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Volumn 50, Issue 1, 2011, Pages 209-232

The controversial role of ABC transporters in clinical oncology

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT;

EID: 84856282091     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSE0500209     Document Type: Article
Times cited : (186)

References (101)
  • 5
    • 33645930969 scopus 로고    scopus 로고
    • Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues
    • Fetsch, P., Abati, A., Litman, T., Morisaki, K., Honjo, Y., Mittal, K. and Bates, S. (2006) Localization of the ABCG2 mitoxantrone resistance- associated protein in normal tissues. Cancer Lett. 235, 84-92
    • (2006) Cancer Lett. , vol.235 , pp. 84-92
    • Fetsch, P.1    Abati, A.2    Litman, T.3    Morisaki, K.4    Honjo, Y.5    Mittal, K.6    Bates, S.7
  • 8
    • 31844455959 scopus 로고    scopus 로고
    • Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
    • Deeley, R. and Cole, S. (2006) Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS Lett. 580, 1103-1111
    • (2006) FEBS Lett. , vol.580 , pp. 1103-1111
    • Deeley, R.1    Cole, S.2
  • 9
    • 0032494133 scopus 로고    scopus 로고
    • Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage
    • Wijnholds, J., Scheffer, G., van der Valk, M., van der Valk, P., Beijnen, J., Scheper, R. and Borst, P. (1998) Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J. Exp. Med. 188, 797-808
    • (1998) J. Exp. Med. , vol.188 , pp. 797-808
    • Wijnholds, J.1    Scheffer, G.2    Van Der Valk, M.3    Van Der Valk, P.4    Beijnen, J.5    Scheper, R.6    Borst, P.7
  • 11
    • 14644444547 scopus 로고    scopus 로고
    • ABC transporters in the balance: Is there a role in multidrug resistance?
    • Polgar, O. and Bates, S. (2005) ABC transporters in the balance: is there a role in multidrug resistance? Biochem. Soc. Trans. 33, 241-245
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 241-245
    • Polgar, O.1    Bates, S.2
  • 12
    • 0033179095 scopus 로고    scopus 로고
    • Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: A Southwest Oncology Group study
    • Leith, C., Kopecky, K., Chen, I., Eijdems, L., Slovak, M., McConnell, T., Head, D., Weick, J., Grever, M., Appelbaum, F. and Willman, C. (1999) Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group study. Blood 94, 1086-1099
    • (1999) Blood , vol.94 , pp. 1086-1099
    • Leith, C.1    Kopecky, K.2    Chen, I.3    Eijdems, L.4    Slovak, M.5    McConnell, T.6    Head, D.7    Weick, J.8    Grever, M.9    Appelbaum, F.10    Willman, C.11
  • 13
    • 0031864247 scopus 로고    scopus 로고
    • Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients
    • Legrand, O., Simonin, G., Perrot, J.Y., Zittoun, R. and Marie, J.P. (1998) Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients. Blood 91, 4480-4488
    • (1998) Blood , vol.91 , pp. 4480-4488
    • Legrand, O.1    Simonin, G.2    Perrot, J.Y.3    Zittoun, R.4    Marie, J.P.5
  • 14
    • 33745957993 scopus 로고    scopus 로고
    • Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
    • Wilson, C., Davidson, G., Martin, S., Andries, E., Potter, J., Harvey, R., Ar, K., Xu, Y., Kopecky, K., Ankerst, D. et al. (2006) Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 108, 685-696
    • (2006) Blood , vol.108 , pp. 685-696
    • Wilson, C.1    Davidson, G.2    Martin, S.3    Andries, E.4    Potter, J.5    Harvey, R.6    Ar, K.7    Xu, Y.8    Kopecky, K.9    Ankerst, D.10
  • 17
    • 0037314795 scopus 로고    scopus 로고
    • RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: Correlation with chemotherapeutic response
    • Burger, H., Foekens, J., Look, M., Meijer-van Gelder, M., Klijn, J., Wiemer, E., Stoter, G. and Nooter, K. (2003) RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin. Cancer Res. 9, 827-836
    • (2003) Clin. Cancer Res. , vol.9 , pp. 827-836
    • Burger, H.1    Foekens, J.2    Look, M.3    Meijer-Van Gelder, M.4    Klijn, J.5    Wiemer, E.6    Stoter, G.7    Nooter, K.8
  • 18
    • 0030920342 scopus 로고    scopus 로고
    • Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp170 expression and its possible functional significance
    • Trock, B.J., Leonessa, F. and Clarke, R. (1997) Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance. J. Natl. Cancer Inst. 89, 917-931
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 917-931
