Interaction of LDS-751 with the drug-binding site of P-glycoprotein: A Trp fluorescence steady-state and lifetime study

Archives of Biochemistry and Biophysics

Volumn 492, Issue 1-2, 2009, Pages 17-28

  Lugo, Miguel R ^a   Sharom, Frances J ^b  

^a FACULTAD DE CIENCIAS   (Venezuela)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

ABC transporter; Drug binding; Excited state; Fluorescence lifetime; Fluorescence spectroscopy; P glycoprotein (ABCB1)

Indexed keywords

2 [4 [4 (DIMETHYLAMINO)PHENYL] 1,3 BUTADIENYL] 3 ETHYLBENZOTHIAZOLIUM PERCHLORATE; GLYCOPROTEIN P; LDS 751; THIAZOLE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; FLUORESCENCE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CYTOSOL; DRUG INTERACTIONS; EXTRACELLULAR SPACE; FLUORESCENT DYES; MEMBRANE PROTEINS; MICE; ORGANIC CHEMICALS; P-GLYCOPROTEIN; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 70450270815     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.10.002     Document Type: Article

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