Adiponectin induces interleukin-6 production and its underlying mechanism in adult rat cardiac fibroblasts

Journal of Cellular Physiology

Volumn 226, Issue 7, 2011, Pages 1793-1802

  Fan, Dong ^a   Li, Li ^a   Wang, Cheng ^a   Cui, Xiao Bing ^a   Zhou, Yun ^a   Wu, Li Ling ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION;

ADIPONECTIN; AGE FACTORS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MYOCARDIUM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADIPONECTIN; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; UP-REGULATION;

MUS; RATTUS;

EID: 79955046971     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22512     Document Type: Article

References (51)

1. Abke S, Neumeier M, Weigert J, Wehrwein G, Eggenhofer E, Schaffler A, Maier K, Aslanidis C, Scholmerich J, Buechler C. 2006. Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes. Cardiovasc Diabetol 5:17.
2. Ajuwon KM, Spurlock ME. 2005. Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol 288:R1220-R1225.
3. Baffet G, Braciak TA, Fletcher RG, Gauldie J, Fey GH, Northemann W. 1991. Autocrine activity of interleukin 6 secreted by hepatocarcinoma cell lines. Mol Biol Med 8:141-156.
4. Banerjee I, Fuseler JW, Intwala AR, Baudino TA. 2009. IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart. Am J Physiol Heart Circ Physiol 296:H1694-H1704.
5. Booz GW, Dostal DE, Baker KM. 1999. Paracrine actions of cardiac fibroblasts on cardiomyocytes: Implications for the cardiac renin-angiotensin system. Am J Cardiol 83:44H-47H.
6. Camelliti P, Borg TK, Kohl P. 2005. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res 65:40-51.
7. Chen M, Li W, Wang N, Zhu Y, Wang X. 2007. ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP-binding cassette transporter A1. Am J Physiol Cell Physiol 292:C1493-C1501.
8. Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A. 2007. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 56:1387-1394.
9. Dawn B, Xuan YT, Guo Y, Rezazadeh A, Stein AB, Hunt G, Wu WJ, Tan W, Bolli R. 2004. IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. Cardiovasc Res 64:61-71.
10. Diaz JA, Booth AJ, Lu G, Wood SC, Pinsky DJ, Bishop DK. 2009. Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant 9:1773-1783.
11. Ding G, Qin Q, He N, Francis-David SC, Hou J, Liu J, Ricks E, Yang Q. 2007. Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma. J Mol Cell Cardiol 43:73-84.
12. Du JH, Xu N, Song Y, Xu M, Lu ZZ, Han C, Zhang YY. 2005. AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: A possible role for AMPK. Biochem Biophys Res Commun 337:1139-1144.
13. Dubey RK, Gillespie DG, Mi Z, Jackson EK. 1997. Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: Role of A2B receptors. Circulation 96:2656-2666.
14. Franchimont N, Durant D, Rydziel S, Canalis E. 1999. Platelet-derived growth factor induces interleukin-6 transcription in osteoblasts through the activator protein-1 complex and activating transcription factor-2. J Biol Chem 274:6783-6789.
15. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF. 2001. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98:2005-2010.
16. Fujioka D, Kawabata K, Saito Y, Kobayashi T, Nakamura T, Kodama Y, Takano H, Obata JE, Kitta Y, Umetani K, Kugiyama K. 2006. Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Am J Physiol Heart Circ Physiol 290:H2409-H2416.
17. Funakoshi Y, Ichiki T, Ito K, Takeshita A. 1999. Induction of interleukin-6 expression by angiotensin II in rat vascular smooth muscle cells. Hypertension 34:118-125.
18. Gray MO, Long CS, Kalinyak JE, Li HT, Karliner JS. 1998. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts. Cardiovasc Res 40:352-363.
19. Han Y, Runge MS, Brasier AR. 1999. Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors. Circ Res 84:695-703.
20. Hattori Y, Hattori S, Kasai K. 2006. Globular adiponectin activates nuclear factor-kappaB in vascular endothelial cells, which in turn induces expression of proinflammatory and adhesion molecule genes. Diabetes Care 29:139-141.
21. Hattori Y, Hattori S, Akimoto K, Nishikimi T, Suzuki K, Matsuoka H, Kasai K. 2007. Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts. Diabetes 56:804-808.
22. Heiker JT, Wottawah CM, Juhl C, Kosel D, Morl K, Beck-Sickinger AG. 2009. Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling. Cell Signal 21:936-942.
