Acute lung injury following inhalation exposure to nerve agent VX in guinea pigs

Inhalation Toxicology

Volumn 18, Issue 6, 2006, Pages 437-448

  Wright, Benjamin S ^a   Rezk, Peter E ^a   Graham, Jacob R ^a   Steele, Keith E ^a   Gordon, Richard K ^a   Sciuto, Alfred M ^b   Nambiar, Madhusoodana P ^a,c  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^c Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL WARFARE AGENT; METHYLPHOSPHONOTHIOIC ACID [2 [BIS(1 METHYLETHYL)AMINO]ETHYL] O ETHYL ESTER; TELAZOL; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; AEROSOL; ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CHEMICAL WARFARE; CONTROLLED STUDY; DILUTION; ENDOTRACHEAL INTUBATION; ENVIRONMENTAL EXPOSURE; GUINEA PIG; HISTOPATHOLOGY; INHALATION; LEUKOCYTE DIFFERENTIAL COUNT; LUNG EDEMA; LUNG LAVAGE; LUNG LOBE; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON; SURVIVAL RATE; TISSUE SECTION;

ACETYLCHOLINESTERASE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; BUTYRYLCHOLINESTERASE; CELL COUNT; CHEMICAL WARFARE AGENTS; FLOW CYTOMETRY; GUINEA PIGS; INHALATION EXPOSURE; LUNG; LYMPHOCYTES; MALE; ORGAN SIZE; ORGANOTHIOPHOSPHORUS COMPOUNDS; PROTEINS; WEIGHT LOSS;

ANIMALIA; CAVIA; CAVIA PORCELLUS;

EID: 33645318981     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370600563847     Document Type: Article

References (47)

