-
1
-
-
0025032340
-
DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion
-
Schulte-Hermann, R., Timmermann-Trosiener, I., Barthel, G., and Bursch, W. ( 1990 ) DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion . Cancer Res., 50, 5127-5135.
-
(1990)
Cancer Res.
, vol.50
, pp. 5127-5135
-
-
Schulte-hermann, R.1
Timmermann-trosiener, I.2
Barthel, G.3
Bursch, W.4
-
2
-
-
0028895237
-
Active cell death (apoptosis) in liver biology and disease
-
Schulte-Hermann, R., Bursch, W., and Grasl-Kraupp, B. ( 1995 ) Active cell death (apoptosis) in liver biology and disease. Prog. Liver Dis., 13, 1-35.
-
(1995)
Prog. Liver Dis.
, vol.13
, pp. 1-35
-
-
Schulte-hermann, R.1
Bursch, W.2
Grasl-kraupp, B.3
-
3
-
-
1842862755
-
TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer
-
Olivier, M., Hussain, S.P., Caron de Fromentel, C., Hainaut, P., and Harris, C.C. ( 2004 ) TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer. IARC Sci. Publ., 157, 247-270.
-
(2004)
IARC Sci. Publ.
, vol.157
, pp. 247-270
-
-
Olivier, M.1
Hussain, S.P.2
Caron De Fromentel, C.3
Hainaut, P.4
Harris, C.C.5
-
4
-
-
18144405011
-
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility
-
Bursch, W., Chabicovsky, M., Wastl, U., Grasl-Kraupp, B., Bukowska, K., Taper, H., and Schulte-Hermann, R. ( 2005 ) Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility. Toxicol. Sci., 85, 515-529.
-
(2005)
Toxicol. Sci.
, vol.85
, pp. 515-529
-
-
Bursch, W.1
Chabicovsky, M.2
Wastl, U.3
Grasl-kraupp, B.4
Bukowska, K.5
Taper, H.6
Schulte-hermann, R.7
-
5
-
-
24644457152
-
Carcinogenic risks of dioxin: mechanistic considerations
-
Schwarz, M., and Appel, K.E. ( 2005 ) Carcinogenic risks of dioxin: mechanistic considerations. Regul. Toxicol. Pharmacol., 43, 19-34.
-
(2005)
Regul. Toxicol. Pharmacol.
, vol.43
, pp. 19-34
-
-
Schwarz, M.1
Appel, K.E.2
-
6
-
-
33947411861
-
Adventures in hepatocarcinogenesis
-
Pitot, H.C. ( 2007 ) Adventures in hepatocarcinogenesis. Annu. Rev. Pathol., 2, 1-29.
-
(2007)
Annu. Rev. Pathol.
, vol.2
, pp. 1-29
-
-
Pitot, H.C.1
-
7
-
-
38849119717
-
Molecular pathogenesis of hepatocellular carcinoma
-
Wong, C.M., and Ng, I.O. ( 2008 ) Molecular pathogenesis of hepatocellular carcinoma. Liver Int., 28, 160-174.
-
(2008)
Liver Int.
, vol.28
, pp. 160-174
-
-
Wong, C.M.1
Ng, I.O.2
-
8
-
-
0346156024
-
PPARalpha agonist-induced rodent tumors: modes of action and human relevance
-
Klaunig, J.E., Babich, M.A., Baetcke, K.P., Cook, J.C., Corton, J.C., David, R.M., DeLuca, J.G., Lai, D.Y., McKee, R.H., Peters, J.M., Roberts, R.A., and Fenner-Crisp, P.A. ( 2003 ) PPARalpha agonist-induced rodent tumors: modes of action and human relevance. Crit. Rev. Toxicol., 33, 655-780.
-
(2003)
Crit. Rev. Toxicol.
, vol.33
, pp. 655-780
-
-
Klaunig, J.E.1
Babich, M.A.2
Baetcke, K.P.3
Cook, J.C.4
Corton, J.C.5
David, R.M.6
DeLuca, J.G.7
Lai, D.Y.8
McKee, R.H.9
Peters, J.M.10
Roberts, R.A.11
Fenner-crisp, P.A.12
-
9
-
-
0042882184
-
Hazard and risk assessment of industrial chemicals in the occupational context in Europe: some current issues
-
Fairhurst, S. ( 2003 ) Hazard and risk assessment of industrial chemicals in the occupational context in Europe: some current issues. Food Chem. Toxicol., 41, 1453-1462.
-
(2003)
Food Chem. Toxicol.