    • Trock, B.J.1    Leonessa, F.2    Clarke, R.3
  • 19
    • 1842477895 scopus 로고    scopus 로고
    • Expression of multidrug resistance-1 protein inversely correlates with paclitaxel response and survival in ovarian cancer patients: A study in serial samples
    • Penson, R.T., Oliva, E., Skates, S.J., Glyptis, T., Fuller, A.F., Jr, Goodman, A. and Seiden, M.V. (2004) Expression of multidrug resistance-1 protein inversely correlates with paclitaxel response and survival in ovarian cancer patients: a study in serial samples. Gynecol. Oncol. 93, 98-106
    • (2004) Gynecol. Oncol. , vol.93 , pp. 98-106
    • Penson, R.T.1    Oliva, E.2    Skates, S.J.3    Glyptis, T.4    Fuller Jr., A.F.5    Goodman, A.6    Seiden, M.V.7
  • 21
    • 0032911283 scopus 로고    scopus 로고
    • P-glycoprotein, lung resistance-related protein and multidrug resistance associated protein in de novo acute non-lymphocytic leukaemias: Biological and clinical implications
    • Michieli, M., Damiani, D., Ermacora, A., Masolini, P., Raspadori, D., Visani, G., Scheper, R.J. and Baccarani, M. (1999) P-glycoprotein, lung resistance-related protein and multidrug resistance associated protein in de novo acute non-lymphocytic leukaemias: biological and clinical implications. Br. J. Haematol. 104, 328-335
    • (1999) Br. J. Haematol. , vol.104 , pp. 328-335
    • Michieli, M.1    Damiani, D.2    Ermacora, A.3    Masolini, P.4    Raspadori, D.5    Visani, G.6    Scheper, R.J.7    Baccarani, M.8
  • 22
    • 20044364737 scopus 로고    scopus 로고
    • Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: The Austrian Breast and Colorectal Cancer Study Group
    • Filipits, M., Pohl, G., Rudas, M., Dietze, O., Lax, S., Grill, R., Pirker, R., Zielinski, C., Hausmaninger, H., Kubista, E. et al. (2005) Clinical role of multidrug resistance protein 1 expression in chemotherapy resistance in early-stage breast cancer: the Austrian Breast and Colorectal Cancer Study Group. J. Clin. Oncol. 23, 1161-1168
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1161-1168
    • Filipits, M.1    Pohl, G.2    Rudas, M.3    Dietze, O.4    Lax, S.5    Grill, R.6    Pirker, R.7    Zielinski, C.8    Hausmaninger, H.9    Kubista, E.10
  • 23
    • 0036903656 scopus 로고    scopus 로고
    • Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression
    • Hsia, T., Lin, C., Wang, J., Ho, S. and Kao, A. (2002) Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression. Lung 180, 173-179
    • (2002) Lung , vol.180 , pp. 173-179
    • Hsia, T.1    Lin, C.2    Wang, J.3    Ho, S.4    Kao, A.5
  • 24
    • 77953363931 scopus 로고    scopus 로고
    • Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy
    • Li, J., Li, Z., Yu, L., Bao, Q., Wu, J., Shi, S. and Li, X. (2010) Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy. Lung Cancer 69, 116-122
    • (2010) Lung Cancer , vol.69 , pp. 116-122
    • Li, J.1    Li, Z.2    Yu, L.3    Bao, Q.4    Wu, J.5    Shi, S.6    Li, X.7
  • 26
    • 0037093101 scopus 로고    scopus 로고
    • Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia
    • van der Kolk, D., Vellenga, E., Scheffer, G., Müller, M., Bates, S., Scheper, R. and de Vries, E. (2002) Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia. Blood 99, 3763-3770
    • (2002) Blood , vol.99 , pp. 3763-3770
    • Van Der Kolk, D.1    Vellenga, E.2    Scheffer, G.3    Müller, M.4    Bates, S.5    Scheper, R.6    De Vries, E.7
  • 28
    • 0037872761 scopus 로고    scopus 로고
    • Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia
    • van der Pol, M., Broxterman, H., Pater, J., Feller, N., van der Maas, M., Weijers, G., Scheffer, G., Allen, J., Scheper, R., van Loevezijn, A. et al. (2003) Function of the ABC transporters, P-glycoprotein, multidrug resistance protein and breast cancer resistance protein, in minimal residual disease in acute myeloid leukemia. Haematologica 88, 134-147
    • (2003) Haematologica , vol.88 , pp. 134-147
    • Van Der Pol, M.1    Broxterman, H.2    Pater, J.3    Feller, N.4    Van Der Maas, M.5    Weijers, G.6    Scheffer, G.7    Allen, J.8    Scheper, R.9    Van Loevezijn, A.10
  • 30
    • 3142663295 scopus 로고    scopus 로고
    • Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: Discordance between expression and function
    • Suvannasankha, A., Minderman, H., O'Loughlin, K.L., Nakanishi, T., Greco, W.R., Ross, D.D. and Baer, M.R. (2004) Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: discordance between expression and function. Leukemia 18, 1252-1257
