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Volumn 583, Issue 2-3, 2008, Pages 263-271

The role of multi-drug resistance p-glycoprotein in glucocorticoid function: Studies in animals and relevance in humans

Author keywords

Endothelial; Glucocorticoid; Multi drug resistance p glycoprotein; neurones; Psychopharmacological

Indexed keywords

ALDOSTERONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CARRIER PROTEIN; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DESIPRAMINE; DEXAMETHASONE; DOXEPIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR ANTAGONIST; GLYCOPROTEIN P; HYDROCORTISONE; MESSENGER RNA; MIFEPRISTONE; MIRTAZAPINE; PAROXETINE; PREDNISOLONE; PROGESTERONE; RU 40555; TRIMIPRAMINE; UNCLASSIFIED DRUG; VENLAFAXINE;

EID: 40849111650     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.11.067     Document Type: Review
Times cited : (52)

References (70)
  • 5
    • 0033828077 scopus 로고    scopus 로고
    • Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy
    • Bolo N.R., Hode Y., Nedelec J.F., Laine E., Wagner G., and Macher J.P. Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy. Neuropsychopharmacology 23 (2000) 428-438
    • (2000) Neuropsychopharmacology , vol.23 , pp. 428-438
    • Bolo, N.R.1    Hode, Y.2    Nedelec, J.F.3    Laine, E.4    Wagner, G.5    Macher, J.P.6
  • 6
    • 0027214172 scopus 로고
    • Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis
    • Bourgeois S., Gruol D.J., Newby R.F., and Rajah F.M. Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol. Endocrinol. 7 (1993) 840-851
    • (1993) Mol. Endocrinol. , vol.7 , pp. 840-851
    • Bourgeois, S.1    Gruol, D.J.2    Newby, R.F.3    Rajah, F.M.4
  • 7
    • 0015754480 scopus 로고
    • Estimation of cortisol, cortisone and corticosterone in cerebral cortex, hypothalamus and other regions of the human brain after natural death and after death by suicide
    • Brooksbank B.W., Brammall M.A., and Shaw D.M. Estimation of cortisol, cortisone and corticosterone in cerebral cortex, hypothalamus and other regions of the human brain after natural death and after death by suicide. Steroids Lipids Res. 4 (1973) 162-183
    • (1973) Steroids Lipids Res. , vol.4 , pp. 162-183
    • Brooksbank, B.W.1    Brammall, M.A.2    Shaw, D.M.3
  • 8
    • 33749048762 scopus 로고    scopus 로고
    • Expression of multidrug resistance type 1 gene (MDR1) P-glycoprotein in intractable epilepsy with different aetiologies: a double-labelling and electron microscopy study
    • Chengyun D., Guoming L., Elia M., Catania M.V., and Qunyuan X. Expression of multidrug resistance type 1 gene (MDR1) P-glycoprotein in intractable epilepsy with different aetiologies: a double-labelling and electron microscopy study. Neurol. Sci. 27 (2006) 245-251
    • (2006) Neurol. Sci. , vol.27 , pp. 245-251
    • Chengyun, D.1    Guoming, L.2    Elia, M.3    Catania, M.V.4    Qunyuan, X.5
  • 9
    • 0032467785 scopus 로고    scopus 로고
    • Brain corticosteroid receptor balance in health and disease
    • de Kloet E.R., Vreugdenhil E., Oitzl M.S., and Joels M. Brain corticosteroid receptor balance in health and disease. Endocr. Rev. 19 (1998) 269-301
    • (1998) Endocr. Rev. , vol.19 , pp. 269-301
    • de Kloet, E.R.1    Vreugdenhil, E.2    Oitzl, M.S.3    Joels, M.4
  • 10
    • 33747871144 scopus 로고    scopus 로고
    • ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response
    • Ebinger M., and Uhr M. ABC drug transporter at the blood-brain barrier: effects on drug metabolism and drug response. Eur. Arch. Psychiatry Clin. Neurosci. 256 (2006) 294-298
    • (2006) Eur. Arch. Psychiatry Clin. Neurosci. , vol.256 , pp. 294-298
    • Ebinger, M.1    Uhr, M.2
  • 11
    • 0036242359 scopus 로고    scopus 로고
    • P-glycoprotein-170 inhibition significantly reduces cortisol and ciclosporin efflux from human intestinal epithelial cells and T lymphocytes
