Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a public health genomics perspective

Italian Journal of Public Health

Volumn 9, Issue 4, 2012, Pages

  Brettfeld, Caroline ^a   Englert, Stephanie ^a   Aumueller, Eva ^a   Haslberger, Alexander G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Epigenetic; Genetic; Obesity; Public health genomics; Thermogenesis

Indexed keywords

EID: 84871550021     PISSN: 17237815     EISSN: None     Source Type: Journal    
DOI: 10.2427/8694     Document Type: Article

References (129)

1. Elmadfa I, Ernährungslehre, 2009, Verlag: Utb; Ulmer (Eugen)
2. Haslam DW, James WP. Obesity. Lancet 2005; 366 (9492): 1197-209
3. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986; 256: 51-4
4. Neel JV, Diabetes mellitus: a thrifty genotype rendered detrimental by progress? Am J Hum Genet 1962; 14: 353-62
5. Manolio TA, et al. Finding the missing heritability of complex diseases. Nature 2009; 461:747-53
6. Painter RC, et al. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr 2006; 84(2): 322-7; quiz 466-7
7. Dolinoy DC, et al. Metastable epialleles, imprinting, and the fetal origins of adult diseases. Pediatr Res 2007; 61(5 Pt 2): 30R-37R
8. Dolinoy DC, Jirtle RL. Environmental epigenomics in human health and disease. Environ Mol Mutagen 2008; 49(1): 4-8
9. Noer A, Boquest AC, Collas P. Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence. BMC Cell Biol 2007; 8: 18
10. He H. Lehming N. Global effects of histone modifications. Brief Funct Genomic Proteomic 2003; 2(3): 234-43
11. Heneghan HM, Miller N, Kerin MJ. Role of microRNAs in obesity and the metabolic syndrome. Obes Rev. 11(5): 354-61
12. Thaler R, Aumüller E, Berner C, Haslberger AG. Interaction of Hereditary and Epigenetic Mechanisms in the Regulation of Gene Expression, in Epigenetics and Human Health, A.G. Haslberger, S. Gressler, Editor. 2010, Wiley-VCH Verlag: Weinheim
13. Misík M, Nersesyan A, Parzefall W, Knasmüller S. Carcinogens in Foods: Occurrence, Modes of Action and Modulation of Human Risks by Genetic Factors and Dietary Constituents, in Epigenetics and Human Health, A.G. Haslberger, S. Gressler, Editor. 2010, WILEY-VCH Verlag: Weinheim
14. Stefanska BM, Fabianowska-Majewska K. Effects of Dietary Natural Compounds on DNA Methylation Related to Cancer Chemoprevention and Anticancer Epigenetic Therapy, in Epigenetics and Human Health, A.G. Haslberger, S. Gressler, Editor. 2010, WILEY-VCH Verlag: Weinheim
15. Rust P. Health Determinants Throughout the Life Cycle, in Epigenetics in Human Health, A.G. Haslberger, S. Gressler, Editor. 2010, WILEY-VCH Verlag: Weinheim
16. W. Genotoxic, Non-Genotoxic and Epigenetic Mechanisms in Chemical Hepatocarcinogenesis: Implications for Safety Evaluation, in Epigenetics and Human Health, A.G. Haslberger, S. Gressler, Editor. 2010, WILEY-VCH Verlag: Weinheim
17. Sato K, et al. Neonatal exposure to diethylstilbestrol alters the expression of DNA methyltransferases and methylation of genomic DNA in the epididymis of mice. Endocr J 2006; 53(3): 331-7
18. Schofield PN. Impact of genomic imprinting on genomic instability and radiation-induced mutation. Int J Radiat Biol 1998; 74(6): 705-10
19. Szyf M, Weaver I, Meaney M. Maternal care, the epigenome and phenotypic differences in behavior. Reprod Toxicol 2007; 24(1): 9-19
20. G. Case Studies on Epigenetic Inheritance, in Epigenetics and Human Health, A.G. Haslberger, S. Gressler, Editor. 2010, WILEY-VCH Verlag: Weinheim
21. Grundy SM, H. Bryan Brewer Jr, Cleeman JI, et al, for the Conference Participants. Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation 2004; 109: 433-8
22. JE Thermogenic mechanisms and their hormonal regulation. Physiol Rev 2006; 86(2): 435-64
23. Oberkofler H, Beer A, Breban D, et al. Human obese gene expression: alternative splicing of mRNA and relation to adipose tissue localization. Obes Surg 1997; 7(5): 390-6
24. Tiraby C, Langin D. Conversion from white to brown adipocytes: a strategy for the control of fat mass? Trends Endocrinol Metab 2003. 14: 439-41
25. Cao W, et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol 2004; 24(7): 3057-67
26. Li M, Pascual G, Glass CK. Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene. Mol Cell Biol 2000; 20(13): 4699-707
27. Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Mol Biol Cell 2006. 7: 885-96
28. Pierola J, Barcelo A, et al. Beta3-Adrenergic receptor Trp64Arg polymorphism and increased body mass index in sleep apnoea. Eur Respir J 2007; 30(4): 743-7
29. Bracale R, Pasanisi F, et al. (2007). Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy. Eur J Clin Nutr 2007. 61(10): 1213-9