, vol.41
, pp. 1453-1462
-
-
Fairhurst, S.1
-
10
-
-
41949135938
-
Towards more efficient testing strategies-analyzing the efficiency of toxicity data requirements in relation to the criteria for classification and labelling
-
Nordberg, A., Ruden, C., and Hansson, S.O. ( 2008 ) Towards more efficient testing strategies-analyzing the efficiency of toxicity data requirements in relation to the criteria for classification and labelling. Regul. Toxicol. Pharmacol., 50, 412-419.
-
(2008)
Regul. Toxicol. Pharmacol.
, vol.50
, pp. 412-419
-
-
Nordberg, A.1
Ruden, C.2
Hansson, S.O.3
-
11
-
-
29544450979
-
Mode of action in relevance of rodent liver tumors to human cancer risk
-
Holsapple, M.P., Pitot, H.C., Cohen, S.M., Boobis, A.R., Klaunig, J.E., Pastoor, T., Dellarco, V.L., and Dragan, Y.P. ( 2006 ) Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol. Sci., 89, 51-56.
-
(2006)
Toxicol. Sci.
, vol.89
, pp. 51-56
-
-
Holsapple, M.P.1
Pitot, H.C.2
Cohen, S.M.3
Boobis, A.R.4
Klaunig, J.E.5
Pastoor, T.6
Dellarco, V.L.7
Dragan, Y.P.8
-
12
-
-
33747335918
-
-
Barlow, S., Renwick, A.G., Kleiner, J., Bridges, J.W., Busk, L., Dybing, E., Edler, L., Eisenbrand, G., Fink-Gremmels, J., Knaap, A., Kroes, R., Liem, D., Muller, D.J., Page, S., Rolland, V., Schlatter, J., Tritscher, A., Tueting, W., and Wurtzen, G. ( 2006 ) Risk assessment of substances that are both genotoxic and carcinogenic report of an International Conferenceorganized by EFSA and WHO with support of ILSI Europe. Food Chem. Toxicol., 44, 1636-1650.
-
(2006)
Food Chem. Toxicol.
, vol.44
, pp. 1636-1650
-
-
Barlow, S.1
Renwick, A.G.2
Kleiner, J.3
Bridges, J.W.4
Busk, L.5
Dybing, E.6
Edler, L.7
Eisenbrand, G.8
Fink-gremmels, J.9
Knaap, A.10
Kroes, R.11
Liem, D.12
Muller, D.J.13
Page, S.14
Rolland, V.15
Schlatter, J.16
Tritscher, A.17
Tueting, W.18
Wurtzen, G.19
-
13
-
-
84884613486
-
-
REACH, Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Commission Regulation (EC) No 1488/94
-
REACH ( 2007 ) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Commission Regulation (EC) No 1488/94
-
(2007)
-
-
-
14
-
-
84884654997
-
Mehrstufenkonzept der Kanzerogense und chenmischen kanzerogenese
-
in Die Onkologie (eds W. Hiddemann, H. Huber, R. Bartram and R. Claus ), Springer Verlag
-
Parzefall, W., and Schulte-Hermann, R. ( 2004 ) Mehrstufenkonzept der Kanzerogense und chenmischen kanzerogenese, in Die Onkologie (eds W. Hiddemann, H. Huber, R. Bartram and R. Claus ), Springer Verlag, pp. 194-240.
-
(2004)
, pp. 194-240
-
-
Parzefall, W.1
Schulte-hermann, R.2
-
15
-
-
35448985442
-
The dynamic epigenome and its implications in toxicology
-
Szyf, M. ( 2007 ) The dynamic epigenome and its implications in toxicology. Toxicol. Sci., 100, 7-23.
-
(2007)
Toxicol. Sci.
, vol.100
, pp. 7-23
-
-
Szyf, M.1
-
16
-
-
33646821720
-
Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations
-
Newbold, R.R., Padilla-Banks, E., and Jefferson, W.N. ( 2006 ) Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology, 147, S11-S17.
-
(2006)
Endocrinology
, vol.147
-
-
Newbold, R.R.1
Padilla-banks, E.2
Jefferson, W.N.3
-
17
-
-
34548472614
-
Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer
-
Skinner, M.K., and Anway, M.D. ( 2007 ) Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer. Crit. Rev. Oncog., 13, 75-82.
-
(2007)
Crit. Rev. Oncog.
, vol.13
, pp. 75-82
-
-
Skinner, M.K.1
Anway, M.D.2
-
18
-
-
39749115590
-
Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents
-
Pogribny, I.P., Rusyn, I., and Beland, F.A. ( 2008 ) Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents. Environ Mol. Mutagen, 49, 9-15.