    • (2004) Leukemia , vol.18 , pp. 1252-1257
    • Suvannasankha, A.1    Minderman, H.2    O'Loughlin, K.L.3    Nakanishi, T.4    Greco, W.R.5    Ross, D.D.6    Baer, M.R.7
  • 31
    • 0036052296 scopus 로고    scopus 로고
    • BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia
    • Steinbach, D., Sell, W., Voigt, A., Hermann, J., Zintl, F. and Sauerbrey, A. (2002) BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Leukemia 16, 1443-1447
    • (2002) Leukemia , vol.16 , pp. 1443-1447
    • Steinbach, D.1    Sell, W.2    Voigt, A.3    Hermann, J.4    Zintl, F.5    Sauerbrey, A.6
  • 32
    • 61449247252 scopus 로고    scopus 로고
    • Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
    • Ota, S., Ishii, G., Goto, K., Kubota, K., Kim, Y., Kojika, M., Murata, Y., Yamazaki, M., Nishiwaki, Y., Eguchi, K. and Ochiai, A. (2009) Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy. Lung Cancer 64, 98-104
    • (2009) Lung Cancer , vol.64 , pp. 98-104
    • Ota, S.1    Ishii, G.2    Goto, K.3    Kubota, K.4    Kim, Y.5    Kojika, M.6    Murata, Y.7    Yamazaki, M.8    Nishiwaki, Y.9    Eguchi, K.10    Ochiai, A.11
  • 33
    • 67349169090 scopus 로고    scopus 로고
    • Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer
    • Kim, Y., Ishii, G., Goto, K., Ota, S., Kubota, K., Murata, Y., Mishima, M., Saijo, N., Nishiwaki, Y. and Ochiai, A. (2009) Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer. Lung Cancer 65, 105-111
    • (2009) Lung Cancer , vol.65 , pp. 105-111
    • Kim, Y.1    Ishii, G.2    Goto, K.3    Ota, S.4    Kubota, K.5    Murata, Y.6    Mishima, M.7    Saijo, N.8    Nishiwaki, Y.9    Ochiai, A.10
  • 34
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean, M., Fojo, T. and Bates, S. (2005) Tumour stem cells and drug resistance. Nat. Rev. Cancer 5, 275-284
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 35
    • 14644444547 scopus 로고    scopus 로고
    • ABC transporters in the balance: Is there a role in multidrug resistance?
    • Polgar, O. and Bates, S.E. (2005) ABC transporters in the balance: is there a role in multidrug resistance? Biochem. Soc. Trans. 33, 241-245
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 241-245
    • Polgar, O.1    Bates, S.E.2
  • 36
    • 0032619948 scopus 로고    scopus 로고
    • Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP): Updated results of a randomized study
    • Groupe Francais des Myelodysplasies (GFM) and Groupe GOELAMS
    • Wattel, E., Solary, E., Hecquet, B., Caillot, D., Ifrah, N., Brion, A., Milpied, N., Janvier, M., Guerci, A., Rochant, H. et al. (1999) Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP): updated results of a randomized study. Groupe Francais des Myelodysplasies (GFM) and Groupe GOELAMS. Adv. Exp. Med. Biol. 457, 35-46
    • (1999) Adv. Exp. Med. Biol. , vol.457 , pp. 35-46
    • Wattel, E.1    Solary, E.2    Hecquet, B.3    Caillot, D.4    Ifrah, N.5    Brion, A.6    Milpied, N.7    Janvier, M.8    Guerci, A.9    Rochant, H.10
  • 37
    • 0035760302 scopus 로고    scopus 로고
    • Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study
    • List, A.F., Kopecky, K.J., Willman, C.L., Head, D.R., Persons, D.L., Slovak, M.L., Dorr, R., Karanes, C., Hynes, H.E., Doroshow, J.H. et al. (2001) Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood 98, 3212-3220
    • (2001) Blood , vol.98 , pp. 3212-3220
    • List, A.F.1    Kopecky, K.J.2    Willman, C.L.3    Head, D.R.4    Persons, D.L.5    Slovak, M.L.6    Dorr, R.7    Karanes, C.8    Hynes, H.E.9    Doroshow, J.H.10
  • 38
    • 0029027893 scopus 로고
    • Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy
    • Wilson, W., Bates, S., Fojo, A., Bryant, G., Zhan, Z., Regis, J., Wittes, R., Jaffe, E., Steinberg, S. and Herdt, J. (1995) Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy. J. Clin. Oncol. 13, 1995-2004
    • (1995) J. Clin. Oncol. , vol.13 , pp. 1995-2004
    • Wilson, W.1    Bates, S.2    Fojo, A.3    Bryant, G.4    Zhan, Z.5    Regis, J.6    Wittes, R.7    Jaffe, E.8    Steinberg, S.9    Herdt, J.10
  • 39
    • 72549101193 scopus 로고    scopus 로고
    • Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia
