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Volumn 41, Issue 4, 2011, Pages 292-320

Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis-Persistent pollutants affect programmed cell death

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Apoptosis; aryl hydrocarbon receptor; carcinogenesis; cell death; immune suppression; TCDD; thymic atrophy; tumor promotion

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 5 (2 BENZOTHIAZOLYL)THIOMETHYL 4 HYDROXY 3 METHOXYBENZYLIDENECYANOACETAMIDE; AROMATIC HYDROCARBON RECEPTOR; BLEOMYCIN; CGP 77675; CYCLOHEXIMIDE; DIETHYLNITROSAMINE; DIOXIN; EPIDERMAL GROWTH FACTOR; ETOPOSIDE; HYDROGEN PEROXIDE; IONOMYCIN; LEPTOMYCIN B; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N (2 FLUORENYL)ACETAMIDE; OCHRATOXIN; PARAQUAT; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; PROTEIN BAX; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; STAUROSPORINE; TACROLIMUS; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79953131106     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2010.524635     Document Type: Review
Times cited : (83)

References (233)
  • 1
    • 14044259245 scopus 로고    scopus 로고
    • Protein kinase Cθ activity is involved in the 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line
    • DOI 10.1111/j.1742-4658.2004.04519.x
    • Ahmed S, Shibazaki M, Takeuchi T, Kikuchi H. (2005). Protein kinase Cθ activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line. FEBS J 272:903-915. (Pubitemid 40278829)
    • (2005) FEBS Journal , vol.272 , Issue.4 , pp. 903-915
    • Ahmed, S.1    Shibazaki, M.2    Takeuchi, T.3    Kikuchi, H.4
  • 2
    • 70350125897 scopus 로고    scopus 로고
    • Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells
    • Al-Anati L, Högberg J, Stenius U. (2009). Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. Chem Biol Interact 182:191-198.
    • (2009) Chem Biol Interact , vol.182 , pp. 191-198
    • Al-Anati, L.1    Högberg, J.2    Stenius, U.3
  • 3
    • 0036952044 scopus 로고    scopus 로고
    • Protein kinase Cθ (PKCθ): A key enzyme in T cell life and death
    • Altman A, Villalba M. (2002). Protein kinase Cθ (PKCθ): A key enzyme in T cell life and death. J Biochem 132:841-846. (Pubitemid 36090648)
    • (2002) Journal of Biochemistry , vol.132 , Issue.6 , pp. 841-846
    • Altman, A.1    Villalba, M.2
  • 4
    • 77954061337 scopus 로고    scopus 로고
    • 2,3, 7,8-Tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by up-regulating expression of the metastasis marker AGR2 in the hepatocarcinoma cell line HepG2
    • Ambolet-Camoit A, Bui LC, Pierre S, Chevallier A, Marchand A, Coumoul X, Garlatti M, Andreau K, Barouki R, Aggerbeck M. (2010). 2,3,7,8- Tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by up-regulating expression of the metastasis marker AGR2 in the hepatocarcinoma cell line HepG2. Toxicol Sci 15:501-512.
    • (2010) Toxicol Sci , vol.15 , pp. 501-512
    • Ambolet-Camoit, A.1    Bui, L.C.2    Pierre, S.3    Chevallier, A.4    Marchand, A.5    Coumoul, X.6    Garlatti, M.7    Andreau, K.8    Barouki, R.9    Aggerbeck, M.10
  • 5
    • 44749085513 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis pathway in cancer
    • Ashkenazi A. (2008). Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev 19:325-331.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 325-331
    • Ashkenazi, A.1
  • 6
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. (1998). Death receptors: Signaling and modulation. Science 281:1305-1308. (Pubitemid 28406815)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 8
    • 19944393241 scopus 로고    scopus 로고
    • IGFBP-6 five years on; not so 'forgotten'?
    • DOI 10.1016/j.ghir.2005.04.001, PII S1096637405000419
    • Bach LA. (2005). IGFBP-6 fve years on; not so 'forgotten′? Growth Horm IGF Res 15:185-192. (Pubitemid 40754120)
    • (2005) Growth Hormone and IGF Research , vol.15 , Issue.3 , pp. 185-192
    • Bach, L.A.1
  • 10
    • 38349100451 scopus 로고    scopus 로고
    • Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling
    • Biswas G, Srinivasan S, Anandatheerthavarada HK, Avadhani NG. (2008). Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling. Proc Natl Acad Sci USA 105:186-191.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 186-191
    • Biswas, G.1    Srinivasan, S.2    Anandatheerthavarada, H.K.3    Avadhani, N.G.4
  • 12
    • 28244461490 scopus 로고    scopus 로고
    • Tetrachlorodibenzo-p-dioxin (TCDD) inhibits diferentiation and increases apoptotic cell death of precursor T cells in the fetal mouse thymus
    • Besteman EG, Zimmerman KL, Holladay SD. (2005). Tetrachlorodibenzo-p- dioxin (TCDD) inhibits diferentiation and increases apoptotic cell death of precursor T cells in the fetal mouse thymus. J Immunotoxicol 2:1-8.
    • (2005) J Immunotoxicol , vol.2 , pp. 1-8
    • Besteman, E.G.1    Zimmerman, K.L.2    Holladay, S.D.3
  • 13
    • 35348980112 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or diethylstilbestrol (DES) cause similar hematopoietic hypocellularity and hepatocellular changes in murine fetal liver, but differentially affect gene expression
    • DOI 10.1080/01926230701584155, PII 783022576
    • Besteman EG, Zimmerman KL, Huckle WR, Prater MR, Gogal RM Jr, Holladay SD. (2007). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or diethylstilbestrol (DES) cause similar hematopoietic hypocellularity and hepatocellular changes in murine fetal liver, but diferentially afect gene expression. Toxicol Pathol 35:786-792. (Pubitemid 47613612)
    • (2007) Toxicologic Pathology , vol.35 , Issue.6 , pp. 786-792
    • Besteman, E.G.1    Zimmerman, K.L.2    Huckle, W.R.3    Prater, M.R.4    Gogal, R.M.5    Holladay, S.D.6
  • 14
    • 72949115099 scopus 로고    scopus 로고
    • Te mammalian aryl hydrocarbon (Ah) receptor: From mediator of dioxin toxicity toward physiological function in skin and liver
    • Bock KW, Köhle C. (2009). Te mammalian aryl hydrocarbon (Ah) receptor: From mediator of dioxin toxicity toward physiological function in skin and liver. Biol Chem 390:1225-1235.
    • (2009) Biol Chem , vol.390 , pp. 1225-1235
    • Bock, K.W.1    Köhle, C.2
  • 15
    • 0034794931 scopus 로고    scopus 로고
    • Inhibition of apoptosis in rat hepatocytes treated with 'non-dioxin-like' polychlorinated biphenyls
    • Bohnenberger S, Wagner B, Schmitz H-J, Schrenk D. (2001). Inhibition of apoptosis in rat hepatocytes treated with 'non-dioxin-like′ polychlorinated biphenyls. Carcinogenesis 22:1601-1606. (Pubitemid 32952137)
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1601-1606
    • Bohnenberger, S.1    Wagner, B.2    Schmitz, H.-J.3    Schrenk, D.4
  • 18
    • 0035855307 scopus 로고    scopus 로고
    • Enhanced activation-induced cell death as a mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity in peripheral T cells
    • DOI 10.1016/S0300-483X(01)00391-2, PII S0300483X01003912
    • Camacho IA, Hassuneh MR, Nagarkatti M, Nagarkatti PS. (2001). Enhanced activation-induced cell death as a mechanism of 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD)-induced immunotoxicity in peripheral T cells. Toxicology 165:51-63. (Pubitemid 32718697)
    • (2001) Toxicology , vol.165 , Issue.1 , pp. 51-63
    • Camacho, I.A.1    Hassuneh, M.R.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 19
    • 0036387704 scopus 로고    scopus 로고
    • 2, 3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces Fas-dependent activation-induced cell death in superantigen-primed T cells
    • Camacho IA, Nagarkatti M, Nagarkatti PS. (2002). 2,3,7,8- Tetrachlorodibenzo-p-dioxin (TCDD) induces Fas-dependent activation-induced cell death in superantigen-primed T cells. Arch Toxicol 76:570-580.
    • (2002) Arch Toxicol , vol.76 , pp. 570-580
    • Camacho, I.A.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 20
    • 1542686218 scopus 로고    scopus 로고
    • Evidence for induction of apoptosis in T cells from murine fetal thymus following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • DOI 10.1093/toxsci/kfh048
    • Camacho IA, Nagarkatti M, Nagarkatti PS. (2004). Evidence for induction of apoptosis in T cells from murine fetal thymus following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 78:96-106. (Pubitemid 38351428)
    • (2004) Toxicological Sciences , vol.78 , Issue.1 , pp. 96-106
    • Camacho, I.A.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 21
    • 21244440594 scopus 로고    scopus 로고
    • Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-κB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells
    • Camacho IA, Singh N, Hegde VL, Nagarkatti M, Nagarkatti PS. (2005). Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-κB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. J Immunol 175:90-103. (Pubitemid 40884305)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 90-103
    • Camacho, I.A.1    Singh, N.2    Hegde, V.L.3    Nagarkatti, M.4    Nagarkatti, P.S.5
  • 22
    • 0031929073 scopus 로고    scopus 로고
    • Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity
    • DOI 10.1006/taap.1997.8309
    • Cantrell SM, Joy-Schlezinger J, Stegeman JJ, Tillitt DE, Hannink M. (1997). Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Toxicol Appl Pharmacol 148:24-34. (Pubitemid 28072772)
    • (1998) Toxicology and Applied Pharmacology , vol.148 , Issue.1 , pp. 24-34
    • Cantrell, S.M.1    Joy-Schlezinger, J.2    Stegeman, J.J.3    Tillitt, D.E.4    Hannink, M.5
  • 24
    • 77954071572 scopus 로고    scopus 로고
    • Endocrine disruptor, dioxin (TCDD)-induced mitochondrial dysfunction and apoptosis in human trophoblast-like JAR cells
    • Chen S-C, Liao T-L, Wei Y-H, Tzeng C-R, Kao S-H. (2010). Endocrine disruptor, dioxin (TCDD)-induced mitochondrial dysfunction and apoptosis in human trophoblast-like JAR cells. Mol Hum Reprod 16:361-372.
    • (2010) Mol Hum Reprod , vol.16 , pp. 361-372
    • Chen, S.-C.1    Liao, T.-L.2    Wei, Y.-H.3    Tzeng, C.-R.4    Kao, S.-H.5
  • 25
    • 49449091484 scopus 로고    scopus 로고
    • Leukotriene A4 metabolites are endogenous ligands for the Ah receptor
    • Chiaro CR, Morales JL, Prabhu KS, Perdew GH. (2008). Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry 47:8445-8455.
    • (2008) Biochemistry , vol.47 , pp. 8445-8455
    • Chiaro, C.R.1    Morales, J.L.2    Prabhu, K.S.3    Perdew, G.H.4
  • 26
    • 57349122123 scopus 로고    scopus 로고
    • 12(R)-Hydroxy-5(Z), 8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor
    • Chiaro CR, Patel RD, Perdew GH. (2008). 12(R)-Hydroxy-5(Z),8(Z),10(E), 14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol 74:1649-1656.
    • (2008) Mol Pharmacol , vol.74 , pp. 1649-1656
    • Chiaro, C.R.1    Patel, R.D.2    Perdew, G.H.3
  • 28
    • 69049085665 scopus 로고    scopus 로고
    • Inhibition of UV-C light-induced apoptosis in liver cells by 2, 3, 7,8-tetrachlorodibenzo-p-dioxin
    • Chopra M, Dharmarajan AM, Meiss G, Schrenk D. (2009). Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 111:49-63.