-
(2008)
Environ Mol. Mutagen
, vol.49
, pp. 9-15
-
-
Pogribny, I.P.1
Rusyn, I.2
Beland, F.A.3
-
19
-
-
17444435854
-
Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis
-
Low-Baselli, A., Hufnagl, K., Parzefall, W., Schulte-Hermann, R., and Grasl-Kraupp, B. ( 2000 ) Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis. Carcinogenesis, 21, 79-86.
-
(2000)
Carcinogenesis
, vol.21
, pp. 79-86
-
-
Low-baselli, A.1
Hufnagl, K.2
Parzefall, W.3
Schulte-hermann, R.4
Grasl-kraupp, B.5
-
20
-
-
34249845990
-
Genetics of hepatocellular carcinoma
-
Teufel, A., Staib, F., Kanzler, S., Weinmann, A., Schulze-Bergkamen, H., and Galle, P.R. ( 2007 ) Genetics of hepatocellular carcinoma. World J. Gastroenterol., 13, 2271-2282.
-
(2007)
World J. Gastroenterol.
, vol.13
, pp. 2271-2282
-
-
Teufel, A.1
Staib, F.2
Kanzler, S.3
Weinmann, A.4
Schulze-bergkamen, H.5
Galle, P.R.6
-
21
-
-
33751008056
-
The activin axis in liver biology and disease
-
Rodgarkia-Dara, C., Vejda, S., Erlach, N., Losert, A., Bursch, W., Berger, W., Schulte-Hermann, R., and Grusch, M. ( 2006 ) The activin axis in liver biology and disease. Mutat. Res., 613, 123-137.
-
(2006)
Mutat. Res.
, vol.613
, pp. 123-137
-
-
Rodgarkia-dara, C.1
Vejda, S.2
Erlach, N.3
Losert, A.4
Bursch, W.5
Berger, W.6
Schulte-hermann, R.7
Grusch, M.8
-
22
-
-
33947236184
-
Hepatitis viruses: live and let die
-
Herzer, K., Sprinzl, M.F., and Galle, P.R. ( 2007 ) Hepatitis viruses: live and let die. Liver Int., 27, 293-301.
-
(2007)
Liver Int.
, vol.27
, pp. 293-301
-
-
Herzer, K.1
Sprinzl, M.F.2
Galle, P.R.3
-
23
-
-
84884641402
-
International Agency forResearch on Cancer (IARC)-summaries & evaluations
-
IARC
-
IARC ( 2002 ) International Agency forResearch on Cancer (IARC)-summaries & evaluations. AFLATOXINS, 82-171.
-
(2002)
AFLATOXINS
, pp. 82-171
-
-
-
24
-
-
33745552897
-
Dysregulation of growth factor signaling in human hepatocellular carcinoma
-
Breuhahn, K., Longerich, T., and Schirmacher, P. ( 2006 ) Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene, 25, 3787-3800.
-
(2006)
Oncogene
, vol.25
, pp. 3787-3800
-
-
Breuhahn, K.1
Longerich, T.2
Schirmacher, P.3
-
25
-
-
35248880645
-
Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma
-
Calvisi, D.F., Pascale, R.M., and Feo, F. ( 2007 ) Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma. Rev. Recent Clin. Trials, 2, 217-236.
-
(2007)
Rev. Recent Clin. Trials
, vol.2
, pp. 217-236
-
-
Calvisi, D.F.1
Pascale, R.M.2
Feo, F.3
-
26
-
-
42249111748
-
The roles of nuclear receptors CAR and PXR in hepatic energy metabolism
-
Konno, Y., Negishi, M., and Kodama, S. ( 2008 ) The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab. Pharmacokinet., 23, 8-13.
-
(2008)
Drug Metab. Pharmacokinet.
, vol.23
, pp. 8-13
-
-
Konno, Y.1
Negishi, M.2
Kodama, S.3
-
27
-
-
33749661607
-
Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to butylbenzylphthalate (BBP) for use in food contact materials
-
EFSA, Adopted on 23 June 2005 by written procedure
-
EFSA ( 2005 ) Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to butylbenzylphthalate (BBP) for use in food contact materials. Adopted on 23 June 2005 by written procedure. EFSA J., 241, 1-14.
-
(2005)
EFSA J.
