Chemical warfare agent and biological toxin-induced pulmonary toxicity: Could stem cells provide potential therapies?

Inhalation Toxicology

Volumn 25, Issue 1, 2013, Pages 37-62

  Angelini, Daniel J ^a,b   Dorsey, Russell M ^a   Willis, Kristen L ^a,b,c   Hong, Charles ^c   Moyer, Robert A ^c   Oyler, Jonathan ^d   Jensen, Neil S ^e   Salem, Harry ^a,f  

^a EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

^b NATIONAL RESEARCH COUNCIL   (United States)

^c DEFENSE THREAT REDUCTION AGENCY   (United States)

^d US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^e Joint Program Executive Office for Chemical and Biological Defense   (United States)

^f Chemical Security Analysis Center   (United States)

Author keywords

Acute lung injury (ALI); Acute respiratory distress syndrome (ARDS); Biological toxin; Chemical warfare agents (CWAs); Respiratory toxicity; Stem cells

Indexed keywords

BOTULINUM TOXIN A; CHEMICAL WARFARE AGENT; CHLORINE; COLLECTIN; CYCLOOXYGENASE 2; DICHLORVOS; EXOENZYME C3; FENTHION; GAMMA INTERFERON; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MALATHION; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MUSTARD GAS; PARATHION; PHOSGENE; RICIN; SARIN; SCATTER FACTOR; SOMAN; SOMATOMEDIN; STAPHYLOCOCCUS ENTEROTOXIN B; TABUN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ACUTE LUNG INJURY; ACUTE RESPIRATORY FAILURE; ACYLATION; ADULT RESPIRATORY DISTRESS SYNDROME; BIOLOGICAL WARFARE; BREATHING RATE; CELL ADHESION; CELL DAMAGE; DNA METHYLATION; EDEMA; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; ENGRAFTMENT; ERYTHROPHAGOCYTOSIS; EXPOSURE; FIBRIN DEPOSITION; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE EXPRESSION; HEMATOPOIETIC CELL; HISTONE MODIFICATION; HUMAN; HYDROLYSIS; IN VITRO STUDY; INFLAMMATORY INFILTRATE; LUNG BLOOD VESSEL; LUNG EDEMA; LUNG MINUTE VOLUME; LUNG TOXICITY; MESENCHYMAL STEM CELL; MORTALITY; NEUTROPENIA; NONHUMAN; PERSONALIZED MEDICINE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RACEMIC MIXTURE; RESPIRATORY BURST; REVIEW; SECONDARY INFECTION; SKIN IRRITATION; SOLDIER; STEM CELL TRANSPLANTATION; STEREOSPECIFICITY; SURVIVAL RATE; TIDAL VOLUME; UPREGULATION; X CHROMOSOME INACTIVATION;

ANIMALS; BIOLOGICAL WARFARE AGENTS; CHEMICAL WARFARE AGENTS; HUMANS; LUNG; RESPIRATORY DISTRESS SYNDROME, ADULT; STEM CELL TRANSPLANTATION; STEM CELLS; TOXINS, BIOLOGICAL;

EID: 84872046089     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2012.750406     Document Type: Review

References (287)

