Degradation of heterotrimeric Gα(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin

Journal of Biological Chemistry

Volumn 275, Issue 3, 2000, Pages 1565-1569

  Busconi, Liliana ^b   Guan, Jiazhen ^a   Denker, Bradley M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Fundacion para Investigaciones Biologicas Aplicadas   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

GELDANAMYCIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN 90; PROTEASOME; SULFUR 35; BENZOQUINONE DERIVATIVE; CYSTEINE PROTEINASE; ENZYME INHIBITOR; MACROCYCLIC LACTAM; MULTIENZYME COMPLEX; QUINONE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; IMMUNOPRECIPITATION; IN VITRO STUDY; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL STRAIN; COMPARATIVE STUDY; DOSE RESPONSE; GENETIC TRANSFECTION; METABOLISM; SERODIAGNOSIS; TIME;

ANIMALS; BENZOQUINONES; CELL LINE; COS CELLS; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HSP90 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MULTIENZYME COMPLEXES; PC12 CELLS; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; QUINONES; RATS; TIME FACTORS; TRANSFECTION;

EID: 0034695257     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.3.1565     Document Type: Article

References (28)

1. Wedegaertner, P. B. (1998) Biol. Signals Recept. 7, 125-135
2. Neer, E. J. (1995) Cell 80, 249-257
3. Hunt, T. W., Carroll, R. C., and Peralta, E. G. (1994) J. Biol. Chem. 269, 29565-29570
4. Lefkowitz, R. J. (1998) J. Biol. Chem, 273, 18677-18680
5. Berman, D. M., and Gilman, A. G. (1998) J. Biol. Chem. 273, 1269-1272
6. Madura, K., and Varshavsky, A. (1994) Science 265, 1454-1458
7. Segnitz, B., and Gehring, U. (1997) J. Biol. Chem. 272, 18694-18701
8. Xu, Y., and Lindquist, S. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 7074-7078
9. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., and Neckers, L. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8324-8328
10. Stebbins, C. E., Russo, A. A., Schneider, C., Rosen, N., Hartl, F. U., and Pavletich, N. P. (1997) Cell 89, 239-250
11. Nusse, O., and Neer, E. J. (1996) J. Cell Sci. 109, 221-228
12. Denker, B. M., Neer, E. J., and Schmidt, C. J. (1992) J. Biol. Chem. 267, 6272-6277
13. Busconi, L., Boutin, P. M., and Denker, B. M. (1997) Biochem. J. 323, 239-244
14. Huff, R. M., Axton, J. M., and Neer, E. J. (1985) J. Biol. Chem. 260, 10864-10871
15. Mimnaugh, E. G., Worland, P. J., Whitesell, L., and Neckers, L. M. (1995) J. Biol. Chem. 270, 28654-28659
16. Buchner, J. (1999) Trends Biochem. Sci. 24, 136-141
17. Ianobe, A., Takahashi, K., and Katada, T. (1994) J. Biochem. (Tokyo) 115, 486-492
18. Busconi, L., and Denker, B. M. (1997) Biochem. J. 328, 23-31
19. Denker, B. M., and Neer, E. J. (1991) FEBS Lett. 279, 98-100
20. Mitch, W. E., and Goldberg, A. L. (1996) N. Engl. J. Med. 335, 1897-1905
21. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., and Goldberg, A. L. (1994) Cell 78, 761-771
22. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. (1994) Cell 78, 773-785
23. Mori, S., Tanaka, K., Omura, S., and Saito, Y. (1995) J. Biol. Chem. 270, 29447-29452
24. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, S. L. (1995) Science 268, 726-731
25. Mitchell, F. M., Buckley, N. J., and Milligan, G. (1993) Biochem. J. 293, 495-499
26. Wise, A., Lee, T. W., MacEwan, D. J., and Milligan, G. (1995) J. Biol. Chem. 270, 17196-17203
27. Levis, M. J., and Bourne, H. R. (1992) J. Cell Biol. 119, 1297-1307
28. Silbert, S., Michel, T., Lee, R., and Neer, E. J. (1990) J. Biol. Chem. 265, 3102-3105