    • Farrell R.J., Menconi M.J., Keates A.C., and Kelly C.P. P-glycoprotein-170 inhibition significantly reduces cortisol and ciclosporin efflux from human intestinal epithelial cells and T lymphocytes. Aliment. Pharmacol. Ther. 16 (2002) 1021-1031
    • (2002) Aliment. Pharmacol. Ther. , vol.16 , pp. 1021-1031
    • Farrell, R.J.1    Menconi, M.J.2    Keates, A.C.3    Kelly, C.P.4
  • 12
    • 0036269538 scopus 로고    scopus 로고
    • P-glycoprotein expression in rat brain endothelial cells: evidence for regulation by transient oxidative stress
    • Felix R.A., and Barrand M.A. P-glycoprotein expression in rat brain endothelial cells: evidence for regulation by transient oxidative stress. J. Neurochem. 80 (2002) 64-72
    • (2002) J. Neurochem. , vol.80 , pp. 64-72
    • Felix, R.A.1    Barrand, M.A.2
  • 13
    • 2442513407 scopus 로고    scopus 로고
    • P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline
    • Grauer M.T., and Uhr M. P-glycoprotein reduces the ability of amitriptyline metabolites to cross the blood brain barrier in mice after a 10-day administration of amitriptyline. J. Psychopharmacol. 18 (2004) 66-74
    • (2004) J. Psychopharmacol. , vol.18 , pp. 66-74
    • Grauer, M.T.1    Uhr, M.2
  • 15
    • 34147214716 scopus 로고    scopus 로고
    • Multiple molecular mechanisms for multidrug resistance transporters
    • Higgins C.F. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446 (2007) 749-757
    • (2007) Nature , vol.446 , pp. 749-757
    • Higgins, C.F.1
  • 16
    • 0033797445 scopus 로고    scopus 로고
    • The corticosteroid receptor hypothesis of depression
    • Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000) 477-501
    • (2000) Neuropsychopharmacology , vol.23 , pp. 477-501
    • Holsboer, F.1
  • 20
    • 14544303537 scopus 로고    scopus 로고
    • Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus
    • Karssen A.M., Meijer O., Pons D., and de Kloet E.R. Localization of mRNA expression of P-glycoprotein at the blood-brain barrier and in the hippocampus. Ann. N. Y. Acad. Sci. 1032 (2004) 308-311
    • (2004) Ann. N. Y. Acad. Sci. , vol.1032 , pp. 308-311
    • Karssen, A.M.1    Meijer, O.2    Pons, D.3    de Kloet, E.R.4
  • 21
    • 27844536884 scopus 로고    scopus 로고
    • Low doses of dexamethasone can produce a hypocorticosteroid state in the brain
    • Karssen A.M., Meijer O.C., Berry A., Sanjuan P.R., and de Kloet E.R. Low doses of dexamethasone can produce a hypocorticosteroid state in the brain. Endocrinology 146 (2005) 5587-5595
    • (2005) Endocrinology , vol.146 , pp. 5587-5595
    • Karssen, A.M.1    Meijer, O.C.2    Berry, A.3    Sanjuan, P.R.4    de Kloet, E.R.5
  • 22
    • 0030035694 scopus 로고    scopus 로고
    • An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones
    • Kralli A., and Yamamoto K.R. An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones. J. Biol. Chem. 271 (1996) 17152-17156
    • (1996) J. Biol. Chem. , vol.271 , pp. 17152-17156
    • Kralli, A.1    Yamamoto, K.R.2
  • 23
    • 0031791723 scopus 로고    scopus 로고
    • Presence of classical multidrug resistance and P-glycoprotein expression in human neuroblastoma cells
    • Kurowski C., and Berthold F. Presence of classical multidrug resistance and P-glycoprotein expression in human neuroblastoma cells. Ann. Oncol. 9 (1998) 1009-1014
    • (1998) Ann. Oncol. , vol.9 , pp. 1009-1014
    • Kurowski, C.1    Berthold, F.2
  • 24
    • 0036851818 scopus 로고    scopus 로고
    • Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure
    • Kwan P., Sills G.J., Butler E., Gant T.W., Meldrum B.S., and Brodie M.J. Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure. Epilepsia 43 (2002) 1318-1323
    • (2002) Epilepsia , vol.43 , pp. 1318-1323
    • Kwan, P.1    Sills, G.J.2    Butler, E.3    Gant, T.W.4    Meldrum, B.S.5    Brodie, M.J.6
  • 25
    • 34249937062 scopus 로고    scopus 로고
    • Neuronal mdr-1 gene expression after experimental focal hypoxia: a new obstacle for neuroprotection?
