-
1
-
-
0022640843
-
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., Coffman, R. L. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
-
(1986)
J. Immunol
, vol.136
, pp. 2348-2357
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
Giedlin, M.A.4
Coffman, R.L.5
-
2
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., Cua, D. J. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240.
-
(2005)
J. Exp. Med
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
3
-
-
32244442562
-
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., Stockinger, B. (2006) TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
4
-
-
60749107176
-
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
-
McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K., O'Shea, J. J., Cua, D. J. (2009) The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 10, 314-324.
-
(2009)
Nat. Immunol
, vol.10
, pp. 314-324
-
-
McGeachy, M.J.1
Chen, Y.2
Tato, C.M.3
Laurence, A.4
Joyce-Shaikh, B.5
Blumenschein, W.M.6
McClanahan, T.K.7
O'Shea, J.J.8
Cua, D.J.9
-
5
-
-
80052752968
-
Mouse T helper 17 phenotype: Not so different than in man after all
-
Annunziato, F., Romagnani, S. (2011) Mouse T helper 17 phenotype: not so different than in man after all. Cytokine 56, 112-115.
-
(2011)
Cytokine
, vol.56
, pp. 112-115
-
-
Annunziato, F.1
Romagnani, S.2
-
6
-
-
37749021324
-
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity
-
Harris, T. J., Grosso, J. F., Yen, H. R., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E. L., Getnet, D., Goldberg, M. V., Maris, C. H., Housseau, F., Yu, H., Pardoll, D. M., Drake, C. G. (2007) Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J. Immunol. 179, 4313-4317.
-
(2007)
J. Immunol
, vol.179
, pp. 4313-4317
-
-
Harris, T.J.1
Grosso, J.F.2
Yen, H.R.3
Xin, H.4
Kortylewski, M.5
Albesiano, E.6
Hipkiss, E.L.7
Getnet, D.8
Goldberg, M.V.9
Maris, C.H.10
Housseau, F.11
Yu, H.12
Pardoll, D.M.13
Drake, C.G.14
-
7
-
-
33748588423
-
The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., Littman, D. R. (2006) The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
8
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., Dong, C. (2007) STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282, 9358-9363.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
Chang, S.H.4
Wang, D.5
Watowich, S.S.6
Dong, C.7
-
9
-
-
37849048599
-
T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and ROR γ
-
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., Watowich, S. S., Tian, Q., Jetten, A. M., Dong, C. (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORα and ROR γ. Immunity 28, 29-39.
-
(2008)
Immunity
, vol.28
, pp. 29-39
-
-
Yang, X.O.1
Pappu, B.P.2
Nurieva, R.3
Akimzhanov, A.4
Kang, H.S.5
Chung, Y.6
Ma, L.7
Shah, B.8
Panopoulos, A.D.9
Schluns, K.S.10
Watowich, S.S.11
Tian, Q.12
Jetten, A.M.13
Dong, C.14
-
10
-
-
68849084891
-
Structure and signalling in the IL-17 receptor family
-
Gaffen, S. L. (2009) Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9, 556-567.
-
(2009)
Nat. Rev. Immunol
, vol.9
, pp. 556-567
-
-
Gaffen, S.L.1
-
11
-
-
34248574863
-
A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
-
Chang, S. H., Dong, C. (2007) A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell. Res. 17, 435-440.
-
(2007)
Cell. Res
, vol.17
, pp. 435-440
-
-
Chang, S.H.1
Dong, C.2
-
12
-
-
38849097777
-
An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
-
Liang, S. C., Long, A. J., Bennett, F., Whitters, M. J., Karim, R., Collins, M., Goldman, S. J., Dunussi-Joannopoulos, K., Williams, C. M., Wright, J. F., Fouser, L. A. (2007) An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J. Immunol. 179, 7791-7799.
-
(2007)
J. Immunol
, vol.179
, pp. 7791-7799
-
-
Liang, S.C.1
Long, A.J.2
Bennett, F.3
Whitters, M.J.4
Karim, R.5
Collins, M.6
Goldman, S.J.7
Dunussi-Joannopoulos, K.8
Williams, C.M.9
Wright, J.F.10
Fouser, L.A.11
-
13
-
-
34250305962
-
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
-
Wright, J. F., Guo, Y., Quazi, A., Luxenberg, D. P., Bennett, F., Ross, J. F., Qiu, Y., Whitters, M. J., Tomkinson, K. N., Dunussi-Joannopoulos, K., Carreno, B. M., Collins, M., Wolfman, N. M. (2007) Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J. Biol. Chem. 282, 13447-13455.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 13447-13455
-
-
Wright, J.F.1
Guo, Y.2
Quazi, A.3
Luxenberg, D.P.4
Bennett, F.5
Ross, J.F.6
Qiu, Y.7
Whitters, M.J.8
Tomkinson, K.N.9
Dunussi-Joannopoulos, K.10
Carreno, B.M.11
Collins, M.12
Wolfman, N.M.13
-
14
-
-
58149231532
-
Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
-
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., Sudo, K., Nakae, S., Sasakawa, C., Iwakura, Y. (2009) Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30, 108-119.
-
(2009)
Immunity
, vol.30
, pp. 108-119
-
-
Ishigame, H.1
Kakuta, S.2
Nagai, T.3
Kadoki, M.4
Nambu, A.5
Komiyama, Y.6
Fujikado, N.7
Tanahashi, Y.8
Akitsu, A.9
Kotaki, H.10
Sudo, K.11
Nakae, S.12
Sasakawa, C.13
Iwakura, Y.14
-
15
-
-
43549110961
-
Regulation of inflammatory responses by IL-17F
-
Yang, X. O., Chang, S. H., Park, H., Nurieva, R., Shah, B., Acero, L., Wang, Y. H., Schluns, K. S., Broaddus, R. R., Zhu, Z., Dong, C. (2008) Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205, 1063-1075.
-
(2008)
J. Exp. Med
, vol.205
, pp. 1063-1075
-
-
Yang, X.O.1
Chang, S.H.2
Park, H.3
Nurieva, R.4
Shah, B.5
Acero, L.6
Wang, Y.H.7
Schluns, K.S.8
Broaddus, R.R.9
Zhu, Z.10
Dong, C.11
-
16
-
-
0028858556
-
Human IL-17: A novel cytokine derived from T cells
-
Yao, Z., Painter, S. L., Fanslow, W. C., Ulrich, D., Macduff, B. M., Spriggs, M. K., Armitage, R. J. (1995) Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155, 5483-5486.
-
(1995)
J. Immunol
, vol.155
, pp. 5483-5486
-
-
Yao, Z.1
Painter, S.L.2
Fanslow, W.C.3
Ulrich, D.4
Macduff, B.M.5
Spriggs, M.K.6
Armitage, R.J.7
-
17
-
-
77954143695
-
Innate IL-17-producing cells: The sentinels of the immune system
-
Cua, D. J., Tato, C. M. (2010) Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489.
-
(2010)
Nat. Rev. Immunol
, vol.10
, pp. 479-489
-
-
Cua, D.J.1
Tato, C.M.2
-
18
-
-
46949089128
-
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
-
Ma, C. S., Chew, G. Y., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G., Cook, M. C. (2008) Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J. Exp. Med. 205, 1551-1557.
-
(2008)
J. Exp. Med
, vol.205
, pp. 1551-1557
-
-
Ma, C.S.1
Chew, G.Y.2
Simpson, N.3
Priyadarshi, A.4
Wong, M.5
Grimbacher, B.6
Fulcher, D.A.7
Tangye, S.G.8
Cook, M.C.9
-
19
-
-
79953284685
-
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
-
Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., Gumbleton, M., Toulon, A., Bodemer, C., El-Baghdadi, J., Whitters, M., Paradis, T., Brooks, J., Collins, M., Wolfman, N. M., Al-Muhsen, S., Galicchio, M., Abel, L., Picard, C., Casanova, J. L. (2011) Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 332, 65-68.
