Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor

Journal of Biological Chemistry

Volumn 282, Issue 1, 2007, Pages 518-525

  Kleinau, Gunnar ^a   Claus, Maren ^b   Jaeschke, Holger ^b   Mueller, Sandra ^b   Neumann, Susanne ^c   Paschke, Ralf ^b   Krause, Gerd ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL ACTIVITY; EXTRACELLULAR LOOP; SIDE CHAIN INTERACTION; THYROID;

AMINO ACIDS; HORMONES; MOLECULAR MODELING; MUTAGENESIS;

CELL MEMBRANES;

ISOLEUCINE; THYROTROPIN RECEPTOR; AMINO ACID;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONFORMATION; GENE MUTATION; MEMBRANE POTENTIAL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN COS1; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; FLOW CYTOMETRY; HUMAN; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; FLOW CYTOMETRY; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROTROPIN;

EID: 33846978093     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606176200     Document Type: Article

References (49)

1. Szkudlinski, M. W., Fremont, V., Ronin, C., and Weintraub, B. D. (2002) Physiol. Rev. 82, 473-502
2. Simoni, M., Gromoll, J., and Nieschlag, E. (1997) Endocr. Rev. 18, 739-773
3. Ascoli, M., Fanelli, F., and Segaloff, D. L. (2002) Endocr. Rev. 23, 141-174
4. Fan, Q. R., and Hendrickson, W. A. (2005) Nature 433, 269-277
5. Laugwitz, K. L., Allgeier, A., Offermanns, S., Spicher, K., Van Sande, J., Dumont, J. E., and Schultz, G. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 116-120
6. Dufau, M. L. (1998) Annu. Rev. Physiol. 60, 461-496
7. Rodien, P., Ho, S. C., Vlaeminck, V., Vassart, G., and Costagliola, S. (2003) Ann. Endocrinol. (Paris) 64, 12-16
8. Kleinau, G., Jäschke, H., Neumann, S., Lättig, J., Paschke, R., and Krause, G. (2004) J. Biol. Chem. 279, 51590-51600
9. Costagliola, S., Urizar, E., Mendive, F., and Vassart, G. (2005) Reproduction (Camb.) 130, 275-281
10. Davies, T. F., Ando, T., Lin, R. Y., Tomer, Y., and Latif, R. (2005) J. Clin. Investig. 115, 1972-1983
11. Van Sande, J., Massart, C., Costagliola, S., Allgeier, A., Cetani, F., Vassart, G., and Dumont, J. E. (1996) Mol. Cell. Endocrinol. 119, 161-168
12. Chen, C. R., Chazenbalk, G. D., McLachlan, S. M., and Rapoport, B. (2003) Endocrinology 144, 3821-3827
13. Moore, S., Jaeschke, H., Kleinau, G., Neumann, S., Costanzi, S., Jiang, J. K., Childress, J., Raaka, B. M., Colson, A., Paschke, R., Krause, G., Thomas, C. J., and Gershengorn, M. C. (2006) J. Med. Chem. 49, 3888-3896
14. Zhang, M. L., Sugawa, H., Kosugi, S., and Mori, T. (1995) Biochem. Biophys. Res. Commun. 211, 205-210
15. Duprez, L., Hermans, J., Van Sande, J., Dumont, J. E., Vassart, G., and Parma, J. (1997) J. Clin. Endocrinol. Metab. 82, 306-308
16. Wonerow, P., Schoneberg, T., Schultz, G., Gudermann, T., and Paschke, R. (1998) J. Biol. Chem. 273, 7900-7905
17. Parma, J., Van Sande, J., Swillens, S., Tonacchera, M., Dumont, J., and Vassart, G. (1995) Mol. Endocrinol. 9, 725-733
18. Claus, M., Maier, J., Paschke, R., Kujat, C., Stumvoll, M., and Fuhrer, D. (2005) Thyroid 15, 1089-1094
19. Tonacchera, M., Van Sande, J., Cetani, F., Swillens, S., Schvartz, C., Winiszewski, P., Portmann, L., Dumont, J. E., Vassart, G., and Parma, J. (1996) J. Clin. Endocrinol. Metab. 81, 547-554
20. Fuhrer, D., Holzapfel, H. P., Wonerow, P., Scherbaum, W. A., and Paschke, R. (1997) J. Clin. Endocrinol. Metab. 82, 3885-3891
21. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