    • Lazarowski A., Caltana L., Merelli A., Rubio M.D., Ramos A.J., and Brusco A. Neuronal mdr-1 gene expression after experimental focal hypoxia: a new obstacle for neuroprotection?. J. Neurol. Sci. 258 (2007) 84-92
    • (2007) J. Neurol. Sci. , vol.258 , pp. 84-92
    • Lazarowski, A.1    Caltana, L.2    Merelli, A.3    Rubio, M.D.4    Ramos, A.J.5    Brusco, A.6
  • 26
    • 0035212257 scopus 로고    scopus 로고
    • Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations
    • Lee G., Dallas S., Hong M., and Bendayan R. Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations. Pharmacol. Rev. 53 (2001) 569-596
    • (2001) Pharmacol. Rev. , vol.53 , pp. 569-596
    • Lee, G.1    Dallas, S.2    Hong, M.3    Bendayan, R.4
  • 27
    • 34249058785 scopus 로고    scopus 로고
    • ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research
    • Leschziner G.D., Andrew T., Pirmohamed M., and Johnson M.R. ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenomics J. 7 (2007) 154-179
    • (2007) Pharmacogenomics J. , vol.7 , pp. 154-179
    • Leschziner, G.D.1    Andrew, T.2    Pirmohamed, M.3    Johnson, M.R.4
  • 28
    • 0032125633 scopus 로고    scopus 로고
    • Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands
    • Marsaud V., Mercier-Bodard C., Fortin D., Le Bihan S., and Renoir J.M. Dexamethasone and triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, rapamycin and their analogues, as well as by other P-glycoprotein ligands. J. Steroid Biochem. Mol. Biol. 66 (1998) 11-25
    • (1998) J. Steroid Biochem. Mol. Biol. , vol.66 , pp. 11-25
    • Marsaud, V.1    Mercier-Bodard, C.2    Fortin, D.3    Le Bihan, S.4    Renoir, J.M.5
  • 29
    • 0032536724 scopus 로고    scopus 로고
    • Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants
    • Medh R.D., Lay R.H., and Schmidt T.J. Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants. Mol. Cell. Endocrinol. 138 (1998) 11-23
    • (1998) Mol. Cell. Endocrinol. , vol.138 , pp. 11-23
    • Medh, R.D.1    Lay, R.H.2    Schmidt, T.J.3
  • 30
    • 0031732606 scopus 로고    scopus 로고
    • Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice
    • Meijer O.C., de Lange E.C., Breimer D.D., de Boer A.G., Workel J.O., and de Kloet E.R. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139 (1998) 1789-1793
    • (1998) Endocrinology , vol.139 , pp. 1789-1793
    • Meijer, O.C.1    de Lange, E.C.2    Breimer, D.D.3    de Boer, A.G.4    Workel, J.O.5    de Kloet, E.R.6
  • 31
    • 0026026642 scopus 로고
    • Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine
    • Merry S., Hamilton T.G., Flanigan P., Freshney R.I., and Kaye S.B. Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine. Eur. J. Cancer 27 (1991) 31-34
    • (1991) Eur. J. Cancer , vol.27 , pp. 31-34
    • Merry, S.1    Hamilton, T.G.2    Flanigan, P.3    Freshney, R.I.4    Kaye, S.B.5
  • 32
    • 0027096289 scopus 로고
    • Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: implications for the dexamethasone suppression test
    • Miller A.H., Spencer R.L., Pulera M., Kang S., McEwen B.S., and Stein M. Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: implications for the dexamethasone suppression test. Biol. Psychiatry 32 (1992) 850-869
    • (1992) Biol. Psychiatry , vol.32 , pp. 850-869
    • Miller, A.H.1    Spencer, R.L.2    Pulera, M.3    Kang, S.4    McEwen, B.S.5    Stein, M.6
  • 33
    • 0042689390 scopus 로고    scopus 로고
    • ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder
    • Muller M.B., Keck M.E., Binder E.B., Kresse A.E., Hagemeyer T.P., Landgraf R., Holsboer F., and Uhr M. ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology 28 (2003) 1991-1999
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1991-1999
    • Muller, M.B.1    Keck, M.E.2    Binder, E.B.3    Kresse, A.E.4    Hagemeyer, T.P.5    Landgraf, R.6    Holsboer, F.7    Uhr, M.8
  • 34
    • 17844364239 scopus 로고    scopus 로고
    • Glucocorticoid receptor function in vitro in patients with major depression
    • Pariante C.M. Glucocorticoid receptor function in vitro in patients with major depression. Stress 7 (2004) 209-219
    • (2004) Stress , vol.7 , pp. 209-219
    • Pariante, C.M.1
  • 35
    • 33750041982 scopus 로고    scopus 로고
    • The glucocorticoid receptor: part of the solution or part of the problem?
