High-Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex

Science

Volumn 302, Issue 5652, 2003, Pages 1981-1984

  Silver, R Angus ^a   Lübke, Joachim ^b   Sakmann, Bert ^c   Feldmeyer, Dirk ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; NEUROLOGY; PROBABILITY;

CORTEX;

BIOCHEMISTRY;

BIOCHEMISTRY;

ADOLESCENT; ANIMAL CELL; ARTICLE; EXCITATORY SYNAPSE; HIGH PROBABILITY UNIQUANTAL TRANSMISSION; INFORMATION PROCESSING; NEUROPHYSIOLOGY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SOMATOSENSORY CORTEX; STELLATE CELL; SYNAPSE; SYNAPSE VESICLE;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; AXONS; CALCIUM; DENDRITES; DIPEPTIDES; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; IMAGE PROCESSING, COMPUTER-ASSISTED; KYNURENIC ACID; LYSINE; PATCH-CLAMP TECHNIQUES; PROBABILITY; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, GLUTAMATE; SOMATOSENSORY CORTEX; SYNAPSES; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 0346243802     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087160     Document Type: Article

References (28)

1. B. Katz, The Release of Neural Transmitter Substances (Liverpool Univ. Press, Liverpool, 1969).
2. D. Vere-Jones, Aust. J. Stat. 8, 53 (1966).
3. A. Zador, J. Neurophysiol. 79, 1219 (1998).
4. M. London, A. Schreibman, M. Häusser, M. E. Larkum, I. Segev, Nature Neurosci. 5, 332 (2002).
5. H. Korn, A. Triller, A. Mallet, D. S. Faber, Science 213, 898 (1981).
6. A. I. Gulyas et al., Nature 366, 683 (1993).
7. J. I. Wadiche, C. E. Jahr, Neuron 32, 301 (2001).
8. T. G. Oertner, B. L. Sabatini, E. A. Nimchinsky, K. Svoboda, Nature Neurosci 5, 657 (2002).
9. D. Feldmeyer, J. Lübke, R. A. Silver, B. Sakmann, J. Physiol. (London) 538, 803 (2002).
10. Methods, table S1, and references are available as supporting online material on Science Online.
11. R. A. Silver, A. Momiyama, S. G. Cull-Candy, J. Physiol. (London) 510, 881 (1998).
12. J. D. Clements, R. A. Silver, Trends Neurosci 23, 105 (2000).
13. C. A. Reid, J. D. Clements, J. Physiol. (London) 518, 121 (1999).
14. J. M. Bekkers, J. D. Ctements, J. Physiol. (London) 516, 227 (1999).
15. R. A. Silver, S. G. Cull-Candy, T. Takahashi, J. Physiol. (London) 494, 231 (1996).
16. M. A. Castro-Alamancos, B. W. Connors, Proc. Natl. Acad. Sci. U.S.A. 94, 4161 (1997).
17. V. N. Murthy, T. J. Sejnowski, C. F. Stevens, Neuron 18, 599 (1997).
18. H. Markram, J. Lübke, M. Frotscher, A. Roth, B. Sakmann, J. Physiol. (London) 500, 409 (1997).
19. J. Lübke, A. Roth, D. Feldmeyer, B. Sakmann, Cereb. Cortex 13, 1051 (2003).
20. J. J. Jack, S. J. Redman, K. Wong, J. Physiol. (London) 321, 65 (1981).
21. P. Jonas, G. Major, B. Sakmann, J. Physiol. (London) 472, 615 (1993).
22. R. A. Silver, in Central Synapses: Quantal Mechanisms and Plasticity, D. S. Faber, H. Korn, S. J. Redman, S. M. Thompson, and J. S. Altman, Eds., 4th Human Frontier Science Workshop, Strasbourg, France, 22 to 24 April 1997 (Human Frontier Science Program, Strasbourg, France, 1998), pp. 130-139.
23. K. A. Foster, A. C. Kreitzer, W. G. Regehr, Neuron 35, 1115 (2002).
24. J. S. Diamond, C. E. Jahr, J. Neurosci. 17, 4672 (1997).
25. M. Brecht, B. Sakmann, J. Physiol. (London) 543, 49 (2002).
26. D. E. Feldman, Neuron 27, 45 (2000).
27. S. B. Laughlin, R. R. de Ruyter van Steveninck, J. C. Anderson, Nature Neurosci. 1, 36 (1998).
28. Supported by the Max-Planck Society and the Wellcome Trust. R.A.S. is in receipt of a Wellcome Trust Senior Fellowship. We thank A. Roth and C. Saviane for help with simulations; D. Attwell, D. DiGregorio, M. Farrant, S. Mitchell, T. Nielsen, and I. Vida for comments on the manuscript; and N. Nestel and B. Joch for technical assistance.