    • (2009) Toxicol Sci , vol.111 , pp. 49-63
    • Chopra, M.1    Dharmarajan, A.M.2    Meiss, G.3    Schrenk, D.4
  • 29
    • 77956264388 scopus 로고    scopus 로고
    • Inhibition of apoptosis by 2, 3, 7,8-tetrachlorodibenzo-p-dioxin depends on protein biosynthesis
    • Chopra M, Gährs M, Haben M, Michels C, Schrenk D. (2010). Inhibition of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin depends on protein biosynthesis. Cell Biol Toxicol 26:391-401.
    • (2010) Cell Biol Toxicol , vol.26 , pp. 391-401
    • Chopra, M.1    Gährs, M.2    Haben, M.3    Michels, C.4    Schrenk, D.5
  • 30
    • 0031695507 scopus 로고    scopus 로고
    • Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens
    • Christensen JG, Gonzales AJ, Cattley RC, Goldsworthy TL. (1998). Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens. Cell Growth Difer 9:815-825. (Pubitemid 28425878)
    • (1998) Cell Growth and Differentiation , vol.9 , Issue.9 , pp. 815-825
    • Christensen, J.G.1    Gonzales, A.J.2    Cattley, R.C.3    Goldsworthy, T.L.4
  • 31
    • 0842281645 scopus 로고    scopus 로고
    • Cell Death: Critical Control Points
    • DOI 10.1016/S0092-8674(04)00046-7
    • Danial NN, Korsmeyer SJ. (2004). Cell death: Critical control points. Cell 116:205-219. (Pubitemid 38167313)
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 32
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell- intrinsic death machinery
    • DOI 10.1016/S0092-8674(00)80405-5
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241. (Pubitemid 27456390)
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Xu, T.3    Masters, S.4    Haian, F.5    Gotoh, Y.6    Greenberg, M.E.7
  • 33
    • 0034062724 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits growth factor withdrawal-induced apoptosis in the human mammary epithelial cell line, MCF-10A
    • Davis JW II, Melendez K, Salas VM, Lauer FT, Burchiel SW. (2000). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits growth factor withdrawal-induced apoptosis in the human mammary epithelial cell line, MCF-10A. Carcinogenesis 21:881-886. (Pubitemid 30265129)
    • (2000) Carcinogenesis , vol.21 , Issue.5 , pp. 881-886
    • Davis II, J.W.1    Melendez, K.2    Salas, V.M.3    Lauer, F.T.4    Burchiel, S.W.5
  • 34
    • 0035870285 scopus 로고    scopus 로고
    • Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: Correlation with increased transforming growth factor α production
    • Davis JW II, Lauer FT, Burdick AD, Hudson LG, Burchiel SW. (2001). Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: Correlation with increased transforming growth factor α production. Cancer Res 61:3314-3320. (Pubitemid 32695019)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3314-3320
    • Davis II, J.W.1    Lauer, F.T.2    Burdick, A.D.3    Hudson, L.G.4    Burchiel, S.W.5
  • 35
    • 0037381221 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor antagonist, 3′methoxy- 4′nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line
    • DOI 10.1016/S0041-008X(03)00012-7
    • Davis JW Jr, Burdick AD, Lauer FT, Burchiel SW. (2003). Te aryl hydrocarbon receptor antagonist, 3′methoxy-4′nitrofavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line. Toxicol Appl Pharmacol 188:42-49. (Pubitemid 36369388)
    • (2003) Toxicology and Applied Pharmacology , vol.188 , Issue.1 , pp. 42-49
    • Davis II, J.W.1    Burdick, A.D.2    Lauer, F.T.3    Burchiel, S.W.4
  • 36
    • 0037079948 scopus 로고    scopus 로고
    • + T cells: The roles of apoptosis, Fas, and TNF
    • DOI 10.1016/S0300-483X(01)00542-X, PII S0300483X0100542X
    • Dearstyne EA, Kerkvliet NI. (2002). Mechanism of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4+ T cells: Te roles of apoptosis, Fas and TNF. Toxicology 170:139-151. (Pubitemid 34031872)
    • (2002) Toxicology , vol.170 , Issue.1-2 , pp. 139-151
    • Dearstyne, E.A.1    Kerkvliet, N.I.2
  • 38
    • 0038768712 scopus 로고    scopus 로고
    • Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals
    • DOI 10.1146/annurev.pharmtox.43.100901.135828
    • Denison MS, Nagy SR. (2003). Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-334. (Pubitemid 37372644)
    • (2003) Annual Review of Pharmacology and Toxicology , vol.43 , pp. 309-334
    • Denison, M.S.1    Nagy, S.R.2
  • 39
    • 0031564831 scopus 로고    scopus 로고
    • Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain
    • DOI 10.1016/S0304-3940(97)00445-X, PII S030439409700445X
    • de Torres C, Munell F, Ferrer I, Reventos J, Macaya A. (1997). Identifcation of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal brain. Neurosci Lett 230:1-4. (Pubitemid 27308517)
    • (1997) Neuroscience Letters , vol.230 , Issue.1 , pp. 1-4
    • De Torres, C.1    Munell, F.2    Ferrer, I.3    Reventos, J.4    Macaya, A.5
  • 40
    • 2342543626 scopus 로고    scopus 로고
    • Te use of body burdens vs. daily dose in comparisons of endo- and exodioxins and in assessing human health risks
    • DeVito M J, Birnbaum L S (1996). Te use of body burdens vs. daily dose in comparisons of endo- and exodioxins and in assessing human health risks. Organohal Comp 29:424-429.
    • (1996) Organohal Comp , vol.29 , pp. 424-429
    • Devito, M.J.1    Birnbaum, L.S.2
  • 41
    • 0026770124 scopus 로고
    • Alterations in the cortical thymic epithelium of rats after in vivo exposure to 2, 3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD): An (immuno)histological study
    • De Waal EJ, Schuurman H-J, Loeber JG, van Loveren H, Vos JG. (1992). Alterations in the cortical thymic epithelium of rats after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): An (immuno)histological study. Toxicol Appl Pharmacol 115:80-88.
    • (1992) Toxicol Appl Pharmacol , vol.115 , pp. 80-88
    • De Waal, E.J.1    Schuurman, H.-J.2    Loeber, J.G.3    Van Loveren, H.4    Vos, J.G.5
  • 42
    • 79551688725 scopus 로고    scopus 로고
    • Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of infammatory signaling
    • DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH. (2010). Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of infammatory signaling. Toxicol Sci 115: 89-97.
    • (2010) Toxicol Sci , vol.115 , pp. 89-97
    • Dinatale, B.C.1    Murray, I.A.2    Schroeder, J.C.3    Flaveny, C.A.4    Lahoti, T.S.5    Laurenzana, E.M.6    Omiecinski, C.J.7    Perdew, G.H.8
  • 43
    • 0037643646 scopus 로고    scopus 로고
    • Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • DOI 10.1016/S0045-6535(03)00112-7
    • Doi H, Baba T, Tohyama C, Nohara K. (2003). Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8- tetrachlorodibenhzo-p-dioxin. Chemosphere 52:655-662. (Pubitemid 36693171)
    • (2003) Chemosphere , vol.52 , Issue.4 , pp. 655-662
    • Doi, H.1    Baba, T.2    Tohyama, C.3    Nohara, K.4
  • 44
    • 0035843922 scopus 로고    scopus 로고
    • 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor
    • DOI 10.1016/S0304-3940(01)01743-8, PII S0304394001017438
    • Dong W, Teraoka H, Kondo S, Hiraga T. (2001). 2,3,7,8-Tetrachlorodibenzo- p-dioxin induces apoptosis in the dorsal midbrain of zebrafsh embryos by activation of arylhydrocarbon receptor. Neurosci Lett 303:169-172. (Pubitemid 32373282)
    • (2001) Neuroscience Letters , vol.303 , Issue.3 , pp. 169-172
    • Dong, W.1    Teraoka, H.2    Kondo, S.3    Hiraga, T.4
  • 45
    • 0030760670 scopus 로고    scopus 로고
    • Apoptosis and the immune system
    • Ekert PG, Vaux DL. (1997). Apoptosis and the immune system. Br Med Bull 53:591-603. (Pubitemid 27397312)
    • (1997) British Medical Bulletin , vol.53 , Issue.3 , pp. 591-603
    • Ekert, P.G.1    Vaux, D.L.2
  • 48
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A Review of Programmed Cell Death
    • DOI 10.1080/01926230701320337, PII 779478428
    • Elmore S. (2007). Apoptosis: A review of programmed cell death. Toxicol Pathol 35:495-516. (Pubitemid 46911891)
    • (2007) Toxicologic Pathology , vol.35 , Issue.4 , pp. 495-516
    • Elmore, S.1
  • 49
    • 0030598390 scopus 로고    scopus 로고
    • Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway
    • DOI 10.1016/S0006-2952(96)00566-7, PII S0006295296005667
    • Enan E, Matsumura F. (1996). Identifcation of c-src as the integral component of the Ah receptor complex, trasnducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Biochem Pharmacol 52:1599-612. (Pubitemid 26375466)
    • (1996) Biochemical Pharmacology , vol.52 , Issue.10 , pp. 1599-1612
    • Enan, E.1    Matsumura, F.2
  • 50
    • 0032135556 scopus 로고    scopus 로고
    • Alterations in the Growth Factor Signal Transduction Pathways and Modulators of the Cell Cycle in Endocervical Cells from Macaques Exposed to TCDD
    • Enan E, El-Sabeawy F, Scott M, Overstreet J, Lasley B. (1998). Alterations in the growth factor signaling transduction pathways and modulators of the cell cycle in endocervical cells from macaques exposed to TCDD. Toxicol Appl Pharmacol 151:283-293. (Pubitemid 128421792)
    • (1998) Toxicology and Applied Pharmacology , vol.151 , Issue.2 , pp. 283-293
    • Enan, E.1    El-Sabeawy, F.2    Scott, M.3    Overstreet, J.4    Lasley, B.5
  • 52
    • 59149086780 scopus 로고    scopus 로고
    • Te immune phenotype of AhR null mouse mutants: Not a simple mirror of xenobiotic over-activation
    • Esser C. (2009). Te immune phenotype of AhR null mouse mutants: Not a simple mirror of xenobiotic over-activation. Biochem Pharmacol 77:597-607.
    • (2009) Biochem Pharmacol , vol.77 , pp. 597-607
    • Esser, C.1
  • 54
    • 0242432345 scopus 로고    scopus 로고
    • Many cuts to ruin: A comprehensive update of caspase substrates
    • DOI 10.1038/sj.cdd.4401160
    • Fischer U, Jänicke RU, Schulze-Osthof. (2003). Many cuts to ruin: A comprehensive update of caspase substrates. Cell Death Difer 10:76-100. (Pubitemid 36511834)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.1 , pp. 76-100
    • Fischer, U.1    Janicke, R.U.2    Schulze-Osthoff, K.3
  • 55
    • 1542476894 scopus 로고    scopus 로고
    • Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity
    • DOI 10.1093/toxsci/kfh058
    • Fisher MT, Nagarkatti M, Nagarkatti PS. (2004). Combined screening of thymocytes using apoptosis-specifc cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Toxicol Sci 78:116-124. (Pubitemid 38351430)
    • (2004) Toxicological Sciences , vol.78 , Issue.1 , pp. 116-124
    • Fisher, M.T.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 56
    • 17044413623 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-dependent induction of loss of mitochondrial membrane potential in epididydimal spermatozoa by 2, 3, 7,8-tetrachlorodibenzo- p-dioxin (TCDD)
    • Fisher MT, Nagarkatti M, Nagarkatti PS. (2005). Aryl hydrocarbon receptor-dependent induction of loss of mitochondrial membrane potential in epididydimal spermatozoa by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Lett 157:99-107.