1. Lung stem cells: looking beyond the hype. Nat Med 17: 788-789.
2. Abdel-Rahman A, Shetty AK, Abou-Donia MB. 2002. Acute exposure to sarin increases blood brain barrier permeability and induces neuropathological changes in the rat brain: dose-response relationships. Neuroscience 113: 721-741.
3. Abu-Qare AW, Abou-Donia MB. 2002. Sarin: health effects, metabolism, and methods of analysis. Food Chem Toxicol 40: 1327-1333.
4. Ahanotu E, Alvelo-Ceron T, Ravita T, Gaunt E. 2006. Staphylococcal enterotoxin B as a biological weapon: recognition, management, and surveillance of staphylococcal enterotoxin. Applied Biosafety 11: 120-126.
5. Ahrens I, Domeij H, Topcic D, Haviv I, Merivirta RM, Agrotis A, Leitner E, Jowett JB, Bode C, Lappas M, Peter K. 2011. Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression. PLoS ONE 6: e23210.
6. Aldridge AJ. 2002. Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur J Surg 168: 204-214.
7. Ali NN, Edgar AJ, Samadikuchaksaraei A, Timson CM, Romanska HM, Polak JM, Bishop AE. 2002. Derivation of type II alveolar epithelial cells from murine embryonic stem cells. Tissue Eng 8: 541-550.
8. Angelini DJ, Hasday JD, Goldblum SE, Bannerman DD. 2005. Tumor necrosis factor-α-mediated pulmonary endothelial barrier dysfunction. Current Respiratory Medicine Reviews 1: 233-246.
9. Angelini DJ, Hyun SW, Grigoryev DN, Garg P, Gong P, Singh IS, Passaniti A, Hasday JD, Goldblum SE. 2006. TNF-α increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia. Am J Physiol Lung Cell Mol Physiol 291: L1232-L1245.
10. Angelini DJ, Su Q, Kolosova IA, Fan C, Skinner JT, Yamaji-Kegan K, Collector M, Sharkis SJ, Johns RA. 2010. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM α) recruits bone marrowderived cells to the murine pulmonary vasculature. PLoS One 5: e11251.
11. Antonini JM, Krishna Murthy GG, Brain JD. 1997. Responses to welding fumes: lung injury, inflammation, and the release of tumor necrosis factor-α and interleukin-1 β. Exp Lung Res 23: 205-227.
12. Anversa P, Kajstura J, Leri A, Loscalzo J. 2011. Tissue-specific adult stem cells in the human lung. Nat Med 17: 1038-1039.
13. Anzueto A, Berdine GG, Moore GT, Gleiser C, Johnson D, White CD, Johanson WG Jr. 1986. Pathophysiology of soman intoxication in primates. Toxicol Appl Pharmacol 86: 56-68.
14. Anzueto A, deLemos RA, Seidenfeld J, Moore G, Hamil H, Johnson D, Jenkinson SG. 1990. Acute inhalation toxicity of soman and sarin in baboons. Fundam Appl Toxicol 14: 676-687.
15. Arnon SS, Schechter R, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, Fine AD, Hauer J, Layton M, Lillibridge S, Osterholm MT, O'Toole T, Parker G, Perl TM, Russell PK, Swerdlow DL, Tonat K; Working Group on Civilian Biodefense. 2001. Botulinum toxin as a biological weapon: medical and public health management. JAMA 285: 1059-1070.
16. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. 1997. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275: 964-967.
17. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. 1967. Acute respiratory distress in adults. Lancet 2: 319-323.
18. Askin FB. 1993. Acute interstitial pneumonia: histopathologic patterns of acute lung injury and the Hamman-Rich syndrome revisited. Radiology 188: 620-621.
19. Atis S, Celekoglu U, Coskun B, Ozge A, Ersa G, Talas D. 2002. Electrophysiological and histopathological evaluation of respiratory tract, diaphragm, and phrenic nerve after dichlorvos inhalation in rats. Inhal Toxicol 14: 199-215.
20. Chien XX, Zafra-Stone S, Bagchi M, Bagchi D. 2006. Bioavailability, antioxidant and immune-enhancing properties of zinc methionine. Biofactors 27: 231-244.
21. Baker CS, Evans TW, Randle BJ, Haslam PL. 1999. Damage to surfactantspecific protein in acute respiratory distress syndrome. Lancet 353: 1232-1237.
22. Ballard-Croft C, Sumpter LR, Broaddus R, Alexander J, Wang D, Zwischenberger JB. 2010. Ovine smoke/burn ARDS model: a new ventilator- controlled smoke delivery system. J Surg Res 164: e155-e162.
23. Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Moseley A, Hoffman R. 2002. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30: 42-48.
24. Bast C, Glass DF. 2009. Phosgene. In: Gupta RC, ed. Handbook of Toxicology of Chemical Warfare Agents. New York, USA: Academic Press.
25. Batchinsky AI, Martini DK, Jordan BS, Dick EJ, Fudge J, Baird CA, Hardin DE, Cancio LC. 2006. Acute respiratory distress syndrome secondary to inhalation of chlorine gas in sheep. J Trauma 60: 944-56; discussion 956.
26. Becker AJ, McCulloch EA, Till JE. 1963. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197: 452-454.
27. Belema-Bedada F, Uchida S, Martire A, Kostin S, Braun T. 2008. Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2. Cell Stem Cell 2: 566-575.
28. Bell DG. 2007. Severe lung injury following exposure to chlorine gas: a case series. Chest Meeting Abstracts 132: 566.
29. Bell DG. 2008. Management of acute respiratory distress syndrome (ARDS) following chlorine exposure (Abstract). Am J Respir Crit Care Med 176: A314.
30. Benson JM, Gomez AP, Wolf ML, Tibbetts BM, March TH. 2011. The acute toxicity, tissue distribution, and histopathology of inhaled ricin in Sprague Dawley rats and BALB/c mice. Inhal Toxicol 23: 247-256.
31. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. 1994. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149: 818-824.
32. Bhatia M, Moochhala S. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 202: 145-156.
33. Bledsoe FH, Seymour EQ. 1972. Acute pulmonary edema associated with parathion poisoning. Radiology 103: 53-56.
34. Borok Z, Danto SI, Lubman RL, Cao Y, Williams MC, Crandall ED. 1998. Modulation of t1α expression with alveolar epithelial cell phenotype in vitro. Am J Physiol 275: L155-L164.
35. Borok Z, Lubman RL, Danto SI, Zhang XL, Zabski SM, King LS, Lee DM, Agre P, Crandall ED. 1998. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am J Respir Cell Mol Biol 18: 554-561.
36. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. 2005. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122: 947-956.
37. Brody JS, Williams MC. 1992. Pulmonary alveolar epithelial cell differentiation. Annu Rev Physiol 54: 351-371.
38. Brown RF, White DE. 1997. Ultrastructure of rat lung following inhalation of ricin aerosol. Int J Exp Pathol 78: 267-276.
39. Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M. 2005. Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med 172: 854-860.
40. Campbell WN, Ding X, Goldblum SE. 1992. Interleukin-1 α and-β augment pulmonary artery transendothelial albumin flux in vitro. Am J Physiol 263: L128-L136.
41. Campbell WN, Fitzpatrick M, Ding X, Jett M, Gemski P, Goldblum SE. 1997. SEB is cytotoxic and alters EC barrier function through protein tyrosine phosphorylation in vitro. Am J Physiol 273: L31-L39.
42. Capacio BR, Smith JR, Gordon RK, Haigh JR, Barr JR, Platoff Jr. 2008. Medical diagnostics. In: Tuorinsky SD, ed. Medical Aspects of Chemical Warfare. Washington, DC, USA: Department of the Army.