    • Chauncey, T., Gundacker, H., Shadman, M., List, A., Dakhil, S., Erba, H., Slovak, M., Chen, I., Willman, C., Kopecky, K. and Appelbaum, F. (2010) Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia. Br. J. Haematol. 148, 48-58
    • (2010) Br. J. Haematol. , vol.148 , pp. 48-58
    • Chauncey, T.1    Gundacker, H.2    Shadman, M.3    List, A.4    Dakhil, S.5    Erba, H.6    Slovak, M.7    Chen, I.8    Willman, C.9    Kopecky, K.10    Appelbaum, F.11
  • 40
    • 0026353317 scopus 로고
    • Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin
    • Twentyman, P. and Bleehen, N. (1991) Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin. Eur. J. Cancer 27, 1639-1642
    • (1991) Eur. J. Cancer , vol.27 , pp. 1639-1642
    • Twentyman, P.1    Bleehen, N.2
  • 41
    • 0026721685 scopus 로고
    • Reversal of typical multid-rug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing the mdr1 phenotype
    • te Boekhorst, P., van Kapel, J., Schoester, M. and Sonneveld, P. (1992) Reversal of typical multid-rug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing the mdr1 phenotype. Cancer Chemother. Pharmacol. 30, 238-242
    • (1992) Cancer Chemother. Pharmacol. , vol.30 , pp. 238-242
    • Te Boekhorst, P.1    Van Kapel, J.2    Schoester, M.3    Sonneveld, P.4
  • 42
    • 0035883604 scopus 로고    scopus 로고
    • A Phase I study of infusional vinblastine in combination with the P-glycoprotein antagonist PSC 833 (valspodar)
    • Bates, S., Kang, M., Meadows, B., Bakke, S., Choyke, P., Merino, M., Goldspiel, B., Chico, I., Smith, T., Chen, C. et al. (2001) A Phase I study of infusional vinblastine in combination with the P-glycoprotein antagonist PSC 833 (valspodar). Cancer 92, 1577-1590
    • (2001) Cancer , vol.92 , pp. 1577-1590
    • Bates, S.1    Kang, M.2    Meadows, B.3    Bakke, S.4    Choyke, P.5    Merino, M.6    Goldspiel, B.7    Chico, I.8    Smith, T.9    Chen, C.10
  • 43
    • 0345411341 scopus 로고    scopus 로고
    • P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
    • Wandel, C., Kim, R., Kajiji, S., Guengerich, P., Wilkinson, G. and Wood, A. (1999) P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. 59, 3944-3948
    • (1999) Cancer Res. , vol.59 , pp. 3944-3948
    • Wandel, C.1    Kim, R.2    Kajiji, S.3    Guengerich, P.4    Wilkinson, G.5    Wood, A.6
  • 44
    • 32544437036 scopus 로고    scopus 로고
    • Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): A trial of the Eastern Cooperative Oncology Group
    • Friedenberg, W., Rue, M., Blood, E., Dalton, W., Shustik, C., Larson, R., Sonneveld, P. and Greipp, P. (2006) Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Group. Cancer 106, 830-838
    • (2006) Cancer , vol.106 , pp. 830-838
    • Friedenberg, W.1    Rue, M.2    Blood, E.3    Dalton, W.4    Shustik, C.5    Larson, R.6    Sonneveld, P.7    Greipp, P.8
  • 45
    • 0037103189 scopus 로고    scopus 로고
    • Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720
    • Baer, M.R., George, S.L., Dodge, R.K., O'Loughlin, K.L., Minderman, H., Caligiuri, M.A., Anastasi, J., Powell, B.L., Kolitz, J.E., Schiffer, C.A. et al. (2002) Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 100, 1224-1232
    • (2002) Blood , vol.100 , pp. 1224-1232
    • Baer, M.R.1    George, S.L.2    Dodge, R.K.3    O'Loughlin, K.L.4    Minderman, H.5    Caligiuri, M.A.6    Anastasi, J.7    Powell, B.L.8    Kolitz, J.E.9    Schiffer, C.A.10
  • 47
    • 3242688711 scopus 로고    scopus 로고
    • A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma
    • Bates, S., Bakke, S., Kang, M., Robey, R., Zhai, S., Thambi, P., Chen, C., Patil, S., Smith, T., Steinberg, S. et al. (2004) A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma. Clin. Cancer Res. 10, 4724-4733
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4724-4733
    • Bates, S.1    Bakke, S.2    Kang, M.3    Robey, R.4    Zhai, S.5    Thambi, P.6    Chen, C.7    Patil, S.8    Smith, T.9    Steinberg, S.10
  • 48
    • 16544385074 scopus 로고    scopus 로고
    • Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: Final induction results of Cancer and Leukemia Group B Study 9621
    • Kolitz, J.E., George, S.L., Dodge, R.K., Hurd, D.D., Powell, B.L., Allen, S.L., Velez-Garcia, E., Moore, J.O., Shea, T.C., Hoke, E. et al. (2004) Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years: final induction results of Cancer and Leukemia Group B Study 9621. J. Clin. Oncol. 22, 4290-4301
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4290-4301
