Concise review: Mesenchymal stem cells for acute lung injury: Role of paracrine soluble factors

Stem Cells

Volumn 29, Issue 6, 2011, Pages 913-919

  Lee, Jae W ^a   Fang, Xiaohui ^a   Krasnodembskaya, Anna ^a   Howard, James P ^b   Matthay, Michael A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute lung injury; Angiopoietin 1; Keratinocyte growth factor; LL 37; Mesenchymal stem cells; Pulmonary edema

Indexed keywords

ANGIOPOIETIN 1; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; KERATINOCYTE GROWTH FACTOR; PROSTAGLANDIN E2;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; DISEASE MODEL; ENGRAFTMENT; FLUID TRANSPORT; HUMAN; IMMUNOMODULATION; LUNG ALVEOLUS EPITHELIUM; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; LUNG FLUID; MESENCHYMAL STEM CELL TRANSPLANTATION; MOLECULAR MECHANICS; NONHUMAN; PERMEABILITY; PROTEIN FUNCTION; SHORT SURVEY;

ACUTE LUNG INJURY; ANIMALS; CAPILLARY PERMEABILITY; CLINICAL TRIALS AS TOPIC; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOMODULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; PARACRINE COMMUNICATION; PNEUMONIA, BACTERIAL; REGENERATION;

BACTERIA (MICROORGANISMS);

EID: 79957619269     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.643     Document Type: Short Survey

References (85)

