Adiponectin receptors in energy homeostasis and obesity pathogenesis

Progress in Molecular Biology and Translational Science

Volumn 114, Issue , 2013, Pages 317-342

  Akingbemi, Benson T ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Adipokine; Adiponectin; AdipoR1; AdipoR2; Adipose tissue; Keywords; Metabolism

Indexed keywords

EID: 84872387023     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386933-3.00009-1     Document Type: Chapter

References (120)

1. K.G. Michalakis, and J.H. Segars The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction Fertil Steril 94 2010 1949 1957
2. M. Chandran, S.A. Phillips, T. Ciaraldi, and R.R. Henry Adiponectin: more than just another fat cell hormone? Diabetes Care 26 2003 2442 2450
3. B.B. Duncan, M.I. Schmidt, J.S. Pankow, H. Bang, D. Couper, and C.M. Ballantyne Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study Diabetes 53 2004 2473 2478
4. N. Halberg, T.D. Schraw, Z.V. Wang, J.Y. Kim, J. Yi, and M.P. Hamilton Systemic fate of the adipocyte-derived factor adiponectin Diabetes 58 2009 1961 1970
5. T. Zhao, M. Hou, M. Xia, Q. Wang, H. Zhu, and Y. Xiao Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways Cell Immunol 238 2005 19 30
6. K. Dadson, Y. Liu, and G. Sweeney Adiponectin action: a combination of endocrine and autocrine/paracrine effects Front Endocrinol (Lausanne) 2 2011 62
7. M. Beylot, C. Pinteur, and O. Peroni Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats Metabolism 55 2006 396 401
8. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, K. Maeda, and H. Kuriyama Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway Circulation 102 2000 1296 1301
9. T. Kadowaki, and T. Yamauchi Adiponectin and adiponectin receptors Endocr Rev 26 2005 439 451
10. T.K. Felder, P. Hahne, S.M. Soyal, K. Miller, H. Hoffinger, and H. Oberkofler Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans Int J Obes (Lond) 34 2010 846 851
11. M. Bjursell, A. Ahnmark, Y.M. Bohlooly, L. William-Olsson, M. Rhedin, and X.R. Peng Opposing effects of adiponectin receptors 1 and 2 on energy metabolism Diabetes 56 2007 583 593
12. G. Ding, Q. Qin, N. He, S.C. Francis-David, J. Hou, and J. Liu Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma J Mol Cell Cardiol 43 2007 73 84
13. C. Bambace, M. Telesca, E. Zoico, A. Sepe, D. Olioso, and A. Rossi Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men Cardiovasc Pathol 20 2011 e153 e156
14. D. Huang, C. Yang, Y. Wang, Y. Liao, and K. Huang PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts Cardiovasc Res 81 2009 98 107
15. D. Fan, L. Li, C. Wang, X.B. Cui, Y. Zhou, and L.L. Wu Adiponectin induces interleukin-6 production and its underlying mechanism in adult rat cardiac fibroblasts J Cell Physiol 226 2011 1793 1802
16. K. Nakanishi, Y. Takeda, S. Tetsumoto, T. Iwasaki, K. Tsujino, and H. Kuhara Involvement of endothelial apoptosis underlying chronic obstructive pulmonary disease-like phenotype in adiponectin-null mice: implications for therapy Am J Respir Crit Care Med 183 2011 1164 1175
17. J.E. Caminos, R. Nogueiras, F. Gaytán, R. Pineda, C.R. González, and M.L. Barreiro Novel expression and direct effects of adiponectin in the rat testis Endocrinology 149 2008 3390 3402
18. X.H. Luo, L.J. Guo, L.Q. Yuan, H. Xie, H.D. Zhou, and X.P. Wu Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway Exp Cell Res 309 2005 99 109
