Correlation of the -3826A>G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from Southern Poland

Journal of Physiology and Pharmacology

Volumn 53, Issue 3, 2002, Pages 477-490

  Kiec Wilk B ^a   Wybranska I ^a   Malczewska Malec, M ^a   Leszczynska Golabek I ^a   Partyka, L ^a   Niedbal S ^a   Jabrocka, A ^a   Dembinska Kiec A ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

FFA; Metabolic disorders; Obesity; OGTT; OLTT; UCP1 polymorphism

Indexed keywords

FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ADULT; ALLELE; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DNA POLYMORPHISM; ENDOTHELIUM INJURY; FAMILY STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NUCLEIC ACID BASE SUBSTITUTION; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PATHOGENESIS; POLAND; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROVOCATION TEST; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BODY MASS INDEX; CARRIER PROTEINS; ENDOTHELIUM, VASCULAR; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; ION CHANNELS; LIPIDS; MALE; MEMBRANE PROTEINS; METABOLIC DISEASES; MIDDLE AGED; MITOCHONDRIAL PROTEINS; OBESITY; PLATELET ACTIVATION; POLAND; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 0036739740     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Urhammer SA, Hansen T, Borch-Johnsen K, Pedersen O. Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379 young Danish subjects. J Clin Endocrinol Metab 2000;85:3151-3154.
2. Schaffler A, Palitzsch KD, Watzlawek E, Drobnik W, Schwer H, Schohnerich J, Schmitz G. Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort. Eur J Clin Invest 1999;29:770-779.
3. Kogure A, Yoshida T, Sakane N, Umekawa T, Takakura Y, Kondo M. Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese. Diabetol 1998;41:1399.
4. Klingenberg M. Thermogenic mechanisms in brown fat. Physiol Rev 1984;64:1-64
5. Cinti S, Zancanaro C, Sbarbati A, Cicolini M, Vogel P, Ricquier D, Fakan S. Immunoelectron microscopical identification of the uncoupling protein in brown adipose tissue mitochondria. Biol Cell 1989;67:359-362.
6. Garruti G, Ricquier D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int J Obes Relat Metab Disord 1992;16:383-390.
7. Klaus S, Casteilla L, Bouillaud F, Ricquier D. The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int J Biochem 1991;23:791-801.
8. Loncar D. Development of thermogenic adipose tissue. Int J Dev Biol 1991;35:321-333.
9. Rehnmark S, Bianco AC, Kieffer JD, Silva JE. Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold. Am J Physiol 1992;262(1 Pt 1):E58-67.
10. Seydoux J, Giacobino JP, Girardier L. Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats. Mol Cell Endocrinol 1982;25:213-226.
11. Rabelo R, Reyes C, Schifman A, Silva JE. Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone. Endocrinology 1996;137:3478-3487.
12. Rabelo R, Reyes C, Schifman A, Silva JE. A complex retinoic acid response element in the uncoupling protein gene defines a novel role for retinoids in thermogenesis. Endocrinology 1996;137:3488-3496.
13. Geloen A, Trayhum P. Regulation of the level of uncoupling protein in brown adipose tissue by insulin requires the mediation of the sympathetic nervous system. FEBS Lett 1990 16;267:265-267.
14. Burcelin R. Kande J, Ricquier D, Girard J. Changes in uncoupling protein and GLUT4 glucose transporter expressions in interscapular brown adipose tissue of diabetic rats: relative roles of hyperglycaemia and hypoinsulinaemia. Biochem J 1993 1;291(Pt 1): 109-113.
15. Geloen A, Trayhurn P. Regulation of the level of uncoupling protein in brown adipose tissue by insulin. Am J Physiol 1990;258 (2 Pt 2):R418-424.
16. Moriscot A, Rabelo R, Bianco AC. Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue. Am J Physiol 1993;265(1 Pt 1):E81-87.
17. Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 1996; 137:21-29.
18. Kopecky J, Rossmeisl M, Hodny Z, Syrovy I, Horakova M, Kolarova P. Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology. Am J Physiol 1996;270(5 Pt 1):E776-786.
19. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993;366(6457):740-742
20. Oppert JM, Vohl MC, Chagnon M, Dionne FT, Cassard-Doulcier AM, Ricquier D, Perusse L, Bouchard C. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes Relat Metab Disord 1994;18:526-531.
21. Cassard-Doulcier AM, Bouillaud F, Chagnon M, Gelly C, Dionne FT, Oppert JM, Bouchard C, Chagnon Y, Ricquier D. The Bcl 1 polymorphism of the human uncoupling protein (ucp) gene is due to a point mutation in the 5′-flanking region. Int J Obes Relat Metab Disord 1996;20:278-279.
22. Oberkofler H, Dallinger G, Liu YM, Hell E, Krempler F, Patsch W. Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 1997;38:2125-2133
23. Esterbauer H, Oberkofler H, Liu YM, Breban D, Hell E, Krempler F, Patsch W. Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J Lipid Res 1998;39:834-844.
24. Clement K, Ruiz J, Cassard-Doulcier AM, Bouillaud F, Ricquier D, Basdevant A, Guy-Grand B, Froguel P. Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Int J Obes Relat Metab Disord 1996;20:1062-1066.
25. Fumeron F, Durack-Bown I, Betoulle D, Cassard-Doulcier AM, Tuzet S, Bouillaud F, Melchior JC, Ricquier D, Apfelbaum M. Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet. Int J Obes Relat Metab Disord 1996;20:1051-1054.
26. Heilbronn LK, Kind KL, Pancewicz E, Morris AM, Noakes M, Clifton PM. Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women. Diabetol 2000;43:242-244.
27. Gagnon J, Lago F, Chagnon YC, Perusse L, Naslund I, Lissner L, Sjostrom L, Bouchard C. DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts. Int J Obes Relat Metab Disord 1998;22:500-505.
28. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetol 1985;28:412-419.
29. Haffner SM, Mykkanen L, Festa A, Burke JP, Stern MP. Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. Circulation 2000;101:975-980.
30. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1467.
31. Sliwowski Z, Lorens K, Konturek SJ, Bielanski W, Zoladz JA. Leptin, gastrointestinal and stress hormones in response to exercise in fasted or fed subjects and before or after blood donation. J Physiol Pharmacol 2001;52:53-70.
32. Konturek PC, Konturek SJ, Brzozowski T, Hahn EG. Gastroprotection and control of food intake by leptin. Comparison with cholecystokinin and prostaglandins. J Physiol Pharmacol 1999;50:39-48.
33. Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles JM. Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 1989;83: 1168-1173.
34. Benthem L, Kuipers F, Steffens AB, Scheurink AJ. Excessive portal venous supply of long-chain free fatty acids to the liver, leading to hypothalamus-pituitary-adrenal-axis and sympathetic activation as a key to the development of syndrome X. A proposed concept for the induction of syndrome X. Ann N Y Acad Sci 1999;892:308-311.
35. Devchand PR, Ijpenberg A, Devesvergne B, Wahli W. PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics. Adv Exp Med Biol 1999;469:231-236.
36. Raspe E, Madsen L, Lefebvre AM, Leitersdorf I, Gelman L, Peinado-Onsurbe J, Dallongeville J, Fruchart JC, Berge R, Staels B. Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation. J Lipid Res 1999;40:2099-2110.
37. Djouadi F, Brandt JM, Weinheimer CJ, Leone TC, Gonzalez FJ, Kelly DP. The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostagland Leukot Essent Fatty Acids 1999;60:339-343.
38. Jump DB, Clarke SD. Regulation of gene expression by dietary fat. Annu Rev Nutr 1999;19:63-90.