메뉴 건너뛰기




Volumn 33, Issue 3, 2009, Pages 443-449

Aberrant DNA methylation of the transcription factor C/EBPα in acute myelogenous leukemia

Author keywords

Acute myelogenous leukemia; C EBP; Cell cycle; DNA methylation; Epigenetics; Transcriptional silencing

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CCAAT ENHANCER BINDING PROTEIN ALPHA;

EID: 58549105082     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2008.07.027     Document Type: Article
Times cited : (23)

References (34)
  • 1
    • 0037315894 scopus 로고    scopus 로고
    • Disruption of differentiation in human cancer: AML shows the way
    • Tenen D.G. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 3 (2003) 89-101
    • (2003) Nat Rev Cancer , vol.3 , pp. 89-101
    • Tenen, D.G.1
  • 2
    • 16444387654 scopus 로고    scopus 로고
    • Disruption of C/EBPalpha function in acute myeloid leukemia
    • Frohling S., and Dohner H. Disruption of C/EBPalpha function in acute myeloid leukemia. N Engl J Med 351 (2004) 2370-2372
    • (2004) N Engl J Med , vol.351 , pp. 2370-2372
    • Frohling, S.1    Dohner, H.2
  • 3
    • 33644836787 scopus 로고    scopus 로고
    • C/EBPalpha and the pathophysiology of acute myeloid leukemia
    • Mueller B.U., and Pabst T. C/EBPalpha and the pathophysiology of acute myeloid leukemia. Curr Opin Hematol 13 (2006) 7-14
    • (2006) Curr Opin Hematol , vol.13 , pp. 7-14
    • Mueller, B.U.1    Pabst, T.2
  • 4
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst T., Mueller B.U., Zhang P., Radomska H.S., Narravula S., Schnittger S., et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet 27 (2001) 263-270
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5    Schnittger, S.6
  • 5
    • 2342544921 scopus 로고    scopus 로고
    • C/EBPalpha mutations in acute myeloid leukaemias
    • Nerlov C. C/EBPalpha mutations in acute myeloid leukaemias. Nat Rev Cancer 4 (2004) 394-400
    • (2004) Nat Rev Cancer , vol.4 , pp. 394-400
    • Nerlov, C.1
  • 6
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones P.A., and Baylin S.B. The epigenomics of cancer. Cell 128 (2007) 683-692
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 7
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman J.G., and Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349 (2003) 2042-2054
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 8
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 358 (2008) 1148-1159
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 9
    • 30844462355 scopus 로고    scopus 로고
    • The fundamental role of epigenetics in hematopoietic malignancies
    • Galm O., Herman J.G., and Baylin S.B. The fundamental role of epigenetics in hematopoietic malignancies. Blood Rev 20 (2006) 1-13
    • (2006) Blood Rev , vol.20 , pp. 1-13
    • Galm, O.1    Herman, J.G.2    Baylin, S.B.3
  • 10
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore S.D., Baylin S., Sugar E., Carraway H., Miller C.B., Carducci M., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 66 (2006) 6361-6369
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3    Carraway, H.4    Miller, C.B.5    Carducci, M.6
  • 11
    • 34250213859 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in cancer
    • Issa J.P. DNA methylation as a therapeutic target in cancer. Clin Cancer Res 13 (2007) 1634-1637
    • (2007) Clin Cancer Res , vol.13 , pp. 1634-1637
    • Issa, J.P.1
  • 12
    • 0028798816 scopus 로고
    • Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding
    • Timchenko N., Wilson D.R., Taylor L.R., Abdelsayed S., Wilde M., Sawadogo M., et al. Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding. Mol Cell Biol 15 (1995) 1192-1202
    • (1995) Mol Cell Biol , vol.15 , pp. 1192-1202