, vol.241
, pp. 1-14
-
-
-
28
-
-
33749661607
-
Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isodecylphthalate (DIDP) for use in food contact materials
-
EFSA, Adopted on 30 July 2005
-
EFSA ( 2005 ) Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isodecylphthalate (DIDP) for use in food contact materials. Adopted on 30 July 2005. EFSA J., 245, 1-14.
-
(2005)
EFSA J.
, vol.245
, pp. 1-14
-
-
-
29
-
-
33748659067
-
Opinion of the scientific committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic
-
EFSA
-
EFSA ( 2005 ) Opinion of the scientific committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA J., 282, 1-31.
-
(2005)
EFSA J.
, vol.282
, pp. 1-31
-
-
-
30
-
-
33749661607
-
Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isononylphthalate (DINP) for use in food contact materials
-
EFSA, Adopted on 30 July 2005
-
EFSA ( 2005 ) Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isononylphthalate (DINP) for use in food contact materials. Adopted on 30 July 2005. EFSA J., 244, 1-18.
-
(2005)
EFSA J.
, vol.244
, pp. 1-18
-
-
-
31
-
-
84884651137
-
-
EFSA, Statement of the scientific panel on food additives, flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission on the possibility of allocating a group-TDI for butylbenzylphthalate (BBP), di-butylphthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP)
-
EFSA ( 2005 ) Statement of the scientific panel on food additives, flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission on the possibility of allocating a group-TDI for butylbenzylphthalate (BBP), di-butylphthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP). http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178620768397.htm.
-
(2005)
-
-
-
32
-
-
56749178706
-
Cell death and autophagy: cytokines, drugs, and nutritional factors
-
Bursch, W., Karwan, A., Mayer, M., Dornetshuber, J., Frohwein, U., Schulte-Hermann, R., Fazi, B., Di Sano, F., Piredda, L., Piacentini, M., Petrovski, G., Fesus, L., and Gerner, C. ( 2008 ) Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology, 254, 147-157.
-
(2008)
Toxicology
, vol.254
, pp. 147-157
-
-
Bursch, W.1
Karwan, A.2
Mayer, M.3
Dornetshuber, J.4
Frohwein, U.5
Schulte-hermann, R.6
Fazi, B.7
Sano, D.F.8
Piredda, L.9
Piacentini, M.10
Petrovski, G.11
Fesus, L.12
Gerner, C.13
-
33
-
-
0028051314
-
Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver
-
U. S. A.
-
Grasl-Kraupp, B., Bursch, W., Ruttkay-Nedecky, B., Wagner, A., Lauer, B., and Schulte-Hermann, R. ( 1994 ) Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc. Natl. Acad. Sci. U. S. A., 91, 9995-9999.
-
(1994)
Proc. Natl. Acad. Sci.
, vol.91
, pp. 9995-9999
-
-
Grasl-kraupp, B.1
Bursch, W.2
Ruttkay-nedecky, B.3
Wagner, A.4
Lauer, B.5
Schulte-hermann, R.6
-
34
-
-
0029876752
-
Transforming growth factor beta 1-induced cell death in preneoplastic foci of rat liver and sensitization by the antiestrogen tamoxifen
-
Mullauer, L., Grasl-Kraupp, B., Bursch, W., and Schulte-Hermann, R. ( 1996 ) Transforming growth factor beta 1-induced cell death in preneoplastic foci of rat liver and sensitization by the antiestrogen tamoxifen. Hepatology, 23, 840-847.
-
(1996)
Hepatology
, vol.23
, pp. 840-847
-
-
Mullauer, L.1
Grasl-kraupp, B.2
Bursch, W.3
Schulte-hermann, R.4
-
35
-
-
46349096337
-
New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis
-
Sagmeister, S., Eisenbauer, M., Pirker, C., Mohr, T., Holzmann, K., Zwickl, H., Bichler, C., Kandioler, D., Wrba, F., Mikulits, W., Gerner, C., Shehata, M., Majdic, O., Streubel, B., Berger, W., Micksche, M., Zatloukal, K., Schulte-Hermann, R., and Grasl-Kraupp, B. ( 2008 ) New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis. Br. J. Cancer, 99, 151-159.
-
(2008)
Br. J. Cancer
, vol.99
, pp. 151-159
-
-
Sagmeister, S.1
Eisenbauer, M.2
Pirker, C.3
Mohr, T.4
Holzmann, K.5
Zwickl, H.6
Bichler, C.7
Kandioler, D.8
Wrba, F.9
Mikulits, W.10
Gerner, C.11
Shehata, M.12
Majdic, O.13
Streubel, B.14
Berger, W.15
Micksche, M.16
Zatloukal, K.17
Schulte-hermann, R.18
Grasl-kraupp, B.19
-
36
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
Majewski, N., Nogueira, V., Bhaskar, P., Coy, P.E., Skeen, J.E., Gottlob, K., Chandel, N.S., Thompson, C.B., Robey, R.B., and Hay, N. ( 2004 ) Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell, 16, 819-830.