23. Kadowaki T, Yamauchi T. 2005. Adiponectin and adiponectin receptors. Endocr Rev 26:439-451.
24. Kamio N, Akifusa S, Yamaguchi N, Yamashita Y. 2008. Induction of granulocyte colony-stimulating factor by globular adiponectin via the MEK-ERK pathway. Mol Cell Endocrinol 292:20-25.
25. Krakoff J, Funahashi T, Stehouwer CD, Schalkwijk CG, Tanaka S, Matsuzawa Y, Kobes S, Tataranni PA, Hanson RL, Knowler WC, Lindsay RS. 2003. Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care 26:1745-1751.
26. Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ. 1995. Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 27:2347-2357.
27. Lee MH, Klein RL, El-Shewy HM, Luttrell DK, Luttrell LM. 2008. The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry 47:11682-11692.
28. Li L, Wu L, Wang C, Liu L, Zhao Y. 2007. Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes. Regul Pept 139:72-79.
29. Liao W, Yu C, Wen J, Jia W, Li G, Ke Y, Zhao S, Campell W. 2009. Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts. Biol Cell 101:263-272.
30. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR. 2006. APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol 26:8928-8941.
31. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. 1996. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221:286-289.
32. Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ. 2006. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 8:516-523.
33. Matsui H, Ihara Y, Fujio Y, Kunisada K, Akira S, Kishimoto T, Yamauchi-Takihara K. 1999. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes. Cardiovasc Res 42:104-112.
34. Matsushita K, Iwanaga S, Oda T, Kimura K, Shimada M, Sano M, Umezawa A, Hata J, Ogawa S. 2005. Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. Lab Invest 85:1210-1223.
35. Nakano Y, Tobe T, Choi-Miura NH, Mazda T, Tomita M. 1996. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J Biochem 120:803-812.
36. Ogunwobi OO, Beales IL. 2006. Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells. Regul Pept 134:105-113.
37. Sano M, Fukuda K, Kodama H, Pan J, Saito M, Matsuzaki J, Takahashi T, Makino S, Kato T, Ogawa S. 2000. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J Biol Chem 275:29717-29723.
38. Sano M, Fukuda K, Sato T, Kawaguchi H, Suematsu M, Matsuda S, Koyasu S, Matsui H, Yamauchi-Takihara K, Harada M, Saito Y, Ogawa S. 2001. ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Circ Res 89:661-669.
39. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. 1995. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749.
40. Shapiro L, Scherer PE. 1998. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 8:335-338.
41. Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR, Kumada M, Sato K, Schiekofer S, Ohashi K, Funahashi T, Colucci WS, Walsh K. 2004. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 10:1384-1389.
42. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K. 2005. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 11:1096-1103.
43. Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, Sam F, Ouchi N, Walsh K. 2007. Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J Mol Cell Cardiol 42:1065-1074.
44. Smart N, Mojet MH, Latchman DS, Marber MS, Duchen MR, Heads RJ. 2006. IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc Res 69:164-177.
45. Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM. 2007. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 179:5483-5492.
46. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, Mabuchi N, Sawaki M, Kinoshita M. 1998. Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31:391-398.
47. Wang C, Li L, Zhang ZG, Fan D, Zhu Y, Wu LL. 2010. Globular adiponectin inhibits angiotensin II-induced nuclear factor kappaB activation through AMP-activated protein kinase in cardiac hypertrophy. J Cell Physiol 222:149-155.
48. Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME. 2004. Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 316:924-929.
49. Xu Y, Wang N, Ling F, Li P, Gao Y. 2009. Receptor for activated C-kinase 1, a novel binding partner of adiponectin receptor 1. Biochem Biophys Res Commun 378:95-98.
50. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. 2003. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-769.
51. 2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem 284:22426-22435.