Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by phosphatidylinositol 3'-kinase inhibition

Molecular and Cellular Biology

Volumn 20, Issue 5, 2000, Pages 1489-1496

  Lee, Adrian V ^a,b   Gooch, Jennifer L ^a   Oesterreich, Steffi ^a,b   Guler, Rebecca L ^a   Yee, Douglas ^a,c  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL KINASE; PROTEASOME; SOMATOMEDIN C;

ARTICLE; CELL STIMULATION; CELL STRAIN MCF 7; DOSE RESPONSE; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; ENZYME INHIBITORS; INSULIN-LIKE GROWTH FACTOR I; PEPTIDE HYDROLASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION;

EID: 0033982719     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.5.1489-1496.2000     Document Type: Article

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