    • (2005) Toxicol Lett , vol.157 , pp. 99-107
    • Fisher, M.T.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 57
    • 11244331752 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances negative selection of T cells in the thymus but allows autoreactive T cells to escape deletion and migrate to the periphery
    • DOI 10.1124/mol.104.005868
    • Fisher MT, Nagarkatti M, Nagarkatti PS. (2005). 2,3,7,8- Tetrachlorodibenzo-p-dioxin enhances negative selection of T cells in the thymus but allows autoreactive T cells to escape deletion and migrate to the periphery. Mol Pharmacol 67:327-335. (Pubitemid 40069994)
    • (2005) Molecular Pharmacology , vol.67 , Issue.1 , pp. 327-335
    • Fisher, M.T.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 58
    • 23044461801 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: A microarray study
    • DOI 10.1016/j.taap.2004.12.003, PII S0041008X04005563
    • Fletcher N, Wahlström D, Lundberg R, Nilsson CB, Nilsson KC, Stockling K, Hellmold H, Hakansson H. (2005). 2,3,7,8-Tetrachlorodibenzo-p- dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: A microarray study. Toxicol Appl Pharmacol 207:1-24. (Pubitemid 41073756)
    • (2005) Toxicology and Applied Pharmacology , vol.207 , Issue.1 , pp. 1-24
    • Fletcher, N.1    Wahlstrom, D.2    Lundberg, R.3    Nilsson, C.B.4    Nilsson, K.C.5    Stockling, K.6    Hellmold, H.7    Hakansson, H.8
  • 59
    • 23844514818 scopus 로고    scopus 로고
    • Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315
    • DOI 10.1038/sj.emboj.7600735
    • Fogal V, Hsieh J-K, Royer C, Zhong S, Lu X. (2005). Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at ser315. EMBO J 24:2768-2782. (Pubitemid 41170026)
    • (2005) EMBO Journal , vol.24 , Issue.15 , pp. 2768-2782
    • Fogal, V.1    Hsieh, J.-K.2    Royer, C.3    Zhong, S.4    Lu, X.5
  • 60
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • DOI 10.1056/NEJMra022366
    • Friedlander RM. (2003). Apoptosis and caspases in neurodegenerative diseases. New Engl J Med 348:1365-1375. (Pubitemid 36384105)
    • (2003) New England Journal of Medicine , vol.348 , Issue.14 , pp. 1365-1375
    • Friedlander, R.M.1
  • 61
    • 1542353401 scopus 로고    scopus 로고
    • Control of apoptosis by p53
    • DOI 10.1038/sj.onc.1207116, Apoptosis - Part 2
    • Friedman JS, Lowe SW. (2003). Control of apoptosis by p53. Oncogene 22:9030-9040. (Pubitemid 38121703)
    • (2003) Oncogene , vol.22 , Issue.REV. ISS. 8 , pp. 9030-9040
    • Fridman, J.S.1    Lowe, S.W.2
  • 62
    • 0035816183 scopus 로고    scopus 로고
    • Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression
    • DOI 10.1016/S0378-4274(01)00364-2, PII S0378427401003642
    • Frueh FW, Hayashibara KC, Brown PO, Whitlock JP Jr. (2001). Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression. Toxicol Lett 122:189-203. (Pubitemid 32727282)
    • (2001) Toxicology Letters , vol.122 , Issue.3 , pp. 189-203
    • Frueh, F.W.1    Hayashibara, K.C.2    Brown, P.O.3    Whitlock Jr., J.P.4
  • 63
    • 77952569598 scopus 로고    scopus 로고
    • Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli
    • Fujii-Kuriyama Y, Kawajiri K. (2010). Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli. Proc Jpn Acad Ser B Phys Biol Sci 86:40-53.
    • (2010) Proc Jpn Acad ser B Phys Biol Sci , vol.86 , pp. 40-53
    • Fujii-Kuriyama, Y.1    Kawajiri, K.2
  • 65
    • 25444526629 scopus 로고    scopus 로고
    • + cells with characteristics of regulatory T cells
    • Funutake CJ, Marshall NB, Steppan LB, Mourich DV, Kerkvliet NI. (2005). Cutting Edge: Activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells. J Immunol 175:4184-4188. (Pubitemid 41361950)
    • (2005) Journal of Immunology , vol.175 , Issue.7 , pp. 4184-4188
    • Funatake, C.J.1    Marshall, N.B.2    Steppan, L.B.3    Mourich, D.V.4    Kerkvliet, N.I.5
  • 66
    • 0026496895 scopus 로고
    • 2, 3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcritpzional and post-transcriptional control
    • Gaido KW, Maness SC, Leonard LS, Greenlee WF. (1992). 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcritpzional and post-transcriptional control. J Biol Chem 267:24591-24595.
    • (1992) J Biol Chem , vol.267 , pp. 24591-24595
    • Gaido, K.W.1    Maness, S.C.2    Leonard, L.S.3    Greenlee, W.F.4
  • 67
    • 77950630137 scopus 로고    scopus 로고
    • Te aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: Implications for benzene-induced hematopoietic toxicity
    • Gasiewicz TA, Singh KP, Casado FL. (2010). Te aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: Implications for benzene-induced hematopoietic toxicity. Chem Biol Interact 184:246-251.
    • (2010) Chem Biol Interact , vol.184 , pp. 246-251
    • Gasiewicz, T.A.1    Singh, K.P.2    Casado, F.L.3
  • 68
    • 65249131750 scopus 로고    scopus 로고
    • Perinatal TCDD exposure and the adult onset of autoimmune disease
    • Gogal RM Jr, Holladay SD. (2008). Perinatal TCDD exposure and the adult onset of autoimmune disease. J Immunotoxicol 5:413-418.
    • (2008) J Immunotoxicol , vol.5 , pp. 413-418
    • Gogal Jr., R.M.1    Holladay, S.D.2
  • 69
    • 0032447116 scopus 로고    scopus 로고
    • Te aryl hydrocarbon receptor: Studies using AHR-null mice
    • Gonzalez FJ, Fernandez-Salguero P. (1998). Te aryl hydrocarbon receptor: Studies using AHR-null mice. Drug Metab Dispos 26:1194-1198.
    • (1998) Drug Metab Dispos , vol.26 , pp. 1194-1198
    • Gonzalez, F.J.1    Fernandez-Salguero, P.2
  • 70
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. (1998). Mitochondria and apoptosis. Science 281:1309-1312. (Pubitemid 28406816)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 71
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • Guengerich FP. (2001). Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 14:611-650. (Pubitemid 32565712)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.6 , pp. 611-650
    • Guengerich, F.P.1
  • 72
  • 73
    • 0033942431 scopus 로고    scopus 로고
    • Te morphology of apoptosis
    • Häcker G. (2000). Te morphology of apoptosis. Cell Tissue Res 301:5-17.
    • (2000) Cell Tissue Res , vol.301 , pp. 5-17
    • Häcker, G.1
  • 74
    • 79953132435 scopus 로고    scopus 로고
    • Te hallmarks of cancer
    • Hannan D, Weinberg RA. (2000). Te hallmarks of cancer. Cell 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hannan, D.1    Weinberg, R.A.2
  • 75
    • 60549084518 scopus 로고    scopus 로고
    • A preliminary operational classifcation system for nonmutagenic modes of action for carcinogens
    • Hattis D, Chu M, Rahmioglu N, Goble R, Verma P, Hartman K, Kozlak M. (2009). A preliminary operational classifcation system for nonmutagenic modes of action for carcinogens. Crit Rev Toxicol 39:97-138.
    • (2009) Crit Rev Toxicol , vol.39 , pp. 97-138
    • Hattis, D.1    Chu, M.2    Rahmioglu, N.3    Goble, R.4    Verma, P.5    Hartman, K.6    Kozlak, M.7
  • 77
    • 0031987276 scopus 로고    scopus 로고
    • Modulation of ovarian follicle maturation and effects on apoptotic cell death in holtzman rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally
    • DOI 10.1016/S0890-6238(97)00101-9, PII S0890623897001019
    • Heimler I, Trewin AL, Chafn CL, Rawlins RG, Hutz RJ. (1998a). Modulation of ovarian follicle maturation and efects on apoptotic cell death in Holtzman rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally. Reprod Toxicol 12:69-73. (Pubitemid 29108287)
    • (1998) Reproductive Toxicology , vol.12 , Issue.1 , pp. 69-73
    • Heimler, I.1    Trewin, A.L.2    Chaffin, C.L.3    Rawlins, R.G.4    Hutz, R.J.5
  • 78
    • 0031733942 scopus 로고    scopus 로고
    • Dioxin perturbs, in a dose- and time-dependent fashion, steroid secretion, and induces apoptosis of human luteinized granulosa cells
    • Heimler I, Rawlins RG, Owen H, Hutz RJ. (1998b). Dioxin pertubates, in a dose- and time-dependent fashion, steroid sectretion, and induces apoptosis of human luteinized granulosa cells. Endocrinology 139:4373-4379. (Pubitemid 28513727)
    • (1998) Endocrinology , vol.139 , Issue.10 , pp. 4373-4379
    • Heimler, I.1    Rawlins, R.G.2    Owen, H.3    Hutz, R.J.4
  • 79
    • 77951528539 scopus 로고    scopus 로고
    • TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fbroblasts
    • Henry EC, Welle SL, Gasiewicz TA. (2010). TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fbroblasts. Toxicol Sci 114:90-100.
    • (2010) Toxicol Sci , vol.114 , pp. 90-100
    • Henry, E.C.1    Welle, S.L.2    Gasiewicz, T.A.3
  • 80
    • 38249024778 scopus 로고
    • Analysis of 2, 3, 7,8-TCDD tumor promotion activity and its relationship to cancer
    • Holder JW, Menzel HM. (1989). Analysis of 2,3,7,8-TCDD tumor promotion activity and its relationship to cancer. Chemosphere 19:861-868.
    • (1989) Chemosphere , vol.19 , pp. 861-868
    • Holder, J.W.1    Menzel, H.M.2
  • 84
    • 12344269060 scopus 로고    scopus 로고
    • Cell death induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in AtT-20 pituitary cells
    • DOI 10.1016/j.tox.2004.10.013, PII S0300483X0400592X
    • Huang P, Tofghi R, Emgard M, Ceccatelli S. (2005). Cell death induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) in AtT-20 pituitary cells. Toxicology 207:391-399. (Pubitemid 40138936)
    • (2005) Toxicology , vol.207 , Issue.3 , pp. 391-399
    • Huang, P.1    Tofighi, R.2    Emgard, M.3    Ceccatelli, S.4
  • 85
    • 0003555535 scopus 로고    scopus 로고
    • International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans Lyon: International Agency for Research on Cancer
    • International Agency for Research on Cancer. (1997). Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans. Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 69. Lyon: International Agency for Research on Cancer.
    • (1997) Polychlorinated Dibenzo-para-dioxins and Polychlorinated Dibenzofurans , vol.69
  • 86
    • 0037063385 scopus 로고    scopus 로고
    • Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems
    • DOI 10.1021/jf020415z
    • Inouye K, Shinkyo R, Takita T, Ohta M, Sakaki T. (2002). Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems. J Agric Food Chem 50:5496-5502. (Pubitemid 35001317)
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , Issue.19 , pp. 5496-5502
    • Inouye, K.1    Shinkyo, R.2    Takita, T.3    Ohta, M.4    Sakaki, T.5
  • 87
    • 77649190726 scopus 로고    scopus 로고
    • Neonatal exposure to low-dose 2, 3, 7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tomerance
    • Ishimaru N, Takagi A, Kohashi M, Yamada A, Arakaki R, Kanno J, Hayashi Y. (2009). Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tomerance. J Immunol 182:6576-6586.
