Stem cells in sepsis and acute lung injury

Critical Care Medicine

Volumn 38, Issue 12, 2010, Pages 2379-2385

  Cribbs, Sushma K ^a   Matthay, Michael A ^b   Martin, Greg S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ARDS; biomarkers; cell based therapy; sepsis; stem cells

Indexed keywords

ACUTE LUNG INJURY; ARTICLE; CELL THERAPY; CLINICAL TRIAL; CRITICALLY ILL PATIENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MEDLINE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; STEM CELL MOBILIZATION;

EID: 78650310959     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181f96f5f     Document Type: Article

References (84)

1. Rubenfeld GD, Caldwell E, Peabody E, et al: Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353:1685-1693
2. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301-1308
3. Bernard GR, Vincent JL, Laterre PF, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
4. Rivers E, Nguyen B, Havstad S, et al: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
5. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
6. Abraham E, Wunderink R, Silverman H, et al: Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome: A randomized, controlled, double-blind, multicenter clinical trial TNF-alpha MAb Sepsis Study Group. JAMA 1995; 273:934-941
7. Mira JP, Cariou A, Grall F, et al: Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study. JAMA 1999; 282:561-568
8. Abraham E: Neutrophils and acute lung injury. Crit Care Med 2003; 31:S195-S199
9. Donnelly SC, Haslett C, Reid PT, et al: Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat Med 1997; 3:320-323
10. Ware LB, Matthay MA: The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349
11. Opal SM, DePalo VA: Anti-inflammatory cy-tokines. Chest 2000; 117:1162-1172
12. Gupta N, Su X, Popov B, et al: Intrapulmo-nary delivery of bone marrow-derived mes-enchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 2007; 179: 1855-1863
13. Ringden O, Uzunel M, Rasmusson I, et al: Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006; 81:1390-1397
14. Rojas M, Xu J, Woods CR, et al: Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33:145-152
15. Chen L, Tredget EE, Wu PY, et al: Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008; 3:e1886
16. Xu J, Woods CR, Mora AL, et al: Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol 2007; 293:L131-L141
17. Burnham EL, Taylor WR, Quyyumi AA, et al: Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med 2005; 172:854-860
18. Rafat N, Hanusch C, Brinkkoetter PT, et al: Increased circulating endothelial progenitor cells in septic patients: Correlation with survival. Crit Care Med 2007; 35:1677-1684
19. McCulloch EA, Till JE: Perspectives on the properties of stem cells. Nat Med 2005; 11: 1026-1028
20. Almstrup K, Sonne SB, Hoei-Hansen CE, et al: From embryonic stem cells to testicular germ cell cancer-Should we be concerned? Int J Androl 2006; 29:211-218
21. Lensch MW, Schlaeger TM, Zon LI, et al: Teratoma formation assays with human embryonic stem cells: A rationale for one type of human-animal chimera. Cell Stem Cell 2007; 1:253-258
22. Pierce GB Jr, Dixon FJ Jr, Verney EL: Ter-atocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies. Lab Invest 1960; 9:583-602
23. Dicker A, Le Blanc K, Astrom G, et al: Functional studies of mesenchymal stem cells derived from adult human adipose tissue. Exp Cell Res 2005; 308:283-290
24. Krampera M, Sartoris S, Liotta F, et al: Immune regulation by mesenchymal stem cells derived from adult spleen and thymus. Stem Cells Dev 2007; 16:797-810
25. Pittenger MF, Mackay AM, Beck SC, et al: Multilineage potential of adult human mes-enchymal stem cells. Science 1999; 284: 143-147
26. Dominici M, Le Blanc K, Mueller I, et al: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8:315-317
27. Nauta AJ, Fibbe WE: Immunomodulatory properties of mesenchymal stromal cells. Blood 2007; 110:3499-3506
28. Rasmusson I, Ringden O, Sundberg B, et al: Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003; 76: 1208-1213
29. Rasmusson I, Uhlin M, Le Blanc K, et al: Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes. J Leukoc Biol 2007; 82:887-893
30. Le Blanc K, Tammik C, Rosendahl K, et al: HLA expression and immunologic properties of differentiated and undifferentiated mesen-chymal stem cells. Exp Hematol 2003; 31: 890-896
31. Asahara T, Murohara T, Sullivan A, et al: Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-967
32. Reyes M, Dudek A, Jahagirdar B, et al: Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002; 109: 337-346
33. Murohara T, Ikeda H, Duan J, et al: Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest 2000; 105:1527-1536
34. Dimmeler S, Zeiher AM: Endothelial cell ap-optosis in angiogenesis and vessel regression. Circ Res 2000; 87:434-439
35. Hill JM, Zalos G, Halcox JP, et al: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003; 348:593-600
36. Ingram DA, Mead LE, Tanaka H, et al: Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004; 104: 2752-2760
37. Prater DN, Case J, Ingram DA, et al: Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007; 21:1141-1149
38. Peichev M, Naiyer AJ, Pereira D, et al: Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 2000; 95:952-958
39. Bryder D, Rossi DJ, Weissman IL: Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol 2006; 169: 338-346
40. Assmus B, Schachinger V, Teupe C, et al: Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 2002; 106:3009-3017
41. Badorff C, Dimmeler S: Neovascularization and cardiac repair by bone marrow-derived stem cells. Handb Exp Pharmacol 2006; 283-298
42. Yoder MC, Mead LE, Prater D, et al: Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007; 109:1801-1809
43. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
44. Brun-Buisson C, Doyon F, Carlet J, et al: Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: A mul-ticenter prospective study in intensive care units French ICU Group for Severe Sepsis. JAMA 1995; 274:968-974