-
(2011)
Science
, vol.332
, pp. 65-68
-
-
Puel, A.1
Cypowyj, S.2
Bustamante, J.3
Wright, J.F.4
Liu, L.5
Lim, H.K.6
Migaud, M.7
Israel, L.8
Chrabieh, M.9
Audry, M.10
Gumbleton, M.11
Toulon, A.12
Bodemer, C.13
El-Baghdadi, J.14
Whitters, M.15
Paradis, T.16
Brooks, J.17
Collins, M.18
Wolfman, N.M.19
Al-Muhsen, S.20
Galicchio, M.21
Abel, L.22
Picard, C.23
Casanova, J.L.24
more..
-
20
-
-
0031282513
-
Molecular characterization of the human interleukin (IL)-17 receptor
-
Yao, Z., Spriggs, M. K., Derry, J. M., Strockbine, L., Park, L. S., Vanden- Bos, T., Zappone, J. D., Painter, S. L., Armitage, R. J. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9, 794-800.
-
(1997)
Cytokine
, vol.9
, pp. 794-800
-
-
Yao, Z.1
Spriggs, M.K.2
Derry, J.M.3
Strockbine, L.4
Park, L.S.5
vanden-Bos, T.6
Zappone, J.D.7
Painter, S.L.8
Armitage, R.J.9
-
21
-
-
33745297345
-
Cutting edge: Interleukin 17 signals through a heteromeric receptor complex
-
Toy, D., Kugler, D., Wolfson, M., Vanden Bos, T., Gurgel, J., Derry, J., Tocker, J., Peschon, J. (2006) Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J. Immunol. 177, 36-39.
-
(2006)
J. Immunol
, vol.177
, pp. 36-39
-
-
Toy, D.1
Kugler, D.2
Wolfson, M.3
vanden Bos, T.4
Gurgel, J.5
Derry, J.6
Tocker, J.7
Peschon, J.8
-
22
-
-
38449094307
-
Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F
-
Kuestner, R. E., Taft, D. W., Haran, A., Brandt, C. S., Brender, T., Lum, K., Harder, B., Okada, S., Ostrander, C. D., Kreindler, J. L., Aujla, S. J., Reardon, B., Moore, M., Shea, P., Schreckhise, R., Bukowski, T. R., Presnell, S., Guerra-Lewis, P., Parrish-Novak, J., Ellsworth, J. L., Jaspers, S., Lewis, K. E., Appleby, M., Kolls, J. K., Rixon, M., West, J. W., Gao, Z., Levin, S. D. (2007) Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J. Immunol. 179, 5462-5473.
-
(2007)
J. Immunol
, vol.179
, pp. 5462-5473
-
-
Kuestner, R.E.1
Taft, D.W.2
Haran, A.3
Brandt, C.S.4
Brender, T.5
Lum, K.6
Harder, B.7
Okada, S.8
Ostrander, C.D.9
Kreindler, J.L.10
Aujla, S.J.11
Reardon, B.12
Moore, M.13
Shea, P.14
Schreckhise, R.15
Bukowski, T.R.16
Presnell, S.17
Guerra-Lewis, P.18
Parrish-Novak, J.19
Ellsworth, J.L.20
Jaspers, S.21
Lewis, K.E.22
Appleby, M.23
Kolls, J.K.24
Rixon, M.25
West, J.W.26
Gao, Z.27
Levin, S.D.28
more..
-
23
-
-
80052025535
-
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)
-
Sun, D., Novotny, M., Bulek, K., Liu, C., Li, X., Hamilton, T. (2011) Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). Nat. Immunol. 12, 853-860.
-
(2011)
Nat. Immunol
, vol.12
, pp. 853-860
-
-
Sun, D.1
Novotny, M.2
Bulek, K.3
Liu, C.4
Li, X.5
Hamilton, T.6
-
24
-
-
80052022606
-
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
-
Bulek, K., Liu, C., Swaidani, S., Wang, L., Page, R. C., Gulen, M. F., Herjan, T., Abbadi, A., Qian, W., Sun, D., Lauer, M., Hascall, V., Misra, S., Chance, M. R., Aronica, M., Hamilton, T., Li, X. (2011) The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation. Nat. Immunol. 12, 844-852.
-
(2011)
Nat. Immunol
, vol.12
, pp. 844-852
-
-
Bulek, K.1
Liu, C.2
Swaidani, S.3
Wang, L.4
Page, R.C.5
Gulen, M.F.6
Herjan, T.7
Abbadi, A.8
Qian, W.9
Sun, D.10
Lauer, M.11
Hascall, V.12
Misra, S.13
Chance, M.R.14
Aronica, M.15
Hamilton, T.16
Li, X.17
-
25
-
-
0035846998
-
IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1
-
Lee, J., Ho, W. H., Maruoka, M., Corpuz, R. T., Baldwin, D. T., Foster, J. S., Goddard, A. D., Yansura, D. G., Vandlen, R. L., Wood, W. I., Gurney, A. L. (2001) IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. J. Biol. Chem. 276, 1660-1664.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 1660-1664
-
-
Lee, J.1
Ho, W.H.2
Maruoka, M.3
Corpuz, R.T.4
Baldwin, D.T.5
Foster, J.S.6
Goddard, A.D.7
Yansura, D.G.8
Vandlen, R.L.9
Wood, W.I.10
Gurney, A.L.11
-
26
-
-
80755133721
-
Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor
-
Chang, S. H., Reynolds, J. M., Pappu, B. P., Chen, G., Martinez, G. J., Dong, C. (2011) Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity 35, 611-621.
-
(2011)
E. Immunity
, vol.35
, pp. 611-621
-
-
Chang, S.H.1
Reynolds, J.M.2
Pappu, B.P.3
Chen, G.4
Martinez, G.J.5
Dong, C.6
-
27
-
-
81255158784
-
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
-
Ramirez-Carrozzi, V., Sambandam, A., Luis, E., Lin, Z., Jeet, S., Lesch, J., Hackney, J., Kim, J., Zhou, M., Lai, J., Modrusan, Z., Sai, T., Lee, W., Xu, M., Caplazi, P., Diehl, L., de Voss, J., Balazs, M., Gonzalez Jr., L., Singh, H., Ouyang, W., Pappu, R. (2011) IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol. 12, 1159-1166.
-
(2011)
Nat. Immunol
, vol.12
, pp. 1159-1166
-
-
Ramirez-Carrozzi, V.1
Sambandam, A.2
Luis, E.3
Lin, Z.4
Jeet, S.5
Lesch, J.6
Hackney, J.7
Kim, J.8
Zhou, M.9
Lai, J.10
Modrusan, Z.11
Sai, T.12
Lee, W.13
Xu, M.14
Caplazi, P.15
Diehl, L.16
de Voss, J.17
Balazs, M.18
Gonzalez, L.19
Singh, H.20
Ouyang, W.21
Pappu, R.22
more..
-
28
-
-
81255158786
-
IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens
-
Song, X., Zhu, S., Shi, P., Liu, Y., Shi, Y., Levin, S. D., Qian, Y. (2011) IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat. Immunol. 12, 1151-1158.
-
(2011)
Nat. Immunol
, vol.12
, pp. 1151-1158
-
-
Song, X.1
Zhu, S.2
Shi, P.3
Liu, Y.4
Shi, Y.5
Levin, S.D.6
Qian, Y.7
-
29
-
-
15844402155
-
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
-
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., Blanchard, D., Gaillard, C., Das Mahapatra, B., Rouvier, E., Golstein, P., Banchereau, J., Lebecque, S. (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183, 2593-2603.
-
(1996)
J. Exp. Med
, vol.183
, pp. 2593-2603
-
-
Fossiez, F.1
Djossou, O.2
Chomarat, P.3
Flores-Romo, L.4
Ait-Yahia, S.5
Maat, C.6
Pin, J.J.7
Garrone, P.8
Garcia, E.9
Saeland, S.10
Blanchard, D.11
Gaillard, C.12
Das Mahapatra, B.13
Rouvier, E.14
Golstein, P.15
Banchereau, J.16
Lebecque, S.17
-
30
-
-
84856833388
-
Psoriasis
-
Perera, G.K., Di Meglio, P., Nestle, F. O. (2012) Psoriasis. Annu. Rev. Pathol. 7, 385-422.