    • (2009) J Immunol , vol.182 , pp. 6576-6586
    • Ishimaru, N.1    Takagi, A.2    Kohashi, M.3    Yamada, A.4    Arakaki, R.5    Kanno, J.6    Hayashi, Y.7
  • 89
    • 39349091818 scopus 로고    scopus 로고
    • Molecular mechanisms of cytochrome P450 induction: Potential for drug-drug interactions
    • DOI 10.2174/138920307783018668
    • Jana S, Paliwal J. (2007). Molecular mechanisms of cytochrome p450 induction: Potential for drug-drug interactions. Curr Protein Pept Sci 8:619-628. (Pubitemid 351266993)
    • (2007) Current Protein and Peptide Science , vol.8 , Issue.6 , pp. 619-628
    • Jana, S.1    Paliwal, J.2
  • 90
    • 79551687759 scopus 로고    scopus 로고
    • Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identifcation
    • Jennen DGJ, Magkoufopoulou C, Ketelsleger HB, van Herwijnen MHM, Kleinjans JCS, van Delft JHM. (2010). Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identifcation. Toxicol Sci 115:66-79.
    • (2010) Toxicol Sci , vol.115 , pp. 66-79
    • Dgj, J.1    Magkoufopoulou, C.2    Ketelsleger, H.B.3    Van Herwijnen Mhm4    Jcs, K.5    Van Delft Jhm6
  • 91
    • 0023735164 scopus 로고
    • Immunological abnormalities 17 years after accidental exposure to 2, 3, 7,8-tetrachlorodibenzo-p-dioxin
    • Jennings AM, Wild G, Ward JD, Ward AM. (1988). Immunological abnormalities 17 years after accidental exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin. Br J Ind Med 45:701-704.
    • (1988) Br J Ind Med , vol.45 , pp. 701-704
    • Jennings, A.M.1    Wild, G.2    Ward, J.D.3    Ward, A.M.4
  • 92
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin Z, El-Deiry WS. (2005). Overview of cell death signaling pathways. Cancer Biol Ter 4:139-163. (Pubitemid 41351311)
    • (2005) Cancer Biology and Therapy , vol.4 , Issue.2 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 93
  • 94
    • 0031062290 scopus 로고    scopus 로고
    • Evidence for the induction of apoptosis in thymocytes by 2,3,7,8- tetrachlorodibenzo-p-dioxin in vivo
    • DOI 10.1006/taap.1996.8049
    • Kamath AB, Xu H, Nagarkatti PS, Nagarkatti M. (1997). Evidence fort he induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo. Toxicol Appl Pharmacol 142:367-377. (Pubitemid 28381028)
    • (1997) Toxicology and Applied Pharmacology , vol.142 , Issue.2 , pp. 367-377
    • Kamath, A.B.1    Xu, H.2    Nagarkatti, P.S.3    Nagarkatti, M.4
  • 95
    • 0031808405 scopus 로고    scopus 로고
    • Characterization of phenotypic alterations induced by 2,3,7,8- tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis
    • DOI 10.1006/taap.1998.8390
    • Kamath AB, Nagarkatti PS, Nagarkatti M. (1998). Characterization of phenytipic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its efect on apoptosis. Toxicol Appl Pharmacol 150:117-124. (Pubitemid 28288426)
    • (1998) Toxicology and Applied Pharmacology , vol.150 , Issue.1 , pp. 117-124
    • Kamath, A.B.1    Nagarkatti, P.S.2    Nagarkatti, M.3
  • 96
    • 0032725896 scopus 로고    scopus 로고
    • Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD)-induced immunotoxicity: Increased resistance of thymocytes from Fas-deficient (lpr) and fas ligand-defective (gld) mice to TCDD-induced toxicity
    • DOI 10.1006/taap.1999.8753
    • Kamath AB, Camacho I, Nagarkatti PS, Nagarkatti M. (1999). Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity: Increased resistance of thymocytes from Fas-defcient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicity. Toxicol Appl Pharmacol 160:141-155. (Pubitemid 29498398)
    • (1999) Toxicology and Applied Pharmacology , vol.160 , Issue.2 , pp. 141-155
    • Kamath, A.B.1    Camacho, I.2    Nagarkatti, P.S.3    Nagarkatti, M.4
  • 97
    • 34547681417 scopus 로고    scopus 로고
    • Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor
    • DOI 10.1016/j.abb.2007.03.038, PII S0003986107001658
    • Kawajiri K, Fujii-Kuriyama Y. (2007). Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor. Arch Biochem Biophys 464:207-212. (Pubitemid 47210921)
    • (2007) Archives of Biochemistry and Biophysics , vol.464 , Issue.2 , pp. 207-212
    • Kawajiri, K.1    Fujii-Kuriyama, Y.2
  • 99
    • 0029549649 scopus 로고
    • Immunological efects of chlorinated dibenzo-p-dioxins
    • Kerkvliet NI. (1995). Immunological efects of chlorinated dibenzo-p-dioxins. Environ Health Perpect 103(Suppl 9):47-53.
    • (1995) Environ Health Perpect , vol.103 , Issue.SUPPL. 9 , pp. 47-53
    • Kerkvliet, N.I.1
  • 100
    • 0036147662 scopus 로고    scopus 로고
    • Recent advances in understanding the mechanisms of TCDD immunotoxicity
    • DOI 10.1016/S1567-5769(01)00179-5, PII S1567576901001795
    • Kerkvliet NI. (2002). Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int Immunopharmacol 2:277-291. (Pubitemid 34075417)
    • (2002) International Immunopharmacology , vol.2 , Issue.2-3 , pp. 277-291
    • Kerkvliet, N.I.1
  • 101
    • 59149104736 scopus 로고    scopus 로고
    • AHR-mediated immunomodulation: Te role of altered gene transcription
    • Kerkvliet NI. (2009). AHR-mediated immunomodulation: Te role of altered gene transcription. Biochem Pharmacol 77:746-760.
    • (2009) Biochem Pharmacol , vol.77 , pp. 746-760
    • Kerkvliet, N.I.1
  • 102
    • 0015383455 scopus 로고
    • Apoptosis: Abasic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. (1972). Apoptosis: Abasic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 103
  • 104
    • 0035040499 scopus 로고    scopus 로고
    • Method for evaluation of immunotoxicity of dioxin compounds using human T-lymphoblastic cell line, L-MAT
    • DOI 10.1016/S0045-6535(00)00438-0, PII S0045653500004380
    • Kikuchi H, Shibazaki M, Ahmed S, Baba T. (2001). Method for evaluation of immunotoxicity of dioxin compounds using human T-lymphoblastic cell line, L-MAT. Chemosphere 43:815-818. (Pubitemid 32405534)
    • (2001) Chemosphere , vol.43 , Issue.4-7 , pp. 815-818
    • Kikuchi, H.1    Shibazaki, M.2    Ahmed, S.3    Baba, T.4
  • 105
    • 0028911483 scopus 로고
    • Upregulation of surface markers on dying thymocytes
    • Kishimoto H, Surh CD, Sprent J. (1995). Upregulation of surface markers on dying thymocytes. J Exp Med 181:649-655.
    • (1995) J Exp Med , vol.181 , pp. 649-655
    • Kishimoto, H.1    Surh, C.D.2    Sprent, J.3
  • 106
    • 33750297793 scopus 로고    scopus 로고
    • Carcinogenicityof 2, 3, 7,8-tetrachlorodibenzo-p-dioxin in experimental models
    • Knerr S, Schrenk D. (2006). Carcinogenicityof 2,3,7,8-tetrachlorodibenzo- p-dioxin in experimental models. Mol Nutr Food Res 50:897-907.
    • (2006) Mol Nutr Food Res , vol.50 , pp. 897-907
    • Knerr, S.1    Schrenk, D.2
  • 107
    • 60249089186 scopus 로고    scopus 로고
    • Calcium/ calmodulin signaling elicits release of cytochrome c during 2, 3, 7,8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line, L-MAT
    • Kobayashi D, Ahmed S, Ishida M, Kasai S, Kikuchi H. (2009). Calcium/ calmodulin signaling elicits release of cytochrome c during 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line, L-MAT. Toxicology 258:25-32.
    • (2009) Toxicology , vol.258 , pp. 25-32
    • Kobayashi, D.1    Ahmed, S.2    Ishida, M.3    Kasai, S.4    Kikuchi, H.5
  • 108
    • 0018074887 scopus 로고
    • Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
    • Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Wade CE, Dittenber DA, Kalnins RP, Frauson LE, Park CN, Barnard SD, Hummel RA, Humiston CG. (1978). Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8- tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 46:279-303. (Pubitemid 9077600)
    • (1978) Toxicology and Applied Pharmacology , vol.46 , Issue.2 , pp. 279-303
    • Kociba, R.J.1    Keyes, D.G.2    Beyer, J.E.3
  • 110
    • 0242320388 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)-Induced Activation of Mitogen-Activated Protein Kinase Signaling Pathway in Jurkat T Cells
    • DOI 10.1034/j.1600-0773.2003.930406.x
    • Kwon M-J, Jeong K-S, Choi EJ, Lee BH. (2003). 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD)-induced activation of mitogen-activated protein kinase signaling pathway in Jurkat T cells. Pharmacol Toxicol 93:186-190. (Pubitemid 37346658)
    • (2003) Pharmacology and Toxicology , vol.93 , Issue.4 , pp. 186-190
    • Kwon, M.-J.1    Jeong, K.-S.2    Choi, E.J.3    Lee, B.H.4
  • 111
    • 0031691686 scopus 로고    scopus 로고
    • Ahr null alleles: Distinctive or different?
    • DOI 10.1016/S0006-2952(98)00134-8, PII S0006295298001348
    • Lahvis GP, Bradfeld CA. (1998). Ahr null alleles: Distinctive or diferent. Biochem Pharmacol 56:781-787. (Pubitemid 28458971)
    • (1998) Biochemical Pharmacology , vol.56 , Issue.7 , pp. 781-787
    • Lahvis, G.P.1    Bradfield, C.A.2
  • 112
    • 0034306058 scopus 로고    scopus 로고
    • Diferential efects of diethylstilbestrol and 2, 3, 7,8- tetrachlorodibenzo-p-dioxin on thymocyte diferentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture
    • Lai Z-W, Fiore NC, Hahn PJ, Gasiewicz TA, Silverstone AE. (2000). Diferential efects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte diferentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicol Appl Pharmacol 168:15-24.