    • Timchenko, N.1    Wilson, D.R.2    Taylor, L.R.3    Abdelsayed, S.4    Wilde, M.5    Sawadogo, M.6
  • 13
    • 33644958558 scopus 로고    scopus 로고
    • Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer
    • Tada Y., Brena R.M., Hackanson B., Morrison C., Otterson G.A., and Plass C. Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J Natl Cancer Inst 98 (2006) 396-406
    • (2006) J Natl Cancer Inst , vol.98 , pp. 396-406
    • Tada, Y.1    Brena, R.M.2    Hackanson, B.3    Morrison, C.4    Otterson, G.A.5    Plass, C.6
  • 14
    • 34250332520 scopus 로고    scopus 로고
    • Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma
    • Bennett K.L., Hackanson B., Smith L.T., Morrison C.D., Lang J.C., Schuller D.E., et al. Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Res 67 (2007) 4657-4664
    • (2007) Cancer Res , vol.67 , pp. 4657-4664
    • Bennett, K.L.1    Hackanson, B.2    Smith, L.T.3    Morrison, C.D.4    Lang, J.C.5    Schuller, D.E.6
  • 15
    • 29144469286 scopus 로고    scopus 로고
    • Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia
    • Galm O., Wilop S., Luders C., Jost E., Gehbauer G., Herman J.G., et al. Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia. Ann Hematol 84 Suppl 1 (2005) 39-46
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 1 , pp. 39-46
    • Galm, O.1    Wilop, S.2    Luders, C.3    Jost, E.4    Gehbauer, G.5    Herman, J.G.6
  • 16
  • 17
    • 22844440606 scopus 로고    scopus 로고
    • Methylation-specific polymerase chain reaction
    • Galm O., and Herman J.G. Methylation-specific polymerase chain reaction. Meth Mol Med 113 (2005) 279-291
    • (2005) Meth Mol Med , vol.113 , pp. 279-291
    • Galm, O.1    Herman, J.G.2
  • 18
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D., Walker H., Oliver F., Wheatley K., Harrison C., Harrison G., et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92 (1998) 2322-2333
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3    Wheatley, K.4    Harrison, C.5    Harrison, G.6
  • 19
    • 21644462493 scopus 로고    scopus 로고
    • Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors
    • Johnson P.F. Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 118 (2005) 2545-2555
    • (2005) J Cell Sci , vol.118 , pp. 2545-2555
    • Johnson, P.F.1
  • 20
    • 0033215453 scopus 로고    scopus 로고
    • p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
    • Cameron E.E., Baylin S.B., and Herman J.G. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood 94 (1999) 2445-2451
    • (1999) Blood , vol.94 , pp. 2445-2451
    • Cameron, E.E.1    Baylin, S.B.2    Herman, J.G.3
  • 21
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr C.J., and Roberts J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9 (1995) 1149-1163
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 22
    • 41249103144 scopus 로고    scopus 로고
    • Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
    • Kirstetter P., Schuster M.B., Bereshchenko O., Moore S., Dvinge H., Kurz E., et al. Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell 13 (2008) 299-310
    • (2008) Cancer Cell , vol.13 , pp. 299-310
    • Kirstetter, P.1    Schuster, M.B.2    Bereshchenko, O.3    Moore, S.4    Dvinge, H.5    Kurz, E.6
  • 23
    • 33751073965 scopus 로고    scopus 로고
    • Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
    • Keeshan K., He Y., Wouters B.J., Shestova O., Xu L., Sai H., et al. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10 (2006) 401-411
    • (2006) Cancer Cell , vol.10 , pp. 401-411
    • Keeshan, K.1    He, Y.2    Wouters, B.J.3    Shestova, O.4    Xu, L.5    Sai, H.6
  • 24
    • 23744483486 scopus 로고    scopus 로고
    • CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)