30. de Luis DA, Aller R, et al. Relation of Trp64Arg polymorphism of beta 3-adrenergic receptor gene to adipocytokines and fat distribution in obese patients. Ann Nutr Metab 2008; 52(4): 267-71
31. Lwow F, Dunajska K, et al. Post-exercise oxidative stress and obesity in postmenopausal women: the role of beta3-adrenergic receptor polymorphism. Gynecol Endocrinol 2007; 23(10): 597-603
32. Gjesing AP, Andersen G, et al. Studies of associations between the Arg389Gly polymorphism of the beta1- adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects. Diabet Med 2007; 24(4): 392-7
33. Zafarmand MH, van der Schouw YT, et al. T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis. J Intern Med 2008. 263(1): 79-89
34. Zawodniak-Szalapska M, Stawerska R, et al. Association of Trp64Arg polymorphism of beta3- adrenergic receptor with insulin resistance in Polish children with obesity. J Pediatr Endocrinol Metab 2008; 21(2): 147-54
35. Dunajska K, Lwow F, et al. Beta(3)-adrenergic receptor polymorphism and metabolic syndrome in postmenopausal women. Gynecol Endocrinol 2008; 24(3): 133-8
36. de Luis DA, Gonzalez Sagrato M, et al. Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. Ann Nutr Metab 2009; 54(2): 104-10
37. Esterbauer H, Oberkofler H, et al. Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. Diabetes 2002; 51(4): 1281-6
38. Ambye L, Rasmussen S, et al. Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome. Diabetes Res Clin Pract 2005; 67(2): 175-9
39. Vohl MC, Houde A, et al. Effects of the peroxisome proliferator-activated receptor-gamma co-activator-1 Gly482Ser variant on features of the metabolic syndrome. Mol Genet Metab 2005; 86(1-2): 300-6
40. Pihlajamaki J, Kinnunen M, et al. Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes. Diabetologia 2005; 48(7): 1331-4
41. Barroso I, Luan J, et al. Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. Diabetologia 2006; 49(3): 501-5
42. Leipold H, Knoefler M, et al. Peroxisome proliferatoractivated receptor gamma coactivator-1alpha gene variations are not associated with gestational diabetes mellitus. J Soc Gynecol Investig 2006; 13(2): 104-7
43. Franks PW, Ekelund U, et al. PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge. Diabetologia 2007; 50(3): 569-73
44. Stefan N, Thamer C, et al. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab 2007; 92(5): 1827-33
45. Deeb SS, Brunzell JD. The Role of the PGC1alpha Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy. PPAR Res 2009: 649286
46. Ling C, Del Guerra S, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008; 51(4): 615-22
47. Barres R, Osler ME, et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab 2009; 10(3): 189-98
48. Gemma C, Sookoian S, et al. Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns. Obesity (Silver Spring) 2009; 17(5): 1032-9
49. Brons C, Jacobsen S, et al. Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J Clin Endocrinol Metab 2010; 95(6): 3048-56
50. Lillycrop KA, Phillips ES, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005; 135(6): 1382-6
51. Noer AA, Boquest C, et al. Dynamics of adipogenic promoter DNA methylation during clonal culture of human adipose stem cells to senescence. BMC Cell Biol 2007; 8: 18
52. Fujiki K, Kano F, et al. Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes. BMC Biol 2009; 7: 38
53. Sorensen AL, Timoskainen S, et al. Lineage-Specific Promoter DNA Methylation Patterns Segregate Adult Progenitor Cell Types. Stem Cells Dev 2010; 19(8): 1257-66
54. Hong SJ, Oh JH, et al. DNA methylation patterns of ulcer-healing genes associated with the normal gastric mucosa of gastric cancers. J Korean Med Sci 2010; 25(3): 405-17
55. Tikoo K, Kumar P, et al. Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats. BMC Cancer 2009; 9: 107
56. Okamura M, Kudo H, et al. COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci USA 2009; 106(14): 5819-24
57. Cho YW, Hong S, et al. Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab 2009; 10(1): 27-39
58. Noer A, Lindeman LC, et al. Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells. Stem Cells Dev 2009; 18(5): 725-36
59. Salma N, Xiao H, et al. Temporal recruitment of transcription factors and SWI/SNF chromatinremodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. Mol Cell Biol 2004; 24(11): 4651-63
60. Badri KR, Zhou Y, et al. Effects of the SANT domain of tension-induced/inhibited proteins (TIPs), novel partners of the histone acetyltransferase p300, on p300 activity and TIP-6-induced adipogenesis. Mol Cell Biol 2008; 28(20): 6358-72
61. Takada I, Suzawa M, et al. Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci 2007; 1116: 182-95