    • (2000) Toxicol Appl Pharmacol , vol.168 , pp. 15-24
    • Lai, Z.-W.1    Fiore, N.C.2    Hahn, P.J.3    Gasiewicz, T.A.4    Silverstone, A.E.5
  • 113
    • 0030296824 scopus 로고    scopus 로고
    • 2,3,7,8-TCDD induces cytochrome P450 enzyme activity but not proliferation or phenotypical changes in human peripheral blood lymphocytes
    • DOI 10.1016/0378-4274(96)03756-3
    • Lang DS, Becker S, Devlin RB, Koren HS. (1996). 2,3,7,8-TCDD induces cytochrome P450 enzyme activity but not proliferation or phenotypical changes in human peripheral blood lymphocytes. Toxicol Lett 88:317-325. (Pubitemid 26361286)
    • (1996) Toxicology Letters , vol.88 , Issue.1-3 , pp. 317-325
    • Lang, D.S.1    Becker, S.2    Devlin, R.B.3    Koren, H.S.4
  • 114
    • 0030175773 scopus 로고    scopus 로고
    • Distribution and behavior of the Ah receptor in murine T lymphocytes
    • DOI 10.1006/taap.1996.0126
    • Lawrence BP, Leid M, Kerkvliet NI. (1996). Distribution and behaviour of the Ah receptor in murine T lymphocytes. Toxicol Appl Pharmacol 138:275-284. (Pubitemid 26227599)
    • (1996) Toxicology and Applied Pharmacology , vol.138 , Issue.2 , pp. 275-284
    • Lawrence, B.P.1    Leid, M.2    Kerkvliet, N.I.3
  • 115
    • 36849074245 scopus 로고    scopus 로고
    • Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria
    • DOI 10.1101/gad.1567107
    • Leu JI, George DL. (2007). Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev 21:3095-3109. (Pubitemid 350223527)
    • (2007) Genes and Development , vol.21 , Issue.23 , pp. 3095-3109
    • Leu, J.I.-J.1    George, D.L.2
  • 117
    • 0035449669 scopus 로고    scopus 로고
    • Treatment of normal human keratinocytes with 2,3,7,8-tetrachlorodibenzo- p-dioxin causes a reduction in cell number, but no increase in apoptosis
    • DOI 10.1006/taap.2001.9201
    • Loertscher JA, Sadek CS, Allen-Hofmann BL. (2001a). Treatment of normal human keratinocytes with 2,3,7,8-tetrachlorodibenzo-p-dioxin causes a reduction in cell number, but no increase in apoptosis. Toxicol Appl Pharmacol 175:114-120. (Pubitemid 32848502)
    • (2001) Toxicology and Applied Pharmacology , vol.175 , Issue.2 , pp. 114-120
    • Loertscher, J.A.1    Sadek, C.S.2    Allen-Hoffmann, B.L.3
  • 118
    • 0035449670 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture
    • DOI 10.1006/taap.2001.9202
    • Loertscher JA, Sattler CA, Allen-Hofmann BL. (2001b). 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the diferentiation pattern of human keratinocytes in organotypic culture. Toxicol Appl Pharmacol 175:121-129. (Pubitemid 32848503)
    • (2001) Toxicology and Applied Pharmacology , vol.175 , Issue.2 , pp. 121-129
    • Loertscher, J.A.1    Sattler, C.A.2    Allen-Hoffmann, B.L.3
  • 119
    • 0142179992 scopus 로고    scopus 로고
    • Cell Proliferation Arrest within Intrathymic Lymphocyte Progenitor Cells Causes Thymic Atrophy Mediated by the Aryl Hydrocarbon Receptor
    • Laiosa MD, Wyman A, Murante FG, Fiore NC, Staples JE, Gasiewicz TA, Silverstone AE. (2003). Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor. J Immunol 171:4582-4591. (Pubitemid 37310574)
    • (2003) Journal of Immunology , vol.171 , Issue.9 , pp. 4582-4591
    • Laiosa, M.D.1    Wyman, A.2    Murante, F.G.3    Fiore, N.C.4    Staples, J.E.5    Gasiewicz, T.A.6    Silverstone, A.E.7
  • 120
    • 0034057320 scopus 로고    scopus 로고
    • Apoptosis in cancer
    • Lowe SW, Lin AW. (2000). Apoptosis in cancer. Carcinogenesis 21:485-495. (Pubitemid 30137934)
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 485-495
    • Lowe, S.W.1    Lin, A.W.2
  • 121
  • 122
  • 123
    • 13444263972 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin
    • DOI 10.1124/mol.104.004010
    • Marchand A, Tomkiewicz C, Marchandeau J-P, Boitier E, Barouki R, Garlatti M. (2005). 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative efect of insulin. Mol Pharmacol 67:444-452. (Pubitemid 40216737)
    • (2005) Molecular Pharmacology , vol.67 , Issue.2 , pp. 444-452
    • Marchand, A.1    Tomkiewicz, C.2    Marchandeau, J.-P.3    Boitier, E.4    Barouki, R.5    Garlatti, M.6
  • 124
  • 125
    • 0028890119 scopus 로고
    • Apoptosis and cancer: Te failure of controls on cell death and cell survival
    • Martin SJ, Green DR. (1995). Apoptosis and cancer: Te failure of controls on cell death and cell survival. Crit Rev Oncol Hematol 18:137-153.
    • (1995) Crit Rev Oncol Hematol , vol.18 , pp. 137-153
    • Martin, S.J.1    Green, D.R.2
  • 126
    • 59149097955 scopus 로고    scopus 로고
    • AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration
    • Mathew LK, Simonrich MT, Tanguay RL. (2009). AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochem Pharmacol 77:498-507.
    • (2009) Biochem Pharmacol , vol.77 , pp. 498-507
    • Mathew, L.K.1    Simonrich, M.T.2    Tanguay, R.L.3
  • 127
    • 59149105386 scopus 로고    scopus 로고
    • Te signifcance of the nongenomic pathway in mediating infammatory signaling of the dioxin-activated Ah receptor to cause toxic efects
    • Matsumura F. (2009). Te signifcance of the nongenomic pathway in mediating infammatory signaling of the dioxin-activated Ah receptor to cause toxic efects. Biochem Pharmacol 77:608-626.
    • (2009) Biochem Pharmacol , vol.77 , pp. 608-626
    • Matsumura, F.1
  • 128
    • 0034994890 scopus 로고    scopus 로고
    • Effects of dioxin, an environmental pollutant, on mouse blastocyst development and apoptosis
    • DOI 10.1016/S0015-0282(01)01802-7, PII S0015028201018027
    • Matthews M, Heimler I, Fahy M, Radwanska E, Hutz R, Trewin A, Rawlins R. (2001). Efects of dioxin, an environmental pollutant, on mouse blastocyst development and apoptosis. Fertil Steril 75:1159-1162. (Pubitemid 32522614)
    • (2001) Fertility and Sterility , vol.75 , Issue.6 , pp. 1159-1162
    • Matthews, M.1    Heimler, I.2    Fahy, M.3    Radwanska, E.4    Hutz, R.5    Trewin, A.6    Rawlins, R.7
  • 129
  • 130
    • 0031860431 scopus 로고    scopus 로고
    • An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis
    • McGregor DB, Partensky C, Wilbourn J, Rice JM. (1998). An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis. Environ Health Perspect 106(Suppl 2):755-760. (Pubitemid 28256787)
    • (1998) Environmental Health Perspectives , vol.106 , Issue.SUPPL. 2 , pp. 755-760
    • McGregor, D.B.1    Partensky, C.2    Wilbourn, J.3    Rice, J.M.4
  • 131
    • 0024286320 scopus 로고
    • 2, 3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation
    • McConkey DJ, Hartzell P, Duddy SK, Hakansson H, Orrenius S. (1988). 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. Science 242:256-259.
    • (1988) Science , vol.242 , pp. 256-259
    • McConkey, D.J.1    Hartzell, P.2    Duddy, S.K.3    Hakansson, H.4    Orrenius, S.5
  • 132
    • 0032104245 scopus 로고    scopus 로고
    • Te extended protein kinase C superfamily
    • Mellor H, Parker PJ. (1998). Te extended protein kinase C superfamily. Biochem J 332:281-292.
    • (1998) Biochem J , vol.332 , pp. 281-292
    • Mellor, H.1    Parker, P.J.2
  • 133
    • 0033152570 scopus 로고    scopus 로고
    • Serum dioxin and immunologic response in veterans of Operation Ranch Hand
    • Michalek JE, Ketchum NS, Check IJ. (1999). Serum dioxin and immunologic response in veterans of operation ranch hand. Am J Epidemiol 149:1038-1046. (Pubitemid 29246869)
    • (1999) American Journal of Epidemiology , vol.149 , Issue.11 , pp. 1038-1046
    • Michalek, J.E.1    Ketchum, N.S.2    Check, I.J.3
  • 134
    • 55949084342 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor
    • Minami K, Nakajima M, Fujiki Y, Katoh M, Gonzales FJ, Yokoi T. (2008). Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor. J Toxicol Sci 33:405-413.
    • (2008) J Toxicol Sci , vol.33 , pp. 405-413
    • Minami, K.1    Nakajima, M.2    Fujiki, Y.3    Katoh, M.4    Gonzales, F.J.5    Yokoi, T.6
  • 135
    • 0346455771 scopus 로고    scopus 로고
    • Te MDM2-p53 interaction
    • Moll UM, Petrenko O. (2003). Te MDM2-p53 interaction. Mol Cancer Res 1:1001-1008.
    • (2003) Mol Cancer Res , vol.1 , pp. 1001-1008
    • Moll, U.M.1    Petrenko, O.2
  • 136
    • 0026501558 scopus 로고
    • Enhanced suppression of humoral immunity in DBA/2 mice following subchronic exposure to 2, 3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • Morris DL, Snyder NK, Gokani V, Blair RE, Holsapple MP. (1992). Enhanced suppression of humoral immunity in DBA/2 mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol 112:128-132.
    • (1992) Toxicol Appl Pharmacol , vol.112 , pp. 128-132
    • Morris, D.L.1    Snyder, N.K.2    Gokani, V.3    Blair, R.E.4    Holsapple, M.P.5
  • 139
    • 30144443217 scopus 로고    scopus 로고
    • Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway
    • DOI 10.1016/j.intimp.2005.08.015, PII S1567576905002390
    • Nagai H, Kubo M, Abe R, Yamamoto M, Nohara K. (2006). Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway. Int Immunopharmacol 6:279-286. (Pubitemid 43052825)
    • (2006) International Immunopharmacology , vol.6 , Issue.2 , pp. 279-286
    • Nagai, H.1    Kubo, M.2    Abe, R.3    Yamamoto, M.4    Nohara, K.5
  • 140
    • 0021893083 scopus 로고
    • Mechanisms of the biological effects of PCBs, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in experimental animals
    • Neal RA. (1985). Mechanisms of the biological efects of PCBs, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in experimental animals. Environ Health Perspect 60:41-46. (Pubitemid 15038883)
    • (1985) Environmental Health Perspectives , vol.VOL. 60 , pp. 41-46
    • Neal, R.A.1
  • 142
    • 66549083848 scopus 로고    scopus 로고
    • Regulatory T cells diferentially modulate maturation and apoptosis of human CD8+ T-cell subsets
    • Nikolova M, Lelievre J-D, Carriere M, Bensussan A, Levy Y. (2009). Regulatory T cells diferentially modulate maturation and apoptosis of human CD8+ T-cell subsets. Blood 113:4556-4565.
    • (2009) Blood , vol.113 , pp. 4556-4565
    • Nikolova, M.1    Lelievre, J.-D.2    Carriere, M.3    Bensussan, A.4    Levy, Y.5
  • 143
    • 20044391611 scopus 로고    scopus 로고
    • Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes
    • Nohara K, Pan X, Tsukumo S-i, Hida A, Ito T, Nagai H, Inouye K, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Tohyama C. (2005). Constitutively active aryl hydrocarbon receptor expressed specifcally in T-lineade cells causes thymus involution and suppresses the immunization-induced increase in splenocytes. J Immunol 174:2770-2777. (Pubitemid 40279693)
    • (2005) Journal of Immunology , vol.174 , Issue.5 , pp. 2770-2777
    • Nohara, K.1    Pan, X.2    Tsukumo, S.-I.3    Hida, A.4    Ito, T.5    Nagai, H.6    Inouye, K.7    Motohashi, H.8    Yamamoto, M.9    Fujii-Kuriyama, Y.10    Tohyama, C.11
  • 144
    • 71049154886 scopus 로고    scopus 로고
    • Simultaneous in vivo time course and dose response evaluation for TCDD-induced impairment of the LPS-stimulated primary IgM response
    • North CM, Crawford RB, Lu H, Kaminski NE. (2009). Simultaneous in vivo time course and dose response evaluation for TCDD-induced impairment of the LPS-stimulated primary IgM response. Toxicol Sci 112:123-132.
    • (2009) Toxicol Sci , vol.112 , pp. 123-132
    • North, C.M.1    Crawford, R.B.2    Lu, H.3    Kaminski, N.E.4
  • 145
  • 146
    • 59149093141 scopus 로고    scopus 로고
    • AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions
    • Ohtake F, Fujii-Kuriyama Y, Kato S. (2009). AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochem Pharmacol 77:474-484.