-
(2012)
Annu. Rev. Pathol
, vol.7
, pp. 385-422
-
-
Perera, G.K.1
Di Meglio, P.2
Nestle, F.O.3
-
31
-
-
58349105187
-
Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin
-
Johansen, C., Usher, P. A., Kjellerup, R. B., Lundsgaard, D., Iversen, L., Kragballe, K. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br. J. Dermatol. 160, 319-324.
-
(2009)
Br. J. Dermatol
, vol.160
, pp. 319-324
-
-
Johansen, C.1
Usher, P.A.2
Kjellerup, R.B.3
Lundsgaard, D.4
Iversen, L.5
Kragballe, K.6
-
32
-
-
34547291787
-
Expression of Th17 cytokines in skin lesions of patients with psoriasis
-
Li, J., Chen, X., Liu, Z., Yue, Q., Liu, H. (2007) Expression of Th17 cytokines in skin lesions of patients with psoriasis. J. Huazhong Univ. Sci. Technolog. Med. Sci. 27, 330-332.
-
(2007)
J. Huazhong Univ. Sci. Technolog. Med. Sci
, vol.27
, pp. 330-332
-
-
Li, J.1
Chen, X.2
Liu, Z.3
Yue, Q.4
Liu, H.5
-
33
-
-
42149087160
-
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
-
Lowes, M. A., Kikuchi, T., Fuentes-Duculan, J., Cardinale, I., Zaba, L. C., Haider, A. S., Bowman, E. P., Krueger, J. G. (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J. Invest. Dermatol. 128, 1207-1211.
-
(2008)
J. Invest. Dermatol
, vol.128
, pp. 1207-1211
-
-
Lowes, M.A.1
Kikuchi, T.2
Fuentes-Duculan, J.3
Cardinale, I.4
Zaba, L.C.5
Haider, A.S.6
Bowman, E.P.7
Krueger, J.G.8
-
34
-
-
0031691282
-
Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
-
Teunissen, M. B., Koomen, C. W., de Waal Malefyt, R., Wierenga, E. A., Bos, J. D. (1998) Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111, 645-649.
-
(1998)
J. Invest. Dermatol
, vol.111
, pp. 645-649
-
-
Teunissen, M.B.1
Koomen, C.W.2
de Waal, M.R.3
Wierenga, E.A.4
Bos, J.D.5
-
35
-
-
77951091571
-
Circulating Th17, Th22, and Th1 cells are increased in psoriasis
-
Kagami, S., Rizzo, H. L., Lee, J. J., Koguchi, Y., Blauvelt, A. (2010) Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J. Invest. Dermatol. 130, 1373-1383.
-
(2010)
J. Invest. Dermatol
, vol.130
, pp. 1373-1383
-
-
Kagami, S.1
Rizzo, H.L.2
Lee, J.J.3
Koguchi, Y.4
Blauvelt, A.5
-
36
-
-
54249130813
-
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
-
Nograles, K. E., Zaba, L. C., Guttman-Yassky, E., Fuentes-Duculan, J., Suarez-Farinas, M., Cardinale, I., Khatcherian, A., Gonzalez, J., Pierson, K. C., White, T. R., Pensabene, C., Coats, I., Novitskaya, I., Lowes, M. A., Krueger, J. G. (2008) Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br. J. Dermatol. 159, 1092-1102.
-
(2008)
Br. J. Dermatol
, vol.159
, pp. 1092-1102
-
-
Nograles, K.E.1
Zaba, L.C.2
Guttman-Yassky, E.3
Fuentes-Duculan, J.4
Suarez-Farinas, M.5
Cardinale, I.6
Khatcherian, A.7
Gonzalez, J.8
Pierson, K.C.9
White, T.R.10
Pensabene, C.11
Coats, I.12
Novitskaya, I.13
Lowes, M.A.14
Krueger, J.G.15
-
37
-
-
47249125726
-
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
-
Pene, J., Chevalier, S., Preisser, L., Venereau, E., Guilleux, M. H., Ghannam, S., Moles, J. P., Danger, Y., Ravon, E., Lesaux, S., Yssel, H., Gascan, H. (2008) Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol. 180, 7423-7430.
-
(2008)
J. Immunol
, vol.180
, pp. 7423-7430
-
-
Pene, J.1
Chevalier, S.2
Preisser, L.3
Venereau, E.4
Guilleux, M.H.5
Ghannam, S.6
Moles, J.P.7
Danger, Y.8
Ravon, E.9
Lesaux, S.10
Yssel, H.11
Gascan, H.12
-
38
-
-
33751546237
-
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
-
Chan, J. R., Blumenschein, W., Murphy, E., Diveu, C., Wiekowski, M., Abbondanzo, S., Lucian, L., Geissler, R., Brodie, S., Kimball, A. B., Gorman, D. M., Smith, K., de Waal Malefyt, R., Kastelein, R. A., McClanahan, T. K., Bowman, E. P. (2006) IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J. Exp. Med. 203, 2577-2587.
-
(2006)
J. Exp. Med
, vol.203
, pp. 2577-2587
-
-
Chan, J.R.1
Blumenschein, W.2
Murphy, E.3
Diveu, C.4
Wiekowski, M.5
Abbondanzo, S.6
Lucian, L.7
Geissler, R.8
Brodie, S.9
Kimball, A.B.10
Gorman, D.M.11
Smith, K.12
de Waal, M.R.13
Kastelein, R.A.14
McClanahan, T.K.15
Bowman, E.P.16
-
39
-
-
3042689555
-
IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy
-
Lee, S., French, M. A., Price, P. (2004) IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy. AIDS 18, 1337-1340.
-
(2004)
AIDS
, vol.18
, pp. 1337-1340
-
-
Lee, S.1
French, M.A.2
Price, P.3
-
40
-
-
31144441631
-
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: Enhanced expression in psoriatic skin
-
Piskin, G., Sylva-Steenland, R. M., Bos, J. D., Teunissen, M. B. (2006) In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J. Immunol. 176, 1908-1915.
-
(2006)
J. Immunol
, vol.176
, pp. 1908-1915
-
-
Piskin, G.1
Sylva-Steenland, R.M.2
Bos, J.D.3
Teunissen, M.B.4
-
41
-
-
80755180843
-
δ T cells in skin inflammation
-
δ T cells in skin inflammation. Immunity 35, 596-610.
-
(2011)
Immunity
, vol.35
, pp. 596-610
-
-
Cai, Y.1
Shen, X.2
Ding, C.3
Qi, C.4
Li, K.5
Li, X.6
Jala, V.R.7
Zhang, H.G.8
Wang, T.9
Zheng, J.10
Yan, J.11
-
42
-
-
78649666553
-
Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis
-
Res, P. C., Piskin, G., de Boer, O. J., van der Loos, C. M., Teeling, P., Bos, J. D., Teunissen, M. B. (2010) Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One 5, e14108.
-
(2010)
PLoS One
, vol.5
-
-
Res, P.C.1
Piskin, G.2
de Boer, O.J.3
van der Loos, C.M.4
Teeling, P.5
Bos, J.D.6
Teunissen, M.B.7
-
43
-
-
77951636478
-
Mast cells express IL-17A in rheumatoid arthritis synovium
-
Hueber, A. J., Asquith, D. L., Miller, A. M., Reilly, J., Kerr, S., Leipe, J., Melendez, A. J., McInnes, I. B. (2010) Mast cells express IL-17A in rheumatoid arthritis synovium. J. Immunol. 184, 3336-3340.
-
(2010)
J. Immunol
, vol.184
, pp. 3336-3340
-
-
Hueber, A.J.1
Asquith, D.L.2
Miller, A.M.3
Reilly, J.4
Kerr, S.5
Leipe, J.6
Melendez, A.J.7
McInnes, I.B.8
-
44
-
-
69449095507
-
IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines
-
Ortega, C., Fernandez, A. S., Carrillo, J. M., Romero, P., Molina, I. J., Moreno, J. C., Santamaria, M. (2009) IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines. J. Leukoc. Biol. 86, 435-443.
