Dnmt3a silences hematopoietic stem cell self-renewal

Nature Genetics

Volumn 44, Issue 1, 2012, Pages 13-14

  Trowbridge, Jennifer J ^a   Orkin, Stuart H ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A;

CELL DIFFERENTIATION; CELL RENEWAL; DNA METHYLATION; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION REGULATION; GENE SILENCING; HEMATOPOIESIS; HUMAN; LEUKEMOGENESIS; NULL CELL; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STEM CELL;

CELL DIFFERENTIATION; CELL DIVISION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; HEMATOPOIETIC STEM CELLS; RNA INTERFERENCE;

EID: 84555191728     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.1043     Document Type: Review

References (12)

1. Ley, T.J. et al. N. Engl. J. Med. 363, 2424-2433 (2010).
2. Walter, M.J. et al. Leukemia 25, 1153-1158 (2011).
3. Challen, G.A. et al. Nat. Genet. 44, 23-31 (2012).
4. Bröske, A.-M. et al. Nat. Genet. 41, 1207-1215 (2009).
5. Trowbridge, J.J., Snow, J.W., Kim, J. & Orkin, S.H. Cell Stem Cell 5, 442-449 (2009).
6. Tadokoro, Y., Ema, H., Okano, M., Li, E. & Nakauchi, H. J. Exp. Med. 204, 715-722 (2007).
7. Bhattacharya, D. et al. J. Exp. Med. 206, 2837-2850 (2009).
8. Miller, S.A., Mohn, S.E. & Weinmann, A.S. Mol. Cell 40, 594-605 (2010).
9. Ndlovu, M.N., Denis, H. & Fuks, F. Trends Biochem. Sci. 36, 381-387 (2011).
10. Gao, Q. et al. Proc. Natl. Acad. Sci. USA 108, 18061-18066 (2011).
11. Wu, H. et al. Science 329, 444-448 (2010).
12. Hervouet, E., Vallette, F.M. & Cartron, P.F. Epigenetics 4, 487-499 (2009).