Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis

American Journal of Respiratory and Critical Care Medicine

Volumn 182, Issue 8, 2010, Pages 1047-1057

  Mei, Shirley H J ^a,d   Haitsma, Jack J ^b   Dos Santos, Claudia C ^b   Deng, Yupu ^b   Lai, Patrick F H ^d   Slutsky, Arthur S ^b,d   Liles, W Conrad ^c,d   Stewart, Duncan J ^a,d  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Acute lung injury; Cell therapy; Mesenchymal stem cells; Multiple organ dysfunction syndrome; Sepsis

Indexed keywords

IMIPENEM; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; RANTES;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM CLEARANCE; CECUM; CELL THERAPY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HOST; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INFLAMMATION; LIGATION; LUNG LAVAGE; MALE; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; MORBIDITY; MORTALITY; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PARACRINE SIGNALING; PHAGOCYTOSIS; PLASMA; PRIORITY JOURNAL; PUNCTURE; SEPSIS; SURVIVAL; UPREGULATION;

ACUTE LUNG INJURY; ANIMALS; ANTI-BACTERIAL AGENTS; COMBINED MODALITY THERAPY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOMODULATION; INFLAMMATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, INBRED C57BL; MULTIPLE ORGAN FAILURE; SEPSIS; SURVIVAL ANALYSIS;

EID: 77956246824     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201001-0010OC     Document Type: Article

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