메뉴 건너뛰기




Volumn 67, Issue 4, 2012, Pages 658-664

Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis

Author keywords

INCB018424; Janus associated kinase inhibitor; psoriasis

Indexed keywords

BETAMETHASONE DIPROPIONATE; CALCIPOTRIOL; JANUS KINASE 2 INHIBITOR; PLACEBO; RUXOLITINIB;

EID: 84864066214     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2011.12.018     Document Type: Article
Times cited : (156)

References (15)
  • 1
    • 12144281223 scopus 로고    scopus 로고
    • Psoriasis: Emerging therapeutic strategies
    • A. Gottlieb Psoriasis: emerging therapeutic strategies Nat Rev Drug Discov 4 2005 19 34
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 19-34
    • Gottlieb, A.1
  • 3
    • 9744265704 scopus 로고    scopus 로고
    • Phase i study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
    • C. Kauffman, N. Aria, E. Toichi, T. McCormick, K. Cooper, and A. Gottlieb Phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis J Invest Dermatol 123 2004 1037 1044
    • (2004) J Invest Dermatol , vol.123 , pp. 1037-1044
    • Kauffman, C.1    Aria, N.2    Toichi, E.3    McCormick, T.4    Cooper, K.5    Gottlieb, A.6
  • 4
    • 39649108216 scopus 로고    scopus 로고
    • Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis
    • A. Kimball, K. Gordon, R. Langley, A. Menter, E. Chartash, and J. Valdes Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis Arch Dermatol 144 2008 200 207
    • (2008) Arch Dermatol , vol.144 , pp. 200-207
    • Kimball, A.1    Gordon, K.2    Langley, R.3    Menter, A.4    Chartash, E.5    Valdes, J.6
  • 5
    • 67349230808 scopus 로고    scopus 로고
    • The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    • A. Di Cesare, P. Di Meglio, and F. Nestle The IL-23/Th17 axis in the immunopathogenesis of psoriasis J Invest Dermatol 129 2009 1339 1350
    • (2009) J Invest Dermatol , vol.129 , pp. 1339-1350
    • Di Cesare, A.1    Di Meglio, P.2    Nestle, F.3
  • 6
    • 34248561238 scopus 로고    scopus 로고
    • Tumor necrosis factor blockade: Mechanism of action
    • A. Gottlieb Tumor necrosis factor blockade: mechanism of action J Investig Dermatol Symp Proc 12 2007 1 4
    • (2007) J Investig Dermatol Symp Proc , vol.12 , pp. 1-4
    • Gottlieb, A.1
  • 7
    • 84866347232 scopus 로고    scopus 로고
    • Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation
    • J. Fridman, P. Scherle, R. Collins, T. Burn, C. Neilan, and D. Hertel Preclinical evaluation of local JAK1 and JAK2 inhibition in cutaneous inflammation J Invest Dermatol 140 2011 138 144
    • (2011) J Invest Dermatol , vol.140 , pp. 138-144
    • Fridman, J.1    Scherle, P.2    Collins, R.3    Burn, T.4    Neilan, C.5    Hertel, D.6
  • 8
    • 80053014000 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers
    • J.G. Shi, X. Chen, R.F. McGee, R.R. Landman, T. Emm, and Y. Lo The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers J Clin Pharmacol 51 2011 1644 1654
    • (2011) J Clin Pharmacol , vol.51 , pp. 1644-1654
    • Shi, J.G.1    Chen, X.2    McGee, R.F.3    Landman, R.R.4    Emm, T.5    Lo, Y.6
  • 9
    • 34548535119 scopus 로고    scopus 로고
    • Targeting TNFα rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation
    • D. Marble, K. Gordon, and B. Nickoloff Targeting TNFα rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation J Dermatol Sci 48 2007 87 101
    • (2007) J Dermatol Sci , vol.48 , pp. 87-101
    • Marble, D.1    Gordon, K.2    Nickoloff, B.3
  • 10
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 2)
    • K. Papp, R. Langley, M. Lebwohl, G. Krueger, P. Szapary, and N. Yeilding Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomized, double-blind, placebo-controlled trial (PHOENIX 2) Lancet 371 2008 1675 1684
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.1    Langley, R.2    Lebwohl, M.3    Krueger, G.4    Szapary, P.5    Yeilding, N.6
  • 11
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • P. Murray The JAK-STAT signaling pathway: input and output integration J Immunol 178 2007 2623 2629
    • (2007) J Immunol , vol.178 , pp. 2623-2629
    • Murray, P.1
  • 12
    • 32144453842 scopus 로고    scopus 로고
    • JAK/STAT signal transduction: Regulators and implication in hematological malignancies
    • L. Valentino, and J. Pierre JAK/STAT signal transduction: regulators and implication in hematological malignancies Biochem Pharmacol 71 2006 713 721
    • (2006) Biochem Pharmacol , vol.71 , pp. 713-721
    • Valentino, L.1    Pierre, J.2
  • 13
    • 77950684805 scopus 로고    scopus 로고
    • Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: Therapeutic implications for the treatment of myeloproliferative neoplasms
    • A. Quintas-Cardama, K. Vaddi, P. Liu, T. Manshouri, J. Li, and P. Scherle Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms Blood 115 2010 3109 3117
    • (2010) Blood , vol.115 , pp. 3109-3117
    • Quintas-Cardama, A.1    Vaddi, K.2    Liu, P.3    Manshouri, T.4    Li, J.5    Scherle, P.6
  • 14
    • 0002966198 scopus 로고    scopus 로고
    • Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17
    • S. Subramaniam, R. Cooper, and S. Adunyah Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17 Biochem Biophys Res Commun 262 1999 14 19
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 14-19
    • Subramaniam, S.1    Cooper, R.2    Adunyah, S.3
  • 15
    • 4344680231 scopus 로고    scopus 로고
    • Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24
    • M. Wang, Z. Tan, E. Thomas, and P. Liang Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24 Genes Immun 5 2004 363 370
    • (2004) Genes Immun , vol.5 , pp. 363-370
    • Wang, M.1    Tan, Z.2    Thomas, E.3    Liang, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.