    • (2009) Biochem Pharmacol , vol.77 , pp. 474-484
    • Ohtake, F.1    Fujii-Kuriyama, Y.2    Kato, S.3
  • 147
    • 0018967058 scopus 로고
    • Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster
    • DOI 10.1016/0041-008X(80)90221-5
    • Olson JR, Holscher MA, Neal RA. (1980). Toxicity of 2,3,7,8- tetrachlorodibenzo-p-dioxin in the Golden Syrian hamster. Toxicol Appl Pharmacol 55:67-78. (Pubitemid 10036692)
    • (1980) Toxicology and Applied Pharmacology , vol.55 , Issue.1 , pp. 67-78
    • Olson, J.R.1    Holscher, M.A.2    Neal, R.A.3
  • 148
    • 13444292318 scopus 로고    scopus 로고
    • TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents
    • DOI 10.1093/carcin/bgh289
    • Pääjärvi G, Viluksela M, Pohjanvirta R, Stenius U, Högberg J. (2005). TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents. Carcinogenesis 26:201-208. (Pubitemid 40214336)
    • (2005) Carcinogenesis , vol.26 , Issue.1 , pp. 201-208
    • Paajarvi, G.1    Viluksela, M.2    Pohjanvirta, R.3    Stenius, U.4    Hogberg, J.5
  • 149
    • 17844380221 scopus 로고    scopus 로고
    • Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines
    • DOI 10.1124/mol.105.010983
    • Pande K, Moran SM, Bradfeld CA. (2005). Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines. Mol Pharmacol 67:1393-1398. (Pubitemid 40594137)
    • (2005) Molecular Pharmacology , vol.67 , Issue.5 , pp. 1393-1398
    • Pande, K.1    Moran, S.M.2    Bradfield, C.A.3
  • 150
    • 36248976097 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1038/ni1536, PII NI1536
    • Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. (2007). CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of efector CD4+ T cells. Nat Immunol 8:1353-1362. (Pubitemid 350131172)
    • (2007) Nature Immunology , vol.8 , Issue.12 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 151
    • 33746622171 scopus 로고    scopus 로고
    • Dioxin-induced chloracne - Reconstructing the cellular and molecular mechanisms of a classic environmental disease
    • DOI 10.1111/j.1600-0625.2006.00476.x
    • Panteleyev AA, Bickers DR. (2006). Dioxin-induced chloracne- Reconstituting the cellular and molecular mechanisms of a classic environmental disease. Exp Dermatol 15:705-730. (Pubitemid 44145241)
    • (2006) Experimental Dermatology , vol.15 , Issue.9 , pp. 705-730
    • Panteleyev, A.A.1    Bickers, D.R.2
  • 153
    • 0142150246 scopus 로고    scopus 로고
    • TCDD-induced apoptosis in EL-4 cells deficient of the aryl hydrocarbon receptor and down-regulation of IGFBP-6 prevented the apoptotic cell death
    • DOI 10.1016/S0378-4274(03)00259-5, PII S0378427403002595
    • Park J-H, Hahn E-J, Kong J-H, Cho H-J, Yoon C-S, Cheong S-W, Oh G-S, Youn H-J. (2003). TCDD-induced apoptosis in EL-4 cells defcient of the aryl hydrocarbon receptor and down-regulation of IGFBP-6 prevented the apoptotic cell death. Toxicol Lett 145:55-68. (Pubitemid 38366129)
    • (2003) Toxicology Letters , vol.145 , Issue.1 , pp. 55-68
    • Park, J.-H.1    Hahn, E.-J.2    Kong, J.-H.3    Cho, H.-J.4    Yoon, C.-S.5    Cheong, S.-W.6    Oh, G.-S.7    Youn, H.-J.8
  • 154
    • 14944348442 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis
    • DOI 10.1124/mol.104.005223
    • Park K-T, Mitchell KA, Huang G, Elferink CJ. (2005). Te aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis. Mol Pharmacol 67:612-622. (Pubitemid 40365308)
    • (2005) Molecular Pharmacology , vol.67 , Issue.3 , pp. 612-622
    • Park, K.-T.1    Mitchell, K.A.2    Huang, G.3    Elferink, C.J.4
  • 155
    • 28844487903 scopus 로고    scopus 로고
    • Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A
    • DOI 10.1016/j.tox.2005.09.002, PII S0300483X05004324
    • Park S, Matsumura F. (2006). Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A. Toxicology 217:139-146. (Pubitemid 41773829)
    • (2006) Toxicology , vol.217 , Issue.2-3 , pp. 139-146
    • Park, S.1    Matsumura, F.2
  • 156
    • 70350647739 scopus 로고    scopus 로고
    • Cancer incidence in the population exposed to dioxin after the "seveso accident": Twenty years of follow-up
    • Pesatori AC, Consonni D, Rubagotti M, Grillo P, Bertazzi PA. (2009). Cancer incidence in the population exposed to dioxin after the "Seveso accident": Twenty years of follow-up. Environ Health 8:39.
    • (2009) Environ Health , vol.8 , pp. 39
    • Pesatori, A.C.1    Consonni, D.2    Rubagotti, M.3    Grillo, P.4    Bertazzi, P.A.5
  • 157
    • 0027244233 scopus 로고
    • Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons
    • Peterson RE, Teobald HM, Kimmel GL. (1993). Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons. Crit Rev Toxicol 23:283-335. (Pubitemid 23274471)
    • (1993) Critical Reviews in Toxicology , vol.23 , Issue.3 , pp. 283-335
    • Peterson, R.E.1    Theobald, H.M.2    Kimmel, G.L.3
  • 159
    • 70349562260 scopus 로고    scopus 로고
    • Nuclear receptors: Te controlling force in drug metabolism of the liver?
    • Plant N, Aouabdi S. (2009). Nuclear receptors: Te controlling force in drug metabolism of the liver? Xenobiotica 39:597-605.
    • (2009) Xenobiotica , vol.39 , pp. 597-605
    • Plant, N.1    Aouabdi, S.2
  • 162
    • 70349437076 scopus 로고    scopus 로고
    • P53 and E2f: Partners in life and death
    • Polager S, Gisberg D. (2009). p53 and E2f: Partners in life and death. Nat Rev Cancer 9:738-748.
    • (2009) Nat Rev Cancer , vol.9 , pp. 738-748
    • Polager, S.1    Gisberg, D.2
  • 164
    • 0033900355 scopus 로고    scopus 로고
    • CTL hyporesponsiveness induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: Role of cytokines and apoptosis
    • DOI 10.1006/taap.2000.8971
    • Prell RA, Dearstyne E, Steppan LG, Vella AT, Kerkvliet NI. (2000). CTL hyporesponsiveness induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: Role of cytokines and apoptosis. Toxicol Appl Pharmacol 166:214-221. (Pubitemid 30640631)
    • (2000) Toxicology and Applied Pharmacology , vol.166 , Issue.3 , pp. 214-221
    • Prell, R.A.1    Dearstyne, E.2    Steppan, L.G.3    Vella, A.T.4    Kerkvliet, N.I.5
  • 165
    • 0032555772 scopus 로고    scopus 로고
    • 1
    • DOI 10.1016/S0300-483X(98)00078-X, PII S0300483X9800078X
    • Pryputniewicz SJ, Nagarkatti M, Nagarkatti PS. (1998). Diferential induction of apoptosis in activated and resting T cells by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and its repercussion on T cell responsiveness. Toxicology 129:211-226. (Pubitemid 29023149)
    • (1998) Toxicology , vol.129 , Issue.2-3 , pp. 211-226
    • Pryputniewicz, S.J.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 166
    • 3042695024 scopus 로고    scopus 로고
    • INK4a
    • DOI 10.1074/jbc.M402771200
    • Ray SS, Swanson HI. (2004). Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a. J Biol Chem 279:27187-27193. (Pubitemid 38812555)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.26 , pp. 27187-27193
    • Ray, S.S.1    Swanson, H.I.2
  • 168
    • 0033809856 scopus 로고    scopus 로고
    • Molecular mechanisms of apoptosis induced by cytotoxic chemicals
    • Robertson JD, Orrenius S. (2000). Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol 30:609-627.
    • (2000) Crit Rev Toxicol , vol.30 , pp. 609-627
    • Robertson, J.D.1    Orrenius, S.2
  • 169
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. (1999). NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401:86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 170
    • 33750345196 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin directly enhances the maturation and apoptosis of dendritic cells in vitro
    • Ruby CE, Funatake CJ, Kerkvliet NI. (2005). 2,3,7,8-Tetrachlorodibenzo-p- dioxin directly enhances the maturation and apoptosis of dendritic cells in vitro. J Immuntoxicol 1:159-166.
    • (2005) J Immuntoxicol , vol.1 , pp. 159-166
    • Ruby, C.E.1    Funatake, C.J.2    Kerkvliet, N.I.3
  • 171
    • 0036783335 scopus 로고    scopus 로고
    • Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes
    • DOI 10.2174/1389200023337171
    • Rushmore TH, Kong AN. (2002). Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab 3:481-490. (Pubitemid 34987481)
    • (2002) Current Drug Metabolism , vol.3 , Issue.5 , pp. 481-490
    • Rushmore, T.H.1    Kong, A.-N.T.2
  • 172
    • 0031431467 scopus 로고    scopus 로고
    • Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds
    • DOI 10.1002/(SICI)1520-6866(1997)17:4/5<285::AID-TCM11>3.0.CO;2-B
    • Safe S (1997). Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds. Teratog Carcinog Mutagen 17:285-304. (Pubitemid 28080831)
    • (1997) Teratogenesis Carcinogenesis and Mutagenesis , vol.17 , Issue.4-5 , pp. 285-304
    • Safe, S.1
  • 173
    • 0031904725 scopus 로고    scopus 로고
    • Positive and negative thymocyte selection
    • Saito T, Watanabe N. (1998). Positive and negative thymocyte selection. Crit Rev Immunol 18:359-370. (Pubitemid 28364151)
    • (1998) Critical Reviews in Immunology , vol.18 , Issue.4 , pp. 359-370
    • Saito, T.1    Watanabe, N.2
  • 174
    • 0029555127 scopus 로고
    • A morphological study of liver lesions in Xenopus larvae exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with special reference to apoptosis of hepatocytes
    • Sakamoto MK, Mima S, Tanimura T. (1995). A morphological study of liver lesions in Xenopus larvae exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with special reference to apoptosis of hepatocytes. J Environ Pathol Toxicol Oncol 14:69-82. (Pubitemid 26097048)
    • (1995) Journal of Environmental Pathology, Toxicology and Oncology , vol.14 , Issue.2 , pp. 69-82
    • Sakamoto, M.K.1    Mima, S.2    Tanimura, T.3
  • 175
    • 0030836565 scopus 로고    scopus 로고
    • Apoptotic cell death of erythrocytes in Xenopus larvae exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Sakamoto MK, Mima S, Takahashi KP, Tanimura T. (1997). Apoptotic cell death of erythrocytes in Xenopus larvae exposed to 2,3,7,8-tetrachlorodibenzo-p- dioxin. Toxicol Pathol 25:398-402. (Pubitemid 27364940)
    • (1997) Toxicologic Pathology , vol.25 , Issue.4 , pp. 398-402
    • Sakamoto, M.K.1    Mlma, S.2    Takahashi, K.P.3    Tanimura, T.4
  • 176
    • 77952670530 scopus 로고    scopus 로고
    • 2,3, 7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis in neural growth factor (NGF)-diferentiated pheochromocytoma PC12 cells
    • Sanchez-Martin FJ, Fernandez-Salguero PM, Merino JM. (2010). 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis in neural growth factor (NGF)-diferentiated pheochromocytoma PC12 cells. Neurotoxicology 31:267-276.
