Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes

Diabetologia

Volumn 48, Issue 7, 2005, Pages 1331-1334

  Pihlajamaki J ^a   Kinnunen, M ^a   Ruotsalainen, E ^a   Salmenniemi, U ^a   Vauhkonen, I ^a   Kuulasmaa, T ^a   Kainulainen, S ^a   Laakso, M ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Haplotypes; Insulin resistance; Insulin secretion; PGC 1 ; PPARGC1A; Type 2 diabetes; Visceral obesity

Indexed keywords

ASPARTIC ACID; GLUCOSE; GLYCINE; METHIONINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; THREONINE; UNCLASSIFIED DRUG;

ADULT; ALLELE; AMINO ACID SEQUENCE; ARTICLE; BODY COMPOSITION; BODY MASS; CODON; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HAPLOTYPE; HUMAN; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION;

BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE TOLERANCE TEST; HEAT-SHOCK PROTEINS; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 23944464632     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1800-9     Document Type: Article

References (10)

1. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
2. Ek J, Andersen G, Urhammer SA et al (2001) Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus. Diabetologia 44: 2220-2226
3. Hara K, Tobe K, Okada T et al (2002) A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to type II diabetes. Diabetologia 45:740-743
4. Patti ME, Butte AJ, Crunkhorn S et al (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100:8466-8471
5. Mootha VK, Lindgren CM, Eriksson KF et al (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273
6. Muller YL, Bogardus C, Pedersen O, Baier L (2003) A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes 52:895-898
7. Salmenniemi U, Ruotsalainen E, Pihlajamäki J et al (2004) Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation 110:3842-3848
8. Abecasis GR, Cardon LR, Cookson WO (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292
9. Oberkofler H, Linnemayr V, Weitgasser R et al (2004) Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes. Diabetes 53:1385-1393
10. Andrulionyte L, Zacharova J, Chiasson JL, Laakso M (2004) Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. Diabetologia 47:2176-2184