-
(2004)
Mol. Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
37
-
-
28544436922
-
Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
-
Pastorino, J.G., Hoek, J.B., and Shulga, N. ( 2005 ) Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res., 65, 10545-10554.
-
(2005)
Cancer Res.
, vol.65
, pp. 10545-10554
-
-
Pastorino, J.G.1
Hoek, J.B.2
Shulga, N.3
-
38
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
Byfield, M.P., Murray, J.T., and Backer, J.M. ( 2005 ) hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem., 280, 33076-33082.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
39
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey, R.B., and Hay, N. ( 2006 ) Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene, 25, 4683-4696.
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
40
-
-
0019813993
-
Inhibitory effects of substrate analogs on lactate production from fructose and glucose in bovine spermatozoa
-
Dills, W.L. Jr., Bell, L.S., and Onuma, E.K. ( 1981 ) Inhibitory effects of substrate analogs on lactate production from fructose and glucose in bovine spermatozoa. Biol. Reprod, 25, 458-465.
-
(1981)
Biol. Reprod
, vol.25
, pp. 458-465
-
-
Dills Jr, W.L.1
Bell, L.S.2
Onuma, E.K.3
-
41
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R.B., and Hay, N. ( 2001 ) Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev., 15, 1406-1418.
-
(2001)
Genes Dev.
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
42
-
-
38449096145
-
Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture
-
Hwang, S.O., and Lee, G.M. ( 2008 ) Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture. Biotechnol. Bioeng., 99, 678-685.
-
(2008)
Biotechnol. Bioeng.
, vol.99
, pp. 678-685
-
-
Hwang, S.O.1
Lee, G.M.2
-
43
-
-
33846705581
-
Epigenetic processes and cancer risk assessment
-
Preston, R.J. ( 2007 ) Epigenetic processes and cancer risk assessment. Mutat. Res., 616, 7-10.
-
(2007)
Mutat. Res.
, vol.616
, pp. 7-10
-
-
Preston, R.J.1
-
44
-
-
34047190317
-
Epigenetic field for cancerization
-
Ushijima, T. ( 2007 ) Epigenetic field for cancerization. J. Biochem. Mol. Biol., 40, 142-150.
-
(2007)
J. Biochem. Mol. Biol.
, vol.40
, pp. 142-150
-
-
Ushijima, T.1
-
45
-
-
36549056015
-
Epigenetic changes in cancer
-
APMIS
-
Gronbaek, K., Hother, C., and Jones, P.A. ( 2007 ) Epigenetic changes in cancer. APMIS, 115, 1039-1059.
-
(2007)
, vol.115
, pp. 1039-1059
-
-
Gronbaek, K.1
Hother, C.2
Jones, P.A.3
-
46
-
-
41849111637
-
DNA methylation in hepatocellular carcinoma
-
Tischoff, I., and Tannapfe, A. ( 2008 ) DNA methylation in hepatocellular carcinoma. World J. Gastroenterol., 14, 1741-1748.
-
(2008)
World J. Gastroenterol.
, vol.14
, pp. 1741-1748
-
-
Tischoff, I.1
Tannapfe, A.2
-
47
-
-
0021157513
-
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens
-
Ghoshal, A.K., and Farber, E. ( 1984 ) The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis, 5, 1367-1370.
-
(1984)
Carcinogenesis
, vol.5
, pp. 1367-1370
-
-
Ghoshal, A.K.1
Farber, E.2
-
48
-
-
0024605537
-
Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver
-
Rao, P.M., Antony, A., Rajalakshmi, S., and Sarma, D.S. ( 1989 ) Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver. Carcinogenesis, 10, 933-937.
-
(1989)
Carcinogenesis
, vol.10
, pp. 933-937
-
-
Rao, P.M.1
Antony, A.2
Rajalakshmi, S.3
Sarma, D.S.4
-
49
-
-
0025744010
-
Nutritional model of hepatocarcinogenesis. Rats fed choline-devoid diet
-
Lombardi, B., Chandar, N., and Locker, J. ( 1991 ) Nutritional model of hepatocarcinogenesis. Rats fed choline-devoid diet. Dig. Dis. Sci., 36, 979-984.
-
(1991)
Dig. Dis. Sci.