    • (2010) Neurotoxicology , vol.31 , pp. 267-276
    • Sanchez-Martin, F.J.1    Fernandez-Salguero, P.M.2    Merino, J.M.3
  • 177
    • 0027509084 scopus 로고
    • α-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation
    • Santostefano M, Merchant M, Arellano L, Morrison V, Denison MS, Safe S. (1993). Alpha-naphthofavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation. Mol Pharmacol 43:200-206. (Pubitemid 23055063)
    • (1993) Molecular Pharmacology , vol.43 , Issue.2 , pp. 200-206
    • Santostefano, M.1    Merchant, M.2    Arellano, L.3    Morrison, V.4    Denison, M.S.5    Safe, S.6
  • 178
    • 0030779146 scopus 로고    scopus 로고
    • Recognition and phagocytosis of cells undergoing apoptosis
    • Savil J. (1997). Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 53:491-508.
    • (1997) Br Med Bull , vol.53 , pp. 491-508
    • Savil, J.1
  • 180
    • 63449118032 scopus 로고    scopus 로고
    • Infuence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells
    • Schreck I, Chudziak D, Schneider S, Seidel A, Platt KL, Oesch F, Weiss C. (2009). Infuence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells. Toxicology 259:91-96.
    • (2009) Toxicology , vol.259 , pp. 91-96
    • Schreck, I.1    Chudziak, D.2    Schneider, S.3    Seidel, A.4    Platt, K.L.5    Oesch, F.6    Weiss, C.7
  • 181
    • 0030631706 scopus 로고    scopus 로고
    • Interactions of TCDD with signal transduction and neoplastic development in c-myc transgenic and TGF-α transgenic mice
    • Schrenk D, Müller M, Merlino G, Torgeirsson SS. (1997). Interactions of TCDD with signal transduction and neoplastic development in c-myc transgenic and TGF-α transgenic mice. Arch Toxicol Suppl 19:367-375.
    • (1997) Arch Toxicol Suppl , vol.19 , pp. 367-375
    • Schrenk, D.1    Müller, M.2    Merlino, G.3    Torgeirsson, S.S.4
  • 182
    • 79953155909 scopus 로고    scopus 로고
    • Modulation of caspase-3-activation by liver tumor promoters in primary rat hepatocytes
    • Schrenk D, Kunz S, Schmitz H-J. (2004). Modulation of caspase-3-activation by liver tumor promoters in primary rat hepatocytes. Toxicol Appl Pharmacol 197:374.
    • (2004) Toxicol Appl Pharmacol , vol.197 , pp. 374
    • Schrenk, D.1    Kunz, S.2    Schmitz, H.-J.3
  • 184
    • 0021889370 scopus 로고
    • Physical/chemical properties of 2, 3, 7,8-TCDD
    • Schroy JM, Hileman FD, Chang SC. (1985). Physical/chemical properties of 2,3,7,8-TCDD. Chemosphere 14:877-880.
    • (1985) Chemosphere , vol.14 , pp. 877-880
    • Schroy, J.M.1    Hileman, F.D.2    Chang, S.C.3
  • 185
  • 186
    • 1142274315 scopus 로고    scopus 로고
    • Apoptosis in cancer- Implications for therapy
    • Schulze-Bergkamen H, Krammer PH. (2004). Apoptosis in cancer- Implications for therapy. Semin Oncol 31:90-119.
    • (2004) Semin Oncol , vol.31 , pp. 90-119
    • Schulze-Bergkamen, H.1    Krammer, P.H.2
  • 187
    • 0034653806 scopus 로고    scopus 로고
    • Ah receptor ligands and tumor promotion: Survival of neoplastic cells
    • DOI 10.1016/S0378-4274(99)00247-7, PII S0378427499002477
    • Schwarz M, Buchmann A, Stinchcombe S, Kalkuhl A, Bock K-W. (2000). Ah receptor ligands and tumor promotion: Survival of neoplastic cells. Toxicol Lett 112-113:69-77. (Pubitemid 30138106)
    • (2000) Toxicology Letters , vol.112-113 , pp. 69-77
    • Schwarz, M.1    Buchmann, A.2    Stinchcombe, S.3    Kalkuhl, A.4    Bock, K.-W.5
  • 189
    • 0021237402 scopus 로고
    • Characterization of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Seefeld MD, Corbett SW, Keesey RE, Peterson RE. (1984). Characterizyteion of the wasting syndrome in rats treated with 2,3,7,8-tetrachlorodibenzo-p- dioxin. Toxicol Appl Pharmacol 73:311-322. (Pubitemid 14135566)
    • (1984) Toxicology and Applied Pharmacology , vol.73 , Issue.2 , pp. 311-322
    • Seefeld, M.D.1    Corbett, S.W.2    Keesey, R.E.3    Peterson, R.E.4
  • 190
    • 69449089766 scopus 로고    scopus 로고
    • TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions
    • Seifert A, Taubert H, Hombach-Klonisch S, Fischer B, Navarrete Santos A. (2009). TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions. Int J Oncol 35:417-424.
    • (2009) Int J Oncol , vol.35 , pp. 417-424
    • Seifert, A.1    Taubert, H.2    Hombach-Klonisch, S.3    Fischer, B.4    Navarrete Santos, A.5
  • 191
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms of caspase activation and inhibition during apoptosis
    • DOI 10.1016/S1097-2765(02)00482-3
    • Shi Y. (2002). Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9:459-470. (Pubitemid 34273778)
    • (2002) Molecular Cell , vol.9 , Issue.3 , pp. 459-470
    • Shi, Y.1
  • 192
    • 74949098017 scopus 로고    scopus 로고
    • Estimates of cancer potency of 2, 3, 7,8-tetrachlorodibenzo(p) dioxin using linear and nonlinear dose-response modeling and toxicokinetics
    • Simon T, Aylward LL, Kirman CR, Rowlands JC, Budinsky RA. (2009). Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p) dioxin using linear and nonlinear dose-response modeling and toxicokinetics. Toxicol Sci 112:490-506.
    • (2009) Toxicol Sci , vol.112 , pp. 490-506
    • Simon, T.1    Aylward, L.L.2    Kirman, C.R.3    Rowlands, J.C.4    Budinsky, R.A.5
  • 193
    • 44249086903 scopus 로고    scopus 로고
    • Primary peripheral T cells become susceptible to 2,3,7,8- tetrachlorodibenzo-p-dioxin-mediated apoptosis in vitro upon activation and in the presence of dendritic cells
    • DOI 10.1124/mol.107.043406
    • Singh NP, Nagarkatti M, Nagarkatti P. (2008). Primary peripheral T cells become susceptible to 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in vitro upon activation and the presence of dentritic cells. Mol Pharmacol 73:1722-1735. (Pubitemid 351724360)
    • (2008) Molecular Pharmacology , vol.73 , Issue.6 , pp. 1722-1735
    • Singh, N.P.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 194
    • 72549085096 scopus 로고    scopus 로고
    • Transcription-independent p53 apoptosis: An alternative route to death
    • Speidel D. (2009). Transcription-independent p53 apoptosis: An alternative route to death. Trends Cell Biol 20:14-24.
    • (2009) Trends Cell Biol , vol.20 , pp. 14-24
    • Speidel, D.1
  • 195
    • 68949192657 scopus 로고    scopus 로고
    • Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior
    • Stanley LA, Horsburgh BC, Ross J, Scheer N,Wolf CR. (2009). Drug transporters: Gatekeepers controlling access of xenobiotics to the cellular interior. Drug Metab Rev 41:27-65.
    • (2009) Drug Metab Rev , vol.41 , pp. 27-65
    • Stanley, L.A.1    Horsburgh, B.C.2    Ross, J.3    Scheer, N.4    Wolf, C.R.5
  • 196
    • 0032522828 scopus 로고    scopus 로고
    • Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells
    • Staples JE, Murante FG, Fiore NC, Gasiewicz TA, Silverstone AE. (1998). Tymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells. J Immunol 160:3844-3854. (Pubitemid 28176089)
    • (1998) Journal of Immunology , vol.160 , Issue.8 , pp. 3844-3854
    • Staples, J.E.1    Murante, F.G.2    Fiore, N.C.3    Gasiewicz, T.A.4    Silverstone, A.E.5
  • 197
    • 0030862389 scopus 로고    scopus 로고
    • Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C
    • DOI 10.1016/S0300-483X(97)00128-5, PII S0300483X97001285
    • Stephen FD, Drahushuk AT, Olson JR. (1997). Cytochome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C. Toxicology 124:39-51. (Pubitemid 27483495)
    • (1997) Toxicology , vol.124 , Issue.1 , pp. 39-51
    • Stephen, F.D.1    Drahushuk, A.T.2    Olson, J.R.3
  • 198
    • 66549106623 scopus 로고    scopus 로고
    • Te aryl hydrocarbon receptor: A perspective on potential roles in the immune system
    • Stevens EA, Mezrich JD, Bradfeld CA. (2009). Te aryl hydrocarbon receptor: A perspective on potential roles in the immune system. Immunology 127:299-311.
    • (2009) Immunology , vol.127 , pp. 299-311
    • Stevens, E.A.1    Mezrich, J.D.2    Bradfeld, C.A.3
  • 199
    • 0029010526 scopus 로고
    • Inhibition of apoptosis during 2, 3, 7,8-tetrachlorodibenzo-p-dioxin- mediated tumour promotion in rat liver
    • Stinchcombe S, Buchmann A, Bock KW, Schwarz M. (1995). Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver. Carcinogenesis 16:1271-1275.
    • (1995) Carcinogenesis , vol.16 , pp. 1271-1275
    • Stinchcombe, S.1    Buchmann, A.2    Bock, K.W.3    Schwarz, M.4
  • 200
    • 0035862998 scopus 로고    scopus 로고
    • Apoptosis in normal and neoplastic mammary gland development
    • DOI 10.1002/1097-0029(20010115)52:2<171::AID-JEMT1003>3.0.CO;2-T
    • Strange R, Metcalfe T, Tackray L, Dang M. (2001). Apoptosis in normal and neoplastc mammary gland development. Microsc Res Tech 52:171-181. (Pubitemid 32107805)
    • (2001) Microscopy Research and Technique , vol.52 , Issue.2 , pp. 171-181
    • Strange, R.1    Metcalfe, T.2    Thackray, L.3    Dang, M.4
  • 201
    • 63149121284 scopus 로고    scopus 로고
    • Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis
    • Strauss L, Bergmann C, Whiteside TL. (2009). Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. J Immunol 182:1469-1480.
    • (2009) J Immunol , vol.182 , pp. 1469-1480
    • Strauss, L.1    Bergmann, C.2    Whiteside, T.L.3
  • 202
    • 4344590127 scopus 로고    scopus 로고
    • Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences
    • DOI 10.1093/nar/gkh782
    • Sun YV, Boverhof DR, Burgoon LD, Fielden MR, Zacharewski TR. (2004). Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Res 32:4512-4523. (Pubitemid 39317729)
    • (2004) Nucleic Acids Research , vol.32 , Issue.15 , pp. 4512-4523
    • Sun, Y.V.1    Boverhof, D.R.2    Burgoon, L.D.3    Fielden, M.R.4    Zacharewski, T.R.5
  • 203
    • 0021844262 scopus 로고
    • Chloracne "the hallmark of dioxin intoxication"
    • Suskind RR. (1985). Chloracne, "the hallmark of dioxin intoxication". Scand J Work Environ Health 11:165-171.
    • (1985) Scand J Work Environ Health , vol.11 , pp. 165-171
    • Suskind, R.R.1
  • 204
    • 76749166159 scopus 로고    scopus 로고
    • AhR and ARNT modulate ER signaling
    • Swedenborg E, Pongratz I. (2010). AhR and ARNT modulate ER signaling. Toxicology 268:132-138.