1. Abou-Donia, M. B. 1993. The cytoskeleton as a target for organophosphorus ester-induced delayed neurotoxicity (OPIDN). Chem. Biol. Interact. 87:383-393.
2. Abu-Qare, A. W., and Abou-Donia, M. B. 2002. Sarin: Health effects, metabolism, and methods of analysis. Food Chem. Toxicol. 40:1327-1333.
3. Bajgar, J., Sevelova, L., Krejcova, G., Fusek, J., Vachek, J., Kassa, J., Herink, J., De long, L. P., and Benschop, H. P. 2004. Biochemical and behavioral effects of soman vapors in low concentrations. Inhal. Toxicol. 16:497-507.
4. Benschop, H. P., Trap, H. C., Spruit, H. E., van der Wiel, H. J., Langenberg, J. P., and De Jong, L. P. 1998. Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs. Toxicol. Appl. Pharmacol. 153:179-185.
5. Benson, J. M., Burt, D. G., Cheng, Y. S., Hahan, F. F., Haley, P. J., Henderson, R. F., Hobbs, C. H., Pickrell, J. A., and Dunnick, J. K. 1989. Biochemical responses of rat and mouse lung to inhaled nickel compounds. Toxicology 57:255-266.
6. Buchanan, K. C., Burge, R. R., and Ruble, G. R. 1998. Evaluation of injectable anesthetics for major surgical procedures in guinea pigs. Contemp. Top. Lab. Anim. Sci. 37:58-63.
7. Cao, C. J., Mioduszewski, R. J., Menking, D. E., Valdes, J. J., Katz, E. J., Eldefrawi, M. E., and Eldefrawi, A. T. 1999. Cytotoxicity of organophosphate anticholinesterases. In Vitro Cell Dev. Biol. Anim. 35:493-500.
8. Caranto, G. R., Waibel, K. H., Asher, J. M., Larrison, R. W., Brecht, K. M., Schutz, M. B., Raveh, L., Ashani, Y., Wolfe, A. D., and Maxwell, D. M. 1994. Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes. Biochem. Pharmacol. 47:347-357.
9. Carlson, K., and Ehrich, M. 2001. Organophosphorus compounds alter intracellular F-actin content in SH-SY5Y human neuroblastoma cells. Neurotoxicology 22:819-827.
10. Clark, A. R. 1996. MDIs: Physics of aerosol formation. J. Aerosol Med. 9(Suppl. 1):S19-S26.
11. Clark, A. R., Gonda, I., and Newhouse, M. T. 1998. Towards meaningful laboratory tests for evaluation of pharmaceutical aerosols. J. Aerosol. Med. 11(Suppl. 1):S1-S7.
12. Cohan, S. L., Pohlmann, J. L., Mikszewski, J., and O'Doherty, D. S. 1976. The pharmacokinetics of pyridostigmine. Neurology 26:536-539.
13. Ellman, G. L., Courtney, K. D., Andres, V., Jr., and Feather-stone, R. M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88-95.
14. Greenfield, R. A., Brown, B. R., Hutchins, J. B., Iandolo, J. J., Jackson, R., Slater, L. N., and Bronze, M. S. 2002. Microbiological, biological, and chemical weapons of warfare and terrorism. Am. J. Med. Sci. 323:326-340.
15. Hamilton, M. G., Hill, I., Conley, J., Sawyer, T. W., Caneva, D. C., and Lundy, P. M. 2004. Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: Effects of application site and decontamination. Mil. Med. 169:856-862.
16. Hartmann, H. M. 2002. Evaluation of risk assessment guideline levels for the chemical warfare agents mustard, GB, and VX. Regul. Toxicol. Pharmacol. 35:347-356.
17. Henderson, R. F. 1984. Use of bronchoalveolar lavage to detect lung damage. Environ. Health Perspect. 56:115-129.
18. Henderson, R. F., Rebar, A. H., Pickrell, J. A., and Newton, G. J. 1979. Early damage indicators in the lung. III. Biochemical and cytological response of the lung to inhaled metals salts. Toxicol. Appl. Pharmacol. 50: 123-136.
19. Henderson, R. F., Benson, J. M., Hahn, F. F., Hobbs, C. H., Jones, R. K., Mauderly, J. L., McClellan, R. O., and Pickrell, J. A. 1985. New approaches for the evaluation of pulmonary toxicity: Bronchoalveolar lavage fluid analysis. Fundam. Appl. Toxicol. 5:451-458.
20. Inoue, N. 2003. [Neurological effects of chemical and biological weapons]. Rinsho Shinkeigaku 43:880-882.
21. Inoue, N., and Miyuki, H. 1995. [General characteristic and toxicity of VX]. Fukuoka Igaku Zasshi 86:405-410.
22. Jimmerson, V. R., Shih, T. M., Maxwell, D. M., Kaminskis, A., and Mailman, R. B. 1989a. The effect of (2-o-cresyl)-4H-1:3:2-benzodioxaphosphorin- 2-oxide on tissue cholinesterase and carboxylesterase activities of the rat. Fundam. Appl. Toxicol. 13:568-575.
23. Jimmerson, V. R., Shih, T. M., Maxwell, D. M., and Mailman, R. B. 1989b. Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat. Toxicol. Lett. 48:93-103.
24. Kabir, K., Gelinas, J. P., Chen, M., Chen, D., Zhang, D., Luo, X., Yang, J. H., Carter, D., and Rabinovici, R. 2002. Characterization of a murine model of endotoxin-induced acute lung injury. Shock 17:300-303.