45. Finfer S, Bellomo R, Lipman J, et al: Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med 2004; 30:589-596
46. Padkin A, Goldfrad C, Brady AR, et al: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003;31:2332-2338
47. Vincent JL, Sakr Y, Sprung CL, et al: Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006; 34: 344-353
48. Lentsch AB, Czermak BJ, Bless NM, et al: Essential role of alveolar macrophages in in-trapulmonary activation of NF-kappaB. Am J Respir Cell Mol Biol 1999; 20:692-698
49. Horwitz EM, Prockop DJ, Fitzpatrick LA, et al: Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5:309-313
50. Ortiz LA, Gambelli F, McBride C, et al: Mes-enchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Nat Acad Sci USA 2003; 100:8407-8411
51. Aggarwal S, Pittenger MF: Human mesen-chymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105: 1815-1822
52. Kahler CM, Wechselberger J, Hilbe W, et al: Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury. Respir Res 2007; 8:50
53. Krause DS, Theise ND, Collector MI, et al: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105:369-377
54. Suratt BT, Cool CD, Serls AE, et al: Human pulmonary chimerism after hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2003; 168:318-322
55. Yamada M, Kubo H, Kobayashi S, et al: Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 2004; 172: 1266-1272
56. Ringden O, Uzunel M, Sundberg B, et al: Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumo-mediastinum and perforated colon. Leukemia 2007; 21:2271-2276
57. Assmus B, Honold J, Schachinger V, et al: Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006; 355:1222-1232
58. Kalka C, Masuda H, Takahashi T, et al: Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascular-ization. Proc Nat Acad Sci USA 2000; 97: 3422-3427
59. Yamada M, Kubo H, Ishizawa K, et al: Increased circulating endothelial progenitor cells in patients with bacterial pneumonia: Evidence that bone marrow derived cells contribute to lung repair. Thorax 2005; 60: 410-413
60. Ripa RS, Haack-Sorensen M, Wang Y, et al: Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial. Circulation 2007; 116:I24-I30
61. Assmus B, Fischer-Rasokat U, Honold J, et al: Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: Results of the TOPCARE-CHD Registry. Circ Res 2007; 100:1234-1241
62. Wang XX, Zhang FR, Shang YP, et al: Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: A pilot randomized controlled trial. J Am Coll Cardiol 2007; 49:1566-1571
63. Bang OY, Lee JS, Lee PH, et al: Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005; 57: 874-882
64. Mutunga M, Fulton B, Bullock R, et al: Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 2001; 163:195-200
65. Tsaganos T, Giamarellos-Bourboulis EJ, Kol-lias S, et al: Kinetics of progenitor hemato-poietic stem cells in sepsis: Correlation with patients survival? BMC Infect Dis 2006; 6:142
66. Burnham EL, Mealer M, Gaydos J, et al: Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Am J Respir Cell Mol Biol 2010; 43:326-333
67. Nemeth K, Leelahavanichkul A, Yuen PS, et al: Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent repro-gramming of host macrophages to increase their interleukin-10 production. Nat Med 2009; 15:42-49
68. Gonzalez-Rey E, Anderson P, Gonzalez MA, et al: Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut 2009; 58:929-939
69. Mei SH, Haitsma JJ, Dos Santos CC, et al: Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med 2010 Jun 17 [Epub ahead of print]
70. Lam CF, Liu YC, Hsu JK, et al: Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits. Anesthesiology 2008; 108:392-401
71. Mao M, Wang SN, Lv XJ, et al: Intravenous delivery of bone marrow-derived endothelial progenitor cells improves survival and attenuates lipopolysaccharide-induced lung injury in rats. Shock 2010; 34:196-204
72. Lee SH, Jang AS, Kim YE, et al: Modulation of cytokine and nitric oxide by mesenchymal stem cell transfer in lung injury/fibrosis. Re-spir Res 2010; 11:16
73. Mei SH, McCarter SD, Deng Y, et al: Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overex-pressing angiopoietin 1. PLoS Med 2007; 4:e269
74. Ortiz LA, Dutreil M, Fattman C, et al: Inter-leukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Nat Acad Sci USA 2007; 104: 11002-11007
75. Zhao F, Zhang YF, Liu YG, et al: Therapeutic effects of bone marrow-derived mesenchymal stem cells engraftment on bleomycin-induced lung injury in rats. Transplant Proc 2008; 40:1700-1705
76. Lee JW, Fang X, Gupta N, et al: Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Nat Acad Sci USA 2009; 106: 16357-16362
77. Franco-Montoya ML, Bourbon JR, Durrm-eyer X, et al: Pulmonary effects of keratino-cyte growth factor in newborn rats exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 2009; 297:L965-L976
78. Yano T, Deterding RR, Simonet WS, et al: Keratinocyte growth factor reduces lung damage due to acid instillation in rats. Am J Respir Cell Mol Biol 1996; 15:433-442
79. Zhao YD, Courtman DW, Deng Y, et al: Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005; 96:442-450
80. Xu J, Qu J, Cao L, et al: Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccha-ride in mice. J Pathol 2008; 214:472-481
81. Johnson C, Sung HJ, Lessner SM, et al: Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of isch-emic tissues: Potential role in capillary branching. Circ Res 2004; 94:262-268
82. Kalka C, Masuda H, Takahashi T, et al: Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res 2000; 86:1198-1202
83. Natori T, Sata M, Washida M, et al: G-CSF stimulates angiogenesis and promotes tumor growth: Potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun 2002; 297: 1058-1061
84. Ohki Y, Heissig B, Sato Y, et al: Granulocyte colony-stimulating factor promotes neovas-cularization by releasing vascular endothelial growth factor from neutrophils. FASEB J 2005; 19:2005-2007