43. Caspi O, Huber I, Kehat I, Habib M, Arbel G, Gepstein A, Yankelson L, Aronson D, Beyar R, Gepstein L. 2007. Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts. J Am Coll Cardiol 50: 1884-1893.
44. Cernak I, Radosevic P, Malicevic Z, Savic J. 1995. Experimental magnesium depletion in adult rabbits caused by blast overpressure. Magnes Res 8: 249-259.
45. Chang JC, Summer R, Sun X, Fitzsimmons K, Fine A. 2005. Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol 33: 335-342.
46. Chavko M, Adeeb S, Ahlers ST, McCarron RM. 2009. Attenuation of pulmonary inflammation after exposure to blast overpressure by N-acetylcysteine amide. Shock 32: 325-331.
47. Choi H, Lee RH, Bazhanov N, Oh JY, Prockop DJ. 2011. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosaninduced mouse peritonitis by decreasing TLR2/NF-?B signaling in resident macrophages. Blood 118: 330-338.
48. Chopra M, Reuben JS, Sharma AC. 2009. Acute lung injury: apoptosis and signaling mechanisms. Exp Biol Med (Maywood) 234: 361-371.
49. Christopherson GT, Nesti LJ. 2011. Stem cell applications in military medicine. Stem Cell Res Ther 2: 40.
50. Cohen J. 2002. The immunopathogenesis of sepsis. Nature 420: 885-891.
51. Contant CF, Valadka AB, Gopinath SP, Hannay HJ, Robertson CS. 2001. Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury. J Neurosurg 95: 560-568.
52. Conti ML, Che MM, Boylan M, Sciuto AM, Gordon RK, Nambiar MP. 2009. Acute microinstillation inhalation exposure to sarin induces changes in respiratory dynamics and functions in guinea pigs. Int J Toxicol 28: 436-447.
53. Coraux C, Nawrocki-Raby B, Hinnrasky J, Kileztky C, Gaillard D, Dani C, Puchelle E. 2005. Embryonic stem cells generate airway epithelial tissue. Am J Respir Cell Mol Biol 32: 87-92.
54. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, Risso M, Gualandi F, Mancardi GL, Pistoia V, Uccelli A. 2006. Human mesenchymal stem cells modulate B-cell functions. Blood 107: 367-372.
55. Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER. 1982. Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 126: 332-337.
56. Cribbs SK, Matthay MA, Martin GS. 2010. Stem cells in sepsis and acute lung injury. Crit Care Med 38: 2379-2385.
57. Crosby LM, Waters CM. 2010. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 298: L715-L731.
58. Czer LS, Appel P, Shoemaker WC. 1980. Pathogenesis of respiratory failure (ARDS) after hemorrhage and trauma: II. Cardiorespiratory patterns after development of ARDS. Crit Care Med 8: 513-518.
59. Dabish PA, Hulet SW, Kristovich R, Mioduszewski RJ. 2008. Inhalation toxicology of nerve agents. In: Romano JA, Lukey BJ, Salem H, eds. Chemical Warfare Agents: Chemistry, Pharmacology, Toxicology, and Therapeutics. Second Edition. Boca Raton, FL, USA: CRC Press.
60. Danchuk S, Ylostalo JH, Hossain F, Sorge R, Ramsey A, Bonvillain RW, Lasky JA, Bunnell BA, Welsh DA, Prockop DJ, Sullivan DE. 2011. Human multipotent stromal cells attenuate lipopolysaccharideinduced acute lung injury in mice via secretion of tumor necrosis factor-a-induced protein 6. Stem Cell Res Ther 2: 27.
61. DaSilva L, Cote D, Roy C, Martinez M, Duniho S, Pitt ML, Downey T, Dertzbaugh M. 2003. Pulmonary gene expression profiling of inhaled ricin. Toxicon 41: 813-822.
62. David J, Wilkinson LJ, Griffiths GD. 2009. Inflammatory gene expression in response to sub-lethal ricin exposure in Balb/c mice. Toxicology 264: 119-130.
63. Delaunois A, Gustin P, Ansay M. 1992. Altered capillary filtration coefficient in parathion-and paraoxon-induced edema in isolated and perfused rabbit lungs. Toxicol Appl Pharmacol 116: 161-169.
64. Deshpande A, Archuletta DC, Valdez YE, Lehnert NM, Stavert DM, Lehert BE. 1996. Tumor necrosis factor-α production by alveolar macrophages during the early development of phosgene-induced lung injury. Inhal Toxicol 8: 65-80.
65. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM. 2002. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99: 3838-3843.
66. Dobbs LG, Williams MC, Brandt AE. 1985. Changes in biochemical characteristics and pattern of lectin binding of alveolar type II cells with time in culture. Biochim Biophys Acta 846: 155-166.
67. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E. 2006. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317.
68. Duniho SM, Martin J, Forster JS, Cascio MB, Moran TS, Carpin LB, Sciuto AM. 2002. Acute changes in lung histopathology and bronchoalveolar lavage parameters in mice exposed to the choking agent gas phosgene. Toxicol Pathol 30: 339-349.
69. Effmann EL, Merten DF, Kirks DR, Pratt PC, Spock A. 1985. Adult respiratory distress syndrome in children. Radiology 157: 69-74.
70. Eggimann P, Harbarth S, Ricou B, Hugonnet S, Ferriere K, Suter P, Pittet D. 2003. Acute respiratory distress syndrome after bacteremic sepsis does not increase mortality. Am J Respir Crit Care Med 167: 1210-1214.
71. Elsayed NM, Gorbunov NV. 2007. Pulmonary biochemical and histological alterations after repeated low-level blast overpressure exposures. Toxicol Sci 95: 289-296.
72. Emad A, Emad V. 2007. Elevated levels of MCP-1, MIP-α and MIP-1 β in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis. Toxicology 240: 60-69.
73. Emad A, Emad Y. 2008. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. J Clin Immunol 28: 298-305.
74. Emad A, Rezaian GR. 1997. The diversity of the effects of sulfur mustard gas inhalation on respiratory system 10 years after a single, heavy exposure: analysis of 197 cases. Chest 112: 734-738.
75. Erices A, Conget P, Minguell JJ. 2000. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 109: 235-242.
76. Ermert L, Brkner H, Walmrath D, Grimminger F, Aktories K, Suttorp N, Duncker HR, Seeger W. 1995. Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs. Am J Physiol 268: L753-L761.
77. Ermert L, Duncker HR, Brkner H, Grimminger F, Hansen T, Rasig R, Aktories K, Seeger W. 1997. Ultrastructural changes of lung capillary endothelium in response to botulinum C2 toxin. J Appl Physiol 82: 382-388.
78. Evans MJ, Kaufman MH. 1981. Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154-156.
79. Fan CG, Tang FW, Zhang QJ, Lu SH, Liu HY, Zhao ZM, Liu B, Han ZB, Han ZC. 2005. Characterization and neural differentiation of fetal lung mesenchymal stem cells. Cell Transplant 14: 311-321.
80. Fan CG, Zhang QJ, Tang FW, Han ZB, Wang GS, Han ZC. 2005. Human umbilical cord blood cells express neurotrophic factors. Neurosci Lett 380: 322-325.
81. Fang X, Neyrinck AP, Matthay MA, Lee JW. 2010. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem 285: 26211-26222.
82. Fein AM, Calalang-Colucci MG. 2000. Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin 16: 289-317.
