Estrogen increases locomotor activity in mice through estrogen receptor α: Specificity for the type of activity

Endocrinology

Volumn 144, Issue 1, 2003, Pages 230-239

  Ogawa, Sonoko ^a   Chan, Johnny ^a   Gustafsson, Jan Åke ^b   Korach, Kenneth S ^c   Pfaff, Donald W ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL BENZOATE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PLACEBO;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GONADECTOMY; HORMONE ACTION; HORMONE DETERMINATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN FUNCTION; RUNNING; SURGICAL TECHNIQUE; WILD TYPE;

ANIMALS; DRUG IMPLANTS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; KINETICS; MALE; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; ORCHIECTOMY; OVARIECTOMY; RECEPTORS, ESTROGEN;

EID: 0037233212     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220519     Document Type: Article

References (30)

1. Wollnik F, Turek FW 1988 Estrous correlated modulations of circadian and ultradian wheel-running activity rhythms in LEW/Ztm rats. Physiol Behav 43:389-396
2. Rodier III WI 1971 Progesterone-estrogen interactions in the control of activity-wheel running in the female rat. J Comp Physiol Psychol 74:365-373
3. Roy EJ, Wade GN 1975 Role of estrogens in androgen-induced spontaneous activity in male rats. J Comp Physiol Psychol 89:573-579
4. Gentry RT, Wade GN 1976 Sex differences in sensitivity of food intake, body weight, and running-wheel activity to ovarian steroids in rats. J Comp Physiol Psychol 90:747-754
5. Ahdieh HB, Wade GN 1982 Effects of hysterectomy on sexual receptivity, food intake, running wheel activity, and hypothalamic estrogen and progestin receptors in rats. J Comp Physiol Psychol 96:886-892
6. Stockman ER, Albers HE, Baum MJ 1985 Activity in the ferret: Oestradiol effects and circadian rhythms. Anim Behav 33:150-154
7. King JM 1979 Effects of lesions of the amygdala, preoptic area, and hypothalamus on estradiol-induced activity in the female rat. J Comp Physiol Psychol 93:360-367
8. Takeo T, Sakuma Y 1995 Diametrically opposite effects of estrogen on the excitability of female rat medial and lateral preoptic neurons with axons to the midbrain locomotor region. Neurosci Res 22:73-80
9. Fahrbach SE, Meisel RL, Pfaff DW 1985 Preoptic implants of estradiol increase wheel running but not the open field activity of female rats. Physiol Behav 35:985-992
10. Shughrue PJ, Scrimo P, Lane M, Askew R, Merchenthaler I 1997 The distribution of estrogen receptor-β mRNA in forebrain regions of the estrogen receptor-α knockout mouse. Endocrinology 138:5649-5652
11. Shughrue PJ, Lane MV, Merchenthaler I 1997 Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388:507-525
12. Shughrue PJ, Scrimo PJ, Merchenthaler I 1998 Evidence for the colocalization of estrogen receptor-β mRNA and estrogen receptor-α immunoreactivity in neurons of the rat forebrain. Endocrinology 139:5267-5270
13. Nomura M, Korach KS, Pfaff DW, Ogawa S, Differential regulation of estrogen receptor (ER)-β immunoreactivity by gonadal steroids in specific brain regions of male wild type and ER-α knockout mice. Mol Brain Res, in press
14. Mitra SW, Wilkinson H, Rohrer S, Liu H, Yuckovitz J, Schaeffer JM, McEwen BS, Pfaff DW, Ogawa S, Hoskin E, Alves SE, Characterization of a novel ERβ antibody and localization of ERβ immunoreactivity in the mouse brain. Program of the 83rd Annual Meeting of The Endocrine Society, Denver, CO, 2001, p 160 (Abstract P1-48)
15. Blizard DA, Lippman HR, Chen JJ 1975 Sex differences in open-field behavior in the rat: The inductive and activational role of gonadal hormones. Physiol Behav 14:601-608
16. Morgan MA, Pfaff DW 2001 Effects of estrogen level on activity and fear-related behaviors in mice. Horm Behav 40:472-482
17. Nagy ZM, Glaser HD 1970 Open-field behavior of C57BL/6J mice: Effects of illumination, age, and number of test days. Psychon Sci 19:143-145
18. Ogawa S, Lubahn DB, Korach KS, Pfaff DW 1997 Behavioral effects of estrogen receptor gene disruption in male mice. Proc Natl Acad Sci USA 94:1476-1481
19. Ogawa S, Chan J, Chester AE, Gustafsson J, Korach KS, Pfaff DW 1999 Survival of reproduction-related behaviors in male and female estrogen receptor β deficient (βERKO) male and female mice. Proc Natl Acad Sci USA 96:12887-12892
20. Ogawa S, Eng V, Taylor JA, Lubahn DB, Korach KS, Pfaff DW 1998 Roles of estrogen receptor-α gene expression in reproduction-related behaviors in female mice. Endocrinology 139:5070-5081
21. Thomas EM, Armstrong SM 1989 Effect of ovariectomy and estradiol on unity of female rat circadian rhythms. Am J Physiol 257:R1241-R1250
22. Albers HE 1981 Gonadal hormones organize and modulate the circadian system of the rat. Am J Physiol 241:R62-R66
23. Zucker I, Fitzgerald KM, Morin LP 1980 Sex differentiation of the circadian system in the golden hamster. Am J Physiol 238:R97-R101
24. Ruiz de Elvira MC, Persaud R, Coen CW 1992 Use of running wheels regulates the effects of the ovaries on circadian rhythms. Physiol Behav 52:277-284
25. Takahashi JS 1995 Molecular neurobiology and genetics of circadian rhythms in mammals. Annu Rev Neurosci 18:531-553
26. King DP, Takahashi JS 2000 Molecular genetics of circadian rhythms in mammals. Annu Rev Neurosci 23:713-742
27. Ogawa S, Krebs CJ, Korach KS, Pfaff DW 1998 Forebrain steroid receptor immunoreactive cells in neonatal and prepubertal estrogen receptor-α gene deficient (ERKO) mice. Soc Neurosci Abstr 24:199
28. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M 2000 Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127(Suppl):4277-4291
29. Krezel W, Dupont S, Krust A, Chambon P, Chapman PF 2001 Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice. Proc Natl Acad Sci USA 98:12278-12282
30. Sacrestano D, McKenna E, Ogawa S, Gustafsson J-Å, Smithies O, Korach KS, Pfaff DW 2000 Spatial learning in gene knockout mice of estrogen receptors α (αERKO) and β (βERKO). Soc Neurosci Abstr 26:1746