1. Friedenstein AJ, Petrakova KV, Kurolesova AI et al. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968;6:230-247.
2. Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 2006;8:315-317.
3. Lee JW, Fang X, Gupta N et al. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 2009;106:16357-16362.
4. Murakami M, Nguyen LT, Zhang ZW et al. The FGF system has a key role in regulating vascular integrity. J Clin Invest 2008;118:3355-3366.
5. Mei SH, McCarter SD, Deng Y et al. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med 2007;4:e269.
6. Fang X, Neyrinck AP, Matthay MA et al. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type ii cells by secretion of angiopoietin-1. J Biol Chem 2010;285:26211-26222.
7. McCarter SD, Mei SH, Lai PF et al. Cell-based angiopoietin-1 gene therapy for acute lung injury. Am J Respir Crit Care Med 2007;175:1014-1026. (Pubitemid 46741753)
8. Ortiz LA, Dutreil M, Fattman C et al. Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci USA 2007;104:11002-11007. (Pubitemid 47175216)
9. Nemeth K, Leelahavanichkul A, Yuen PS et al. Bone marrow stromal cells attenuate sepsis via prostaglandin e(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 2009;15:42-49.
10. Gupta N, Su X, Popov B et al. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol 2007;179:1855-1863.
11. Mei SH, Haitsma JJ, Dos Santos CC et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med;182:1047-1057.
12. Krasnodembskaya A, Song Y, Fang X et al. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells 2010;28:2229-2238.
13. Patel SA, Sherman L, Munoz J et al. Immunological properties of mesenchymal stem cells and clinical implications. Arch Immunol Ther Exp (Warsz) 2008;56:1-8.
14. Chan JL, Tang KC, Patel AP et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood 2006;107:4817-4824. (Pubitemid 43882633)
15. Stagg J, Pommey S, Eliopoulos N et al. Interferon-gamma-stimulated marrow stromal cells: A new type of nonhematopoietic antigen-presenting cell. Blood 2006;107:2570-2577. (Pubitemid 43348704)
16. Stagg J. Immune regulation by mesenchymal stem cells: Two sides to the coin. Tissue Antigens 2007;69:1-9. (Pubitemid 46025333)
17. Nauta AJ, Westerhuis G, Kruisselbrink AB et al. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood 2006;108:2114-2120. (Pubitemid 44395028)
18. Li TS, Hayashi M, Ito H et al. Regeneration of infarcted myocardium by intramyocardial implantation of ex vivo transforming growth factor-beta- preprogrammed bone marrow stem cells. Circulation 2005;111:2438-2445. (Pubitemid 40696131)
19. Miyahara Y, Nagaya N, Kataoka M et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 2006;12:459-465.
20. Iso Y, Spees JL, Serrano C et al. Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun 2007;354:700-706. (Pubitemid 46186241)
21. Lee RH, Pulin AA, Seo MJ et al. Intravenous HMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009;5:54-63.
22. Lee RH, Seo MJ, Reger RL et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci USA 2006;103:17438-17443. (Pubitemid 44788987)
23. Parekkadan B, van Poll D, Suganuma K et al. Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One 2007;2:e941.
24. Togel F, Hu Z, Weiss K et al. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 2005;289:F31-F42. (Pubitemid 40863570)
25. Ortiz LA, Gambelli F, McBride C et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003;100:8407-8411. (Pubitemid 36842558)
26. Yamada M, Kubo H, Kobayashi S et al. Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J Immunol 2004;172:1266-1272. (Pubitemid 38113790)
27. Rojas M, Xu J, Woods CR et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005;33:145-152. (Pubitemid 41473051)
28. Xu J, Woods CR, Mora AL et al. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am J Physiol Lung Cell Mol Physiol 2007;293:L131-L141. (Pubitemid 47080721)
29. Zhen G, Liu H, Gu N et al. Mesenchymal stem cells transplantation protects against rat pulmonary emphysema. Front Biosci 2008;13:3415-3422. (Pubitemid 351594692)
30. Xu J, Qu J, Cao L et al. Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J Pathol 2008;214:472-481. (Pubitemid 351340567)
31. Islam MN, Otsu K, Houser SD et al. Mitochondrial donation by mesenchymal stromal cells rescues alveolar surfactant secretion in sepsis. FASEB J 2010;24:612.24.
32. Krause DS, Theise ND, Collector MI et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377. (Pubitemid 32455343)
33. Wagers AJ, Sherwood RI, Christensen JL et al. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002;297:2256-2259.
34. Kotton DN, Fabian AJ, Mulligan RC. Failure of bone marrow to reconstitute lung epithelium. Am J Respir Cell Mol Biol 2005;33:328-334. (Pubitemid 41416282)
35. Loi R, Beckett T, Goncz KK et al. Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Am J Respir Crit Care Med 2006;173:171-179. (Pubitemid 43187889)
36. Sueblinvong V, Loi R, Eisenhauer PL et al. Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells. Am J Respir Crit Care Med 2008;177:701-711. (Pubitemid 351490557)
37. Wong AP, Dutly AE, Sacher A et al. Targeted cell replacement with bone marrow cells for airway epithelial regeneration. Am J Physiol Lung Cell Mol Physiol 2007;293:L740-L752. (Pubitemid 47358837)
38. Wong AP, Keating A, Lu WY et al. Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. J Clin Invest 2009;119:336-348.
39. Kim CF, Jackson EL, Woolfenden AE et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005; 121:823-835. (Pubitemid 40806415)
40. Hennrick KT, Keeton AG, Nanua S et al. Lung cells from neonates show a mesenchymal stem cell phenotype. Am J Respir Crit Care Med 2007;175:1158-1164. (Pubitemid 46855457)
41. Jarvinen L, Badri L, Wettlaufer S et al. Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol 2008;181:4389-4396.
42. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105:1815-1822. (Pubitemid 40223708)
43. Beyth S, Borovsky Z, Mevorach D et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005;105:2214-2219. (Pubitemid 40731815)
44. Corcione A, Benvenuto F, Ferretti E et al. Human mesenchymal stem cells modulate B-cell functions. Blood 2006;107:367-372. (Pubitemid 43053565)