19. K. Sharma, S. Ramachandrarao, G. Qiu, H.K. Usui, Y. Zhu, and S.R. Dunn Adiponectin regulates albuminuria and podocyte function in mice J Clin Invest 118 2008 1645 1656
20. N. Wijesekara, M. Krishnamurthy, A. Bhattacharjee, A. Suhail, G. Sweeney, and M.B. Wheeler Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion J Biol Chem 285 2010 33623 33631
21. J.P. Wen, W.S. Lv, J. Yang, A.F. Nie, X.B. Cheng, and Y. Yang Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential Biochem Biophys Res Commun 371 2008 756 761
22. A. Pfaehler, M.K. Nanjappa, E.S. Coleman, M. Mansour, D. Wanders, and E.P. Plaisance Regulation of adiponectin secretion by soy isoflavones has implication for endocrine function of the testis Toxicol Lett 209 2012 78 85
23. O.M. Ocón-Grove, S.M. Krzysik-Walker, S.R. Maddineni, G.L. Hendricks III, and R. Ramachandran Adiponectin and its receptors are expressed in the chicken testis: influence of sexual maturation on testicular ADIPOR1 and ADIPOR2 mRNA abundance Reproduction 136 2008 627 638
24. E. Lord, S. Ledoux, B.D. Murphy, D. Beaudry, and M.F. Palin Expression of adiponectin and its receptors in swine J Anim Sci 83 2005 565 578
25. S. Ledoux, D.B. Campos, F.L. Lopes, M. Dobias-Goff, M.F. Palin, and B.D. Murphy Adiponectin induces periovulatory changes in ovarian follicular cells Endocrinology 147 2006 5178 5186
26. E. Chappaz, M.S. Albornoz, D. Campos, L. Che, M.F. Palin, and B.D. Murphy Adiponectin enhances in vitro development of swine embryos Domest Anim Endocrinol 35 2008 198 207
27. M. Archanco, J. Gomez-Ambrosi, M. Tena-Sempere, G. Fruhbeck, and M.A. Burrell Expression of leptin and adiponectin in the rat oviduct J Histochem Cytochem 55 2007 1027 1037
28. G. Gutman, V. Barak, S. Maslovitz, A. Amit, J.B. Lessing, and E. Geva Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo: implications for enhanced insulin sensitivity Fertil Steril 91 2009 1837 1841
29. Y. Kotani, I. Yokota, S. Kitamura, J. Matsuda, E. Naito, and Y. Kuroda Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight Clin Endocrinol (Oxf) 61 2004 418 423
30. N. Stefan, J.C. Bunt, A.D. Salbe, T. Funahashi, Y. Matsuzawa, and P.A. Tataranni Plasma adiponectin concentrations in children: relationships with obesity and insulinemia J Clin Endocrinol Metab 87 2002 4652 4656
31. N. Stefan, B. Vozarova, T. Funahashi, Y. Matsuzawa, C. Weyer, and R.S. Lindsay Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans Diabetes 51 2002 1884 1888
32. T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, and K. Hara The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nat Med 7 2001 941 946
33. S.A. Polyzos, J. Kountouras, C. Zavos, and G. Deretzi The potential adverse role of leptin resistance in nonalcoholic fatty liver disease: a hypothesis based on critical review of the literature J Clin Gastroenterol 45 2011 50 54
34. A. Woods, D. Azzout-Marniche, M. Foretz, S.C. Stein, P. Lemarchand, and P. Ferre Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase Mol Cell Biol 20 2000 6704 6711
35. T. Yamauchi, Y. Nio, T. Maki, M. Kobayashi, T. Takazawa, and M. Iwabu Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13 2007 332 339
36. T. Yamauchi, J. Kamon, Y. Minokoshi, Y. Ito, H. Waki, and S. Uchida Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med 8 2002 1288 1295
37. R.B. Ceddia, R. Somwar, A. Maida, X. Fang, G. Bikopoulos, and G. Sweeney Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells Diabetologia 48 2005 132 139
38. M.J. Yoon, G.Y. Lee, J.J. Chung, Y.H. Ahn, S.H. Hong, and J.B. Kim Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha Diabetes 55 2006 2562 2570
