G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Müller, Anne ^a   Kleinau, Gunnar ^a   Piechowski, Carolin L ^a   Müller, Timo D ^b   Finan, Brian ^b   Pratzka, Juliane ^a   Grüters, Annette ^a   Krude, Heiko ^a   Tschöp, Matthias ^b,c   Biebermann, Heike ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYSTEINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 83; GLUTAMIC ACID; HISTIDINE; HOMODIMER; MAGNESIUM ION; MUTANT PROTEIN; UNCLASSIFIED DRUG; ZINC ION;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; METAL BINDING; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PROTEIN BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CHLORIDES; COS CELLS; GENE EXPRESSION; HEK293 CELLS; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; ZINC COMPOUNDS;

EID: 84872425037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053347     Document Type: Article

References (70)

1. Alexander SP, Mathie A, Peters JA, (2011) Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164Suppl 1: S1-324.
2. Baughman G, Harrigan MT, Campbell NF, Nurrish SJ, Bourgeois S, (1991) Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol Endocrinol 5: 637-644.
3. Harrigan MT, Baughman G, Campbell NF, Bourgeois S, (1989) Isolation and characterization of glucocorticoid- and cyclic AMP-induced genes in T lymphocytes. Mol Cell Biol 9: 3438-3446.
4. Harrigan MT, Campbell NF, Bourgeois S, (1991) Identification of a gene induced by glucocorticoids in murine T-cells: a potential G protein-coupled receptor. Mol Endocrinol 5: 1331-1338.
5. Adams F, Grassie M, Shahid M, Hill DR, Henry B, (2003) Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced receptor (GIR) mRNA in rodent brain: potential role in HPA-axis function. Brain Res Mol Brain Res 117: 39-46.
6. Brezillon S, Detheux M, Parmentier M, Hokfelt T, Hurd YL, (2001) Distribution of an orphan G-protein coupled receptor (JP05) mRNA in the human brain. Brain Res 921: 21-30.
7. Lu LF, Gavin MA, Rasmussen JP, Rudensky AY, (2007) G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol 27: 8065-8072.
8. Pesini P, Detheux M, Parmentier M, Hokfelt T, (1998) Distribution of a glucocorticoid-induced orphan receptor (JP05) mRNA in the central nervous system of the mouse. Brain Res Mol Brain Res 57: 281-300.
9. Sah R, Pritchard LM, Richtand NM, Ahlbrand R, Eaton K, et al. (2005) Expression of the glucocorticoid-induced receptor mRNA in rat brain. Neuroscience 133: 281-292.
10. Sah R, Parker SL, Sheriff S, Eaton K, Balasubramaniam A, et al. (2007) Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides 28: 302-309.
11. Dubins JS, Sanchez-Alavez M, Zhukov V, Sanchez-Gonzalez A, Moroncini G, et al. (2012) Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin. Metabolism in press.
12. Parnot C, Miserey-Lenkei S, Bardin S, Corvol P, Clauser E, (2002) Lessons from constitutively active mutants of G protein-coupled receptors. Trends Endocrinol Metab 13: 336-343.
13. Schoneberg T, Schulz A, Biebermann H, Hermsdorf T, Rompler H, et al. (2004) Mutant G-protein-coupled receptors as a cause of human diseases. Pharmacol Ther 104: 173-206.
14. Biebermann H, Winkler F, Handke D, Teichmann A, Gerling B, et al. (2012) New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR. J Clin Endocrinol Metab 97: E228-232.
15. Winkler F, Kleinau G, Tarnow P, Rediger A, Grohmann L, et al. (2010) A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6. J Clin Endocrinol Metab 95: 3605-3610.
16. Schwartz TW, Frimurer TM, Holst B, Rosenkilde MM, Elling CE, (2006) Molecular mechanism of 7TM receptor activation-a global toggle switch model. Annu Rev Pharmacol Toxicol 46: 481-519.
17. Ballesteros JA, Weinstein H, (1995) Integrated Methods for the Construction of Three-Dimensional Models and Computational Probing of Structure-Function Relationships in G-Protein Coupled Receptors. Methods Neurosci 25: 366-428.