, vol.36
, pp. 979-984
-
-
Lombardi, B.1
Chandar, N.2
Locker, J.3
-
50
-
-
0033999104
-
Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies
-
Feo, F., Pascale, R.M., Simile, M.M., De Miglio, M.R., Muroni, M.R., and Calvisi, D. ( 2000 ) Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies. Crit. Rev. Oncog., 11, 19-62.
-
(2000)
Crit. Rev. Oncog.
, vol.11
, pp. 19-62
-
-
Feo, F.1
Pascale, R.M.2
Simile, M.M.3
Miglio, D.R.M.4
Muroni, M.R.5
Calvisi, D.6
-
51
-
-
0036024252
-
Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine
-
Pascale, R.M., Simile, M.M., De Miglio, M.R., and Feo, F. ( 2002 ) Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine. Alcohol, 27, 193-198.
-
(2002)
Alcohol
, vol.27
, pp. 193-198
-
-
Pascale, R.M.1
Simile, M.M.2
Miglio, D.R.M.3
Feo, F.4
-
52
-
-
33744937935
-
NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma
-
Macheiner, D., Heller, G., Kappel, S., Bichler, C., Stattner, S., Ziegler, B., Kandioler, D., Wrba, F., Schulte-Hermann, R., Zochbauer-Muller, S., and Grasl-Kraupp, B. ( 2006 ) NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma. J. Hepatol., 45, 81-89.
-
(2006)
J. Hepatol.
, vol.45
, pp. 81-89
-
-
Macheiner, D.1
Heller, G.2
Kappel, S.3
Bichler, C.4
Stattner, S.5
Ziegler, B.6
Kandioler, D.7
Wrba, F.8
Schulte-hermann, R.9
Zochbauer-muller, S.10
Grasl-kraupp, B.11
-
53
-
-
0037428664
-
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
-
Zhang, Y.J., Chen, Y., Ahsan, H., Lunn, R.M., Lee, P.H., Chen, C.J., and Santella, R.M. ( 2003 ) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma. Int. J. Cancer, 103, 440-444.
-
(2003)
Int. J. Cancer
, vol.103
, pp. 440-444
-
-
Zhang, Y.J.1
Chen, Y.2
Ahsan, H.3
Lunn, R.M.4
Lee, P.H.5
Chen, C.J.6
Santella, R.M.7
-
54
-
-
16244420106
-
Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma
-
Zhang, Y.J., Chen, Y., Ahsan, H., Lunn, R.M., Chen, S.Y., Lee, P.H., Chen, C.J., and Santella, R.M. ( 2005 ) Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma. Cancer Lett., 221, 135-143.
-
(2005)
Cancer Lett.
, vol.221
, pp. 135-143
-
-
Zhang, Y.J.1
Chen, Y.2
Ahsan, H.3
Lunn, R.M.4
Chen, S.Y.5
Lee, P.H.6
Chen, C.J.7
Santella, R.M.8
-
55
-
-
33947186795
-
Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis
-
Tryndyak, V.P., Kovalchuk, O., Muskhelishvili, L., Montgomery, B., Rodriguez-Juarez, R., Melnyk, S., Ross, S.A., Beland, F.A., and Pogribny, I.P. ( 2007 ) Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Mol. Carcinog., 46, 187-197.
-
(2007)
Mol. Carcinog.
, vol.46
, pp. 187-197
-
-
Tryndyak, V.P.1
Kovalchuk, O.2
Muskhelishvili, L.3
Montgomery, B.4
Rodriguez-juarez, R.5
Melnyk, S.6
Ross, S.A.7
Beland, F.A.8
Pogribny, I.P.9
-
56
-
-
0035996058
-
Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis
-
Watson, R.E., and Goodman, J.I. ( 2002 ) Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis. Toxicol. Sci., 68, 51-58.
-
(2002)
Toxicol. Sci.
, vol.68
, pp. 51-58
-
-
Watson, R.E.1
Goodman, J.I.2
-
57
-
-
33645130686
-
Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency
-
Bachman, A.N., Kamendulis, L.M., and Goodman, J.I. ( 2006 ) Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency. Toxicol. Sci., 90, 317-325.
-
(2006)
Toxicol. Sci.
, vol.90
, pp. 317-325
-
-
Bachman, A.N.1
Kamendulis, L.M.2
Goodman, J.I.3
-
58
-
-
33744802237
-
Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice
-
Bachman, A.N., Phillips, J.M., and Goodman, J.I. ( 2006 ) Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice. Toxicol. Sci., 91, 393-405.