83. Franis S, Bensidhoum M, Mouiseddine M, Mazurier C, Allenet B, Semont A, Frick J, SachA, Bouchet S, Thierry D, Gourmelon P, Gorin NC, Chapel A. 2006. Local irradiation not only induces homing of human mesenchymal stem cells at exposed sites but promotes their widespread engraftment to multiple organs: a study of their quantitative distribution after irradiation damage. Stem Cells 24: 1020-1029.
84. Franz DR, Jaax NK. 1997. Ricin toxin. In: Sidell FR, Takfuji ET, Franz DR, eds. Textbook of Military Medicine Part 1. Warfare, Weaponry, and the Casualty: Medical Aspects of Chemical and Biological Warfare. Washington, DC, USA: Department of the Army.
85. Franz DR, Pitt LM, Clayton MA, Hanes MA, Rose KJ. 1993. Efficacy of prophylactic and therapeutic administration of antitoxin for inhalation botulism. In: Das Gupta B, ed. Botulinum and Tetanus Neurotoxins and Biomedical Aspects. New York, USA: Plenum Press.
86. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. 1968. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 6: 230-247.
87. Ghanei M, Harandi AA. 2011. Molecular and cellular mechanism of lung injuries due to exposure to sulfur mustard: a review. Inhal Toxicol 23: 363-371.
88. Goldman G, Welbourn R, Klausner JM, Alexander S, Kobzik L, Valeri CR, Shepro D, Hechtman HB. 1990. Attenuation of acid aspiration edema with phalloidin. Am J Physiol 259: L378-L383.
89. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB. 1990. Tumor necrosis factor-α mediates acid aspiration-induced systemic organ injury. Ann Surg 212: 513-9; discussion 519.
90. Gotts JE, Matthay MA. 2011. Mesenchymal stem cells and acute lung injury. Crit Care Clin 27: 719-733.
91. Grange-Messent V, Bouchaud C, Jamme M, Lallement G, Foquin A, Carpentier P. 1999. Seizure-related opening of the blood-brain barrier produced by the anticholinesterase compound, soman: new ultrastructural observations. Cell Mol Biol (Noisy-le-grand) 45: 1-14.
92. Greenfield RA, Brown BR, Hutchins JB, Iandolo JJ, Jackson R, Slater LN, Bronze MS. 2002. Microbiological, biological, and chemical weapons of warfare and terrorism. Am J Med Sci 323: 326-340.
93. Griffiths GD, Phillips GJ, Holley J. 2007. Inhalation toxicology of ricin preparations: animal models, prophylactic and therapeutic approaches to protection. Inhal Toxicol 19: 873-887.
94. Gulati R, Jevremovic D, Peterson TE, Chatterjee S, Shah V, Vile RG, Simari RD. 2003. Diverse origin and function of cells with endothelial phenotype obtained from adult human blood. Circ Res 93: 1023-1025.
95. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. 2007. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 179: 1855-1863.
96. Hamilton MG, Hill I, Conley J, Sawyer TW, Caneva DC, Lundy PM. 2004. Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination. Mil Med 169: 856-862.
97. Hannoush EJ, Sifri ZC, Elhassan IO, Mohr AM, Alzate WD, Offin M, Livingston DH. 2011. Impact of enhanced mobilization of bone marrow derived cells to site of injury. J Trauma 71: 283-9.
98. Herzog EL, Van Arnam J, Hu B, Krause DS. 2006. Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells 24: 1986-1992.
99. Hilmas CJ, Smart JK, Hill Jr. 2008. History of chemical warfare. In: Tuorinsky SD, ed. Medical Aspects of Chemical Warfare. Washington, DC, USA: Department of the Army.
100. Hjorts E, Qvist J, Bud MI, Thomsen JL, Andersen JB, Wiberg-Jgensen F, Jensen NK, Jones R, Reid LM, Zapol WM. 1988. ARDS after accidental inhalation of zinc chloride smoke. Intensive Care Med 14: 17-24.
101. Hober D, Delannoy AS, Benyoucef S, De Groote D, WattrP. 1996. High levels of sTNFR p75 and TNF α in dengue-infected patients. Microbiol Immunol 40: 569-573.
102. Hober D, Poli L, Roblin B, Gestas P, Chungue E, Granic G, Imbert P, Pecarere JL, Vergez-Pascal R, Wattre P. 1993. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1 β (IL-1 β) in dengue-infected patients. Am J Trop Med Hyg 48: 324-331.
103. Hosseini-khalili A, Haines DD, Modirian E, Soroush M, Khateri S, Joshi R, Zendehdel K, Ghanei M, Giardina C. 2009. Mustard gas exposure and carcinogenesis of lung. Mutat Res 678: 1-6.
104. Hoyle GW, Chang W, Chen J, Schlueter CF, Rando RJ. 2010. Deviations from Haber's Law for multiple measures of acute lung injury in chlorine-exposed mice. Toxicol Sci 118: 696-703.
105. In 't Anker PS, Scherjon SA, Kleijburg-van der Keur C, de Groot-Swings GM, Claas FH, Fibbe WE, Kanhai HH. 2004. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells 22: 1338-1345.
106. Isakson BE, Lubman RL, Seedorf GJ, Boitano S. 2001. Modulation of pulmonary alveolar type II cell phenotype and communication by extracellular matrix and KGF. Am J Physiol, Cell Physiol 281: C1291-C1299.
107. Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, Mao N. 2005. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105: 4120-4126.
108. Johnson ER, Matthay MA. 2010. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv 23: 243-252.
109. Jones KH, Dechkovskaia AM, Herrick EA, Abdel-Rahman AA, Khan WA, Abou-Donia MB. 2000. Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. J Toxicol Environ Health Part A 61: 695-707.
110. Kaler CM, Wechselberger J, Hilbe W, Gschwendtner A, Colleselli D, Niederegger H, Boneberg EM, Spizzo G, Wendel A, Gunsilius E, Patsch JR, Hamacher J. 2007. Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res 8: 50.
111. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. 2009. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458: 771-775.
112. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P. 2011. Evidence for human lung stem cells. N Engl J Med 364: 1795-1806.
113. Karki P, Ansari JA, Bhandary S, Koirala S. 2004. Cardiac and electrocardiographical manifestations of acute organophosphate poisoning. Singapore Med J 45: 385-389.
114. Kass R, Kochar G, Lippman M. 1991. Adult respiratory distress syndrome from organophosphate poisoning. Am J Emerg Med 9: 32-33.
115. Katz R. 1987. Adult respiratory distress syndrome in children. Clin Chest Med 8: 635-639.
116. Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. 2005. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121: 823-835.
117. King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE Jr, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF. 2011. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. N Engl J Med 365: 222-230.
118. Kopen GC, Prockop DJ, Phinney DG. 1999. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 96: 10711-10716.
119. Korcheva V, Wong J, Corless C, Iordanov M, Magun B. 2005. Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome. Am J Pathol 166: 323-339.
120. Korcheva V, Wong J, Lindauer M, Jacoby DB, Iordanov MS, Magun B. 2007. Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages. Mol Immunol 44: 2761-2771.
121. Kotton DN, Fabian AJ, Mulligan RC. 2005. Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol 33: 328-334.
122. Kotton DN, Fine A. 2008. Lung stem cells. Cell Tissue Res 331: 145-156.
123. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. 2010. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells 28: 2229-2238.
