Epigenetic modification of CCAAT/enhancer binding protein α expression in acute myeloid leukemia

Cancer Research

Volumn 68, Issue 9, 2008, Pages 3142-3151

  Hackanson, Björn ^a,c   Bennett, Kristi L ^a   Brena, Romulo M ^a   Jiang, Jinmai ^a   Claus, Rainer ^a,c   Chen, Shih Shih ^a   Blagitko Dorfs, Nadya ^c   Maharry, Katie ^a,b   Whitman, Susan P ^a   Schmittgen, Thomas D ^a   Lübbert, Michael ^c   Marcucci, Guido ^a   Bloomfield, Clara D ^a   Plass, Christoph ^a,d  

^a OHIO STATE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; MESSENGER RNA; MICRORNA; MICRORNA 124, HUMAN; MICRORNA-124, HUMAN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CYTOGENETICS; DNA METHYLATION; DNA MODIFICATION; DOWN REGULATION; GENE SILENCING; HEAD AND NECK CANCER; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG CANCER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; UPREGULATION; CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN K 562; CELL STRAIN U937; CHROMOSOME ANALYSIS; CLASSIFICATION; CLUSTER ANALYSIS; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE;

CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CLUSTER ANALYSIS; CYTOGENETIC ANALYSIS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, LEUKEMIC; HEMATOPOIESIS; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; MICRORNAS; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; RNA, MESSENGER; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 44849121373     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0483     Document Type: Article

References (49)

1. Mrozek K, Bloomfield CD. Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia. Hematology (Am Soc Hematol Educ Program) 2006;1:169-77.
2. Estey E, Döhner H. Acute myeloid leukaemia. Lancet 2006;368:1894-907.
3. Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 2004;350:1617-28.
4. Gilliland DG, Jordan CT, Felix CA. The molecular basis of leukemia. Hematology (Am Soc Hematol Educ Program) 2004;1:80-97.
5. Birkenmeier EH, Gwynn B, Howard S, et al. Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 1989;3:1146-56.
6. Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc Natl Acad Sci U S A 1997;94:569-74.
7. Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol 1998;18:4301-14.
8. Pabst T, Mueller BU, Harakawa N, et al. AML1-ETO down-regulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia. Nat Med 2001;7:444-51.
9. Fröhling S, Döhner H. Disruption of C/EBPα function in acute myeloid leukemia. N Engl J Med 2004;351:2370-72.
10. Perrotti D, Cesi V, Trotta R, et al. BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2. Nat Genet 2002;30:48-58.
11. Helbling D, Mueller BU, Timchenko NA, et al. CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood 2005;106:1369-75.
12. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
13. Toyota M, Kopecky KJ, Toyota MO, Jair KW, Willman CL, Issa JP. Methylation profiling in acute myeloid leukemia. Blood 2001;97:2823-9.
14. Gaudet F, Hodgson JG, Eden A, et al. Induction of tumors in mice by genomic hypomethylation. Science 2003;300:489-92.
15. Rush LJ, Dai Z, Smiraglia DJ, et al. Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci. Blood 2001;97:3226-33.
16. Rüter B, Wijermans PW, Lübbert M. DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia. Int J Hematol 2004;80:128-35.
17. Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase I/II study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia. Blood 2006;108:3271-9.
18. Göttlicher M, Minucci S, Zhu P, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001;20:6969-78.
19. Gore SD. Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies. Nat Clin Pract Oncol 2005;2:30-5.
20. Gius D, Cui H, Bradbury CM, et al. Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell 2004;6:361-71.
21. Schmelz K, Sattler N, Wagner M, Lübbert M, Dorken B, Tamm I. Induction of gene expression by 5-aza-2′-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms. Leukemia 2005;19:103-11.
22. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004;5:522-31.
23. Meltzer PS. Cancer genomics: small RNAs with big impacts. Nature 2005;435:745-6.
24. Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005;353:1793-801.
25. Fazi F, Rosa A, Fatica A, et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis. Cell 2005;123:819-31.
26. Fukao T, Fukuda Y, Kiga K, et al. An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 2007;129:617-31.
27. Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-43.
28. Lujambio A, Ropero S, Ballestar E, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007;67:1424-9.
29. Brueckner B, Stresemann C, Kuner R, et al. The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function. Cancer Res 2007;67:1419-23.
30. Wouters BJ, Jorda M., Keeshan, K, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood 2007;110:3706-14.
31. Tada Y, Brena RM, Hackanson B, Morrison C, Otterson GA, Plass C. Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein α activity in lung cancer. J Natl Cancer Inst 2006;98:396-406.
32. Bennett KL, Hackanson B, Smith LT, et al. Tumor suppressor activity of CCAAT/enhancer binding protein a is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Res 2007;67:4657-64.
33. Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 1992;89:1827-31.
34. Brena RM, Auer H, Kornacker K, et al. Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform. Nucleic Acids Res 2006;34:e17.
35. Ehrich M, Nelson MR, Stanssens P, et al. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci U S A 2005;102:15785-90.
36. Felli N, Fontana L, Pelosi E, et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci U S A 2005;102:18081-6.
37. Yu L, Liu C, Vandeusen J, et al. Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat Genet 2005;37:265-74.
38. Chim CS, Wong AS, Kwong, YL. Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia. Br J Haematol 2002;119:988-90.
39. Agrawal S, Hofmann WK, Tidow N, et al. The C/EBP{δ} tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood 2007;108:3895-905.
40. Timchenko N, Wilson DR, Taylor LR, et al. Autoregulation of the human C/EBP α gene by stimulation of upstream stimulatory factor binding. Mol Cell Biol 1995;15:1192-202.
41. Cilloni D, Carturan S, Gottardi E, et al. Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias. Blood 2003;102:2705-6.
42. Blum W, Klisovic RB, Hackanson B, et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 2007;25:3884-91.
43. Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005;433:769-73.
44. Nerlov C. C/EBPα mutations in acute myeloid leukaemias. Nat Rev Cancer 2004;4:394-400.
45. Rosenbauer F, Wagner K, Kutok JL, et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet 2004;36:624-30.
46. Kim JW, Monila H, Pandey A, Lane MD. Upstream stimulatory factors regulate the C/EBP α gene during differentiation of 3T3-1 preadipocytes. Biochem Biophys Res Commun 2007;354:517-21.
47. Di Croce L, Raker VA, Corsaro M, et al. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 2002;295:1079-82.
48. Liu S, Shen T, Huynh L, et al. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res 2005;65:1277-84.
49. Neben K, Tews B, Wrobel G, et al. Gene expression patterns in acute myeloid leukemia correlate with centrosome aberrations and numerical chromosome changes. Oncogene 2004;23:2379-84.