-
(2009)
J. Leukoc. Biol
, vol.86
, pp. 435-443
-
-
Ortega, C.1
Fernandez, A.S.2
Carrillo, J.M.3
Romero, P.4
Molina, I.J.5
Moreno, J.C.6
Santamaria, M.7
-
45
-
-
33846608131
-
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
-
Cargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., Leong, D. U., Panko, J. M., McAllister, L. B., Hansen, C. B., Papenfuss, J., Prescott, S. M., White, T. J., Leppert, M. F., Krueger, G. G., Begovich, A. B. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet. 80, 273-290.
-
(2007)
Am. J. Hum. Genet
, vol.80
, pp. 273-290
-
-
Cargill, M.1
Schrodi, S.J.2
Chang, M.3
Garcia, V.E.4
Brandon, R.5
Callis, K.P.6
Matsunami, N.7
Ardlie, K.G.8
Civello, D.9
Catanese, J.J.10
Leong, D.U.11
Panko, J.M.12
McAllister, L.B.13
Hansen, C.B.14
Papenfuss, J.15
Prescott, S.M.16
White, T.J.17
Leppert, M.F.18
Krueger, G.G.19
Begovich, A.B.20
more..
-
46
-
-
70349753261
-
Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis
-
Harper, E. G., Guo, C., Rizzo, H., Lillis, J. V., Kurtz, S. E., Skorcheva, I., Purdy, D., Fitch, E., Iordanov, M., Blauvelt, A. (2009) Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J. Invest. Dermatol. 129, 2175-2183.
-
(2009)
J. Invest. Dermatol
, vol.129
, pp. 2175-2183
-
-
Harper, E.G.1
Guo, C.2
Rizzo, H.3
Lillis, J.V.4
Kurtz, S.E.5
Skorcheva, I.6
Purdy, D.7
Fitch, E.8
Iordanov, M.9
Blauvelt, A.10
-
47
-
-
0034660183
-
Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis
-
Homey, B., Dieu-Nosjean, M. C., Wiesenborn, A., Massacrier, C., Pin, J. J., Oldham, E., Catron, D., Buchanan, M. E., Muller, A., DeWaal Malefyt, R., Deng, G., Orozco, R., Ruzicka, T., Lehmann, P., Lebecque, S., Caux, C., Zlotnik, A. (2000) Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164, 6621-6632.
-
(2000)
J. Immunol
, vol.164
, pp. 6621-6632
-
-
Homey, B.1
Dieu-Nosjean, M.C.2
Wiesenborn, A.3
Massacrier, C.4
Pin, J.J.5
Oldham, E.6
Catron, D.7
Buchanan, M.E.8
Muller, A.9
de Waal, M.R.10
Deng, G.11
Orozco, R.12
Ruzicka, T.13
Lehmann, P.14
Lebecque, S.15
Caux, C.16
Zlotnik, A.17
-
48
-
-
33749318470
-
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
-
Liang, S. C., Tan, X. Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., Fouser, L. A. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279.
-
(2006)
J. Exp. Med
, vol.203
, pp. 2271-2279
-
-
Liang, S.C.1
Tan, X.Y.2
Luxenberg, D.P.3
Karim, R.4
Dunussi-Joannopoulos, K.5
Collins, M.6
Fouser, L.A.7
-
49
-
-
78650706586
-
Cutting edge: A critical functional role for IL-23 in psoriasis
-
Tonel, G., Conrad, C., Laggner, U., Di Meglio, P., Grys, K., McClanahan, T. K., Blumenschein, W. M., Qin, J. Z., Xin, H., Oldham, E., Kastelein, R., Nickoloff, B. J., Nestle, F. O. (2010) Cutting edge: a critical functional role for IL-23 in psoriasis. J. Immunol. 185, 5688-5691.
-
(2010)
J. Immunol
, vol.185
, pp. 5688-5691
-
-
Tonel, G.1
Conrad, C.2
Laggner, U.3
Di Meglio, P.4
Grys, K.5
McClanahan, T.K.6
Blumenschein, W.M.7
Qin, J.Z.8
Xin, H.9
Oldham, E.10
Kastelein, R.11
Nickoloff, B.J.12
Nestle, F.O.13
-
50
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng, Y., Danilenko, D. M., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., Ouyang, W. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651.
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
Danilenko, D.M.2
Valdez, P.3
Kasman, I.4
Eastham-Anderson, J.5
Wu, J.6
Ouyang, W.7
-
51
-
-
79251569587
-
IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A
-
Rizzo, H. L., Kagami, S., Phillips, K. G., Kurtz, S. E., Jacques, S. L., Blauvelt, A. (2011) IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A. J. Immunol. 186, 1495-1502.
-
(2011)
J. Immunol
, vol.186
, pp. 1495-1502
-
-
Rizzo, H.L.1
Kagami, S.2
Phillips, K.G.3
Kurtz, S.E.4
Jacques, S.L.5
Blauvelt, A.6
-
52
-
-
79955045064
-
Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model
-
Nakajima, K., Kanda, T., Takaishi, M., Shiga, T., Miyoshi, K., Nakajima, H., Kamijima, R., Tarutani, M., Benson, J. M., Elloso, M. M., Gutshall, L. L., Naso, M. F., Iwakura, Y., DiGiovanni, J., Sano, S. (2011) Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. J. Immunol. 186, 4481-4489.
-
(2011)
J. Immunol
, vol.186
, pp. 4481-4489
-
-
Nakajima, K.1
Kanda, T.2
Takaishi, M.3
Shiga, T.4
Miyoshi, K.5
Nakajima, H.6
Kamijima, R.7
Tarutani, M.8
Benson, J.M.9
Elloso, M.M.10
Gutshall, L.L.11
Naso, M.F.12
Iwakura, Y.13
Digiovanni, J.14
Sano, S.15
-
53
-
-
80051930220
-
T helper 17 cell heterogeneity and pathogenicity in autoimmune disease
-
Ghoreschi, K., Laurence, A., Yang, X. P., Hirahara, K., O'Shea, J. J. (2011) T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol. 32, 395-401.
-
(2011)
Trends Immunol
, vol.32
, pp. 395-401
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
Hirahara, K.4
O'Shea, J.J.5
-
54
-
-
58149331211
-
Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells
-
Zaba, L. C., Fuentes-Duculan, J., Eungdamrong, N. J., Abello, M. V., Novitskaya, I., Pierson, K. C., Gonzalez, J., Krueger, J. G., Lowes, M. A. (2009) Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J. Invest. Dermatol. 129, 79-88.
-
(2009)
J. Invest. Dermatol
, vol.129
, pp. 79-88
-
-
Zaba, L.C.1
Fuentes-Duculan, J.2
Eungdamrong, N.J.3
Abello, M.V.4
Novitskaya, I.5
Pierson, K.C.6
Gonzalez, J.7
Krueger, J.G.8
Lowes, M.A.9
-
55
-
-
33749151636
-
An anti-IL-12p40 antibody downregulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis
-
Toichi, E., Torres, G., McCormick, T. S., Chang, T., Mascelli, M. A., Kauffman, C. L., Aria, N., Gottlieb, A. B., Everitt, D. E., Frederick, B., Pendley, C. E., Cooper, K. D. (2006) An anti-IL-12p40 antibody downregulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. J. Immunol. 177, 4917-4926.
-
(2006)
J. Immunol
, vol.177
, pp. 4917-4926
-
-
Toichi, E.1
Torres, G.2
McCormick, T.S.3
Chang, T.4
Mascelli, M.A.5
Kauffman, C.L.6
Aria, N.7
Gottlieb, A.B.8
Everitt, D.E.9
Frederick, B.10
Pendley, C.E.11
Cooper, K.D.12
-
56
-
-
43449111187
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
-
Leonardi, C. L., Kimball, A. B., Papp, K. A., Yeilding, N., Guzzo, C., Wang, Y., Li, S., Dooley, L. T., Gordon, K. B. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371, 1665-1674.