124. Krause DS. 2008. Bone marrow-derived cells and stem cells in lung repair. Proc Am Thorac Soc 5: 323-327.
125. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. 2001. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369-377.
126. Kubo K, Hanaoka M, Yamaguchi S, Hayano T, Hayasaka M, Koizumi T, Fujimoto K, Kobayashi T, Honda T. 1996. Cytokines in bronchoalveolar lavage fluid in patients with high altitude pulmonary oedema at moderate altitude in Japan. Thorax 51: 739-742.
127. Lam CF, Liu YC, Hsu JK, Yeh PA, Su TY, Huang CC, Lin MW, Wu PC, Chang PJ, Tsai YC. 2008. Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits. Anesthesiology 108: 392-401.
128. Lama VN, Smith L, Badri L, Flint A, Andrei AC, Murray S, Wang Z, Liao H, Toews GB, Krebsbach PH, Peters-Golden M, Pinsky DJ, Martinez FJ, Thannickal VJ. 2007. Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest 117: 989-996.
129. Lau AC, Yam LY, So LK. 2004. Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS). Int J Med Sci 1: 1-10.
130. Lawson GW, Van Winkle LS, Toskala E, Senior RM, Parks WC, Plopper CG. 2002. Mouse strain modulates the role of the ciliated cell in acute tracheobronchial airway injury-distal airways. Am J Pathol 160: 315-327.
131. LeClaire RD, Hunt RE, Bavari S, Estep JE, Nelson GO, Wilhelmsen CL. 1996. Potentiation of inhaled staphylococcal enterotoxin B-induced toxicity by lipopolysaccharide in mice. Toxicol Pathol 24: 619-626.
132. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. 2009. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxininduced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 106: 16357-16362.
133. Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA. 2011. Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells 29: 913-919.
134. Lee JW, Gupta N, Serikov V, Matthay MA. 2009. Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther 9: 1259-1270.
135. Lew TW, Kwek TK, Tai D, Earnest A, Loo S, Singh K, Kwan KM, Chan Y, Yim CF, Bek SL, Kor AC, Yap WS, Chelliah YR, Lai YC, Goh SK. 2003. Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome. JAMA 290: 374-380.
136. Lewis JF, Jobe AH. 1993. Surfactant and the adult respiratory distress syndrome. Am Rev Respir Dis 147: 218-233.
137. Li C, Miller WT, Jiang J. 1989. Pulmonary edema due to ingestion of organophosphate insecticide. AJR Am J Roentgenol 152: 265-266.
138. Li J, Li D, Liu X, Tang S, Wei F. 2012. Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPSinduced acute lung injury in rats. J Inflamm (Lond) 9: 33.
139. Liang ZX, Sun JP, Wang P, Tian Q, Yang Z, Chen LA. 2011. Bone marrowderived mesenchymal stem cells protect rats from endotoxininduced acute lung injury. Chin Med J 124: 2715-2722.
140. Lim SC, Yang JY, Jang AS, Park YU, Kim YC, Choi IS, Park KO. 1996. Acute lung injury after phosgene inhalation. Korean J Intern Med 11: 87-92.
141. Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S. 2009. A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808.
142. Lindauer ML, Wong J, Iwakura Y, Magun BE. 2009. Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling. J Immunol 183: 1419-1426.
143. Ma N, Gai H, Mei J, Ding FB, Bao CR, Nguyen DM, Zhong H. 2011. Bone marrow mesenchymal stem cells can differentiate into type II alveolar epithelial cells in vitro. Cell Biol Int 35: 1261-1266.
144. Malaviya R, Sunil VR, Cervelli J, Anderson DR, Holmes WW, Conti ML, Gordon RE, Laskin JD, Laskin DL. 2010. Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicol Appl Pharmacol 248: 89-99.
145. Mao M, Wang SN, Lv XJ, Wang Y, Xu JC. 2010. Intravenous delivery of bone marrow-derived endothelial progenitor cells improves survival and attenuates lipopolysaccharide-induced lung injury in rats. Shock 34: 196-204.
146. Martin GR. 1981. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78: 7634-7638.
147. Mason RJ, Dobbs LG, Greenleaf RD, Williams MC. 1977. Alveolar type II cells. Fed Proc 36: 2697-2702.
148. Mason RJ, Williams MC. 1977. Type II alveolar cell. Defender of the alveolus. Am Rev Respir Dis 115: 81-91.
149. Mason RJ, Williams MC, Greenleaf RD, Clements JA. 1977. Isolation and properties of type II alveolar cells from rat lung. Am Rev Respir Dis 115: 1015-1026.
150. Matthay MA. 2010. Advances and challenges in translating stem cell therapies for clinical diseases. Transl Res 156: 107-111.
151. Matthay MA, Goolaerts A, Howard JP, Lee JW. 2010. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med 38: S569-S573.
152. Matthay MA, Thompson BT, Read EJ, McKenna DH Jr, Liu KD, Calfee CS, Lee JW. 2010. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest 138: 965-972.
153. Matthay MA, Zemans RL. 2011. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol 6: 147-163.
154. Mattix ME, Hunt RE, Wilhelmsen CL, Johnson AJ, Baze WB. 1995. Aerosolized staphylococcal enterotoxin B-induced pulmonary lesions in rhesus monkeys (Macaca mulatta). Toxicol Pathol 23: 262-268.
155. Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, Liles WC, Stewart DJ. 2010. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med 182: 1047-1057.
156. Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ. 2007. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med 4: e269.
157. Menaouar A, Anglade D, Baussand P, Pelloux A, Corboz M, Lantuejoul S, Benchetrit G, Grimbert FA. 1997. Chlorine gas induced acute lung injury in isolated rabbit lung. Eur Respir J 10: 1100-1107.
158. Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A. 2008. Dissecting direct reprogramming through integrative genomic analysis. Nature 454: 49-55.
159. Millard CB, Leclaire RD. 2008. Ricin and related toxins: review and perspective. In: Romano JA, Lukey BJ, Salem H, eds. Chemical Warfare Agents: Chemistry, Pharmacology, Toxicology, and Therapeutics. Second Edition. Boca Raton, FL, USA: CRC Press.
160. Miller EJ, Cohen AB, Matthay MA. 1996. Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med 24: 1448-1454.
161. Moin-Azad Tehrani MS, Soltaninejad K, Yazdani S, Nelson LS, Shadnia S. 2011. Bilateral loculated pleural effusion as a manifestation of acute parenteral organophosphate intoxication: a case report. J Emerg Med 41: 630-634.
162. Montecucco C. 1995. Clostridial neurotoxins: the molecular pathogenesis of tetanus and botulism.
163. Mori M, Rothman AL, Kurane I, Montoya JM, Nolte KB, Norman JE, Waite DC, Koster FT, Ennis FA. 1999. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis 179: 295-302.
164. Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. 2012. Generation of multipotent
165. Nambiar MP, Gordon RK, Rezk PE, Katos AM, Wajda NA, Moran TS, Steele KE, Doctor BP, Sciuto AM. 2007. Medical countermeasure against respiratory toxicity and acute lung injury following inhalation exposure to chemical warfare nerve agent VX. Toxicol Appl Pharmacol 219: 142-150.
166. Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE. 2006. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J Immunol 177: 2080-2087.
167. Naeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15: 42-49.
168. Niederman MS, Fein AM. 1990. Sepsis syndrome, the adult respiratory distress syndrome, and nosocomial pneumonia. A common clinical sequence. Clin Chest Med 11: 633-656.
169. Niehage C, Steenblock C, Pursche T, Bornhser M, Corbeil D, Hoflack B. 2011. The cell surface proteome of human mesenchymal stromal cells. PLoS ONE 6: e20399.
170. Norman JG, Fink GW, Franz MG. 1995. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch Surg 130: 966-970.
171. Nussbaum E. 1983. Adult-type respiratory distress syndrome in children. Experience with seven cases. Clin Pediatr (Phila) 22: 401-406.
172. Oh JY, Roddy GW, Choi H, Lee RH, Yltalo JH, Rosa RH Jr, Prockop DJ. 2010. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc Natl Acad Sci USA 107: 16875-16880.
173. Olivera DS, Alves DA, Varney TR, Whitten K, Kan RK, Collins JL, Simons JB, Rodriguez AM, Bowens CM, Witriol AM, Lyman EA, Sciuto AM. A toxicological, biochemical, and physiological assessment of lung and systemic injury in rats exposed to inhaled sulfur mustard across dose and time. chemical and biological defense science and technology conference, 2011 Las Vegas, NV.
174. Olsnes S. 2004. The history of ricin, abrin and related toxins. Toxicon 44: 361-370.
175. Olsnes S, Refsnes K, Pihl A. 1974. Mechanism of action of the toxic lectins abrin and ricin. Nature 249: 627-631.
176. Ombrellaro M, Goldthorn JF, Harnar TJ, Shires GT. 1994. Extracorporeal life support for the treatment of adult respiratory distress syndrome after burn injury. Surgery 115: 523-526.
177. Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, Phinney DG. 2007. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 104: 11002-11007.
178. Oud L. 2009. From DaNang lung to combat trauma-associated acute lung injury-closing the loop. South Med J 102: 567-568.
179. Pati S, Gerber MH, Menge TD, Wataha KA, Zhao Y, Baumgartner JA, Zhao J, Letourneau PA, Huby MP, Baer LA, Salsbury JR, Kozar RA, Wade CE, Walker PA, Dash PK, Cox CS Jr, Doursout MF, Holcomb JB. 2011. Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock. PLoS One 6: e25171.
180. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM. 2007. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol 19: 789-810.
181. Peiris-John RJ, Ruberu DK, Wickremasinghe AR, van-der-Hoek W. 2005. Low-level exposure to organophosphate pesticides leads to restrictive lung dysfunction. Respir Med 99: 1319-1324.
182. Perkins MW, Pierre Z, Rezk P, Song J, Oguntayo S, Morthole V, Sciuto AM, Doctor BP, Nambiar MP. 2011. Protective effects of aerosolized scopolamine against soman-induced acute respiratory toxicity in guinea pigs. Int J Toxicol 30: 639-649.
183. Perkins MW, Pierre Z, Rezk P, Song J, Oguntayo S, Sciuto AM, Doctor BP, Nambiar MP. 2011. Acute changes in pulmonary function following microinstillation inhalation exposure to soman in nonatropenized guinea pigs. Int J Toxicol 30: 348-357.
184. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP. 1999. Bone marrow as a potential source of hepatic oval cells. Science 284: 1168-1170.
185. Petrali JP, Maxwell DM, Lenz DE, Mills KR. 1991. Effect of an anticholinesterase compound on the ultrastructure and function of the rat blood-brain barrier: a review and experiment. J Submicrosc Cytol Pathol 23: 331-338.
186. PettilV, Takkunen O, Tukiainen P. 2000. Zinc chloride smoke inhalation: a rare cause of severe acute respiratory distress syndrome. Intensive Care Med 26: 215-217.
187. Pierdomenico L, Bonsi L, Calvitti M, Rondelli D, Arpinati M, Chirumbolo G, Becchetti E, Marchionni C, Alviano F, Fossati V, Staffolani N, Franchina M, Grossi A, Bagnara GP. 2005. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation 80: 836-842.
188. Pison U, Brand M, Joka T, Obertacke U, Bruch J. 1988. Distribution and function of alveolar cells in multiply injured patients with traumainduced ARDS. Intensive Care Med 14: 602-609.
189. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147.
190. Plews JR, Li J, Jones M, Moore HD, Mason C, Andrews PW, Na J. 2010. Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach. PLoS One 5: e14397.
191. Plopper CG, Macklin J, Nishio SJ, Hyde DM, Buckpitt AR. 1992. Relationship of cytochrome P-450 activity to Clara cell cytotoxicity. III. Morphometric comparison of changes in the epithelial populations of terminal bronchioles and lobar bronchi in mice, hamsters, and rats after parenteral administration of naphthalene. Lab Invest 67: 553-565.
192. Plotnikov EY, Khryapenkova TG, Vasileva AK, Marey MV, Galkina SI, Isaev NK, Sheval EV, Polyakov VY, Sukhikh GT, Zorov DB. 2008. Cell-to-cell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture. J Cell Mol Med 12: 1622-1631.
193. Pohl C, Papritz M, Moisch M, Wbeke C, Hermanns MI, Uboldi C, Dei-Anang J, Mayer E, Kirkpatrick CJ, Kehe K. 2009. Acute morphological and toxicological effects in a human bronchial coculture model after sulfur mustard exposure. Toxicol Sci 112: 482-489.
194. Prytherch Z, Job C, Marshall H, Oreffo V, Foster M, BaubK. 2011. Tissue-Specific stem cell differentiation in an in vitro airway model. Macromol Biosci 11: 1467-1477.
195. Qin M, Tai G, Collas P, Polak JM, Bishop AE. 2005. Cell extract-derived differentiation of embryonic stem cells. Stem Cells 23: 712-718.
196. Raffaghello L, Bianchi G, Bertolotto M, Montecucco F, Busca A, Dallegri F, Ottonello L, Pistoia V. 2008. Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche. Stem Cells 26: 151-162.
197. Rajagopalan G, Sen MM, Singh M, Murali NS, Nath KA, Iijima K, Kita H, Leontovich AA, Gopinathan U, Patel R, David CS. 2006. Intranasal exposure to staphylococcal enterotoxin B elicits an acute systemic inflammatory response. Shock 25: 647-656.
198. Ramasamy R, Fazekasova H, Lam EW, Soeiro I, Lombardi G, Dazzi F. 2007. Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle. Transplantation 83: 71-76.
199. Rawlins EL. 2008. Lung epithelial progenitor cells: lessons from development. Proc Am Thorac Soc 5: 675-681.
200. Rawlins EL, Hogan BL. 2006. Epithelial stem cells of the lung: privileged few or opportunities for many? Development 133: 2455-2465.
201. Ray R, Keyser B, Benton B, Daher A, Simbulan-Rosenthal CM, Rosenthal DS. 2008. Sulfur mustard induces apoptosis in cultured normal human airway epithelial cells: evidence of a dominant caspase-8-mediated pathway and differential cellular responses. Drug Chem Toxicol 31: 137-148.
202. Ridge KM, Rutschman DH, Factor P, Katz AI, Bertorello AM, Sznajder JL. 1997. Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells. Am J Physiol 273: L246-L255.
203. Rippon HJ, Ali NN, Polak JM, Bishop AE. 2004. Initial observations on the effect of medium composition on the differentiation of murine embryonic stem cells to alveolar type II cells. Cloning Stem Cells 6: 49-56.
204. Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, Randell SH, Hogan BL. 2009. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA 106: 12771-12775.