    • Helbling D., Mueller B.U., Timchenko N.A., Schardt J., Eyer M., Betts D.R., et al. CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood 106 (2005) 1369-1375
    • (2005) Blood , vol.106 , pp. 1369-1375
    • Helbling, D.1    Mueller, B.U.2    Timchenko, N.A.3    Schardt, J.4    Eyer, M.5    Betts, D.R.6
  • 26
    • 35348896184 scopus 로고    scopus 로고
    • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
    • Wouters B.J., Jorda M.A., Keeshan K., Louwers I., Erpelinck-Verschueren C.A., Tielemans D., et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood 110 (2007) 3706-3714
    • (2007) Blood , vol.110 , pp. 3706-3714
    • Wouters, B.J.1    Jorda, M.A.2    Keeshan, K.3    Louwers, I.4    Erpelinck-Verschueren, C.A.5    Tielemans, D.6
  • 27
    • 34247348182 scopus 로고    scopus 로고
    • The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia
    • Agrawal S., Hofmann W.K., Tidow N., Ehrich M., van den Boom D., Koschmieder S., et al. The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood 109 (2007) 3895-3905
    • (2007) Blood , vol.109 , pp. 3895-3905
    • Agrawal, S.1    Hofmann, W.K.2    Tidow, N.3    Ehrich, M.4    van den Boom, D.5    Koschmieder, S.6
  • 28
    • 0036456441 scopus 로고    scopus 로고
    • Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia
    • Chim C.S., Wong A.S., and Kwong Y.L. Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia. Br J Haematol 119 (2002) 988-990
    • (2002) Br J Haematol , vol.119 , pp. 988-990
    • Chim, C.S.1    Wong, A.S.2    Kwong, Y.L.3
  • 29
    • 44849121373 scopus 로고    scopus 로고
    • Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia
    • Hackanson B., Bennett K.L., Brena R.M., Jiang J., Claus R., Chen S.S., et al. Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia. Cancer Res 68 (2008) 3142-3151
    • (2008) Cancer Res , vol.68 , pp. 3142-3151
    • Hackanson, B.1    Bennett, K.L.2    Brena, R.M.3    Jiang, J.4    Claus, R.5    Chen, S.S.6
  • 30
    • 34548012182 scopus 로고    scopus 로고
    • Reintroduction of C/EBP{alpha} in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis
    • Schepers H., Wierenga A.T., van Gosliga D., Eggen B.J., Vellenga E., and Schuringa JJ. Reintroduction of C/EBP{alpha} in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis. Blood 110 (2007) 1317-1325
    • (2007) Blood , vol.110 , pp. 1317-1325
    • Schepers, H.1    Wierenga, A.T.2    van Gosliga, D.3    Eggen, B.J.4    Vellenga, E.5    Schuringa JJ6
  • 31
    • 31444431706 scopus 로고    scopus 로고
    • Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    • Hsu C.L., King-Fleischman A.G., Lai A.Y., Matsumoto Y., Weissman I.L., and Kondo M. Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc Natl Acad Sci USA 103 (2006) 672-677
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 672-677
    • Hsu, C.L.1    King-Fleischman, A.G.2    Lai, A.Y.3    Matsumoto, Y.4    Weissman, I.L.5    Kondo, M.6
  • 32
    • 38449102306 scopus 로고    scopus 로고
    • Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
    • Pongubala J.M., Northrup D.L., Lancki D.W., Medina K.L., Treiber T., Bertolino E., et al. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol 9 (2008) 203-215
    • (2008) Nat Immunol , vol.9 , pp. 203-215
    • Pongubala, J.M.1    Northrup, D.L.2    Lancki, D.W.3    Medina, K.L.4    Treiber, T.5    Bertolino, E.6
  • 34
    • 33847223121 scopus 로고    scopus 로고
    • Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders
    • Jost E., do Ó N., Dahl E., Maintz C.E., Jousten P., Habets L., et al. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. Leukemia 21 (2007) 505-510
    • (2007) Leukemia , vol.21 , pp. 505-510
    • Jost, E.1    do Ó, N.2    Dahl, E.3    Maintz, C.E.4    Jousten, P.5    Habets, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.