    • Kolitz, J.E.1    George, S.L.2    Dodge, R.K.3    Hurd, D.D.4    Powell, B.L.5    Allen, S.L.6    Velez-Garcia, E.7    Moore, J.O.8    Shea, T.C.9    Hoke, E.10
  • 49
    • 1842532997 scopus 로고    scopus 로고
    • VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    • Minderman, H., O'Loughlin, K.L., Pendyala, L. and Baer, M.R. (2004) VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin. Cancer Res. 10, 1826-1834
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1826-1834
    • Minderman, H.1    O'Loughlin, K.L.2    Pendyala, L.3    Baer, M.R.4
  • 50
    • 0036445653 scopus 로고    scopus 로고
    • A phase II study of the MDR inhibitor biricodar (INCEL, VX-710) and paclitaxel in women with advanced ovarian cancer refractory to paclitaxel therapy
    • Seiden, M., Swenerton, K., Matulonis, U., Campos, S., Rose, P., Batist, G., Ette, E., Garg, V., Fuller, A., Harding, M. and Charpentier, D. (2002) A phase II study of the MDR inhibitor biricodar (INCEL, VX-710) and paclitaxel in women with advanced ovarian cancer refractory to paclitaxel therapy. Gynecol. Oncol. 86, 302-310
    • (2002) Gynecol. Oncol. , vol.86 , pp. 302-310
    • Seiden, M.1    Swenerton, K.2    Matulonis, U.3    Campos, S.4    Rose, P.5    Batist, G.6    Ette, E.7    Garg, V.8    Fuller, A.9    Harding, M.10    Charpentier, D.11
  • 51
    • 0036190730 scopus 로고    scopus 로고
    • Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma
    • Bramwell, V., Morris, D., Ernst, D., Hings, I., Blackstein, M., Venner, P., Ette, E., Harding, M., Waxman, A. and Demetri, G. (2002) Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma. Clin. Cancer Res. 8, 383-393
    • (2002) Clin. Cancer Res. , vol.8 , pp. 383-393
    • Bramwell, V.1    Morris, D.2    Ernst, D.3    Hings, I.4    Blackstein, M.5    Venner, P.6    Ette, E.7    Harding, M.8    Waxman, A.9    Demetri, G.10
  • 52
    • 0032695270 scopus 로고    scopus 로고
    • Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR
    • de Bruin, M., Miyake, K., Litman, T., Robey, R. and Bates, S.E. (1999) Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett. 146, 117-126
    • (1999) Cancer Lett. , vol.146 , pp. 117-126
    • De Bruin, M.1    Miyake, K.2    Litman, T.3    Robey, R.4    Bates, S.E.5
  • 54
    • 34250686621 scopus 로고    scopus 로고
    • A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients
    • Kuppens, I., Witteveen, E., Jewell, R., Radema, S., Paul, E., Mangum, S., Beijnen, J., Voest, E. and Schellens, J. (2007) A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients. Clin. Cancer Res. 13, 3276-3285
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3276-3285
    • Kuppens, I.1    Witteveen, E.2    Jewell, R.3    Radema, S.4    Paul, E.5    Mangum, S.6    Beijnen, J.7    Voest, E.8    Schellens, J.9
  • 57
    • 33745746815 scopus 로고    scopus 로고
    • Pharmacological strategies for overcoming multidrug resistance
    • Nobili, S., Landini, I., Giglioni, B. and Mini, E. (2006) Pharmacological strategies for overcoming multidrug resistance. Curr. Drug Targets 7, 861-879
    • (2006) Curr. Drug Targets , vol.7 , pp. 861-879
    • Nobili, S.1    Landini, I.2    Giglioni, B.3    Mini, E.4
  • 58
    • 34247646575 scopus 로고    scopus 로고
    • Tariquidar (XR9576): A P-glycoprotein drug efflux pump inhibitor
    • Fox, E. and Bates, S. (2007) Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. Expert Rev. Anticancer Ther. 7, 447-459
    • (2007) Expert Rev. Anticancer Ther. , vol.7 , pp. 447-459
    • Fox, E.1    Bates, S.2
  • 59
    • 67349183943 scopus 로고    scopus 로고
    • A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia
    • Lancet, J., Baer, M., Duran, G., List, A., Fielding, R., Marcelletti, J., Multani, P. and Sikic, B. (2009) A phase I trial of continuous infusion of the multidrug resistance inhibitor zosuquidar with daunorubicin and cytarabine in acute myeloid leukemia. Leuk. Res. 33, 1055-1061
    • (2009) Leuk. Res. , vol.33 , pp. 1055-1061
    • Lancet, J.1    Baer, M.2    Duran, G.3    List, A.4    Fielding, R.5    Marcelletti, J.6    Multani, P.7    Sikic, B.8
  • 60
    • 3242781758 scopus 로고    scopus 로고
    • Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine
    • Gerrard, G., Payne, E., Baker, R., Jones, D., Potter, M., Prentice, H., Ethell, M., McCullough, H., Burgess, M., Mehta, A. and Ganeshaguru, K. (2004) Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine. Haematologica 89, 782-790