22. Libert, F., Lefort, A., Gerard, C., Parmentier, M., Perret, J., Ludgate, M., Dumont, J. E., and Vassart, G. (1989) Biochem. Biophys. Res. Commun. 165, 1250-1255
23. Berridge, M. J. (1983) Biochem. J. 212, 849-858
24. Ballesteros, J. A., Jensen, A. D., Liapakis, G., Rasmussen, S. G., Shi, L., Gether, U., and Javitch, J. A. (2001) J. Biol. Chem. 276, 29171-29177
25. Jäschke, H., Neumann, S., Moore, S., Thomas, C., Colson, A. O., Constanzi, S., Kleinau, G., Jiang, J. K., Paschke, R., Raaka, B. M., Krause, G., and Gershengorn, M. (2006) J. Biol. Chem. 281, 9841-9844
26. Aarons, E. J., Beddows, S., Willingham, T., Wu, L., and Koup, R. A. (2001) Virology 287, 382-390
27. Dragic, T., Trkola, A., Lin, S. W., Nagashima, K. A., Kajumo, F., Zhao, L., Olson, W. C., Wu, L., Mackay, C. R., Allaway, G. P., Sakmar, T. P., Moore, J. P., and Maddon, P. J. (1998) J. Virol. 72, 279-285
28. Lee, B., Sharron, M., Blanpain, C., Doranz, B. J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H. R., Durell, S. R., Parmentier, M., Chang, C. N., Price, K., Tsang, M., and Doms, R. W. (1999) J. Biol. Chem. 274, 9617-9626
29. Kosugi, S., Ban, T., Akamizu, T., and Kohn, L, D. (1992) Biochem. Biophys. Res. Commun. 189, 1754-1762
30. Ryu, K., Lee, H., Kim, S., Beauchamp, J., Tung, C. S., Isaacs, N. W., Ji, I., and Ji, T. H. (1998) J. Biol. Chem. 273, 6285-6291
31. Meduri, G., Touraine, P., Beau, I., Lahuna, O., Desroches, A., Vacher-Lavenu, M. C., Kuttenn, F., and Misrahi, M. (2003) J. Clin. Endocrinol. Metab. 88, 3491-3498
32. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-428
33. Sudo, S., Kumagai, J., Nishi, S., Layfield, S., Ferraro, T., Bathgate, R. A., and Hsueh, A. J. (2003) J. Biol. Chem. 278, 7855-7862
34. Zoffmann, S., Chollet, A., and Galzi, J. L. (2002) Mol. Pharmacol. 62, 729-736
35. Herold, C. L., Qi, A. D., Harden, T. K., and Nicholas, R. A. (2004) J. Biol. Chem. 279, 11456-11464
36. Seong, J. Y., Wang, L., Oh, D. Y., Yun, O., Maiti, K., Li, J. H., Soh, J. M., Choi, H. S., Kim, K., Vaudry, H., and Kwon, H. B. (2003) Endocrinology 144, 454-466
37. Couture, L., Remy, J. J., Rabesona, H., Troalen, F., Pajot-Augy, E., Bozon, V., Haertle, T., Bidart, J. M., and Salesse, R. (1996) Eur. J. Biochem. 241, 627-632
38. Li, S., Liu, X., Min, L., and Ascoli, M. (2001) J. Biol. Chem. 276, 7968-7973
39. Claus, M., Jaeschke, H., Kleinau, G., Neumann, S., Krause, G., and Paschke, R. (2005) Endocrinology 146, 5197-5203
40. Neumann, S., Krause, G., Chey, S., and Paschke, R. (2001) Mol. Endocrinol. 15, 1294-1305
41. Neumann, S., Krause, G., Claus, M., and Paschke, R. (2005) Endocrinology 146, 477-485
42. Biebermann, H., Schoneberg, T., Schulz, A., Krause, G., Gruters, A., Schultz, G., and Gudermann, T. (1998) FASEB J. 12, 1461-1471
43. Urizar, E., Claeysen, S., Deupi, X., Govaerts, C., Costagliola, S., Vassart, G., and Pardo, L. (2005) J. Biol. Chem. 280, 17135-17141
44. Li, J., Edwards, P. C., Burghammer, M., Villa, C., and Schertler, G. F. (2004) J. Mol. Biol. 343, 1409-1438
45. Wuller, S., Wiesner, B., Löffler, A., Furkert, J., Krause, G., Hermosilla, R., Schaefer, M., Schülein, R., Rosenthal, W., and Oksche, A. (2004) J. Biol. Chem. 279, 47254-47263
46. Costanzi, S., Mamedova, L., Gao, Z. G., and Jacobson, K. A. (2004) J. Med. Chem. 47, 5393-5404
47. Liu, S., Fan, S., and Sun, Z. (2003) J. Mol. Model. 9, 329-336
48. Schwartz, T. W., Frimurer, T. M., Holst, B., Rosenkilde, M. M., and Elling, C. E. (2006) Annu. Rev. Pharmacol. Toxicol. 46, 481-519
49. Vassart, G., Pardo, L., and Costagliola, S. (2004) Trends Biochem. Sci. 29, 119-126