010 665 667
-
(2010)
Nat Genet
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.2
Kuiper, R.P.3
-
97
-
-
77957987676
-
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
-
H. Makishima, A.M. Jankowska, R.V. Tiu Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies Leukemia 24 2010 1799 1804
-
(2010)
Leukemia
, vol.24
, pp. 1799-1804
-
-
Makishima, H.1
Jankowska, A.M.2
Tiu, R.V.3
-
98
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
G. van Haaften, G.L. Dalgliesh, H. Davies Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat Genet 41 2009 521 523
-
(2009)
Nat Genet
, vol.41
, pp. 521-523
-
-
Van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
-
99
-
-
79953299687
-
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression
-
L.D. Wartman, D.E. Larson, Z. Xiang Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression J Clin Invest 121 2011 1445 1455
-
(2011)
J Clin Invest
, vol.121
, pp. 1445-1455
-
-
Wartman, L.D.1
Larson, D.E.2
Xiang, Z.3
-
100
-
-
0028939603
-
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)
-
R.J. Gibbons, D.J. Picketts, L. Villard, D.R. Higgs Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome) Cell 80 1995 837 845
-
(1995)
Cell
, vol.80
, pp. 837-845
-
-
Gibbons, R.J.1
Picketts, D.J.2
Villard, L.3
Higgs, D.R.4
-
101
-
-
77957146789
-
The molecular pathogenesis of myelodysplastic syndromes
-
M.S. Davids, D.P. Steensma The molecular pathogenesis of myelodysplastic syndromes Cancer Biol Ther 10 2010 309 319
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 309-319
-
-
Davids, M.S.1
Steensma, D.P.2
-
102
-
-
33645702778
-
A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome
-
D.B. Costa, C.A. Fisher, K.B. Miller A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome Eur J Haematol 76 2006 432 435
-
(2006)
Eur J Haematol
, vol.76
, pp. 432-435
-
-
Costa, D.B.1
Fisher, C.A.2
Miller, K.B.3
-
103
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
T.J. Ley, L. Ding, M.J. Walter DNMT3A mutations in acute myeloid leukemia N Engl J Med 363 2010 2424 2433
-
(2010)
N Engl J Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
-
104
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
X.J. Yan, J. Xu, Z.H. Gu Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia Nat Genet 43 2011 309 315
-
(2011)
Nat Genet
, vol.43
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
-
105
-
-
14344257055
-
MicroRNAs as regulators of mammalian hematopoiesis
-
DOI 10.1016/j.smim.2005.01.001
-
C.Z. Chen, H.F. Lodish MicroRNAs as regulators of mammalian hematopoiesis Semin Immunol 17 2005 155 165 (Pubitemid 40292054)
-
(2005)
Seminars in Immunology
, vol.17
, pp. 155-165
-
-
Chen, C.-Z.1
Lodish, H.F.2
-
106
-
-
77956270732
-
MicroRNA miR-125a controls hematopoietic stem cell number
-
S. Guo, J. Lu, R. Schlanger MicroRNA miR-125a controls hematopoietic stem cell number Proc Natl Acad Sci U S A 107 2010 14229 14234
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 14229-14234
-
-
Guo, S.1
Lu, J.2
Schlanger, R.3
-
107
-
-
38049123402
-
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
-
S. Mi, J. Lu, M. Sun MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia Proc Natl Acad Sci U S A 104 2007 19971 19976
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19971-19976
-
-
Mi, S.1
Lu, J.2
Sun, M.3
-
108
-
-
44849121373
-
Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia
-
B. Hackanson, K.L. Bennett, R.M. Brena Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia Cancer Res 68 2008 3142 3151
-
(2008)
Cancer Res
, vol.68
, pp. 3142-3151
-
-
Hackanson, B.1
Bennett, K.L.2
Brena, R.M.3
-
109
-
-
65549083102
-
The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2
-
J.M. Friedman, G. Liang, C.C. Liu The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2 Cancer Res 69 2009 2623 2629
-
(2009)
Cancer Res
, vol.69
, pp. 2623-2629
-
-
Friedman, J.M.1
Liang, G.2
Liu, C.C.3
|