-
1
-
-
12144281223
-
Psoriasis: Emerging therapeutic strategies
-
A. Gottlieb Psoriasis: emerging therapeutic strategies Nat Rev Drug Discov 4 2005 19 34
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 19-34
-
-
Gottlieb, A.1
-
3
-
-
9744265704
-
Phase i study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
-
C. Kauffman, N. Aria, E. Toichi, T. McCormick, K. Cooper, and A. Gottlieb Phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis J Invest Dermatol 123 2004 1037 1044
-
(2004)
J Invest Dermatol
, vol.123
, pp. 1037-1044
-
-
Kauffman, C.1
Aria, N.2
Toichi, E.3
McCormick, T.4
Cooper, K.5
Gottlieb, A.6
-
4
-
-
39649108216
-
Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis
-
A. Kimball, K. Gordon, R. Langley, A. Menter, E. Chartash, and J. Valdes Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis Arch Dermatol 144 2008 200 207
-
(2008)
Arch Dermatol
, vol.144
, pp. 200-207
-
-
Kimball, A.1
Gordon, K.2
Langley, R.3
Menter, A.4
Chartash, E.5
Valdes, J.6
-
5
-
-
67349230808
-
The IL-23/Th17 axis in the immunopathogenesis of psoriasis
-
A. Di Cesare, P. Di Meglio, and F. Nestle The IL-23/Th17 axis in the immunopathogenesis of psoriasis J Invest Dermatol 129 2009 1339 1350
-
(2009)
J Invest Dermatol
, vol.129
, pp. 1339-1350
-
-
Di Cesare, A.1
Di Meglio, P.2
Nestle, F.3
-
6
-
-
34248561238
-
Tumor necrosis factor blockade: Mechanism of action
-
A. Gottlieb Tumor necrosis factor blockade: mechanism of action J Investig Dermatol Symp Proc 12 2007 1 4
-
(2007)
J Investig Dermatol Symp Proc
, vol.12
, pp. 1-4
-
-
Gottlieb, A.1
-
7
-
-
84866347232
-
Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation
-
J. Fridman, P. Scherle, R. Collins, T. Burn, C. Neilan, and D. Hertel Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation J Invest Dermatol 140 2011 138 144
-
(2011)
J Invest Dermatol
, vol.140
, pp. 138-144
-
-
Fridman, J.1
Scherle, P.2
Collins, R.3
Burn, T.4
Neilan, C.5
Hertel, D.6
-
8
-
-
80053014000
-
The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers
-
J.G. Shi, X. Chen, R.F. McGee, R.R. Landman, T. Emm, and Y. Lo The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers J Clin Pharmacol 51 2011 1644 1654
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 1644-1654
-
-
Shi, J.G.1
Chen, X.2
McGee, R.F.3
Landman, R.R.4
Emm, T.5
Lo, Y.6
-
9
-
-
34548535119
-
Targeting TNFα rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation
-
D. Marble, K. Gordon, and B. Nickoloff Targeting TNFα rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation J Dermatol Sci 48 2007 87 101
-
(2007)
J Dermatol Sci
, vol.48
, pp. 87-101
-
-
Marble, D.1
Gordon, K.2
Nickoloff, B.3
-
10
-
-
43449139402
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 2)
-
K. Papp, R. Langley, M. Lebwohl, G. Krueger, P. Szapary, and N. Yeilding Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 2) Lancet 371 2008 1675 1684
-
(2008)
Lancet
, vol.371
, pp. 1675-1684
-
-
Papp, K.1
Langley, R.2
Lebwohl, M.3
Krueger, G.4
Szapary, P.5
Yeilding, N.6
-
11
-
-
33847351136
-
The JAK-STAT signaling pathway: Input and output integration
-
P. Murray The JAK-STAT signaling pathway: input and output integration J Immunol 178 2007 2623 2629
-
(2007)
J Immunol
, vol.178
, pp. 2623-2629
-
-
Murray, P.1
-
12
-
-
32144453842
-
JAK/STAT signal transduction: Regulators and implication in hematological malignancies
-
L. Valentino, and J. Pierre JAK/STAT signal transduction: regulators and implication in hematological malignancies Biochem Pharmacol 71 2006 713 721
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 713-721
-
-
Valentino, L.1
Pierre, J.2
-
13
-
-
77950684805
-
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
-
A. Quintas-Cardama, K. Vaddi, P. Liu, T. Manshouri, J. Li, and P. Scherle Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms Blood 115 2010 3109 3117
-
(2010)
Blood
, vol.115
, pp. 3109-3117
-
-
Quintas-Cardama, A.1
Vaddi, K.2
Liu, P.3
Manshouri, T.4
Li, J.5
Scherle, P.6
-
14
-
-
0002966198
-
Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17
-
S. Subramaniam, R. Cooper, and S. Adunyah Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17 Biochem Biophys Res Commun 262 1999 14 19
-
(1999)
Biochem Biophys Res Commun
, vol.262
, pp. 14-19
-
-
Subramaniam, S.1
Cooper, R.2
Adunyah, S.3
-
15
-
-
4344680231
-
Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24
-
M. Wang, Z. Tan, E. Thomas, and P. Liang Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24 Genes Immun 5 2004 363 370
-
(2004)
Genes Immun
, vol.5
, pp. 363-370
-
-
Wang, M.1
Tan, Z.2
Thomas, E.3
Liang, P.4
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