    • (2004) Haematologica , vol.89 , pp. 782-790
    • Gerrard, G.1    Payne, E.2    Baker, R.3    Jones, D.4    Potter, M.5    Prentice, H.6    Ethell, M.7    McCullough, H.8    Burgess, M.9    Mehta, A.10    Ganeshaguru, K.11
  • 61
    • 34247213414 scopus 로고    scopus 로고
    • Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar. 3HCl trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin's lymphoma
    • Morschhauser, F., Zinzani, P., Burgess, M., Sloots, L., Bouafia, F. and Dumontet, C. (2007) Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar. 3HCl trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin's lymphoma. Leuk. Lymphoma 48, 708-715
    • (2007) Leuk. Lymphoma , vol.48 , pp. 708-715
    • Morschhauser, F.1    Zinzani, P.2    Burgess, M.3    Sloots, L.4    Bouafia, F.5    Dumontet, C.6
  • 62
    • 68149149796 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen
    • Ruff, P., Vorobiof, D., Jordaan, J., Demetriou, G., Moodley, S., Nosworthy, A., Werner, I., Raats, J. and Burgess, L. (2009) A randomized, placebo-controlled, double-blind phase 2 study of docetaxel compared to docetaxel plus zosuquidar (LY335979) in women with metastatic or locally recurrent breast cancer who have received one prior chemotherapy regimen. Cancer Chemother. Pharmacol. 64, 763-768
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 763-768
    • Ruff, P.1    Vorobiof, D.2    Jordaan, J.3    Demetriou, G.4    Moodley, S.5    Nosworthy, A.6    Werner, I.7    Raats, J.8    Burgess, L.9
  • 64
    • 39749135394 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1®
    • Robey, R., Shukla, S., Finley, E., Oldham, R., Barnett, D., Ambudkar, S., Fojo, T. and Bates, S. (2008) Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1®. Biochem. Pharmacol. 75, 1302-1312
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 1302-1312
    • Robey, R.1    Shukla, S.2    Finley, E.3    Oldham, R.4    Barnett, D.5    Ambudkar, S.6    Fojo, T.7    Bates, S.8
  • 65
    • 0031978273 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of CBT-1 as a multidrug resistance modulator in the treatment of patients with advanced cancer
    • Oldham, R., Reid, W., Preisler, H. and Barnett, D. (1998) A phase I and pharmacokinetic study of CBT-1 as a multidrug resistance modulator in the treatment of patients with advanced cancer. Cancer Biother. Radiopharm. 13, 71-80
    • (1998) Cancer Biother. Radiopharm. , vol.13 , pp. 71-80
    • Oldham, R.1    Reid, W.2    Preisler, H.3    Barnett, D.4
  • 66
    • 0034068093 scopus 로고    scopus 로고
    • Phase I study of CBT-1 and Taxol in patients with Taxol resistant cancers
    • Oldham, R., Reid, W. and Barnett, D. (2000) Phase I study of CBT-1 and Taxol in patients with Taxol resistant cancers. Cancer Biother. Radiopharm. 15, 153-159
    • (2000) Cancer Biother. Radiopharm. , vol.15 , pp. 153-159
    • Oldham, R.1    Reid, W.2    Barnett, D.3
  • 67
    • 69249105956 scopus 로고    scopus 로고
    • Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer
    • Pajic, M., Iyer, J., Kersbergen, A., van der Burg, E., Nygren, A., Jonkers, J., Borst, P. and Rottenberg, S. (2009) Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Cancer Res. 69, 6396-6404
    • (2009) Cancer Res. , vol.69 , pp. 6396-6404
    • Pajic, M.1    Iyer, J.2    Kersbergen, A.3    Van Der Burg, E.4    Nygren, A.5    Jonkers, J.6    Borst, P.7    Rottenberg, S.8
  • 69
    • 0031839226 scopus 로고    scopus 로고
    • Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1
    • Holló, Z., Homolya, L., Hegedûs, T., Müller, M., Szakács, G., Jakab, K., Antal, F. and Sarkadi, B. (1998) Parallel functional and immunological detection of human multidrug resistance proteins, P-glycoprotein and MRP1. Anticancer Res. 18, 2981-2987
    • (1998) Anticancer Res. , vol.18 , pp. 2981-2987
    • Holló, Z.1    Homolya, L.2    Hegedûs, T.3    Müller, M.4    Szakács, G.5    Jakab, K.6    Antal, F.7    Sarkadi, B.8
  • 72
    • 70450270719 scopus 로고    scopus 로고
    • The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors
    • Patel, K. and Tannock, I. (2009) The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors. BMC Cancer 9, 356
    • (2009) BMC Cancer , vol.9 , pp. 356
    • Patel, K.1    Tannock, I.2
  • 75
    • 34250825286 scopus 로고    scopus 로고
    • Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical out-come in patients with advanced non-small cell lung cancer
    • Han, J., Lim, H., Yoo, Y., Shin, E., Park, Y., Lee, S., Lee, J., Lee, D., Kim, H. and Lee, J. (2007) Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical out-come in patients with advanced non-small cell lung cancer. Cancer 110, 138-147
    • (2007) Cancer , vol.110 , pp. 138-147
    • Han, J.1    Lim, H.2    Yoo, Y.3    Shin, E.4    Park, Y.5    Lee, S.6    Lee, J.7    Lee, D.8    Kim, H.9    Lee, J.10
  • 77
    • 1942532906 scopus 로고    scopus 로고
    • Functional C3435T polymorphism of MDR1 gene: An impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia
    • Jamroziak, K., Młynarski, W., Balcerczak, E., Mistygacz, M., Trelinska, J., Mirowski, M., Bodalski, J. and Robak, T. (2004) Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia. Eur. J. Haematol. 72, 314-321
    • (2004) Eur. J. Haematol. , vol.72 , pp. 314-321
    • Jamroziak, K.1    Młynarski, W.2    Balcerczak, E.3    Mistygacz, M.4    Trelinska, J.5    Mirowski, M.6    Bodalski, J.7    Robak, T.8
  • 79
    • 34250171217 scopus 로고    scopus 로고
    • CNS metastasis: An old problem in a new guise
    • Aragon-Ching, J. and Zujewski, J. (2007) CNS metastasis: an old problem in a new guise. Clin. Cancer Res. 13, 1644-1647
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1644-1647
    • Aragon-Ching, J.1    Zujewski, J.2
  • 81
    • 59649115878 scopus 로고    scopus 로고
    • An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5- ({[2-(methylsulfonyl)ethyl]amino} methyl)-2-furyl]-4-quinazolinamine; GW572016)
    • Polli, J., Olson, K., Chism, J., John-Williams, L., Yeager, R., Woodard, S., Otto, V., Castellino, S. and Demby, V. (2009) An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl] amino} methyl)-2-furyl]-4-quinazolinamine; GW572016). Drug Metab. Dispos. 37, 439-442
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 439-442
    • Polli, J.1    Olson, K.2    Chism, J.3    John-Williams, L.4    Yeager, R.5    Woodard, S.6    Otto, V.7    Castellino, S.8    Demby, V.9
  • 83
    • 65249151331 scopus 로고    scopus 로고
    • Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment
    • Lagas, J., van Waterschoot, R., van Tilburg, V., Hillebrand, M., Lankheet, N., Rosing, H., Beijnen, J. and Schinkel, A. (2009) Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. Clin. Cancer Res. 15, 2344-2351
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2344-2351
    • Lagas, J.1    Van Waterschoot, R.2    Van Tilburg, V.3    Hillebrand, M.4    Lankheet, N.5    Rosing, H.6    Beijnen, J.7    Schinkel, A.8
  • 89
    • 20444482337 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines
    • Rumpold, H., Wolf, A.M., Gruenewald, K., Gastl, G., Gunsilius, E. and Wolf, D. (2005) RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines. Exp. Hematol. 33, 767-775
    • (2005) Exp. Hematol. , vol.33 , pp. 767-775
    • Rumpold, H.1    Wolf, A.M.2    Gruenewald, K.3    Gastl, G.4    Gunsilius, E.5    Wolf, D.6
  • 91
    • 65649147504 scopus 로고    scopus 로고
    • Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: Substrates and/or inhibitors?
    • Hegedus, C., Ozvegy-Laczka, C., Szakács, G. and Sarkadi, B. (2009) Interaction of ABC multidrug transporters with anticancer protein kinase inhibitors: substrates and/or inhibitors? Curr. Cancer Drug Targets 9, 252-272
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 252-272
    • Hegedus, C.1    Ozvegy-Laczka, C.2    Szakács, G.3    Sarkadi, B.4
  • 94
    • 84900286414 scopus 로고    scopus 로고
    • Multidrug resistance mediated by MDR-ABC transporters
    • (Mehta, K. and Siddik, Z.H., eds), Springer, New York
    • Szakacs, G., To, K.K. W., Polgar, O., Robey, R.W. and Bates, S.E. (2009) Multidrug resistance mediated by MDR-ABC transporters. In Drug Resistance in Cancer Cells (Mehta, K. and Siddik, Z.H., eds), Springer, New York
    • (2009) Drug Resistance in Cancer Cells
    • Szakacs, G.1    To, K.K.W.2    Polgar, O.3    Robey, R.W.4    Bates, S.E.5
  • 95
    • 0034988112 scopus 로고    scopus 로고
    • Comparison of 'sequential' versus 'standard' chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): Results of the UK Medical Research Council AML-R trial