45. Glennie S, Soeiro I, Dyson PJ et al. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood 2005;105:2821-2827. (Pubitemid 40446275)
46. Ajuebor MN, Das AM, Virag L et al. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10. J Immunol 1999;162:1685-1691. (Pubitemid 29307046)
47. Geiser T, Atabai K, Jarreau PH et al. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Am J Respir Crit Care Med 2001;163:1384-1388. (Pubitemid 32506603)
48. Rasmusson I, Le Blanc K, Sundberg B et al. Mesenchymal stem cells stimulate antibody secretion in human B cells. Scand J Immunol 2007;65:336-343. (Pubitemid 46481102)
49. Raffaghello L, Bianchi G, Bertolotto M et al. Human mesenchymal stem cells inhibit neutrophil apoptosis: A model for neutrophil preservation in the bone marrow niche. Stem Cells 2008;26:151-162.
50. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 1990;142(6 pt 1):1250-1257.
51. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 2001;163:1376-1383. (Pubitemid 32506602)
52. Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 2002;82:569-600. (Pubitemid 34743332)
53. Folkesson HG, Matthay MA. Alveolar epithelial ion and fluid transport: Recent progress. Am J Respir Cell Mol Biol 2006;35:10-19. (Pubitemid 43993149)
54. Pugin J, Verghese G, Widmer MC et al. The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 1999;27:304-312. (Pubitemid 29113539)
55. Olman MA, White KE, Ware LB et al. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol 2004;172:2668-2677. (Pubitemid 38182419)
56. Lee JW, Fang X, Dolganov G et al. Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J Biol Chem 2007;282:24109-24119. (Pubitemid 47328055)
57. Nemzek JA, Ebong SJ, Kim J et al. Keratinocyte growth factor pre-treatment is associated with decreased macrophage inflammatory protein-2alpha concentrations and reduced neutrophil recruitment in acid aspiration lung injury. Shock 2002;18:501-506.
58. Yano T, Deterding RR, Simonet WS et al. Keratinocyte growth factor reduces lung damage due to acid instillation in rats. Am J Respir Cell Mol Biol 1996;15:433-442. (Pubitemid 126440569)
59. Sugahara K, Iyama K, Kuroda MJ et al. Double intratracheal instillation of keratinocyte growth factor prevents bleomycin-induced lung fibrosis in rats. J Pathol 1998;186:90-98. (Pubitemid 28407493)
60. Yi ES, Salgado M, Williams S et al. Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB expression, and alveolar type II cell loss in bleomycin-induced lung injury. Inflammation 1998;22:315-325. (Pubitemid 28234159)
61. Barazzone C, Donati YR, Rochat AF et al. Keratinocyte growth factor protects alveolar epithelium and endothelium from oxygen-induced injury in mice. Am J Pathol 1999;154:1479-1487. (Pubitemid 29226443)
62. Panos RJ, Bak PM, Simonet WS et al. Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. J Clin Invest 1995;96:2026-2033.
63. Viget NB, Guery BP, Ader F et al. Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2000;279:L1199-L1209. (Pubitemid 32009506)
64. Wang Y, Folkesson HG, Jayr C et al. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. J Appl Physiol 1999;87:1852-1860.
65. Guery BP, Mason CM, Dobard EP et al. Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs. Am J Respir Crit Care Med 1997;155:1777-1784. (Pubitemid 27216692)
66. Dada LA, Sznajder JI. Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: Role of the Na,K-ATPase. Crit Care Med 2003;31(suppl 4):S248-S252. (Pubitemid 36458175)
67. Planes C, Blot-Chabaud M, Matthay MA et al. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem 2002;277:47318-47324. (Pubitemid 36159245)
68. Kwak HJ, So JN, Lee SJ et al. Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett 1999;448:249-253. (Pubitemid 29168496)
69. Gamble JR, Drew J, Trezise L et al. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ Res 2000;87:603-607.
70. Thurston G, Suri C, Smith K et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999;286:2511-2514.
71. Kim I, Moon SO, Park SK et al. Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression. Circ Res 2001;89:477-479. (Pubitemid 34132640)
72. Pizurki L, Zhou Z, Glynos K et al. Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. Br J Pharmacol 2003;139:329-336. (Pubitemid 36760365)
73. Mason CM, Guery BP, Summer WR et al. Keratinocyte growth factor attenuates lung leak induced by alpha-naphthylthiourea in rats. Crit Care Med 1996;24:925-931.
74. Welsh DA, Summer WR, Dobard EP et al. Keratinocyte growth factor prevents ventilator-induced lung injury in an ex vivo rat model. Am J Respir Crit Care Med 2000;162(3 pt 1):1081-1086.
75. Birukova AA, Alekseeva E, Mikaelyan A et al. HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway. FASEB J 2007;21:2776-2786. (Pubitemid 47372745)
76. Singleton PA, Salgia R, Moreno-Vinasco L et al. CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-met, Tiam1/Rac1, dynamin 2, and cortactin. J Biol Chem 2007;282:30643-30657. (Pubitemid 350035212)
77. Rubenfeld GD, Caldwell E, Peabody E et al. Incidence and outcomes of acute lung injury. N Engl J Med 2005;353:1685-1693. (Pubitemid 41464707)
78. Gonzalez-Rey E, Anderson P, Gonzalez MA et al. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut 2009;58:929-939.
79. Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol 2009;37:1445-1453.
80. Nemeth K, Mayer B, Mezey E. Modulation of bone marrow stromal cell functions in infectious diseases by toll-like receptor ligands. J Mol Med 2010;88:5-10.
81. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342:1334-1349. (Pubitemid 30408719)
82. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network. N Engl J Med 2000;342:1301-1308.
83. Wiedemann HP, Wheeler AP, Bernard GR et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006;354:2564-2575. (Pubitemid 43882352)
84. Matthay MA, Thompson BT, Read EJ et al. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest 2010;138:965-972.
85. Larson BL, Ylostalo J, Prockop DJ. Human multipotent stromal cells undergo sharp transition from division to development in culture. Stem Cells 2008;26:193-201.