-
(2008)
Lancet
, vol.371
, pp. 1665-1674
-
-
Leonardi, C.L.1
Kimball, A.B.2
Papp, K.A.3
Yeilding, N.4
Guzzo, C.5
Wang, Y.6
Li, S.7
Dooley, L.T.8
Gordon, K.B.9
-
57
-
-
43449139402
-
Efficacy and safety of ustekinumab, a human interleukin- 12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
-
Papp, K. A., Langley, R. G., Lebwohl, M., Krueger, G. G., Szapary, P., Yeilding, N., Guzzo, C., Hsu, M. C., Wang, Y., Li, S., Dooley, L. T., Reich, K. (2008) Efficacy and safety of ustekinumab, a human interleukin- 12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 371, 1675-1684.
-
(2008)
Lancet
, vol.371
, pp. 1675-1684
-
-
Papp, K.A.1
Langley, R.G.2
Lebwohl, M.3
Krueger, G.G.4
Szapary, P.5
Yeilding, N.6
Guzzo, C.7
Hsu, M.C.8
Wang, Y.9
Li, S.10
Dooley, L.T.11
Reich, K.12
-
58
-
-
74249094930
-
Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
-
Griffiths, C. E., Strober, B. E., van de Kerkhof, P., Ho, V., Fidelus- Gort, R., Yeilding, N., Guzzo, C., Xia, Y., Zhou, B., Li, S., Dooley, L. T., Goldstein, N. H., Menter, A. (2010) Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N. Engl. J. Med. 362, 118-128.
-
(2010)
N. Engl. J. Med
, vol.362
, pp. 118-128
-
-
Griffiths, C.E.1
Strober, B.E.2
van de Kerkhof, P.3
Ho, V.4
Fidelus-Gort, R.5
Yeilding, N.6
Guzzo, C.7
Xia, Y.8
Zhou, B.9
Li, S.10
Dooley, L.T.11
Goldstein, N.H.12
Menter, A.13
-
59
-
-
80054949734
-
A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis
-
Reich, K., Langley, R. G., Papp, K. A., Ortonne, J. P., Unnebrink, K., Kaul, M., Valdes, J. M. (2011) A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis. N. Engl. J. Med. 365, 1586-1596.
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 1586-1596
-
-
Reich, K.1
Langley, R.G.2
Papp, K.A.3
Ortonne, J.P.4
Unnebrink, K.5
Kaul, M.6
Valdes, J.M.7
-
60
-
-
84855938590
-
A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis
-
Gordon, K. B., Langley, R. G., Gottlieb, A. B., Papp, K. A., Krueger, G. G., Strober, B. E., Williams, D. A., Gu, Y., Valdes, J. M. (2012) A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis. J. Invest. Dermatol. 132, 304-314.
-
(2012)
J. Invest. Dermatol
, vol.132
, pp. 304-314
-
-
Gordon, K.B.1
Langley, R.G.2
Gottlieb, A.B.3
Papp, K.A.4
Krueger, G.G.5
Strober, B.E.6
Williams, D.A.7
Gu, Y.8
Valdes, J.M.9
-
61
-
-
84855709124
-
Briakinumab for the treatment of plaque psoriasis
-
Traczewski, P., Rudnicka, L. (2012) Briakinumab for the treatment of plaque psoriasis. BioDrugs 26, 9-20.
-
(2012)
BioDrugs
, vol.26
, pp. 9-20
-
-
Traczewski, P.1
Rudnicka, L.2
-
62
-
-
77958072084
-
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
-
Hueber, W., Patel, D. D., Dryja, T., Wright, A. M., Koroleva, I., Bruin, G., Antoni, C., Draelos, Z., Gold, M. H., Durez, P., Tak, P. P., Gomez- Reino, J. J., Foster, C. S., Kim, R. Y., Samson, C. M., Falk, N. S., Chu, D. S., Callanan, D., Nguyen, Q. D., Rose, K., Haider, A., Di Padova, F. (2010) Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci. Transl. Med. 2, 52ra72.
-
(2010)
Sci. Transl. Med
, vol.2
-
-
Hueber, W.1
Patel, D.D.2
Dryja, T.3
Wright, A.M.4
Koroleva, I.5
Bruin, G.6
Antoni, C.7
Draelos, Z.8
Gold, M.H.9
Durez, P.10
Tak, P.P.11
Gomez-Reino, J.J.12
Foster, C.S.13
Kim, R.Y.14
Samson, C.M.15
Falk, N.S.16
Chu, D.S.17
Callanan, D.18
Nguyen, Q.D.19
Rose, K.20
Haider, A.21
Di Padova, F.22
more..
-
63
-
-
77950535421
-
LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, doubleblind, placebo-controlled, proof-of-concept study
-
Genovese, M. C., Van den Bosch, F., Roberson, S. A., Bojin, S., Biagini, I. M., Ryan, P., Sloan-Lancaster, J. (2010) LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, doubleblind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 62, 929-939.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 929-939
-
-
Genovese, M.C.1
Van den Bosch, F.2
Roberson, S.A.3
Bojin, S.4
Biagini, I.M.5
Ryan, P.6
Sloan-Lancaster, J.7
-
64
-
-
84859073115
-
Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
-
Leonardi, C., Matheson, R., Zachariae, C., Cameron, G., Li, L., Edson- Heredia, E., Braun, D., Banerjee, S. (2012) Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 366, 1190-1199.
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1190-1199
-
-
Leonardi, C.1
Matheson, R.2
Zachariae, C.3
Cameron, G.4
Li, L.5
Edson-Heredia, E.6
Braun, D.7
Banerjee, S.8
-
65
-
-
84859017988
-
Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
-
Papp, K. A., Leonardi, C., Menter, A., Ortonne, J. P., Krueger, J. G., Kricorian, G., Aras, G., Li, J., Russell, C. B., Thompson, E. H., Baumgartner, S. (2012) Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N. Engl. J. Med. 366, 1181-1189.
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 1181-1189
-
-
Papp, K.A.1
Leonardi, C.2
Menter, A.3
Ortonne, J.P.4
Krueger, J.G.5
Kricorian, G.6
Aras, G.7
Li, J.8
Russell, C.B.9
Thompson, E.H.10
Baumgartner, S.11
-
66
-
-
66949162673
-
Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis
-
van der Fits, L., Mourits, S., Voerman, J. S., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A. M., Florencia, E., Prens, E. P., Lubberts, E. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182, 5836-5845.
-
(2009)
J. Immunol
, vol.182
, pp. 5836-5845
-
-
van der Fits, L.1
Mourits, S.2
Voerman, J.S.3
Kant, M.4
Boon, L.5
Laman, J.D.6
Cornelissen, F.7
Mus, A.M.8
Florencia, E.9
Prens, E.P.10
Lubberts, E.11
-
67
-
-
77952358850
-
Ligand regulation of retinoic acid receptor-related orphan receptors: Implications for development of novel therapeutics
-
Solt, L. A., Griffin, P. R., Burris, T. P. (2010) Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Curr. Opin. Lipidol. 21, 204-211.
-
(2010)
Curr. Opin. Lipidol
, vol.21
, pp. 204-211
-
-
Solt, L.A.1
Griffin, P.R.2
Burris, T.P.3
-
68
-
-
47749124186
-
Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt
-
Ichiyama, K., Yoshida, H., Wakabayashi, Y., Chinen, T., Saeki, K., Nakaya, M., Takaesu, G., Hori, S., Yoshimura, A., Kobayashi, T. (2008) Foxp3 inhibits RORγt-mediated IL-17A mRNA transcription through direct interaction with RORγt. J. Biol. Chem. 283, 17003-17008.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 17003-17008
-
-
Ichiyama, K.1
Yoshida, H.2
Wakabayashi, Y.3
Chinen, T.4
Saeki, K.5
Nakaya, M.6
Takaesu, G.7
Hori, S.8
Yoshimura, A.9
Kobayashi, T.10
-
69
-
-
0028197552
-
Isoform-specific amino-terminal domains dictate DNA-binding properties of RORγ, a novel family of orphan hormone nuclear receptors
-
Giguere, V., Tini, M., Flock, G., Ong, E., Evans, R. M., Otulakowski, G. (1994) Isoform-specific amino-terminal domains dictate DNA-binding properties of RORγ, a novel family of orphan hormone nuclear receptors. Genes Dev. 8, 538-553.