    • Liu Yin, J.A., Wheatley, K., Rees, J.K. and Burnett, A.K. (2001) Comparison of 'sequential' versus 'standard' chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): results of the UK Medical Research Council AML-R trial. Br. J. Haematol. 113, 713-726
    • (2001) Br. J. Haematol. , vol.113 , pp. 713-726
    • Liu Yin, J.A.1    Wheatley, K.2    Rees, J.K.3    Burnett, A.K.4
  • 96
    • 0035673972 scopus 로고    scopus 로고
    • Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: An EORTC-HOVON randomized phase III study (06914)
    • Sonneveld, P., Suciu, S., Weijermans, P., Beksac, M., Neuwirtova, R., Solbu, G., Lokhorst, H., van der Lelie, J., Dohner, H., Gerhartz, H. et al. (2001) Cyclosporin A combined with vincristine, doxorubicin and dexamethasone (VAD) compared with VAD alone in patients with advanced refractory multiple myeloma: an EORTC-HOVON randomized phase III study (06914). Br. J. Haematol. 115, 895-902
    • (2001) Br. J. Haematol. , vol.115 , pp. 895-902
    • Sonneveld, P.1    Suciu, S.2    Weijermans, P.3    Beksac, M.4    Neuwirtova, R.5    Solbu, G.6    Lokhorst, H.7    Van Der Lelie, J.8    Dohner, H.9    Gerhartz, H.10
  • 97
    • 27144508406 scopus 로고    scopus 로고
    • The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis
    • van der Holt, B., Lowenberg, B., Burnett, A.K., Knauf, W.U., Shepherd, J., Piccaluga, P.P., Ossenkoppele, G.J., Verhoef, G.E., Ferrant, A., Crump, M. et al. (2005) The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis. Blood 106, 2646-2654
    • (2005) Blood , vol.106 , pp. 2646-2654
    • Van Der Holt, B.1    Lowenberg, B.2    Burnett, A.K.3    Knauf, W.U.4    Shepherd, J.5    Piccaluga, P.P.6    Ossenkoppele, G.J.7    Verhoef, G.E.8    Ferrant, A.9    Crump, M.10
  • 98
    • 0003360972 scopus 로고    scopus 로고
    • A phase 3 study of PSC 833 in combination with paclitaxel and carboplatin (PC-PSC) versus paclitaxel and carboplatin (PC) alone in patients with stage IV or suboptimally debulked stage III epithelial ovarian cancer or primary cancer of the peritoneum
    • Abstract 806
    • Joly, F., Joly, F., Mangioni, C., Nicoletto, M., Manikhas, G.M., Walker, J., Mietlowski, W., Jones, G., Wysowskyj, H. and Dugan, M. (2002) A phase 3 study of PSC 833 in combination with paclitaxel and carboplatin (PC-PSC) versus paclitaxel and carboplatin (PC) alone in patients with stage IV or suboptimally debulked stage III epithelial ovarian cancer or primary cancer of the peritoneum. Proc. Am. Soc. Clin. Oncol. 21, Abstract 806
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Joly, F.1    Joly, F.2    Mangioni, C.3    Nicoletto, M.4    Manikhas, G.M.5    Walker, J.6    Mietlowski, W.7    Jones, G.8    Wysowskyj, H.9    Dugan, M.10
  • 99
    • 1842457644 scopus 로고    scopus 로고
    • Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: A phase III trial (E2995)
    • Greenberg, P.L., Lee, S.J., Advani, R., Tallman, M.S., Sikic, B.I., Letendre, L., Dugan, K., Lum, B., Chin, D.L., Dewald, G. et al. (2004) Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995). J. Clin. Oncol. 22, 1078-1086
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1078-1086
    • Greenberg, P.L.1    Lee, S.J.2    Advani, R.3    Tallman, M.S.4    Sikic, B.I.5    Letendre, L.6    Dugan, K.7    Lum, B.8    Chin, D.L.9    Dewald, G.10
  • 100
    • 33846999327 scopus 로고    scopus 로고
    • Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer
    • Saeki, T., Nomizu, T., Toi, M., Ito, Y., Noguchi, S., Kobayashi, T., Asaga, T., Minami, H., Yamamoto, N., Aogi, K. et al. (2007) Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer. J. Clin. Oncol. 25, 411-417
    • (2007) J. Clin. Oncol. , vol.25 , pp. 411-417
    • Saeki, T.1    Nomizu, T.2    Toi, M.3    Ito, Y.4    Noguchi, S.5    Kobayashi, T.6    Asaga, T.7    Minami, H.8    Yamamoto, N.9    Aogi, K.10
  • 101
    • 78549238612 scopus 로고    scopus 로고
    • Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: A randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999
    • Cripe, L.D., Uno, H., Paietta, E.M., Litzow, M.R., Ketterling, R.P., Bennett, J.M., Rowe, J.M., Lazarus, H.M., Luger, S. and Tallman, M.S. (2010) Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood 116, 4077-4085
    • (2010) Blood , vol.116 , pp. 4077-4085
    • Cripe, L.D.1    Uno, H.2    Paietta, E.M.3    Litzow, M.R.4    Ketterling, R.P.5    Bennett, J.M.6    Rowe, J.M.7    Lazarus, H.M.8    Luger, S.9    Tallman, M.S.10


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