Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

BMC Biochemistry

Volumn 13, Issue 1, 2012, Pages

  Layton, Meredith J ^a   Saad, Mirette ^b   Church, Nicole L ^d   Pearson, Richard B ^a,b,c   Mitchell, Christina A ^a   Phillips, Wayne A ^a,b,c  

^a MONASH UNIVERSITY   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Kinase; Mutation; Oncogene; Phosphoinositide; Phosphorylation; PI3K; PIK3CA

Indexed keywords

LIPID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; SERINE;

ARTICLE; AUTOPHOSPHORYLATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; IN VITRO STUDY; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; HUMANS; KINETICS; MUTATION; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; RECOMBINANT PROTEINS; SERINE; UP-REGULATION;

EID: 84871594746     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/1471-2091-13-30     Document Type: Article

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