-
(1994)
Genes Dev
, vol.8
, pp. 538-553
-
-
Giguere, V.1
Tini, M.2
Flock, G.3
Ong, E.4
Evans, R.M.5
Otulakowski, G.6
-
70
-
-
0035238364
-
The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes
-
Jetten, A. M., Kurebayashi, S., Ueda, E. (2001) The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog. Nucleic Acids Res. Mol. Biol. 69, 205-247.
-
(2001)
Prog. Nucleic Acids Res. Mol. Biol
, vol.69
, pp. 205-247
-
-
Jetten, A.M.1
Kurebayashi, S.2
Ueda, E.3
-
71
-
-
79955538365
-
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
-
Huh, J. R., Leung, M. W., Huang, P., Ryan, D. A., Krout, M. R., Malapaka, R. R., Chow, J., Manel, N., Ciofani, M., Kim, S. V., Cuesta, A., Santori, F. R., Lafaille, J. J., Xu, H. E., Gin, D. Y., Rastinejad, F., Littman, D. R. (2011) Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature 472, 486-490.
-
(2011)
Nature
, vol.472
, pp. 486-490
-
-
Huh, J.R.1
Leung, M.W.2
Huang, P.3
Ryan, D.A.4
Krout, M.R.5
Malapaka, R.R.6
Chow, J.7
Manel, N.8
Ciofani, M.9
Kim, S.V.10
Cuesta, A.11
Santori, F.R.12
Lafaille, J.J.13
Xu, H.E.14
Gin, D.Y.15
Rastinejad, F.16
Littman, D.R.17
-
72
-
-
79955526989
-
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand
-
Solt, L. A., Kumar, N., Nuhant, P., Wang, Y., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidovic, D., Schurer, S. C., Xu, J., Wagoner, G., Drew, P. D., Griffin, P. R., Burris, T. P. (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472, 491-494.
-
(2011)
Nature
, vol.472
, pp. 491-494
-
-
Solt, L.A.1
Kumar, N.2
Nuhant, P.3
Wang, Y.4
Lauer, J.L.5
Liu, J.6
Istrate, M.A.7
Kamenecka, T.M.8
Roush, W.R.9
Vidovic, D.10
Schurer, S.C.11
Xu, J.12
Wagoner, G.13
Drew, P.D.14
Griffin, P.R.15
Burris, T.P.16
-
73
-
-
79959538387
-
Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγ t protein
-
Xu, T., Wang, X., Zhong, B., Nurieva, R. I., Ding, S., Dong, C. (2011) Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγ t protein. J. Biol. Chem. 286, 22707-22710.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 22707-22710
-
-
Xu, T.1
Wang, X.2
Zhong, B.3
Nurieva, R.I.4
Ding, S.5
Dong, C.6
-
74
-
-
84860176210
-
Identification of SR2211: A potent synthetic RORγ-selective modulator
-
Kumar, N., Lyda, B., Chang, M. R., Lauer, J. L., Solt, L. A., Burris, T. P., Kamenecka, T. M., Griffin, P. R. (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem. Biol. 7, 672-677.
-
(2012)
ACS Chem. Biol
, vol.7
, pp. 672-677
-
-
Kumar, N.1
Lyda, B.2
Chang, M.R.3
Lauer, J.L.4
Solt, L.A.5
Burris, T.P.6
Kamenecka, T.M.7
Griffin, P.R.8
-
75
-
-
84868089340
-
Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells
-
Epub ahead of print
-
Solt, L. A., Kumar, N., He, Y., Kamenecka, T. M., Griffin, P. R., Burris, T. P. (2012) Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells. ACS Chem. Biol., Epub ahead of print.
-
(2012)
ACS Chem. Biol
-
-
Solt, L.A.1
Kumar, N.2
He, Y.3
Kamenecka, T.M.4
Griffin, P.R.5
Burris, T.P.6
-
76
-
-
23744437421
-
Noncalcemic actions of vitamin D receptor ligands
-
Nagpal, S., Na, S., Rathnachalam, R. (2005) Noncalcemic actions of vitamin D receptor ligands. Endocr. Rev. 26, 662-687.
-
(2005)
Endocr. Rev
, vol.26
, pp. 662-687
-
-
Nagpal, S.1
Na, S.2
Rathnachalam, R.3
-
77
-
-
79955048926
-
Calcipotriol/betamethasone dipropionate: A review of its use in the treatment of psoriasis vulgaris of the trunk, limbs and scalp
-
McCormack, P. L. (2011) Calcipotriol/betamethasone dipropionate: a review of its use in the treatment of psoriasis vulgaris of the trunk, limbs and scalp. Drugs 71, 709-730.
-
(2011)
Drugs
, vol.71
, pp. 709-730
-
-
McCormack, P.L.1
-
78
-
-
84855836920
-
A nonsecosteroidal vitamin D receptor modulator ameliorates experimental autoimmune encephalomyelitis without causing hypercalcemia
-
Na, S., Ma, Y., Zhao, J., Schmidt, C., Zeng, Q. Q., Chandrasekhar, S., Chin, W. W., Nagpal, S. (2011) A nonsecosteroidal vitamin D receptor modulator ameliorates experimental autoimmune encephalomyelitis without causing hypercalcemia. Autoimmune Dis. 2011, 132958.
-
(2011)
Autoimmune Dis
, vol.2011
, pp. 132958
-
-
Na, S.1
Ma, Y.2
Zhao, J.3
Schmidt, C.4
Zeng, Q.Q.5
Chandrasekhar, S.6
Chin, W.W.7
Nagpal, S.8
-
79
-
-
80052387833
-
1,25-Dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
-
Joshi, S., Pantalena, L. C., Liu, X. K., Gaffen, S. L., Liu, H., Rohowsky- Kochan, C., Ichiyama, K., Yoshimura, A., Steinman, L., Christakos, S., Youssef, S. (2011) 1,25-Dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol. Cell. Biol. 31, 3653-3669.
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 3653-3669
-
-
Joshi, S.1
Pantalena, L.C.2
Liu, X.K.3
Gaffen, S.L.4
Liu, H.5
Rohowsky-Kochan, C.6
Ichiyama, K.7
Yoshimura, A.8
Steinman, L.9
Christakos, S.10
Youssef, S.11
-
80
-
-
78049265765
-
1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells
-
Ikeda, U., Wakita, D., Ohkuri, T., Chamoto, K., Kitamura, H., Iwakura, Y., Nishimura, T. (2010) 1α,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells. Immunol. Lett. 134, 7-16.
-
(2010)
Immunol. Lett
, vol.134
, pp. 7-16
-
-
Ikeda, U.1
Wakita, D.2
Ohkuri, T.3
Chamoto, K.4
Kitamura, H.5
Iwakura, Y.6
Nishimura, T.7
-
81
-
-
39549091298
-
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
-
Chen, Z., Laurence, A., O'Shea, J. J. (2007) Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin. Immunol. 19, 400-408.
-
(2007)
Semin. Immunol
, vol.19
, pp. 400-408
-
-
Chen, Z.1
Laurence, A.2
O'Shea, J.J.3
-
82
-
-
33847351136
-
The JAK-STAT signaling pathway: Input and output integration
-
Murray, P. J. (2007) The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178, 2623-2629.
-
(2007)
J. Immunol
, vol.178
, pp. 2623-2629
-
-
Murray, P.J.1
-
83
-
-
61849086101
-
Janus kinases in immune cell signaling
-
Ghoreschi, K., Laurence, A., O'Shea, J. J. (2009) Janus kinases in immune cell signaling. Immunol. Rev. 228, 273-287.