39. M. Iwabu, T. Yamauchi, M. Okada-Iwabu, K. Sato, T. Nakagawa, and M. Funata Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2 +) and AMPK/SIRT1 Nature 464 2010 1313 1319
40. T. Christiansen, S.K. Paulsen, J.M. Bruun, T. Ploug, S.B. Pedersen, and B. Richelsen Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin J Clin Endocrinol Metab 95 2010 911 919
41. Y. Liu, S. Chewchuk, C. Lavigne, S. Brule, G. Pilon, and V. Houde Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment Am J Physiol Endocrinol Metab 297 2009 E657 E664
42. R. Summer, C.A. Fiack, Y. Ikeda, K. Sato, D. Dwyer, and N. Ouchi Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease Am J Physiol Lung Cell Mol Physiol 297 2009 L432 L438
43. M. Fasshauer, S. Kralisch, M. Klier, U. Lossner, M. Bluher, and J. Klein Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes Biochem Biophys Res Commun 301 2003 1045 1050
44. S.A. Shore, R.D. Terry, L. Flynt, A. Xu, and C. Hug Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice J Allergy Clin Immunol 118 2006 389 395
45. J.M. Bruun, A.S. Lihn, C. Verdich, S.B. Pedersen, S. Toubro, and A. Astrup Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans Am J Physiol Endocrinol Metab 285 2003 E527 E533
46. N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa, and K. Walsh Obesity, adiponectin and vascular inflammatory disease Curr Opin Lipidol 14 2003 561 566
47. M. Shimano, N. Ouchi, R. Shibata, K. Ohashi, D.R. Pimentel, and T. Murohara Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response J Mol Cell Cardiol 49 2010 210 220
48. R. Shibata, K. Sato, D.R. Pimentel, Y. Takemura, S. Kihara, and K. Ohashi Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms Nat Med 11 2005 1096 1103
49. S. Lee, Y. Park, K.C. Dellsperger, and C. Zhang Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice Am J Physiol Heart Circ Physiol 301 2011 H306 H314
50. Y. Okamoto, Y. Arita, M. Nishida, M. Muraguchi, N. Ouchi, and M. Takahashi An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls Horm Metab Res 32 2000 47 50
51. N. Ouchi, S. Kihara, Y. Arita, M. Nishida, A. Matsuyama, and Y. Okamoto Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages Circulation 103 2001 1057 1063
52. N. Ouchi, S. Kihara, Y. Arita, K. Maeda, H. Kuriyama, and Y. Okamoto Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin Circulation 100 1999 2473 2476
53. Y. Okamoto, S. Kihara, N. Ouchi, M. Nishida, Y. Arita, and M. Kumada Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice Circulation 106 2002 2767 2770
54. M. Nishimura, Y. Izumiya, A. Higuchi, R. Shibata, J. Qiu, and C. Kudo Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms Circulation 117 2008 216 223
55. T. Yamauchi, J. Kamon, H. Waki, Y. Imai, N. Shimozawa, and K. Hioki Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis J Biol Chem 278 2003 2461 2468
56. Y. Cao, L. Tao, Y. Yuan, X. Jiao, W.B. Lau, and Y. Wang Endothelial dysfunction in adiponectin deficiency and its mechanisms involved J Mol Cell Cardiol 46 2009 413 419
57. O.H. Lee, D.H. Seo, C.S. Park, and Y.C. Kim Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells Biofactors 36 2010 459 467
58. M. Nishimura, and H. Takahashi Potential of plasma adiponectin concentrations as a predictive marker for in-stent restenosis after percutaneous coronary intervention in patients on hemodialysis Rinsho Byori 59 2011 795 800