-
(2006)
Toxicol. Sci.
, vol.91
, pp. 393-405
-
-
Bachman, A.N.1
Phillips, J.M.2
Goodman, J.I.3
-
59
-
-
45549092837
-
Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation
-
Phillips, J.M., and Goodman, J.I. ( 2008 ) Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation. Toxicol. Sci., 104, 86-99.
-
(2008)
Toxicol. Sci.
, vol.104
, pp. 86-99
-
-
Phillips, J.M.1
Goodman, J.I.2
-
60
-
-
38949133743
-
IPCS framework for analyzing the relevance of a noncancer mode of action for humans
-
Boobis, A.R., Doe, J.E., Heinrich-Hirsch, B., Meek, M.E., Munn, S., Ruchirawat, M., Schlatter, J., Seed, J., and Vickers, C. ( 2008 ) IPCS framework for analyzing the relevance of a noncancer mode of action for humans. Crit. Rev. Toxicol., 38, 87-96.
-
(2008)
Crit. Rev. Toxicol.
, vol.38
, pp. 87-96
-
-
Boobis, A.R.1
Doe, J.E.2
Heinrich-hirsch, B.3
Meek, M.E.4
Munn, S.5
Ruchirawat, M.6
Schlatter, J.7
Seed, J.8
Vickers, C.9
-
61
-
-
40749139957
-
S-Adenosylmethionine in cell growth, apoptosis and liver cancer
-
Lu, S.C., and Mato, J.M. ( 2008 ) S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J. Gastroenterol. Hepatol., 23 ( Suppl. 1 ), S73-S77.
-
(2008)
J. Gastroenterol. Hepatol.
, vol.23
, Issue.1 SUPPL.
-
-
Lu, S.C.1
Mato, J.M.2
-
62
-
-
0034886485
-
Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPARalpha)
-
Hasmall, S., James, N., Hedley, K., Olsen, K., and Roberts, R. ( 2001 ) Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPARalpha). Arch. Toxicol., 75, 357-361.
-
(2001)
Arch. Toxicol.
, vol.75
, pp. 357-361
-
-
Hasmall, S.1
James, N.2
Hedley, K.3
Olsen, K.4
Roberts, R.5
-
63
-
-
0034677712
-
Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation
-
Rose, M.L., Rusyn, I., Bojes, H.K., Belyea, J., Cattley, R.C., and Thurman, R.G. ( 2000 ) Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation. Mutat. Res., 448, 179-192.
-
(2000)
Mutat. Res.
, vol.448
, pp. 179-192
-
-
Rose, M.L.1
Rusyn, I.2
Bojes, H.K.3
Belyea, J.4
Cattley, R.C.5
Thurman, R.G.6
-
64
-
-
0023735167
-
Activation of liver macrophages following phenobarbital treatment of rats
-
Laskin, D.L., Robertson, F.M., Pilaro, A.M., and Laskin, J.D. ( 1988 ) Activation of liver macrophages following phenobarbital treatment of rats. Hepatology, 8, 1051-1055.
-
(1988)
Hepatology
, vol.8
, pp. 1051-1055
-
-
Laskin, D.L.1
Robertson, F.M.2
Pilaro, A.M.3
Laskin, J.D.4
-
65
-
-
0032842632
-
Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells
-
Kroll, B., Kunz, S., Klein, T., and Schwarz, L.R. ( 1999 ) Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells. Carcinogenesis, 20, 1411-1416.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1411-1416
-
-
Kroll, B.1
Kunz, S.2
Klein, T.3
Schwarz, L.R.4
-
66
-
-
0035112937
-
Endotoxin, endotoxin-neutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease
-
Urbaschek, R., McCuskey, R.S., Rudi, V., Becker, K.P., Stickel, F., Urbaschek, B., and Seitz, H.K. ( 2001 ) Endotoxin, endotoxin-neutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease. Alcohol. Clin. Exp. Res., 25, 261-268.
-
(2001)
Alcohol. Clin. Exp. Res.
, vol.25
, pp. 261-268
-
-
Urbaschek, R.1
McCuskey, R.S.2
Rudi, V.3
Becker, K.P.4
Stickel, F.5
Urbaschek, B.6
Seitz, H.K.7
-
67
-
-
0035893937
-
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radical Biol
-
Wheeler, M.D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G.E., Gabele, E., Rusyn, I., Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B.U., Smutney, O.M., Connor, H.D., Mason, R.P., Goyert, S.M., Peters, J.M., Gonzalez, F.J., Samulski, R.J., and Thurman, R.G. ( 2001 ) The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radical Biol. Med., 31, 1544-1549.