-
(2009)
Immunol. Rev
, vol.228
, pp. 273-287
-
-
Ghoreschi, K.1
Laurence, A.2
O'Shea, J.J.3
-
84
-
-
84860238507
-
Dynamics and non-canonical aspects of JAK/STAT signalling
-
Mohr, A., Chatain, N., Domoszlai, T., Rinis, N., Sommerauer, M., Vogt, M., Muller-Newen, G. (2012) Dynamics and non-canonical aspects of JAK/STAT signalling. Eur. J. Cell Biol. 91, 524-532.
-
(2012)
Eur. J. Cell Biol
, vol.91
, pp. 524-532
-
-
Mohr, A.1
Chatain, N.2
Domoszlai, T.3
Rinis, N.4
Sommerauer, M.5
Vogt, M.6
Muller-Newen, G.7
-
85
-
-
79960392815
-
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/ Th17 axes in vivo
-
Ishizaki, M., Akimoto, T., Muromoto, R., Yokoyama, M., Ohshiro, Y., Sekine, Y., Maeda, H., Shimoda, K., Oritani, K., Matsuda, T. (2011) Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/ Th17 axes in vivo. J. Immunol. 187, 181-189.
-
(2011)
J. Immunol
, vol.187
, pp. 181-189
-
-
Ishizaki, M.1
Akimoto, T.2
Muromoto, R.3
Yokoyama, M.4
Ohshiro, Y.5
Sekine, Y.6
Maeda, H.7
Shimoda, K.8
Oritani, K.9
Matsuda, T.10
-
86
-
-
33845897463
-
Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
-
Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, I., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H. D., Renner, E. D., Jansson, A., Belohradsky, B. H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., Karasuyama, H. (2006) Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25, 745-755.
-
(2006)
Immunity
, vol.25
, pp. 745-755
-
-
Minegishi, Y.1
Saito, M.2
Morio, T.3
Watanabe, K.4
Agematsu, K.5
Tsuchiya, S.6
Takada, H.7
Hara, T.8
Kawamura, N.9
Ariga, T.10
Kaneko, H.11
Kondo, N.12
Tsuge, I.13
Yachie, A.14
Sakiyama, Y.15
Iwata, T.16
Bessho, F.17
Ohishi, T.18
Joh, K.19
Imai, K.20
Kogawa, K.21
Shinohara, M.22
Fujieda, M.23
Wakiguchi, H.24
Pasic, S.25
Abinun, M.26
Ochs, H.D.27
Renner, E.D.28
Jansson, A.29
Belohradsky, B.H.30
Metin, A.31
Shimizu, N.32
Mizutani, S.33
Miyawaki, T.34
Nonoyama, S.35
Karasuyama, H.36
more..
-
87
-
-
80051667225
-
JAK inhibitors in myeloproliferative neoplasms: Rationale, current data and perspective
-
Tefferi, A., Pardanani, A. (2011) JAK inhibitors in myeloproliferative neoplasms: rationale, current data and perspective. Blood Rev. 25, 229-237.
-
(2011)
Blood Rev
, vol.25
, pp. 229-237
-
-
Tefferi, A.1
Pardanani, A.2
-
88
-
-
77954531991
-
Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: Preclinical characterization of INCB028050
-
Fridman, J. S., Scherle, P. A., Collins, R., Burn, T. C., Li, Y., Li, J., Covington, M. B., Thomas, B., Collier, P., Favata, M. F., Wen, X., Shi, J., McGee, R., Haley, P. J., Shepard, S., Rodgers, J. D., Yeleswaram, S., Hollis, G., Newton, R. C., Metcalf, B., Friedman, S. M., Vaddi, K. (2010) Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J. Immunol. 184, 5298-5307.
-
(2010)
J. Immunol
, vol.184
, pp. 5298-5307
-
-
Fridman, J.S.1
Scherle, P.A.2
Collins, R.3
Burn, T.C.4
Li, Y.5
Li, J.6
Covington, M.B.7
Thomas, B.8
Collier, P.9
Favata, M.F.10
Wen, X.11
Shi, J.12
McGee, R.13
Haley, P.J.14
Shepard, S.15
Rodgers, J.D.16
Yeleswaram, S.17
Hollis, G.18
Newton, R.C.19
Metcalf, B.20
Friedman, S.M.21
Vaddi, K.22
more..
-
89
-
-
77955375143
-
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
-
Meyer, D. M., Jesson, M. I., Li, X., Elrick, M. M., Funckes-Shippy, C. L., Warner, J. D., Gross, C. J., Dowty, M. E., Ramaiah, S. K., Hirsch, J. L., Saabye, M. J., Barks, J. L., Kishore, N., Morris, D. L. (2010) Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J. Inflamm. (Lond.) 7, 41.
-
(2010)
J. Inflamm. (Lond.)
, vol.7
, pp. 41
-
-
Meyer, D.M.1
Jesson, M.I.2
Li, X.3
Elrick, M.M.4
Funckes-Shippy, C.L.5
Warner, J.D.6
Gross, C.J.7
Dowty, M.E.8
Ramaiah, S.K.9
Hirsch, J.L.10
Saabye, M.J.11
Barks, J.L.12
Kishore, N.13
Morris, D.L.14
-
90
-
-
84856699985
-
Incyte comes of age with JAK inhibitor approval
-
Moran, N. (2012) Incyte comes of age with JAK inhibitor approval. Nat. Biotechnol. 30, 3-5.
-
(2012)
Nat. Biotechnol
, vol.30
, pp. 3-5
-
-
Moran, N.1
-
91
-
-
84864066214
-
Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis
-
Epub ahead of print
-
Punwani, N., Scherle, P., Flores, R., Shi, J., Liang, J., Yeleswaram, S., Levy, R., Williams, W., Gottlieb, A. (2012) Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis. J. Am. Acad. Dermatol., Epub ahead of print.
-
(2012)
J. Am. Acad. Dermatol
-
-
Punwani, N.1
Scherle, P.2
Flores, R.3
Shi, J.4
Liang, J.5
Yeleswaram, S.6
Levy, R.7
Williams, W.8
Gottlieb, A.9
-
92
-
-
80051788025
-
Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation
-
Fridman, J. S., Scherle, P. A., Collins, R., Burn, T., Neilan, C. L., Hertel, D., Contel, N., Haley, P., Thomas, B., Shi, J., Collier, P., Rodgers, J. D., Shepard, S., Metcalf, B., Hollis, G., Newton, R. C., Yeleswaram, S., Friedman, S. M., Vaddi, K. (2011) Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation. J. Invest. Dermatol. 131, 1838-1844.
-
(2011)
J. Invest. Dermatol
, vol.131
, pp. 1838-1844
-
-
Fridman, J.S.1
Scherle, P.A.2
Collins, R.3
Burn, T.4
Neilan, C.L.5
Hertel, D.6
Contel, N.7
Haley, P.8
Thomas, B.9
Shi, J.10
Collier, P.11
Rodgers, J.D.12
Shepard, S.13
Metcalf, B.14
Hollis, G.15
Newton, R.C.16
Yeleswaram, S.17
Friedman, S.M.18
Vaddi, K.19
-
93
-
-
70349736206
-
Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis
-
Boy, M. G., Wang, C., Wilkinson, B. E., Chow, V. F., Clucas, A. T., Krueger, J. G., Gaweco, A. S., Zwillich, S. H., Changelian, P. S., Chan, G. (2009) Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis. J. Invest. Dermatol. 129, 2299-2302.
-
(2009)
J. Invest. Dermatol
, vol.129
, pp. 2299-2302
-
-
Boy, M.G.1
Wang, C.2
Wilkinson, B.E.3
Chow, V.F.4
Clucas, A.T.5
Krueger, J.G.6
Gaweco, A.S.7
Zwillich, S.H.8
Changelian, P.S.9
Chan, G.10
-
94
-
-
84866156845
-
A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
-
Kremer, J. M., Cohen, S., Wilkinson, B. E., Connell, C. A., French, J. L., Gomez-Reino, J., Gruben, D., Kanik, K. S., Krishnaswami, S., Pascual- Ramos, V., Wallenstein, G., Zwillich, S. H. (2012) A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum. 64, 970-981.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 970-981
-
-
Kremer, J.M.1
Cohen, S.2
Wilkinson, B.E.3
Connell, C.A.4
French, J.L.5
Gomez-Reino, J.6
Gruben, D.7
Kanik, K.S.8
Krishnaswami, S.9
Pascual-Ramos, V.10
Wallenstein, G.11
Zwillich, S.H.12
-
95
-
-
79955027327
-
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
-
Ghoreschi, K., Jesson, M. I., Li, X., Lee, J. L., Ghosh, S., Alsup, J. W., Warner, J. D., Tanaka, M., Steward-Tharp, S. M., Gadina, M., Thomas, C. J., Minnerly, J. C., Storer, C. E., LaBranche, T. P., Radi, Z. A., Dowty, M. E., Head, R. D., Meyer, D. M., Kishore, N., O'Shea, J. J. (2011) Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J. Immunol. 186, 4234-4243.