59. T.P. Combs, U.B. Pajvani, A.H. Berg, Y. Lin, L.A. Jelicks, and M. Laplante A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity Endocrinology 145 2004 367 383
60. T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo, and S. Kita Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 2003 762 769
61. A. Naaz, M. Zakroczymski, P. Heine, J. Taylor, P. Saunders, and D. Lubahn Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta) Horm Metab Res 34 2002 758 763
62. M. Mohlig, U. Wegewitz, M. Osterhoff, F. Isken, M. Ristow, and A.F. Pfeiffer Insulin decreases human adiponectin plasma levels Horm Metab Res 34 2002 655 658
63. T.P. Combs, A.H. Berg, M.W. Rajala, S. Klebanov, P. Iyengar, and J.C. Jimenez-Chillaron Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin Diabetes 52 2003 268 276
64. F. Rodriguez-Pacheco, A.J. Martinez-Fuentes, S. Tovar, L. Pinilla, M. Tena-Sempere, and C. Dieguez Regulation of pituitary cell function by adiponectin Endocrinology 148 2007 401 410
65. A.H. Berg, T.P. Combs, and P.E. Scherer ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism Trends Endocrinol Metab 13 2002 84 89
66. P. Pierre, P. Froment, D. Negre, C. Rame, V. Barateau, and C. Chabrolle Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN Hum Reprod 24 2009 2890 2901
67. C. Chabrolle, L. Tosca, and J. Dupont Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis Reproduction 133 2007 719 731
68. Y. Qi, N. Takahashi, S.M. Hileman, H.R. Patel, A.H. Berg, and U.B. Pajvani Adiponectin acts in the brain to decrease body weight Nat Med 10 2004 524 529
69. A. Coope, M. Milanski, E.P. Araujo, M. Tambascia, M.J. Saad, and B. Geloneze AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus FEBS Lett 582 2008 1471 1476
70. N. Kubota, W. Yano, T. Kubota, T. Yamauchi, S. Itoh, and H. Kumagai Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake Cell Metab 6 2007 55 68
71. Q. Tu, J. Zhang, L.Q. Dong, E. Saunders, E. Luo, and J. Tang Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1 J Biol Chem 286 14 2011 12542 12553
72. T. Tamura, M. Yoneda, K. Yamane, S. Nakanishi, R. Nakashima, and M. Okubo Serum leptin and adiponectin are positively associated with bone mineral density at the distal radius in patients with type 2 diabetes mellitus Metabolism 56 2007 623 628
73. J. Chen, B. Tan, E. Karteris, S. Zervou, J. Digby, and E.W. Hillhouse Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines Diabetologia 49 2006 1292 1302
74. Y. Wang, L. Tao, Y. Yuan, W.B. Lau, R. Li, and B.L. Lopez Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action Am J Physiol Endocrinol Metab 297 2009 E384 E391
75. J.P. Thyfault, E.M. Hedberg, R.M. Anchan, O.P. Thorne, C.M. Isler, and E.R. Newton Gestational diabetes is associated with depressed adiponectin levels J Soc Gynecol Investig 12 2005 41 45
76. J. Jarvenpaa, J.T. Vuoristo, M. Santaniemi, O. Ukkola, E.R. Savolainen, and M. Jaaskelainen Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR J Perinat Med 37 2009 257 262
77. B. Kollerits, D. Fliser, I.M. Heid, E. Ritz, and F. Kronenberg Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study Kidney Int 71 2007 1279 1286
78. H. Liu, S. Chen, S. Zhang, C. Xiao, Y. Ren, and H. Tian Adiponectin gene variation -4522C/T is associated with type 2 diabetic obesity and insulin resistance in Chinese J Genet Genomics 34 2007 877 884
79. U.B. Pajvani, M. Hawkins, T.P. Combs, M.W. Rajala, T. Doebber, and J.P. Berger Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity J Biol Chem 279 2004 12152 12162