25. Langenberg, J. P., Spruit, H. E., van der Wiel, H. J., Trap, H. C., Helmich, R. B., Bergers, W. W., van Helden, H. P., and Benschop, H. P. 1998. Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor. Toxicol. Appl. Pharmacol. 151: 79-87.
26. 14C-HD vapor by the hairless guinea pig. Drug. Chem. Toxicol. 22:375-387.
27. Maxwell, D. M., and Brecht, K. M. 1991. The role of carboxylesterase in species variation of oxime protection against soman. Neurosci. Biobehav. Rev. 15:135-139.
28. Maxwell, D. M., Brecht, K. M., and O'Neill, B. L. 1987 The effect of carboxylesterase inhibition on interspecies differences in soman toxicity. Toxicol. Lett. 39:35-42.
29. Munro, N. 1994. Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: Implications for Public Protection. Environ. Health Perspect. 102:18-37.
30. Nambiar, M. P., Krishnan, S., and Tsokos, G. C. 2004. T-cell signaling abnormalities in human systemic lupus erythematosus. Methods Mol. Med. 102: 31-47.
31. Nambiar, M. P., Wright B. S., Rezk P. E., Smith K. B., Moran T. S., Richards S. M., Gordon R. K., and Sciuto A. M. 2005. Development of a microinstillation model of inhalation exposure to assess lung injury following exposure to toxic chemical and nerve agents in guinea pigs. J. Toxicol. Mechanism Methods.
32. Newth, C. J., and Clark, A. R. 1989. In vitro performance of the small particle aerosol generator (SPAG-2). Pediatr. Pulmonol. 7:183-188.
33. Niven, A. S., and Roop, S. A. 2004. Inhalational exposure to nerve agents. Respir. Care Clin. North. Am. 10:59-74.
34. Ray, R., Clark, O. E., III, Ford, K. W., Knight, K. R., Harris, L. W., and Broomfield, C. A. 1991. A novel tertiary pyridostigmine derivative [3-(N,N-dimethylcarbamyloxy)-1-methyl-delta 3-tetrahydropyridine]: anticholinesterase properties and efficacy against soman. Fundam. Appl. Toxicol. 16:267-274.
35. Rosenthal, C., Caronia, C., Quinn, C., Lugo, N., and Sagy, M. 1998. A comparison among animal models of acute lung injury. Crit Care Med. 26:912-916.
36. Segura, P., Chavez, J., Montano, L. M., Vargas, M. H., Delaunois, A., Carbajal, V., and Gustin, P. 1999. Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn Schmiedebergs Arch. Pharmacol. 360:699-710.
37. Shih, T. M., and McDonough, J. H., Jr. 1999. Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment. Pharmacol. Biochem. Behav. 64:147-153.
38. Song, X., Perkins, S., Jortner, B. S., and Ehrich, M. 1997. Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells. Neurotoxicology 18:341-353.
39. Spruit, H. E., Langenberg, J. P., Trap, H. C., van der Wiel, H. J., Helmich, R. B., van Helden, H. P., and Benschop, H. P. 2000a. Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs. Toxicol. Appl. Pharmacol. 169:249-254.
40. Takahashi, K. 2001. The linkage between beta1 integrin and the actin cytoskeleton is differentially regulated by tyrosine and serine/threonine phosphorylation of beta1 integrin in normal and cancerous human breast cells. BMC. Cell Biol. 2:23.
41. van der Schans, M. J., Lander, B. J., van der Wiel, H., Langenberg, J. P., and Benschop, H. P. 2003. Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol. Appl. Pharmacol. 191: 48-62.
42. van Helden, H. P., Trap, H. C., Kuijpers, W. C., Oostdijk, J. P., Benschop, H. P., and Langenberg, J. P. 2004a. Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis. J. Appl. Toxicol. 24:59-68.
43. van Helden, H. P., Vanwersch, R. A., Kuijpers, W. C., Trap, H. C., Philippens, I. H., and Benschop, H. P. 2004b. Low levels of sarin affect the EEG in marmoset monkeys: A pilot study. J. Appl. Toxicol. 24:475-483.
44. Wessler, I. K., and Kirkpatrick, C. J. 2001. The Non-neuronal cholinergic system: An emerging drug target in the airways. Pulm. Pharmacol Ther. 14:423-434.
45. Wessler, I., Kirkpatrick, C. J., and Racke, K. 1998. Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: Expression and function in humans. Pharmacol. Ther. 77:59-79.
46. Wester, R. M., Tanojo, H., Maibach, H. I., and Wester, R. C. 2000. Predicted chemical warfare agent VX toxicity to uniformed soldier using parathion in vitro human skin exposure and absorption. Toxicol. Appl. Pharmacol. 168:149-152.
47. Wilson, B. W., Henderson, J. D., Chow, E., Schreider, J., Goldman, M., Culbertson, R., and Dacre, J. C. 1988. Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken. J. Toxicol. Environ. Health 23:103-113.