-
(2011)
J. Immunol
, vol.186
, pp. 4234-4243
-
-
Ghoreschi, K.1
Jesson, M.I.2
Li, X.3
Lee, J.L.4
Ghosh, S.5
Alsup, J.W.6
Warner, J.D.7
Tanaka, M.8
Steward-Tharp, S.M.9
Gadina, M.10
Thomas, C.J.11
Minnerly, J.C.12
Storer, C.E.13
Labranche, T.P.14
Radi, Z.A.15
Dowty, M.E.16
Head, R.D.17
Meyer, D.M.18
Kishore, N.19
O'Shea, J.J.20
more..
-
96
-
-
77953201731
-
4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease
-
Fitzpatrick, L. R., Deml, L., Hofmann, C., Small, J. S., Groeppel, M., Hamm, S., Lemstra, S., Leban, J., Ammendola, A. (2010) 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm. Bowel Dis. 16, 1763-1777.
-
(2010)
Inflamm. Bowel Dis
, vol.16
, pp. 1763-1777
-
-
Fitzpatrick, L.R.1
Deml, L.2
Hofmann, C.3
Small, J.S.4
Groeppel, M.5
Hamm, S.6
Lemstra, S.7
Leban, J.8
Ammendola, A.9
-
97
-
-
77953227262
-
4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL- (Fas)lpr mice
-
Kulkarni, O. P., Sayyed, S. G., Kantner, C., Ryu, M., Schnurr, M., Sardy, M., Leban, J., Jankowsky, R., Ammendola, A., Doblhofer, R., Anders, H. J. (2010) 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL- (Fas)lpr mice. Am. J. Pathol. 176, 2840-2847.
-
(2010)
Am. J. Pathol
, vol.176
, pp. 2840-2847
-
-
Kulkarni, O.P.1
Sayyed, S.G.2
Kantner, C.3
Ryu, M.4
Schnurr, M.5
Sardy, M.6
Leban, J.7
Jankowsky, R.8
Ammendola, A.9
Doblhofer, R.10
Anders, H.J.11
-
98
-
-
38449114897
-
A new orally active anti-rheumatic drug targets IL-15 and IL-17
-
Chiba, K. (2007) [A new orally active anti-rheumatic drug targets IL-15 and IL-17]. Nihon Rinsho Meneki Gakkai Kaishi 30, 375-382.
-
(2007)
Nihon Rinsho Meneki Gakkai Kaishi
, vol.30
, pp. 375-382
-
-
Chiba, K.1
-
99
-
-
33846864685
-
Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor
-
Wada, Y., Lu, R., Zhou, D., Chu, J., Przewloka, T., Zhang, S., Li, L., Wu, Y., Qin, J., Balasubramanyam, V., Barsoum, J., Ono, M. (2007) Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood 109, 1156-1164.
-
(2007)
Blood
, vol.109
, pp. 1156-1164
-
-
Wada, Y.1
Lu, R.2
Zhou, D.3
Chu, J.4
Przewloka, T.5
Zhang, S.6
Li, L.7
Wu, Y.8
Qin, J.9
Balasubramanyam, V.10
Barsoum, J.11
Ono, M.12
-
100
-
-
77953693548
-
Randomized, double-blind, placebo- controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease
-
Sands, B. E., Jacobson, E. W., Sylwestrowicz, T., Younes, Z., Dryden, G., Fedorak, R., Greenbloom, S. (2010) Randomized, double-blind, placebo- controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease. Inflamm. Bowel Dis. 16, 1209-1218.
-
(2010)
Inflamm. Bowel Dis
, vol.16
, pp. 1209-1218
-
-
Sands, B.E.1
Jacobson, E.W.2
Sylwestrowicz, T.3
Younes, Z.4
Dryden, G.5
Fedorak, R.6
Greenbloom, S.7
-
101
-
-
84857762846
-
Brief report: A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an IL-12/IL-23 inhibitor, in patients with rheumatoid arthritis
-
Krausz, S., Boumans, M. J., Gerlag, D. M., Lufkin, J., van Kuijk, A. W., Bakker, A., de Boer, M., Lodde, B. M., Reedquist, K. A., Jacobson, E. W., O'Meara, M., Tak, P. P. (2012) Brief report: a phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an IL-12/IL-23 inhibitor, in patients with rheumatoid arthritis. Arthritis Rheum. 64, 1750-1755.
-
(2012)
Arthritis Rheum
, vol.64
, pp. 1750-1755
-
-
Krausz, S.1
Boumans, M.J.2
Gerlag, D.M.3
Lufkin, J.4
van Kuijk, A.W.5
Bakker, A.6
de Boer, M.7
Lodde, B.M.8
Reedquist, K.A.9
Jacobson, E.W.10
O'Meara, M.11
Tak, P.P.12
-
102
-
-
67650224449
-
Crohn's disease: Th1, Th17 or both? The change of a paradigm: New immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
-
Brand, S. (2009) Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 58, 1152-1167.
-
(2009)
Gut
, vol.58
, pp. 1152-1167
-
-
Brand, S.1
-
103
-
-
77952722679
-
Benefit-risk assessment of tumour necrosis factor antagonists in the treatment of psoriasis
-
Langley, R. G., Strober, B. E., Gu, Y., Rozzo, S. J., Okun, M. M. (2010) Benefit-risk assessment of tumour necrosis factor antagonists in the treatment of psoriasis. Br. J. Dermatol. 162, 1349-1358.
-
(2010)
Br. J. Dermatol
, vol.162
, pp. 1349-1358
-
-
Langley, R.G.1
Strober, B.E.2
Gu, Y.3
Rozzo, S.J.4
Okun, M.M.5
-
104
-
-
38949197817
-
IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?
-
Lubberts, E. (2008) IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine 41, 84-91.
-
(2008)
Cytokine
, vol.41
, pp. 84-91
-
-
Lubberts, E.1
-
105
-
-
84868680312
-
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Epub ahead of print
-
Hueber, W., Sands, B. E., Lewitzky, S., Vandemeulebroecke, M., Reinisch, W., Higgins, P. D., Wehkamp, J., Feagan, B. G., Yao, M. D., Karczewski, M., Karczewski, J., Pezous, N., Bek, S., Bruin, G., Mellgard, B., Berger, C., Londei, M., Bertolino, A. P., Tougas, G., Travis, S. P. (2012) Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut Epub ahead of print.
-
(2012)
Gut
-
-
Hueber, W.1
Sands, B.E.2
Lewitzky, S.3
Vandemeulebroecke, M.4
Reinisch, W.5
Higgins, P.D.6
Wehkamp, J.7
Feagan, B.G.8
Yao, M.D.9
Karczewski, M.10
Karczewski, J.11
Pezous, N.12
Bek, S.13
Bruin, G.14
Mellgard, B.15
Berger, C.16
Londei, M.17
Bertolino, A.P.18
Tougas, G.19
Travis, S.P.20
more..
-
106
-
-
53049091561
-
A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn, W. J., Feagan, B. G., Fedorak, R. N., Scherl, E., Fleisher, M. R., Katz, S., Johanns, J., Blank, M., Rutgeerts, P. (2008) A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 135, 1130-1141.
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
Scherl, E.4
Fleisher, M.R.5
Katz, S.6
Johanns, J.7
Blank, M.8
Rutgeerts, P.9
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