-
(2001)
Med.
, vol.31
, pp. 1544-1549
-
-
Wheeler, M.D.1
Kono, H.2
Yin, M.3
Nakagami, M.4
Uesugi, T.5
Arteel, G.E.6
Gabele, E.7
Rusyn, I.8
Yamashina, S.9
Froh, M.10
Adachi, Y.11
Iimuro, Y.12
Bradford, B.U.13
Smutney, O.M.14
Connor, H.D.15
Mason, R.P.16
Goyert, S.M.17
Peters, J.M.18
Gonzalez, F.J.19
Samulski, R.J.20
Thurman, R.G.21
more..
-
68
-
-
0025665128
-
Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization
-
Noji, S., Tashiro, K., Koyama, E., Nohno, T., Ohyama, K., Taniguchi, S., and Nakamura, T. ( 1990 ) Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization. Biochem. Biophys. Res. Commun., 173, 42-47.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.173
, pp. 42-47
-
-
Noji, S.1
Tashiro, K.2
Koyama, E.3
Nohno, T.4
Ohyama, K.5
Taniguchi, S.6
Nakamura, T.7
-
69
-
-
0035680610
-
Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats
-
Luckey, S.W., and Petersen, D.R. ( 2001 ) Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats. Exp. Mol. Pathol., 71, 226-240.
-
(2001)
Exp. Mol. Pathol.
, vol.71
, pp. 226-240
-
-
Luckey, S.W.1
Petersen, D.R.2
-
70
-
-
1842585519
-
Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells
-
U. S. A.
-
Chou, W.C., Jie, C., Kenedy, A.A., Jones, R.J., Trush, M.A., and Dang, C.V. ( 2004 ) Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc. Natl. Acad. Sci. U. S. A., 101, 4578-4583.
-
(2004)
Proc. Natl. Acad. Sci.
, vol.101
, pp. 4578-4583
-
-
Chou, W.C.1
Jie, C.2
Kenedy, A.A.3
Jones, R.J.4
Trush, M.A.5
Dang, C.V.6
-
71
-
-
13844297437
-
Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice
-
Teufelhofer, O., Parzefall, W., Kainzbauer, E., Ferk, F., Freiler, C., Knasmuller, S., Elbling, L., Thurman, R., and Schulte-Hermann, R. ( 2005 ) Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice. Carcinogenesis, 26, 319-329.
-
(2005)
Carcinogenesis
, vol.26
, pp. 319-329
-
-
Teufelhofer, O.1
Parzefall, W.2
Kainzbauer, E.3
Ferk, F.4
Freiler, C.5
Knasmuller, S.6
Elbling, L.7
Thurman, R.8
Schulte-hermann, R.9
-
72
-
-
84865962395
-
Study on enhancing the endocrine disruptor priority list with focus on low production volume chemicals
-
ENV.D.4/ETU/2005/028
-
Petersen, G., Rasmussen, D., and Gustavson, K. ( 2007 ) Study on enhancing the endocrine disruptor priority list with focus on low production volume chemicals. ENV.D.4/ETU/2005/028.
-
(2007)
-
-
Petersen, G.1
Rasmussen, D.2
Gustavson, K.3
-
73
-
-
0043093697
-
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
-
Waterland, R.A., and Jirtle, R.L. ( 2003 ) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol., 23, 5293-5300.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 5293-5300
-
-
Waterland, R.A.1
Jirtle, R.L.2
-
74
-
-
33751533712
-
Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
-
Anway, M.D., Leathers, C., and Skinner, M.K. ( 2006 ) Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease. Endocrinology, 147, 5515-5523.
-
(2006)
Endocrinology
, vol.147
, pp. 5515-5523
-
-
Anway, M.D.1
Leathers, C.2
Skinner, M.K.3
-
75
-
-
22144440895
-
Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation
-
Zambrano, E., Martinez-Samayoa, P.M., Bautista, C.J., Deas, M., Guillen, L., Rodriguez-Gonzalez, G.L., Guzman, C., Larrea, F., and Nathanielsz, P.W. ( 2005 ) Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. J. Physiol., 566, 225-236.
-
(2005)
J. Physiol.
, vol.566
, pp. 225-236
-
-
Zambrano, E.1
Martinez-samayoa, P.M.2
Bautista, C.J.3
Deas, M.4
Guillen, L.5
Rodriguez-gonzalez, G.L.6
Guzman, C.7
Larrea, F.8
Nathanielsz, P.W.9
|