62. Zhu NL, Wang J, et al. The Necdin-Wnt pathway causes epigenetic PPAR{gamma} repression in hepatic stellate cells. J Biol Chem 2010; 285(40): 30463-71
63. Wakabayashi K, Okamura M, et al. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 2009; 29(13): 3544-55
64. Heilbronn LK, Kind KL, et al. Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women. Diabetologia 2000; 43(2): 242-4
65. Ramis JM, Gonzalez-Sanchez JL, et al. The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population. Metabolism 2004; 53(11): 1411-6
66. Sramkova D, Krejbichova S, et al. The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population. Exp Clin Endocrinol Diabetes 2007; 115(5): 303-7
67. Clement K, Ruiz J, et al. Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Int J Obes Relat Metab Disord 1996; 20(12): 1062-6
68. Urhammer SA, Fridberg M, et al. Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity. J Clin Endocrinol Metab 1997; 82(12): 4069-74
69. Olofsson LE, Orho-Melander M, et al. CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides. J Clin Endocrinol Metab 2008; 93(12): 4880-6
70. Schaffler A, Palitzsch KD, et al. Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort. Eur J Clin Invest 1999; 29(9): 770-9
71. Kiec-Wilk B, Wybranska I, et al. Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland. J Physiol Pharmacol 2002; 53(3): 477-90
72. Nieters A, Becker N, et al. Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur J Nutr 2002; 41(5): 210-21
73. Herrmann SM, Wang JG, et al. Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio. J Mol Med 2003; 81(5): 327-32
74. Valve R, Heikkinen S, et al. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3- adrenergic receptor genes on basal metabolic rate in obese Finns. Diabetologia 1998; 41(3): 357-61
75. Fogelholm M, Valve R, et al. Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women. J Clin Endocrinol Metab 1998; 83(12): 4246-50
76. Ukkola O, Tremblay A, et al. Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding. Eur J Clin Nutr 2001; 55(11): 1008-15.
77. Kiskinis E, Hallberg M, et al. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J 2007; 26(23): 4831-40
78. Shore A, Karamitri A, et al. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia 2010; 53(6): 1164-73
79. Tateishi K, Okada Y, et al. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009; 458(7239): 757-61
80. Bennett CE, Nsengimana J, et al. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. Diab Vasc Dis Res 2010; 7(3): 195-203.
81. Chim CS, Wong AS, et al. Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia. Br J Haematol 2002; 119(4): 988-90
82. Takai N, Kawamata N, et al. (2005). Discovery of epigenetically masked tumor suppressor genes in endometrial cancer. Mol Cancer Res 2005; 3(5): 261-9
83. Dannenberg LO, Edenberg HJ. Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics 2006; 7: 181
84. Tada Y, Brena RM, et al. Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J Natl Cancer Inst 2006; 98(6): 396-406
85. Hackanson B, Bennett KL, et al. Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia. Cancer Res 2008; 68(9): 3142-51
86. Katari S, Turan N, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet 2009; 18(20): 3769-78
87. Guibal FC, Alberich-Jorda M, et al. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood 2009; 114(27): 5415-25
88. Bennett KL, Romigh T, et al. Activator protein 2 alpha (AP2alpha) suppresses 42 kDa C/CAAT enhancer binding protein alpha (p42(C/EBPalpha)) in head and neck squamous cell carcinoma. Int J Cancer 2009; 124(6): 1285-92
89. Kumagai T, Wakimoto N, et al. Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells Int J Cancer 2007; 121(3): 656-65.
90. Jost E, Do ON, et al. Aberrant DNA methylation of the transcription factor C/EBPalpha in acute myelogenous leukemia. Leuk Res 2009; 33(3): 443-9
91. Lu GD, Leung CH, et al. C/EBPalpha is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation. Gastroenterology 2010; 139(2): 632-43, 643.e1-4
92. Sertic J, Juricic L, et al. Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity. BMC Res Notes 2009; 2: 203
93. Corella D, Guillen M, et al. Gender specific associations of the Trp64Arg mutation in the beta3-adrenergic receptor gene with obesity-related phenotypes in a Mediterranean population: interaction with a common lipoprotein lipase gene variation. J Intern Med 2001; 250(4): 348-60
94. Garenc, C, Perusse L, et al. Evidence of LPL geneexercise interaction for body fat and LPL activity: the HERITAGE Family Study. J Appl Physiol 2001; 91(3): 1334-40
