IL-23 and IFN-γ deficiency in immunodeficient HIV patients who achieved a long-term increase in CD4 T-cell counts on highly active antiretroviral therapy

AIDS

Volumn 18, Issue 9, 2004, Pages 1337-1340

  Lee, Silvia ^a   French, Martyn A H ^a   Price, Patricia ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 23; MESSENGER RNA;

ARTICLE; BLOOD CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; LONG TERM CARE; MALE; MEMORY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; HIV INFECTIONS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-23; INTERLEUKIN-23 SUBUNIT P19; INTERLEUKINS; LYMPHOCYTES; MALE; REVERSE TRANSCRIPTASE INHIBITORS; RNA, MESSENGER;

EID: 3042689555     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200406180-00014     Document Type: Article

References (20)

1. Kirk O, Reiss P, Uberti-Foppa C, Bickel M, Gerstoft J, Pradier C, et al. Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy. Ann Intern Med 2002, 137:239-250.
2. Komanduri KV, Feinberg J, Hutchins RK, Frame RD, Schmidt DK, Viswanathan MN, et al. Loss of cytomegalovirus-specific CD4+ T cell responses in human immunodeficiency virus type 1-infected patients with high CD4+ T cell counts and recurrent retinitis. J Infect Dis 2001, 183:1285-1289.
3. Johnson SC, Benson CA, Johnson DW, Weinberg A. Recurrences of cytomegalovirus retinitis in a human immunodeficiency virus-infected patient, despite potent antiretroviral therapy and apparent immune reconstitution. Clin Infect Dis 2001, 32:815-819.
4. D'Offizi G, Ciapparoni V, Gioia C, Goletti D, Agrati C, Pucillo LP, et al. The loss of CMV-specific CD27(-) T-cell effectors in a patient with recurrences of CMV retinitis is independent of HIV-1 viremia. Infection 2002, 30:323-325.
5. Lilleri D, Piccinini G, Baldanti F, Seminari E, Galloni D, Gerna G. Multiple relapses of human cytomegalovirus retinitis during HAART in an AIDS patient with reconstitution of CD4+ T cell count in the absence of HCMV-specific CD4+ T cell response. J Clin Virol 2003, 26:95-100.
6. + T cell frequency by cytokine flow cytometry as a possible indicator for discontinuation of HCMV secondary prophylaxis in HAART-treated AIDS patients. J Clin Virol 2003; 29:297-307.
7. 3. AIDS 2001, 15:1912-1913.
8. Degen O, ven Lunzen J, Horstkotte MA, Sobottka I, Stellbrink HJ. Pneumocystis carinii pneumonia after the discontinuation of secondary prophylaxis. AIDS 2002, 16:1433-1434.
9. Crothers K, Huang L. Recurrence of Pneumocystis carinii pneumonia in an HIV-infected patient: apparent selective immune reconstitution after initiation of antiretroviral therapy. HIV Med 2003, 4:346-349.
10. Murray R, Mallal S, Heath C, French M. Cerebral Mycobacterium avium infection in an HIV-infected patient following immune reconstitution and cessation of therapy for disseminated Mycobacterium avium complex infection. Eur J Clin Microbiol Infect Dis 2001, 20:199-201.
11. Aberg JA, Chin-Hong PV, McCutchan A, Koletar SL, Currier JS. Localized osteomyelitis due to Mycobacterium avium complex in patients with human immunodeficiency virus receiving highly active antiretroviral therapy. Clin infect Dis 2002, 35:8-13.
12. Aberg JA, Williams PL, Liu T, Lederman HM, Hafner R, Torriani FJ, et al. A study of discontinuing maintenance therapy in human immunodeficiency virus-infected subjects with disseminated Mycobacterium avium complex: AIDS Clinical Trial Croup 393 Study Team. J Infect Dis 2003, 187:1046-1052.
13. Stout JE, Lai JC, Giner J, Hamilton CD. Reactivation of retinal toxoplasmosis despite evidence of immune response to highly active antiretroviral therapy. Clin Infect Dis 2002, 35:37-39.
14. Shearer GM, Clerici M. Cytokine profiles in HIV type 1 disease and protection. AIDS Res Hum Retroviruses 1998, 14 (Suppl. 2):S149-S152.
15. Lammas DA, Casanova JL, Kumararatne DS. Clinical consequences of defects in the IL-12-dependent interferon-gamma (IFN-gamma) pathway. Clin Exp Immunol 2000, 121:417-425.
16. Marshall JD, Chehimi J, Gri G, Kostman JR, Montaner LJ, Trichieri G. The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals. Blood 1999, 94:1003-1011.
17. Chougnet C, Wynn TA, Clerici M, Landay AL, Kessler HA, Rusnak J, et al. Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. J Infect Dis 1996, 174:46-53.
18. Lankford CSR, Frucht DM. A unique role for IL-23 in promoting cellular immunity. J Leukoc Biol 2003, 73:49-56.
19. Lange CG, Lederman MM, Medvik K, Asaad R, Wild M, Kalayjian R, et al. Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection. AIDS 2003, 17:2015-2023.
20. Keane NM, Price P, Lee S, Almeida CA, Stone SF, James I, et al. Restoration of CD4 T-cell responses to cytomegalovirus is short-lived in severely immunodeficient HIV patients responding to HAART. HIV Medicine 2004, in press.