    • Pariante C.M. The glucocorticoid receptor: part of the solution or part of the problem?. J. Psychopharmacol. 20 (2006) 79-84
    • (2006) J. Psychopharmacol. , vol.20 , pp. 79-84
    • Pariante, C.M.1
  • 36
    • 0035280252 scopus 로고    scopus 로고
    • Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    • Pariante C.M., and Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49 (2001) 391-404
    • (2001) Biol. Psychiatry , vol.49 , pp. 391-404
    • Pariante, C.M.1    Miller, A.H.2
  • 37
    • 0030760364 scopus 로고    scopus 로고
    • Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine
    • Pariante C.M., Pearce B.D., Pisell T.L., Owens M.J., and Miller A.H. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol. Pharmacol. 52 (1997) 571-581
    • (1997) Mol. Pharmacol. , vol.52 , pp. 571-581
    • Pariante, C.M.1    Pearce, B.D.2    Pisell, T.L.3    Owens, M.J.4    Miller, A.H.5
  • 38
    • 0035197083 scopus 로고    scopus 로고
    • Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters
    • Pariante C.M., Makoff A., Lovestone S., Feroli S., Heyden A., Miller A.H., and Kerwin R.W. Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. Br. J. Pharmacol. 134 (2001) 1335-1343
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 1335-1343
    • Pariante, C.M.1    Makoff, A.2    Lovestone, S.3    Feroli, S.4    Heyden, A.5    Miller, A.H.6    Kerwin, R.W.7
  • 39
    • 0035001218 scopus 로고    scopus 로고
    • The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells
    • Pariante C.M., Pearce B.D., Pisell T.L., Su C., and Miller A.H. The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells. J. Endocrinol. 169 (2001) 309-320
    • (2001) J. Endocrinol. , vol.169 , pp. 309-320
    • Pariante, C.M.1    Pearce, B.D.2    Pisell, T.L.3    Su, C.4    Miller, A.H.5
  • 40
    • 0141446215 scopus 로고    scopus 로고
    • The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones
    • Pariante C.M., Hye A., Williamson R., Makoff A., Lovestone S., and Kerwin R.W. The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology 28 (2003) 1553-1561
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1553-1561
    • Pariante, C.M.1    Hye, A.2    Williamson, R.3    Makoff, A.4    Lovestone, S.5    Kerwin, R.W.6
  • 41
    • 0042168887 scopus 로고    scopus 로고
    • Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters
    • Pariante C.M., Kim R.B., Makoff A., and Kerwin R.W. Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters. Br. J. Pharmacol. 139 (2003) 1111-1118
    • (2003) Br. J. Pharmacol. , vol.139 , pp. 1111-1118
    • Pariante, C.M.1    Kim, R.B.2    Makoff, A.3    Kerwin, R.W.4
  • 42
  • 43
    • 0442272538 scopus 로고    scopus 로고
    • When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    • Raison C.L., and Miller A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am. J. Psychiatry 160 (2003) 1554-1565
    • (2003) Am. J. Psychiatry , vol.160 , pp. 1554-1565
    • Raison, C.L.1    Miller, A.H.2
  • 44
    • 0031724003 scopus 로고    scopus 로고
    • Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells
    • Regina A., Koman A., Piciotti M., El Hafny B., Center M.S., Bergmann R., Couraud P.O., and Roux F. Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J. Neurochem. 71 (1998) 705-715
    • (1998) J. Neurochem. , vol.71 , pp. 705-715
    • Regina, A.1    Koman, A.2    Piciotti, M.3    El Hafny, B.4    Center, M.S.5    Bergmann, R.6    Couraud, P.O.7    Roux, F.8
  • 45
    • 0033549263 scopus 로고    scopus 로고
    • Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium
    • Rochat B., Baumann P., and Audus K.L. Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium. Brain Res. 831 (1999) 229-236
    • (1999) Brain Res. , vol.831 , pp. 229-236
    • Rochat, B.1    Baumann, P.2    Audus, K.L.3
  • 46
    • 0031938630 scopus 로고    scopus 로고
    • Involvement of intestinal P-glycoprotein in the restricted absorption of methylprednisolone from rat small intestine
