Testosterone and Sex Hormone-Binding Globulin Predict the Metabolic Syndrome and Diabetes in Middle-Aged Men

Diabetes Care

Volumn 27, Issue 5, 2004, Pages 1036-1041

  Laaksonen, David E ^a,b   Niskanen, Leo ^a   Punnonen, Kari ^a   Nyyssönen, Kristiina ^b   Tuomainen, Tomi Pekka ^b   Valkonen, Veli Pekka ^b   Salonen, Riitta ^b   Salonen, Jukka T ^b,c  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c Inner Savo Health Centre   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGE; ALCOHOL CONSUMPTION; ARTICLE; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; FOLLOW UP; GLUCOSE METABOLISM; HUMAN; INSULIN METABOLISM; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; PATHOGENESIS; RISK FACTOR; SMOKING; SOCIOECONOMICS;

BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FOLLOW-UP STUDIES; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; ODDS RATIO; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN; SMOKING; TESTOSTERONE;

EID: 2342644814     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.27.5.1036     Document Type: Article

References (39)

1. Phillips GB: Relationship between serum sex hormones and glucose, insulin and lipid abnormalities in men with myocardial infarction. Proc Natl Acad Sci U S A 74:1729-1733, 1977
2. Phillips GB: Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity. Metabolism 42:116-120, 1993
3. Haffner SM, Karhapaa P, Mykkanen L, Laakso M: Insulin resistance, body fat distribution, and sex hormones in men. Diabetes 43:212-219, 1994
4. Haffner SM, Valdez RA, Mykkanen L, Stern MP, Katz MS: Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. Metabolism 43: 599-603, 1994
5. Haffner SM: Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation. Int J Obes Relat Metab Disord 24 (Suppl. 2):S56-S58, 2000
6. Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen T-P, Salonen R, Rauramaa R, Salonen JT: Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol 149:601-608, 2003
7. Phillips GB, Jing T, Heymsfield SB: Relationships in men of sex hormones, insulin, adiposity, and risk factors for myocardial infarction. Metabolism 52: 784-790, 2003
8. Haffner SM, Mykkanen L, Valdez RA, Katz MS: Relationship of sex hormones to lipids and lipoproteins in nondiabetic men. J Clin Endocrinol Metab 77:1610-1615, 1993
9. Tsai EC, Boyko EJ, Leonetti DL, Fujimoto WY: Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. Int J Obes Relat Metab Disord 24:485-491, 2000
10. Marin P, Holmang S, Jonsson L, Sjostrom L, Kvist H, Holm G, Lindstedt G, Bjorntorp P: The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord 16:991-997, 1992
11. Walker BR: Steroid metabolism in metabolic syndrome X. Best Pract Res Clin Endocrinol Metab 15:111-122, 2001
12. Rask E, Olsson T, Soderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR: Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86:1418-1421, 2001
13. Matilainen V, Koskela P, Keinanen-Kiukaanniemi S: Early androgenetic alopecia as a marker of insulin resistance (Letter). Lancet 356:1165-1166, 2000
14. Holmang A, Bjorntorp P: The effects of testosterone on insulin sensitivity in male rats. Acta Physiol Scand 146:505-510, 1992
15. Marin P: Testosterone and regional fat distribution. Obes Res 3 (Suppl. 4):609S-612S, 1995.
16. Liu PY, Wishart SM, Celermajer DS, Jimenez M, Pierro ID, Conway AJ, Handelsman DJ: Do reproductive hormones modify insulin sensitivity and metabolism in older men? A randomized, placebo-controlled clinical trial of recombinant human chorionic gonadotropin. Eur J Endocrinol 148:55-66, 2003
17. Haffner SM, Shaten J, Stern MP, Smith GD, Kuller L: Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men: MRFIT Research Group: Multiple Risk Factor Intervention Trial. Am J Epidemiol 143:889-897, 1996
18. Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB: Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study. Diabetes Care 23:490-494, 2000
19. Oh JY, Barrett-Connor E, Wedick NM, Wingard DL: Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo Study. Diabetes Care 25:55-60, 2002
20. Salonen JT: Is there a continuing need for longitudinal epidemiologic research? The Kuopio Ischaemic Heart Disease Risk Factor Study. Ann Clin Res 20:46-50, 1988
21. Anderson DC, Thorne MO, Fisher RA, Woodham JP, Goble HL, Besser CM: Effects of hormonal treatment on plasma unbound androgen levels in hirsute women (Abstract). Acta Endocrinol (Copenh) 90: 224, 1975
22. Wheeler MJ: The determination of bioavailable testosterone. Ann Clin Biochem 32:345-357, 1995
23. Nanjee MN, Wheeler MJ: Plasma free testosterone: is an index sufficient? Ann Clin Biochem 22:387-390, 1985
24. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus: provisional report of a WHO consultation. Diabet Med 15:539-553, 1998
25. National Cholesterol Education Program: Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486-2497, 2001
26. Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT: Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med 330:1549-1554, 1994
27. Lynch JW, Kaplan GA, Cohen RD, Kauhanen J, Wilson TW, Smith NL, Salonen JT: Childhood and adult socioeconomic status as predictors of mortality in Finland. Lancet 343:524-527, 1994
28. Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA: Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 25:1612-1618, 2002
29. Vermeulen A, Verdonck L, Kaufman JM: A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672, 1999
30. Davani B, Khan A, Hult M, Martensson E, Okret S, Efendic S, Jornvall H, Oppermann UC: Type 1 11beta-hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. J Biol Chem 275:34841-34844, 2000
31. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS: A transgenic model of visceral obesity and the metabolic syndrome. Science 294: 2166-2170, 2001
32. Dotsch J, Rascher W: The role of 11beta-hydroxysteroid dehydrogenase activity in the metabolic syndrome: lessons learned from the animal model. Eur J Endocrinol 146:603-605, 2002
33. Pasquali R, Casimirri F, De lasio R, Mesini P, Boschi S, Chierici R, Flamia R, Biscotti M, Vicennati V: Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men. J Clin Endocrinol Metab 80:654-658, 1995
34. Plymate SR, Matej LA, Jones RE, Friedl KE: Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab 67:460-464, 1988
35. Heinlein CA, Chang C: The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 16:2181-2187, 2002
36. Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A: Changes in sex hormone binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. In press
37. Kaukua J, Pekkarinen T, Sane T, Mustajoki P: Sex hormones and sexual function in obese men losing weight. Obes Res 11: 689-694, 2003
38. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M: Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N EnglJ Med 344:1343-1350, 2001
39. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002