18. Ahuja S, Smith SO, (2009) Multiple switches in G protein-coupled receptor activation. Trends Pharmacol Sci 30: 494-502.
19. Nygaard R, Frimurer TM, Holst B, Rosenkilde MM, Schwartz TW, (2009) Ligand binding and micro-switches in 7TM receptor structures. Trends Pharmacol Sci 30: 249-259.
20. Rosenkilde MM, Lucibello M, Holst B, Schwartz TW, (1998) Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor. FEBS Lett 439: 35-40.
21. Ciolek J, Maiga A, Marcon E, Servent D, Gilles N, (2011) Pharmacological characterization of zinc and copper interaction with the human alpha(1A)-adrenoceptor. Eur J Pharmacol 655: 1-8.
22. Elling CE, Frimurer TM, Gerlach LO, Jorgensen R, Holst B, et al. (2006) Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. J Biol Chem 281: 17337-17346.
23. Holst B, Elling CE, Schwartz TW, (2002) Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors. J Biol Chem 277: 47662-47670.
24. Storjohann L, Holst B, Schwartz TW, (2008) Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39. FEBS Lett 582: 2583-2588.
25. Swaminath G, Lee TW, Kobilka B, (2003) Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor. J Biol Chem 278: 352-356.
26. Swaminath G, Steenhuis J, Kobilka B, Lee TW, (2002) Allosteric modulation of beta2-adrenergic receptor by Zn(2+). Mol Pharmacol 61: 65-72.
27. Thiel G, Lesch A, Keim A, (2012) Transcriptional response to calcium-sensing receptor stimulation. Endocrinology 153: 4716-4728.
28. Rediger A, Tarnow P, Bickenbach A, Schaefer M, Krude H, et al. (2009) Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation. Obes Facts 2: 80-86.
29. Biebermann H, Schoneberg T, Krude H, Schultz G, Gudermann T, et al. (1997) Mutations of the human thyrotropin receptor gene causing thyroid hypoplasia and persistent congenital hypothyroidism. J Clin Endocrinol Metab 82: 3471-3480.
30. Staubert C, Tarnow P, Brumm H, Pitra C, Gudermann T, et al. (2007) Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology 148: 4642-4648.
31. Van Sande J, Raspe E, Perret J, Lejeune C, Maenhaut C, et al. (1990) Thyrotropin activates both the cyclic AMP and the PIP2 cascades in CHO cells expressing the human cDNA of TSH receptor. Mol Cell Endocrinol 74: R1-6.
32. Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, et al. (1994) The human thyrotropin receptor activates G-proteins Gs and Gq/11. J Biol Chem 269: 13733-13735.
33. Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD (1999) "Chapter 13: Serotonin Receptors". In: Siegel GJ, editor. Basic Neurochemistry: Molecular, Cellular, and Medical Aspects. Philadelphia: Lippincott-Raven. 263-292.
34. Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, et al. (2007) GPR39 signaling is stimulated by zinc ions but not by obestatin. Endocrinology 148: 13-20.
35. Schulz A, Grosse R, Schultz G, Gudermann T, Schoneberg T, (2000) Structural implication for receptor oligomerization from functional reconstitution studies of mutant V2 vasopressin receptors. J Biol Chem 275: 2381-2389.
36. Kobilka B, Schertler GF, (2008) New G-protein-coupled receptor crystal structures: insights and limitations. Trends Pharmacol Sci 29: 79-83.
37. Zhao Q, Wu BL, (2012) Ice breaking in GPCR structural biology. Acta Pharmacol Sin 33: 324-334.
38. Hanson MA, Stevens RC, (2009) Discovery of new GPCR biology: one receptor structure at a time. Structure 17: 8-14.
39. Costanzi S, (2010) Modeling G Protein-Coupled Receptors: a Concrete Possibility. Chim Oggi 28: 26-31.
40. Carlsson J, Coleman RG, Setola V, Irwin JJ, Fan H, et al. (2011) Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat Chem Biol 7: 769-778.