    • (2010) Toxicology , vol.268 , pp. 132-138
    • Swedenborg, E.1    Pongratz, I.2
  • 205
    • 59349114674 scopus 로고    scopus 로고
    • Ah receptor and NF-kappaB interplay on the stage of epigenome
    • Tian Y. (2009). Ah receptor and NF-kappaB interplay on the stage of epigenome. Biochem Pharmacol 77:670-680.
    • (2009) Biochem Pharmacol , vol.77 , pp. 670-680
    • Tian, Y.1
  • 208
    • 0035400978 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos
    • DOI 10.1016/S0166-445X(00)00161-2, PII S0166445X00001612
    • Toomey BH, Bello S, Hahn ME, Cantrell S, Wright P, Tillitt DE, Di Guilio RT. (2001). 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquat Toxicol 53:127-138. (Pubitemid 32318545)
    • (2001) Aquatic Toxicology , vol.53 , Issue.2 , pp. 127-138
    • Toomey, B.H.1    Bello, S.2    Hahn, M.E.3    Cantrell, S.4    Wright, P.5    Tillitt, D.E.6    Di Giulio, R.T.7
  • 209
    • 34249694142 scopus 로고    scopus 로고
    • Waf1/Cip1 by activating p53 and MEK/ERK1/2 MAPK pathways
    • DOI 10.1074/jbc.M609623200
    • Tu Y, Wu W, wu T, Cao Z, Wilkins R, Toh B-H, Cooper ME, Chai Z. (2007). Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21Waf1/Cip1 by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem 282:11722-11731. (Pubitemid 47100724)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.16 , pp. 11722-11731
    • Tu, Y.1    Wu, W.2    Wu, T.3    Cao, Z.4    Wilkins, R.5    Toh, B.-H.6    Cooper, M.E.7    Chai, Z.8
  • 210
    • 79953147469 scopus 로고
    • US Environmental Protection Agency Washington, DC: Ofce of Research and Development, National Center for Environmental Assessment Ofce of Research and Development US Environmental Protection Agency
    • US Environmental Protection Agency. (1994). Health assessment document for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCPD) and related compounds [external review draft] [3 volumes]. Washington, DC: Ofce of Research and Development, National Center for Environmental Assessment Ofce of Research and Development, US Environmental Protection Agency.
    • (1994) Health Assessment Document for 2, 3,7,8-tetrachlorodibenzo-p-dioxin (TCPD) and Related Compounds [External Review Draft] [3 Volumes]
  • 211
    • 79953149994 scopus 로고    scopus 로고
    • US Environmental Protection Agency 2006 An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United States for the Years 1987, 1995, and 2000. Washington, DC: National Center for Environmental Assessment Ofce of Research and Development US Environmental Protection Agency
    • US Environmental Protection Agency. (2006). An Inventory of Sources and Environmental Releases of Dioxin-Like Compounds in the United States for the Years 1987, 1995, and 2000. Washington, DC: National Center for Environmental Assessment Ofce of Research and Development US Environmental Protection Agency.
  • 212
    • 0038032435 scopus 로고    scopus 로고
    • US National Toxicology Program US Research Triangle Park, NC: Department of Health and Human Services, Public Health Service, National Toxicology Program
    • US National Toxicology Program. (2005). Report on Carcinogens, Eleventh Edition. US Research Triangle Park, NC: Department of Health and Human Services, Public Health Service, National Toxicology Program.
    • (2005) Report on Carcinogens, Eleventh Edition
  • 213
    • 0028295329 scopus 로고
    • The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity
    • van den Berg M, de Jongh J, Poiger H, Olson J R. (1994). Te toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit Rev Toxicol 24: 1-74. (Pubitemid 24122407)
    • (1994) Critical Reviews in Toxicology , vol.24 , Issue.1 , pp. 1-74
    • Van Den Berg, M.1    De Jongh, J.2    Poiger, H.3    Olson, J.R.4
  • 216
    • 42649106556 scopus 로고    scopus 로고
    • H17-cell-mediated autoimmunity to environmental toxins
    • DOI 10.1038/nature06881, PII NATURE06881
    • Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld J-C, Stockinger B. (2008). Te aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453:106-109. (Pubitemid 351630329)
    • (2008) Nature , vol.453 , Issue.7191 , pp. 106-109
    • Veldhoen, M.1    Hirota, K.2    Westendorf, A.M.3    Buer, J.4    Dumoutier, L.5    Renauld, J.-C.6    Stockinger, B.7
  • 217
    • 33750306678 scopus 로고    scopus 로고
    • + regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism
    • Venet F, Pachot A, Debard A-L, Bohe J, Bienvenu J, Lepape A, Powell WS, Monneret G. (2006). Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J Immunol 177:6540-6547. (Pubitemid 44628873)
    • (2006) Journal of Immunology , vol.177 , Issue.9 , pp. 6540-6547
    • Venet, F.1    Pachot, A.2    Debard, A.-L.3    Bohe, J.4    Bienvenu, J.5    Lepape, A.6    Powell, W.S.7    Monneret, G.8
  • 219
    • 36348988444 scopus 로고    scopus 로고
    • Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression
    • DOI 10.2353/ajpath.2007.070406
    • Vogel CFA, Li W, Sciullo E, Newman J, Hammock B, Reader JR, Tuscano J, Matsumura F. (2007). Pathogenesis of aryl hydracarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. Am J Pathol 171:1538-1548. (Pubitemid 350158315)
    • (2007) American Journal of Pathology , vol.171 , Issue.5 , pp. 1538-1548
    • Vogel, C.F.A.1    Li, W.2    Sciullo, E.3    Newman, J.4    Hammock, B.5    Reader, J.R.6    Tuscano, J.7    Matsumura, F.8
  • 220
    • 0015698090 scopus 로고
    • Efect of 2, 3, 7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals
    • Vos JG, Moore JA, Zinkl JG. (1973). Efect of 2,3,7,8-tetrachlorodibenzo- p-dioxin on the immune system of laboratory animals. Environ Health Perspect 5:149-162.
    • (1973) Environ Health Perspect , vol.5 , pp. 149-162
    • Vos, J.G.1    Moore, J.A.2    Zinkl, J.G.3
  • 222
    • 34247551104 scopus 로고    scopus 로고
    • Key stages in mammary gland development Involution: Apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ
    • Watson CJ. (2006). Key stages in mammary gland development. Involution: Apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ. Breast Cancer Res 8:203.
    • (2006) Breast Cancer Res , vol.8 , pp. 203
    • Watson, C.J.1
  • 223
    • 77449145601 scopus 로고    scopus 로고
    • Key signalling nodes in mammary gland development and cancer Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammalian gland development
    • Whyte J, Bergin O, Bianchi A, McNally S, Martin F. (2009). Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammalian gland development. Breast Cancer Res 11:209.
    • (2009) Breast Cancer Res , vol.11 , pp. 209
    • Whyte, J.1    Bergin, O.2    Bianchi, A.3    McNally, S.4    Martin, F.5
  • 224
    • 68249149633 scopus 로고    scopus 로고
    • Characterization of MCF mammary epithelial cells overexpressing the arylhydrocarbon receptor (AhR)
    • Wong PS, Li W, Vogel CF, Matsumura F. (2009). Characterization of MCF mammary epithelial cells overexpressing the arylhydrocarbon receptor (AhR). BMC Cancer 9:234.
    • (2009) BMC Cancer , vol.9 , pp. 234
    • Wong, P.S.1    Li, W.2    Vogel, C.F.3    Matsumura, F.4
  • 225
    • 0029878895 scopus 로고    scopus 로고
    • Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor β1
    • Wörner W, Schrenk D. (1996). Infuence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofuorene, ultraviolet light, or transforming growth factor β1. Cancer Res 56:1272-1278. (Pubitemid 26080969)
    • (1996) Cancer Research , vol.56 , Issue.6 , pp. 1272-1278
    • Worner, W.1    Schrenk, D.2
  • 226
    • 0032433399 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes
    • DOI 10.1016/S1382-6689(98)00040-4, PII S1382668998000404
    • Wörner W, Schrenk D. (1998). 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes. Environ Toxicol Pharmacol 6:239-247. (Pubitemid 29070815)
    • (1998) Environmental Toxicology and Pharmacology , vol.6 , Issue.4 , pp. 239-247
    • Worner, W.1    Schrenk, D.2
  • 227
    • 0030746401 scopus 로고    scopus 로고
    • Apoptosis and carcinogenesis
    • Wyllie AH. Apoptosis and carcinogenesis. Eur J Cell Biol 73:189-197.
    • Eur J Cell Biol , vol.73 , pp. 189-197
    • Wyllie, A.H.1
  • 228
    • 23344450788 scopus 로고    scopus 로고
    • Induction of phase I, II and III drug metabolism/transport by xenobiotics
    • Xu C, Li CY, Kong AN. (2005). Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 28:249-268. (Pubitemid 44698742)
    • (2005) Archives of Pharmacal Research , vol.28 , Issue.3 , pp. 249-268
    • Xu, C.1    Li, C.Y.-T.2    Kong, A.-N.T.3
  • 229
    • 18144415048 scopus 로고    scopus 로고
    • Mechanisms of exocrine pancreatic toxicity induced by oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley rats
    • DOI 10.1093/toxsci/kfi121
    • Yoshizawa K, Marsh T, Foley JF, Cai B, Peddada S, Walker NJ, Nyska A. (2005). Mechanisms of exocrine pancreatic toxicity induced by oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Harlan Sprague-Dawley rats. Toxicol Sci 85:594-606. (Pubitemid 40614288)
    • (2005) Toxicological Sciences , vol.85 , Issue.1 , pp. 594-606
    • Yoshizawa, K.1    Marsh, T.2    Foley, J.F.3    Cai, B.4    Peddada, S.5    Walker, N.J.6    Nyska, A.7
  • 230
    • 0033570026 scopus 로고    scopus 로고
    • P53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor
    • Yun J, Chae H-D, Choy HE, Chung J, Yoo H-S, Han M-H, Shin DY. (1999). p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor. J Biol Chem 274:29677-29682.
    • (1999) J Biol Chem , vol.274 , pp. 29677-29682
    • Yun, J.1    Chae, H.-D.2    Choy, H.E.3    Chung, J.4    Yoo, H.-S.5    Han, M.-H.6    Shin, D.Y.7
  • 231
    • 0037119867 scopus 로고    scopus 로고
    • Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced gene expression profile in vivo using pathway-specific cDNA arrays
    • DOI 10.1016/S0300-483X(02)00230-5, PII S0300483X02002305
    • Zeytun A, McKallip RJ, Fisher M, Camacho I, Nagarkatti M, Nagarkatti PS. (2002). Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced gene expression profle in vivo using pathway-specifc cDNA arrays. Toxicology 178:241-260. (Pubitemid 34880022)
    • (2002) Toxicology , vol.178 , Issue.3 , pp. 241-260
    • Zeytun, A.1    McKallip, R.J.2    Fisher, M.3    Camacho, I.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 232
    • 65549089505 scopus 로고    scopus 로고
    • Role of NF-kappaB in the regulation of cytochrome P450 enzymes
    • Zordoky BN, El-Kadi AO. (2009). Role of NF-kappaB in the regulation of cytochrome P450 enzymes. Curr Drug Metab 10:164-178.
    • (2009) Curr Drug Metab , vol.10 , pp. 164-178
    • Zordoky, B.N.1    El-Kadi, A.O.2
  • 233
    • 65549089505 scopus 로고    scopus 로고
    • Role of NF-kappaB in the regulation of cytochrome P450 enzymes
    • Zordoky BN, El-Kadi AO. (2009). Role of NF-kappaB in the regulation of cytochrome P450 enzymes. Curr Drug Metab 10:164-178.
    • (2009) Curr Drug Metab , vol.10 , pp. 164-178
    • Zordoky, B.N.1    El-Kadi, A.O.2


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