Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans

Diabetes

Volumn 51, Issue 6, 2002, Pages 1884-1888

  Stefan, Norbert ^a,e   Vozarova, Barbora ^a,e   Funahashi, Tohru ^b,e   Matsuzawa, Yuji ^b,e   Weyer, Christian ^a,e   Lindsay, Robert S ^a,e   Youngren, Jack F ^c,e   Havel, Peter J ^d,e   Pratley, Richard E ^a,e   Bogardus, Clifton ^a,e   Antonio Tataranni, P ^a,e  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Clinic Diabetes and Nutri Section   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; INSULIN; INSULIN RECEPTOR;

AMERICAN INDIAN; ARTICLE; BODY COMPOSITION; BODY FAT; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MUSCLE BIOPSY; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE;

EID: 0036266897     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.6.1884     Document Type: Article

References (30)

1. Obesity and insulin resistance
2. Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein, and adiponectin
3. A novel serum protein similar to C1q, produced exclusively in adipocytes
4. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
5. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1)
6. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
7. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
8. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
9. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
10. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
11. Obesity and insulin resistance: Lessons learned from the Pima Indians
12. Decreased muscle insulin receptor kinase correlates with insulin resistance in normoglycemic Pima Indians
13. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
14. A method for underwater weighing and the determination of body density
15. Dual-energy X-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition
16. Use of dual-energy X-ray absorptiometry in obese individuals
17. Body composition from fluid spaces and density: Analysis of methods
18. Impaired glucose tolerance as a disorder of insulin action: Longitudinal and cross-sectional studies in Pima Indians
19. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
20. A nonradioactive assay for the insulin receptor tyrosine kinase: Use in monitoring receptor kinase activity after activation of overexpressed protein kinase C alpha and high glucose treatment
21. Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus
22. Molecular mechanism of insulin resistance in type 2 diabetes mellitus: Role of the insulin receptor variant forms
23. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
24. Insulin signal transduction in skeletal muscle from glucose-intolerant relatives with type 2 diabetes
25. Tumor necrosis factor alpha inhibits signaling from the insulin receptor
26. Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus
27. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes
28. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity
29. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
30. The adipocyte-secreted protein Acrp 30 enhances hepatic insulin action