205. Rushing SR, Saylor ML, Hale ML. 2009. Translocation of ricin across polarized human bronchial epithelial cells. Toxicon 54: 184-191.
206. Reter B, Gatig S, Ludwig RJ, Bistrian R, Maler S, Seifried E, Gille J, Henschler R. 2006. Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells. Blood 108: 3938-3944.
207. Saeed AI, Rieder SA, Price RL, Barker J, Nagarkatti P, Nagarkatti M. 2012. Acute lung injury induced by Staphylococcal enterotoxin B: disruption of terminal vessels as a mechanism of induction of vascular leak. Microsc Microanal 18: 445-452.
208. Sage EK, Loebinger MR, Polak J, Janes SM. 2008. The role of bone marrow-derived stem cells in lung regeneration and repair. Stem Book.
209. Salem HK, Morsi HA, Zakaria A. 2007. Management of high-grade renal injuries in children after blunt abdominal trauma: experience of 40 cases. J Pediatr Urol 3: 223-229.
210. Salem H, Ternay AL, Jr, Smart JK. 2008. Brief history and use of chemical warfare agents in warfare. In: Romano JA, Jr, Lukey BJ, Salem H, eds. Chemical Warfare Agents: Chemistry, Pharmacology, Toxicology, and Therapeutics. Second Edition. Boca Raton, FL, USA: CRC Press.
211. Samadikuchaksaraei A, Cohen S, Isaac K, Rippon HJ, Polak JM, Bielby RC, Bishop AE. 2006. Derivation of distal airway epithelium from human embryonic stem cells. Tissue Eng 12: 867-875.
212. Samal A, Honovar J, White CR, Patel RP. 2010. Potential for chlorine gas-induced injury in the extrapulmonary vasculature. Proc Am Thorac Soc 7: 290-293.
213. Savransky V, Rostapshov V, Pinelis D, Polotsky Y, Korolev S, Komisar J, Fegeding K. 2003. Murine lethal toxic shock caused by intranasal administration of staphylococcal enterotoxin B. Toxicol Pathol 31: 373-378.
214. Sciuto AM, Clapp DL, Hess ZA, Moran TS. 2003. The temporal profile of cytokines in the bronchoalveolar lavage fluid in mice exposed to the industrial gas phosgene. Inhal Toxicol 15: 687-700.
215. Seagrave J, Weber WM, Grotendorst GR. 2010. Sulfur mustard vapor effects on differentiated human lung cells. Inhal Toxicol 22: 896-902.
216. Segura P, Chez J, Monta LM, Vargas MH, Delaunois A, Carbajal V, Gustin P. 1999. Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn Schmiedebergs Arch Pharmacol 360: 699-710.
217. Seidelin R. 1961. The inhalation of phosgene in a fire extinguisher accident. Thorax 16: 91-93.
218. Shi S, Gronthos S. 2003. Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 18: 696-704.
219. Shoemaker WC, Appel P, Czer LS, Bland R, Schwartz S, Hopkins JA. 1980. Pathogenesis of respiratory failure (ARDS) after hemorrhage and trauma: I. Cardiorespiratory patterns preceding the development of ARDS. Crit Care Med 8: 504-512.
220. Simpson LL. 1986. Molecular pharmacology of botulinum toxin and tetanus toxin. Annu Rev Pharmacol Toxicol 26: 427-453.
221. Smith MG, Stone W, Guo RF, Ward PA, Suntres Z, Mukherjee S, Das SK. 2008. Vesicants and oxidative stress. In: Romano JA, Lukey BJ, Salem H, eds. Chemical Warfare Agents: Chemistry, Pharmacology, Toxicology, and Therapeutics. Second Edition. Boca Raton, FL, USA: CRC Press.
222. Snyder RW, Mishel HS, Christensen GC 3rd. 1992. Pulmonary toxicity following exposure to methylene chloride and its combustion product, phosgene. Chest 101: 860-861.
223. Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN. 2010. Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 28: 1728-1740.
224. Sorkine P, Setton A, Halpern P, Miller A, Rudick V, Marmor S, Klausner JM, Goldman G. 1995. Soluble tumor necrosis factor receptors reduce bowel ischemia-induced lung permeability and neutrophil sequestration. Crit Care Med 23: 1377-1381.
225. Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. 2006. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 107: 1484-1490.
226. Spees JL, Olson SD, Ylostalo J, Lynch PJ, Smith J, Perry A, Peister A, Wang MY, Prockop DJ. 2003. Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci USA 100: 2397-2402.
227. Spees JL, Pociask DA, Sullivan DE, Whitney MJ, Lasky JA, Prockop DJ, Brody AR. 2007. Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. Am J Respir Crit Care Med 176: 385-394.
228. Stelzel W. 1996. Hantavirus pulmonary syndrome: epidemiology, prevention, and case presentation of a new viral strain. Nurse Pract 21: 89-90, 93, 96 passim.
229. Stripp BR, Reynolds SD. 2008. Maintenance and repair of the bronchiolar epithelium. Proc Am Thorac Soc 5: 328-333.
230. Sun CK, Yen CH, Lin YC, Tsai TH, Chang LT, Kao YH, Chua S, Fu M, Ko SF, Leu S, Yip HK. 2011. Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model. J Transl Med 9: 118.
231. Suratt BT, Cool CD, Serls AE, Chen L, Varella-Garcia M, Shpall EJ, Brown KK, Worthen GS. 2003. Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med 168: 318-322.
232. Szema AM, Peters MC, Weissinger KM, Gagliano CA, Chen JJ. 2010. New-onset asthma among soldiers serving in Iraq and Afghanistan. Allergy Asthma Proc 31: 67-71.
233. Takahashi K, Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
234. Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, Magner M, Isner JM, Asahara T. 1999. Ischemia-and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 5: 434-438.
235. Talmage SS. 2009. Chlorine. In: Gupta RC, ed. Handbook of Toxicology of Chemical Warfare Agents. New York, USA: Academic Press.
236. Taysse L, Daulon S, Calvet J, Delamanche S, Hilaire D, Bellier B, Breton P. 2005. Induction of acute lung injury after intranasal administration of toxin botulinum a complex. Toxicol Pathol 33: 336-342.
237. Teixidor HS, Novick G, Rubin E. 1983. Pulmonary complications in burn patients. J Can Assoc Radiol 34: 264-270.
238. Ten Have-Opbroek AA. 1979. Immunological study of lung development in the mouse embryo. II. First appearance of the great alveolar cell, as shown by immunofluorescence microscopy. Dev Biol 69: 408-423.
239. Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. 2002. Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Exp Hematol 30: 1333-1338.
240. Thomason JW, Rice TW, Milstone AP. 2003. Bronchiolitis obliterans in a survivor of a chemical weapons attack. JAMA 290: 598-599.
241. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
242. Tian X, Tao H, Brisolara J, Chen J, Rando RJ, Hoyle GW. 2008. Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal Toxicol 20: 783-793.
243. Till JE, McCulloch EA. 1963. Early repair processes in marrow cells irradiated and proliferating in vivo. Radiat Res 18: 96-105.
244. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. 2003. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 75: 389-397.
245. Tsushima K, King LS, Aggarwal NR, De Gorordo A, D'Alessio FR, Kubo K. 2009. Acute lung injury review. Intern Med 48: 621-630.
246. Turnage RH, Nwariaku F, Murphy J, Schulman C, Wright K, Yin H. 2002. Mechanisms of pulmonary microvascular dysfunction during severe burn injury. World J Surg 26: 848-853.