    • Saitoh H., Hatakeyama M., Eguchi O., Oda M., and Takada M. Involvement of intestinal P-glycoprotein in the restricted absorption of methylprednisolone from rat small intestine. J. Pharm. Sci. 87 (1998) 73-75
    • (1998) J. Pharm. Sci. , vol.87 , pp. 73-75
    • Saitoh, H.1    Hatakeyama, M.2    Eguchi, O.3    Oda, M.4    Takada, M.5
  • 47
    • 0028293935 scopus 로고
    • Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock
    • Sanchez E.R., Hu J.L., Zhong S., Shen P., Greene M.J., and Housley P.R. Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock. Mol. Endocrinol. 8 (1994) 408-421
    • (1994) Mol. Endocrinol. , vol.8 , pp. 408-421
    • Sanchez, E.R.1    Hu, J.L.2    Zhong, S.3    Shen, P.4    Greene, M.J.5    Housley, P.R.6
  • 48
    • 0033526176 scopus 로고    scopus 로고
    • P-Glycoprotein, a gatekeeper in the blood-brain barrier
    • Schinkel A.H. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Rev. 36 (1999) 179-194
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , pp. 179-194
    • Schinkel, A.H.1
  • 49
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel A.H., Wagenaar E., van D.L., Mol C.A., and Borst P. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest 96 (1995) 1698-1705
    • (1995) J. Clin. Invest , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    van, D.L.3    Mol, C.A.4    Borst, P.5
  • 50
    • 0035559193 scopus 로고    scopus 로고
    • Molecular and pharmacological strategies to overcome multidrug resistance
    • Shabbits J.A., Krishna R., and Mayer L.D. Molecular and pharmacological strategies to overcome multidrug resistance. Expert. Rev. Anticancer Ther. 1 (2001) 585-594
    • (2001) Expert. Rev. Anticancer Ther. , vol.1 , pp. 585-594
    • Shabbits, J.A.1    Krishna, R.2    Mayer, L.D.3
  • 52
    • 34047232381 scopus 로고
    • A fatal case of poisoning with amitriptyline
    • Sunshine I., and Baeumler J. A fatal case of poisoning with amitriptyline. Nature 199 (1963) 1103-1104
    • (1963) Nature , vol.199 , pp. 1103-1104
    • Sunshine, I.1    Baeumler, J.2
  • 53
    • 0032958446 scopus 로고    scopus 로고
    • Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo
    • Szabo D., Szabo Jr. G., Ocsovszki I., Aszalos A., and Molnar J. Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo. Cancer Lett. 139 (1999) 115-119
    • (1999) Cancer Lett. , vol.139 , pp. 115-119
    • Szabo, D.1    Szabo Jr., G.2    Ocsovszki, I.3    Aszalos, A.4    Molnar, J.5
  • 54
    • 0026487058 scopus 로고
    • Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone
    • Ueda K., Okamura N., Hirai M., Tanigawara Y., Saeki T., Kioka N., Komano T., and Hori R. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 267 (1992) 24248-24252
    • (1992) J. Biol. Chem. , vol.267 , pp. 24248-24252
    • Ueda, K.1    Okamura, N.2    Hirai, M.3    Tanigawara, Y.4    Saeki, T.5    Kioka, N.6    Komano, T.7    Hori, R.8
  • 55
    • 0037400655 scopus 로고    scopus 로고
    • abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice
    • Uhr M., and Grauer M.T. abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice. J. Psychiatr. Res. 37 (2003) 179-185
    • (2003) J. Psychiatr. Res. , vol.37 , pp. 179-185
    • Uhr, M.1    Grauer, M.T.2
  • 56
    • 0033952456 scopus 로고    scopus 로고
    • Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption
    • Uhr M., Steckler T., Yassouridis A., and Holsboer F. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption. Neuropsychopharmacology 22 (2000) 380-387
    • (2000) Neuropsychopharmacology , vol.22 , pp. 380-387
    • Uhr, M.1    Steckler, T.2    Yassouridis, A.3    Holsboer, F.4
  • 57
    • 0036736477 scopus 로고    scopus 로고
    • Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins
    • Uhr M., Holsboer F., and Muller M.B. Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins. J. Neuroendocrinol. 14 (2002) 753-759