80. J.P. Whitehead, A.A. Richards, I.J. Hickman, G.A. Macdonald, and J.B. Prins Adiponectin - a key adipokine in the metabolic syndrome Diabetes Obes Metab 8 2006 264 280
81. M.L. Narasimhan, M.A. Coca, J. Jin, T. Yamauchi, Y. Ito, and T. Kadowaki Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor Mol Cell 17 2005 171 180
82. J.A. Sennello, R. Fayad, A.M. Morris, R.H. Eckel, E. Asilmaz, and J. Montez Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin Endocrinology 146 2005 2157 2164
83. M. Adachi, and D.A. Brenner High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase Hepatology 47 2008 677 685
84. T.W. Jung, Y.J. Lee, M.W. Lee, and S.M. Kim Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-Jun NH2 terminal kinase FEBS J 276 2009 2278 2284
85. X. Mao, J.Y. Hong, and L.Q. Dong The adiponectin signaling pathway as a novel pharmacological target Mini Rev Med Chem 6 2006 1331 1340
86. X. Mao, C.K. Kikani, R.A. Riojas, P. Langlais, L. Wang, and F.J. Ramos APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function Nat Cell Biol 8 2006 516 523
87. S.S. Deepa, and L.Q. Dong APPL1: role in adiponectin signaling and beyond Am J Physiol Endocrinol Metab 296 2009 E22 E36
88. M. Neumeier, J. Weigert, R. Buettner, J. Wanninger, A. Schaffler, and A.M. Muller Detection of adiponectin in cerebrospinal fluid in humans Am J Physiol Endocrinol Metab 293 2007 E965 E969
89. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, and J. Miyagawa Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1999 79 83
90. A. Tsuchida, T. Yamauchi, Y. Ito, Y. Hada, T. Maki, and S. Takekawa Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity J Biol Chem 279 2004 30817 30822
91. K. Inukai, Y. Nakashima, M. Watanabe, N. Takata, T. Sawa, and S. Kurihara Regulation of adiponectin receptor gene expression in diabetic mice Am J Physiol Endocrinol Metab 288 2005 E876 E882
92. M. Tena-Sempere, and M.L. Barreiro Leptin in male reproduction: the testis paradigm Mol Cell Endocrinol 188 2002 9 13
93. P.A. Heine, J.A. Taylor, G.A. Iwamoto, D.B. Lubahn, and P.S. Cooke Increased adipose tissue in male and female estrogen receptor-alpha knockout mice Proc Natl Acad Sci U S A 97 2000 12729 12734
94. Q. Gao, G. Mezei, Y. Nie, Y. Rao, C.S. Choi, and I. Bechmann Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals Nat Med 13 2007 89 94
95. S. Ogawa, J. Chan, J.A. Gustafsson, K.S. Korach, and D.W. Pfaff Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity Endocrinology 144 2003 230 239
96. K.M. Robertson, L. O'Donnell, M.E. Jones, S.J. Meachem, W.C. Boon, and C.R. Fisher Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene Proc Natl Acad Sci U S A 96 1999 7986 7991
97. P.S. Cooke, and A. Naaz Role of estrogens in adipocyte development and function Exp Biol Med (Maywood) 229 2004 1127 1135
98. M. Gambacciani, M. Ciaponi, B. Cappagli, L. Piaggesi, and A.R. Genazzani Effects of combined low dose of the isoflavone derivative ipriflavone and estrogen replacement on bone mineral density and metabolism in postmenopausal women Maturitas 28 1997 75 81
99. C. Carani, K. Qin, M. Simoni, M. Faustini-Fustini, S. Serpente, and J. Boyd Effect of testosterone and estradiol in a man with aromatase deficiency N Engl J Med 337 1997 91 95
100. M.E. Jones, A.W. Thorburn, K.L. Britt, K.N. Hewitt, M.L. Misso, and N.G. Wreford Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity Proc Natl Acad Sci U S A 97 23 2000 12735 12740