41. Kontoyianni M, Liu Z, (2012) Structure-based design in the GPCR target space. Curr Med Chem 19: 544-556.
42. Mason JS, Bortolato A, Congreve M, Marshall FH, (2012) New insights from structural biology into the druggability of G protein-coupled receptors. Trends Pharmacol Sci 33: 249-260.
43. Shoichet BK, Kobilka BK, (2012) Structure-based drug screening for G-protein-coupled receptors. Trends Pharmacol Sci 33: 268-272.
44. Worth CL, Kleinau G, Krause G, (2009) Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models. PLoS One 4: e7011.
45. Worth CL, Kreuchwig A, Kleinau G, Krause G, (2011) GPCR-SSFE: a comprehensive database of G-protein-coupled receptor template predictions and homology models. BMC Bioinformatics 12: 185.
46. Costanzi S, (2012) Homology modeling of class a g protein-coupled receptors. Methods Mol Biol 857: 259-279.
47. Schetz JA, Chu A, Sibley DR, (1999) Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms. J Pharmacol Exp Ther 289: 956-964.
48. Vallee BL, Auld DS, (1990) Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry 29: 5647-5659.
49. Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, et al. (2010) Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature 463: 108-112.
50. Massotte D, Kieffer BL, (2005) The second extracellular loop: a damper for G protein-coupled receptors? Nat Struct Mol Biol 12: 287-288.
51. Peeters MC, van Westen GJ, Li Q, Ijzerman AP, (2011) Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol Sci 32: 35-42.
52. Wheatley M, Simms J, Hawtin SR, Wesley VJ, Wootten D, et al. (2007) Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors. Biochem Soc Trans 35: 717-720.
53. Wheatley M, Wootten D, Conner MT, Simms J, Kendrick R, et al. (2012) Lifting the lid on GPCRs: the role of extracellular loops. Br J Pharmacol 165: 1688-1703.
54. Bouvier M, (2001) Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2: 274-286.
55. George SR, O'Dowd BF, Lee SP, (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 1: 808-820.
56. Assaf SY, Chung SH, (1984) Release of endogenous Zn2+ from brain tissue during activity. Nature 308: 734-736.
57. Xie X, Smart TG, (1994) Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc. Pflugers Arch 427: 481-486.
58. Fowler CB, Pogozheva ID, LeVine H 3rd, Mosberg HI (2004) Refinement of a homology model of the mu-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites. Biochemistry 43: 8700-8710.
59. Elinder F, Arhem P, (2003) Metal ion effects on ion channel gating. Q Rev Biophys 36: 373-427.
60. Norgaard-Nielsen K, Gether U (2006) Zn2+ modulation of neurotransmitter transporters. Handb Exp Pharmacol: 1-22.
61. Tapiero H, Tew KD, (2003) Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother 57: 399-411.
62. Barwell J, Woolley MJ, Wheatley M, Conner AC, Poyner DR, (2012) The role of the extracellular loops of the CGRP receptor, a family B GPCR. Biochem Soc Trans 40: 433-437.
63. Kleinau G, Claus M, Jaeschke H, Mueller S, Neumann S, et al. (2007) Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor. J Biol Chem 282: 518-525.
64. Brown EM, (1991) Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiol Rev 71: 371-411.
65. Nicholson C, Bruggencate GT, Steinberg R, Stockle H, (1977) Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci U S A 74: 1287-1290.
66. Silver RA, Lubke J, Sakmann B, Feldmeyer D, (2003) High-probability uniquantal transmission at excitatory synapses in barrel cortex. Science 302: 1981-1984.
67. Kleinau G, Krause G, (2009) Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr Rev 30: 133-151.
68. Guo W, Shi L, Filizola M, Weinstein H, Javitch JA, (2005) Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A 102: 17495-17500.
69. Vilardaga JP, Nikolaev VO, Lorenz K, Ferrandon S, Zhuang Z, et al. (2008) Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nat Chem Biol 4: 126-131.
70. Brock C, Oueslati N, Soler S, Boudier L, Rondard P, et al. (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J Biol Chem 282: 33000-33008.