    • (2002) J. Neuroendocrinol. , vol.14 , pp. 753-759
    • Uhr, M.1    Holsboer, F.2    Muller, M.B.3
  • 58
    • 0141783736 scopus 로고    scopus 로고
    • Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
    • Uhr M., Grauer M.T., and Holsboer F. Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol. Psychiatry 54 (2003) 840-846
    • (2003) Biol. Psychiatry , vol.54 , pp. 840-846
    • Uhr, M.1    Grauer, M.T.2    Holsboer, F.3
  • 59
    • 33750736012 scopus 로고    scopus 로고
    • Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls
    • Uhr M., Grauer M.T., Yassouridis A., and Ebinger M. Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls. J. Psychiatr. Res. 41 (2007) 179-188
    • (2007) J. Psychiatr. Res. , vol.41 , pp. 179-188
    • Uhr, M.1    Grauer, M.T.2    Yassouridis, A.3    Ebinger, M.4
  • 60
    • 34347338588 scopus 로고    scopus 로고
    • Cerebral uptake of drugs in humans
    • Upton R.N. Cerebral uptake of drugs in humans. Clin. Exp. Pharmacol. Physiol. 34 (2007) 695-701
    • (2007) Clin. Exp. Pharmacol. Physiol. , vol.34 , pp. 695-701
    • Upton, R.N.1
  • 63
    • 0346729785 scopus 로고    scopus 로고
    • Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures
    • Volk H.A., Burkhardt K., Potschka H., Chen J., Becker A., and Loscher W. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123 (2004) 751-759
    • (2004) Neuroscience , vol.123 , pp. 751-759
    • Volk, H.A.1    Burkhardt, K.2    Potschka, H.3    Chen, J.4    Becker, A.5    Loscher, W.6
  • 64
    • 29144522875 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function by several antidepressants may not contribute to clinical efficacy
    • Weber C.C., Kressmann S., Ott M., Fricker G., and Muller W.E. Inhibition of P-glycoprotein function by several antidepressants may not contribute to clinical efficacy. Pharmacopsychiatry 38 (2005) 293-300
    • (2005) Pharmacopsychiatry , vol.38 , pp. 293-300
    • Weber, C.C.1    Kressmann, S.2    Ott, M.3    Fricker, G.4    Muller, W.E.5
  • 65
    • 33750215448 scopus 로고    scopus 로고
    • Effects of antidepressants on the brain/plasma distribution of corticosterone
    • Weber C.C., Eckert G.P., and Muller W.E. Effects of antidepressants on the brain/plasma distribution of corticosterone. Neuropsychopharmacology 31 (2006) 2443-2448
    • (2006) Neuropsychopharmacology , vol.31 , pp. 2443-2448
    • Weber, C.C.1    Eckert, G.P.2    Muller, W.E.3
  • 66
    • 0036877355 scopus 로고    scopus 로고
    • Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response
    • Webster J.I., and Carlstedt-Duke J. Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response. J. Steroid Biochem. Mol. Biol. 82 (2002) 277-288
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.82 , pp. 277-288
    • Webster, J.I.1    Carlstedt-Duke, J.2
  • 68
    • 0032619135 scopus 로고    scopus 로고
    • The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation
    • Xia Z., Bergstrand A., DePierre J.W., and Nassberger L. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J. Biochem. Mol. Toxicol. 13 (1999) 338-347
    • (1999) J. Biochem. Mol. Toxicol. , vol.13 , pp. 338-347
    • Xia, Z.1    Bergstrand, A.2    DePierre, J.W.3    Nassberger, L.4
  • 70
    • 34948826840 scopus 로고    scopus 로고
    • The antidepressant desipramine requires the ABCB1 (Mdr1)-Type p-glycoprotein to upregulate the glucocorticoid receptor in mice
    • Yau J.L., Noble J., Thomas S., Kerwin R., Morgan P.E., Lightman S., Seckl J.R., and Pariante C.M. The antidepressant desipramine requires the ABCB1 (Mdr1)-Type p-glycoprotein to upregulate the glucocorticoid receptor in mice. Neuropsychopharmacology 32 (2007) 2520-2529
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2520-2529
    • Yau, J.L.1    Noble, J.2    Thomas, S.3    Kerwin, R.4    Morgan, P.E.5    Lightman, S.6    Seckl, J.R.7    Pariante, C.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.