247. Uccelli A, Moretta L, Pistoia V. 2008. Mesenchymal stem cells in health and disease. Nat Rev Immunol 8: 726-736.
248. Ulrich RG, Wilhelmsen CL, Krakauer T. 1997. Staphylococcal enterotoxin B and related toxins. In: Sidell FR, Takfuji ET, Franz DR, eds. Textbook of Military Medicine Part 1. Warfare, Weaponry, and the Casualty: Medical Aspects of Chemical and Biological Warfare. Washington, DC, USA: Department of the Army.
249. USAMRICD 2007. Medical Management of Chemical Casualties Handbook, U.S. Government Printing Office.
250. Van Sickle D, Wenck MA, Belflower A, Drociuk D, Ferdinands J, Holguin F, Svendsen E, Bretous L, Jankelevich S, Gibson JJ, Garbe P, Moolenaar RL. 2009. Acute health effects after exposure to chlorine gas released after a train derailment. Am J Emerg Med 27: 1-7.
251. Vijayaraghavan R, Kumar P, Dubey DK, Singh R. 2002. Evaluation of CC2 as a decontaminant in various hydrophilic and lipophilic formulations against sulphur mustard. Biomed Environ Sci 15: 25-35.
252. Wadia RS, Sadagopan C. 1973. Organophosphates and pulmonary edema. N Engl J Med 289: 104.
253. Wang D, Haviland DL, Burns AR, Zsigmond E, Wetsel RA. 2007. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 104: 4449-4454.
254. Wang D, Morales JE, Calame DG, Alcorn JL, Wetsel RA. 2010. Transplantation of human embryonic stem cell-derived alveolar epithelial type II cells abrogates acute lung injury in mice. Mol Ther 18: 625-634.
255. Wang G, Bunnell BA, Painter RG, Quiniones BC, Tom S, Lanson NA Jr, Spees JL, Bertucci D, Peister A, Weiss DJ, Valentine VG, Prockop DJ, Kolls JK. 2005. Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. Proc Natl Acad Sci USA 102: 186-191.
256. Wang YT, Lee LK, Poh SC. 1987. Phosgene poisoning from a smoke grenade. Eur J Respir Dis 70: 126-128.
257. Wardeh A, Marik P. 1998. Acute lung injury due to parvovirus pneumonia. J Intern Med 244: 257-260.
258. Ware LB, Matthay MA. 2000. The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349.
259. Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. 2010. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7: 618-630.
260. Waterer GW, Robertson H. 2009. Bioterrorism for the respiratory physician. Respirology 14: 5-11.
261. Weinberger B, Laskin JD, Sunil VR, Sinko PJ, Heck DE, Laskin DL. 2011. Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther 24: 92-99.
262. Weiss DJ, Kolls JK, Ortiz LA, Panoskaltsis-Mortari A, Prockop DJ. 2008. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc 5: 637-667.
263. Werrlein RJ, Madren-Whalley JS, Kirby SD. 1994. Phosgene effects on F-actin organization and concentration in cells cultured from sheep and rat lung. Cell Biol Toxicol 10: 45-58.
264. White CW, Martin JG. 2010. Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models. Proc Am Thorac Soc 7: 257-263.
265. Wijte D, Alblas MJ, Noort D, Langenberg JP, van Helden HP. 2011. Toxic effects following phosgene exposure of human epithelial lung cells in vitro using a CULTEX? system. Toxicol In Vitro 25: 2080-2087.
266. Wilhelmsen CL, Pitt ML. 1996. Lesions of acute inhaled lethal ricin intoxication in rhesus monkeys. Vet Pathol 33: 296-302.
267. Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hlnen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A. 2009. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458: 766-770.
268. Wong J, Korcheva V, Jacoby DB, Magun B. 2007. Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage. Am J Pathol 170: 1497-1510.
269. Wong J, Korcheva V, Jacoby DB, Magun BE. 2007. Proinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-kappaB. Am J Physiol Lung Cell Mol Physiol 293: L1385-L1394.
270. Wright BS, Rezk PE, Graham JR, Steele KE, Gordon RK, Sciuto AM, Nambiar MP. 2006. Acute lung injury following inhalation exposure to nerve agent VX in guinea pigs. Inhal Toxicol 18: 437-448.
271. Xu J, Woods CR, Mora AL, Joodi R, Brigham KL, Iyer S, Rojas M. 2007. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol 293: L131-L141.
272. Yadav AK, Bracher A, Doran SF, Leustik M, Squadrito GL, Postlethwait EM, Matalon S. 2010. Mechanisms and modification of chlorineinduced lung injury in animals. Proc Am Thorac Soc 7: 278-283.
273. Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. 2010. Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn. Cell Transplant 19: 823-830.
274. Yamada M, Kubo H, Kobayashi S, Ishizawa K, Numasaki M, Ueda S, Suzuki T, Sasaki H. 2004. Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 172: 1266-1272.
275. Yang H, Wen Y, Bin J, Hou-You Y, Yu-Tong W. 2011. Protection of bone marrow mesenchymal stem cells from acute lung injury induced by paraquat poisoning. Clin Toxicol (Phila) 49: 298-302.
276. Yang KY, Shih HC, How CK, Chen CY, Hsu HS, Yang CW, Lee YC, Perng RP, Peng CH, Li HY, Chang CM, Mou CY, Chiou SH. 2011. IV delivery of induced pluripotent stem cells attenuates endotoxininduced acute lung injury in mice. Chest 140: 1243-1253.
277. Yavuz Y, Kaya E, Yurumez Y, Sahin O, Bas O, Fidan H, Sezer M. 2008. Technetium-99m diethylenetriaminepentaacetic acid radioaerosol scintigraphy in organophosphate induced pulmonary toxicity: experimental study. Clin Toxicol (Phila) 46: 711-715.
278. Yoon CH, Hur J, Park KW, Kim JH, Lee CS, Oh IY, Kim TY, Cho HJ, Kang HJ, Chae IH, Yang HK, Oh BH, Park YB, Kim HS. 2005. Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases. Circulation 112: 1618-1627.
279. Young RA, Bast C. 2009. Mustards and vesicants. In: Gupta RC, ed. Handbook of Toxicology of Chemical Warfare Agents. New York, USA: Academic Press.
280. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920.
281. Yuan X, Wan H, Zhao X, Zhu S, Zhou Q, Ding S. 2011. Combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts. Stem Cells.
282. Yurumez Y, Ikizceli I, Sozuer EM, Soyuer I, Yavuz Y, Avsarogullari L, Durukan P. 2007. Effect of interleukin-10 on tissue damage caused by organophosphate poisoning. Basic Clin Pharmacol Toxicol 100: 323-327.
283. Zander DS, Baz MA, Cogle CR, Visner GA, Theise ND, Crawford JM. 2005. Bone marrow-derived stem-cell repopulation contributes minimally to the Type II pneumocyte pool in transplanted human lungs. Transplantation 80: 206-212.
284. Zhang XD, Hai CX, Cai FL, Liang X, Liu R, Chen HL, Qin XJ, Feng AJ. 2008. Time course for expression of VEGF and its receptor and regulator levels of contraction and relaxation in increased vascular permeability of lung induced by phosgene. Inhal Toxicol 20: 805-812.
285. Zhao YD, Ohkawara H, Vogel SM, Malik AB, Zhao YY. 2010. Bone marrow-derived progenitor cells prevent thrombin-induced increase in lung vascular permeability. Am J Physiol Lung Cell Mol Physiol 298: L36-L44.
286. Zhu YG, Qu JM, Zhang J, Jiang HN, Xu JF. 2011. Novel interventional approaches for ALI/ARDS: cell-based gene therapy. Mediators Inflamm 2011: 560194.
287. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. 2001. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211-228.