P-glycoprotein is fully active after multiple tryptophan substitutions

Biochimica et Biophysica Acta - Biomembranes

Volumn 1828, Issue 3, 2013, Pages 1159-1168

  Swartz, Douglas J ^a,b   Weber, Joachim ^b,c   Urbatsch, Ina L ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c TEXAS TECH UNIVERSITY   (United States)

Author keywords

Conservative tryptophan substitutions; Drug binding sites; Membrane bilayer; Native tryptophans; P glycoprotein; Polyspecificity

Indexed keywords

ADENOSINE TRIPHOSPHATASE; FUNGICIDE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; MUTANT PROTEIN; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELLULAR PARAMETERS; CONTROLLED STUDY; DRUG BINDING; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; FUNGAL REPRODUCTION; INTRACELLULAR COUPLING HELIX; MATING; MEMBRANE BINDING; NONHUMAN; PHOTOCHEMICAL QUENCHING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; WILD TYPE;

ADENOSINE TRIPHOSPHATASES; ANTIFUNGAL AGENTS; BINDING SITES; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, FUNGAL; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; P-GLYCOPROTEIN; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; TACROLIMUS; TRYPTOPHAN; VALINOMYCIN; VERAPAMIL;

SACCHAROMYCES CEREVISIAE;

EID: 84872144837     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2012.12.005     Document Type: Article

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