95. Noer A, Sorensen AL, et al. Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue. Mol Biol Cell 2006; 17(8): 3543-56
96. Kim JW, Cheng Y, et al. Genetic and epigenetic inactivation of LPL gene in human prostate cancer. Int J Cancer 2009; 124(3): 734-8
97. Lee JH, Kim KA, et al. Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells. Int J Mol Med 2007; 20(1): 59-64
98. Fu M, Rao M, et al. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 2005; 280(17): 16934-41
99. Lee J, Saha PK, et al. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci USA 2008; 105(49): 19229-34
100. Ochoa MC, Marti A, et al. Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents. Int J Obes Relat Metab Disord 2004; 28 Suppl 3: S37-41
101. Ek J, Andersen G, et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 2001; 44(12): 2220-6
102. Kurokawa N, et al. The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals. Int J Obes (Lond) 2008; 32(8): 1240-9
103. Masud S, Ye S. Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis. J Med Genet 2003; 40(10): 773-80
104. Tonjes A, et al. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: metaanalysis of 57 studies on nondiabetic individuals. Diabetes Care 2006; 29(11): 2489-97
105. Hegele RA, Cao H. Single nucleotide polymorphisms of RXRA encoding retinoid X receptor alpha. J Hum Genet 2001; 46(7): 423-5
106. Volate, SR, et al. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Mol Carcinog 2009; 48(10): 920-33
107. Barak Y et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999. 4(4): 585-95
108. Khoury MJ, et al. Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol 2009; 170(3): 269-79
109. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology 2008, Philadelphia: Lippincott Williams & Wilkins
110. Moonesinghe R, et al. Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci USA 2008; 105(2): 617-22
111. Kitsios GD, Zintzaras E. Genomic convergence of genome-wide investigations for complex traits. Ann Hum Genet 2009; 73(Pt 5): 514-9
112. Ioannidis JP. Why most published research findings are false. PLoS Med 2005; 2(8): e124
113. Janssens AC, Gwinn M, Bradley LA, et al. A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet 2008; 82: 593-9
114. van der Net JB, et al. Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia. Am J Cardiol 2009; 103(3): 375-80
115. Botto LD, Khoury MJ. Facing the Challenge of Complex Genotypes and Gene-Environment Interaction: The Basic Epidemiologic Units in Case- Control and Case-Only Designs, in Human genome epidemiology: a scientific foundation for using genetic information to improve health and prevent disease, M.J. Khoury, J. Little, and W. Burke, Editors 2004, Oxford University Press: New York: 111-26
116. Rothman N, et al. The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. Biochim Biophys Acta 2001; 1471(2): C1-10
117. Palla L, et al. Challenges in the use of literaturebased meta-analysis to examine gene-environment interactions. Am J Epidemiol 2010; 171(11): 1225-32
118. Foley DL, et al. Prospects for epigenetic epidemiology. Am J Epidemiol 2009; 169(4): 389-400
119. Eckhardt F, et al. DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet 2006; 38(12): 1378-85
120. Tal O, Kisdi E, Jablonka E. Epigenetic contribution to covariance between relatives. Genetics 184(4): 1037-50
121. Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet 2004; 20(8): 350-8
122. Khoury MJ, Milikan R, Gwinn M. Genetic and Molecular Epidemiology, in Modern epidemiology, K.J. Rothman, S. Greenland, and T.L. Lash, Editors. 2008, LIPPINCOTT WILLIAMS & WILKINS: Philadelphia. p. 564-579
123. Figueroa ME, et al. An integrative genomic and epigenomic approach for the study of transcriptional regulation. PLoS One 2008; 3(3): e1882
124. Zhang Y, et al. Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information. BMC Med Genomics 2010; 3: 1
125. Boccia S, Brand A, Brand H, Ricciardi G. The integration of genome-based information for common diseases into health policy and healthcare as a major challenge for Public Health Genomics: The example of the methylenetetrahydrofolate reductase gene in non-cancer diseases. Mutat Res 2009; 667: 27-34
126. Brand A, Brand H, Schulte in den Baumen T. The impact of genetics and genomics on public health. Eur J Hum Genet 2008; 16(1): 5-13
127. Barbatelli G, et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab 2010; 298(6): E1244-53
128. Gagnon J, Lago F, et al. DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts. Int J Obes Relat Metab Disord 1998; 22(6): 500-5
129. Malczewska-Malec M, Wybranska I, et al. Analysis of candidate genes in Polish families with obesity. Clin Chem Lab Med 2004; 42(5): 487-93