HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gαi2 for degradation through ubiquitination

Journal of Biological Chemistry

Volumn 287, Issue 49, 2012, Pages 41481-41498

  Chandrasekaran, Prabha ^a   Buckley, Monica ^a   Moore, Victoria ^a   Wang, Long Qin ^a   Kehrl, John H ^a   Venkatesan, Sundararajan ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MOTILITY; CELL SURFACE RECEPTORS; CELL TYPES; CRITICAL DETERMINANT; DYNAMIN; GENE TRANSFECTION; HETEROTRIMERIC G-PROTEIN; HIV INFECTION; HIV-1 NEF; LEUKOCYTE MIGRATION; N-TERMINALS; PARTIAL RECOVERY; PATHOGENIC FACTORS; PROTEIN TRANSDUCTION; RECEPTOR SIGNALING; TERNARY COMPLEX; UBIQUITINATION;

AMINO ACIDS; BIOCHEMISTRY; CELL MEMBRANES; MOLECULAR BIOLOGY;

PROTEINS;

ATROPHIN INTERACTING PROTEIN 4; CELL PROTEIN; CHEMOKINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NEF PROTEIN; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL HOMING; CELL TYPE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKOCYTE MIGRATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STEADY STATE; UBIQUITINATION;

CHEMOKINES; CHEMOTAXIS; DIMERIZATION; ENDOSOMES; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEINS; HELA CELLS; HUMANS; IMMUNE SYSTEM; JURKAT CELLS; LENTIVIRUS; LYMPHOCYTES; LYSOSOMES; MICROSCOPY, CONFOCAL; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84870352487     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.361782     Document Type: Article

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