101. C. Ohlsson, N. Hellberg, P. Parini, O. Vidal, Y.M. Bohlooly, and M. Rudling Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice Biochem Biophys Res Commun 278 2000 640 645
102. A. Foryst-Ludwig, M. Clemenz, S. Hohmann, M. Hartge, C. Sprang, and N. Frost Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma PLoS Genet 4 2008 e1000108
103. P. Baillie-Hamilton Chemical toxins: a hypothesis to explain the global obesity epidemic J Altern Complement Med 8 2002 185 192
104. C.R. Cederroth, and S. Nef Soy, phytoestrogens and metabolism: A review Mol Cell Endocrinol 304 2009 30 42
105. N. Ben-Jonathan, E.R. Hugo, and T.D. Brandebourg Effects of bisphenol A on adipokine release from human adipose tissue: implications for the metabolic syndrome Mol Cell Endocrinol 304 2009 49 54
106. E. Barrett-Connor, K.T. Khaw, and S.S. Yen Endogenous sex hormone levels in older adult men with diabetes mellitus Am J Epidemiol 132 1990 895 901
107. S. Anderson 7 care tips for managing patients with diabetes Am J Nurs 94 1994 36 38
108. P. Dandona, and S. Dhindsa Update: Hypogonadotropic hypogonadism in type 2 diabetes and obesity J Clin Endocrinol Metab 96 2011 2643 2651
109. D.E. Laaksonen, L. Niskanen, K. Punnonen, K. Nyyssonen, T.P. Tuomainen, and V.P. Valkonen Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men Diabetes Care 27 2004 1036 1041
110. D.E. Laaksonen, L. Niskanen, K. Punnonen, K. Nyyssonen, T.P. Tuomainen, and V.P. Valkonen The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study J Clin Endocrinol Metab 90 2005 712 719
111. N. Pitteloud, J. Villegas, A.A. Dwyer, W.F. Crowley Jr., M.J. McPhaul, and F.J. Hayes Acute stress masking the biochemical phenotype of partial androgen insensitivity syndrome in a patient with a novel mutation in the androgen receptor J Clin Endocrinol Metab 89 2004 1053 1058
112. Y. Yamamoto, H. Hirose, I. Saito, M. Tomita, M. Taniyama, and K. Matsubara Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population Clin Sci (Lond) 103 2002 137 142
113. C. Buechler, J. Wanninger, and M. Neumeier Adiponectin, a key adipokine in obesity related liver diseases World J Gastroenterol 17 23 2011 2801 2811
114. H. Kondo, I. Shimomura, Y. Matsukawa, M. Kumada, M. Takahashi, and M. Matsuda Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome Diabetes 51 2002 2325 2328
115. H. Mori, H. Ikegami, Y. Kawaguchi, S. Seino, N. Yokoi, and J. Takeda The Pro12 →Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes Diabetes 50 2001 891 894
116. O. Treeck, I. Juhasz-Boess, C. Lattrich, F. Horn, R. Goerse, and O. Ortmann Effects of exon-deleted estrogen receptor beta transcript variants on growth, apoptosis and gene expression of human breast cancer cell lines Breast Cancer Res Treat 110 2008 507 520
117. N.E. Gulcelik, Y. Aral, R. Serter, and G. Koc Association of hypoadiponectinemia with metabolic syndrome in patients with polycystic ovary syndrome J Natl Med Assoc 100 2008 64 68
118. K.A. Toulis, D.G. Goulis, E.M. Kolibianakis, C.A. Venetis, B.C. Tarlatzis, and I. Papadimas Risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systematic review and a meta-analysis Fertil Steril 92 2009 667 677
119. N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, and H. Nagaretani Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 Nat Med 8 2002 731 737
120. R.S. Lindsay, T. Funahashi, R.L. Hanson, Y. Matsuzawa, S. Tanaka, and P.A. Tataranni Adiponectin and development of type 2 diabetes in the Pima Indian population Lancet 360 2002 57 58