HIV-1 Nef disrupts maturation of CD4+ T cells through CD4/Lck modulation

Journal of Immunology

Volumn 185, Issue 7, 2010, Pages 3948-3959

  Chrobak, Pavel ^a   Simard, Marie Chantal ^a   Bouchard, Nathalie ^a   Ndolo, Thomas Mutushi ^a   Guertin, Joël ^a   Hanna, Zaher ^a,c,e   Dave, Vibhuti ^b,c,e   Jolicoeur, Paul ^a,d,e  

^a Lab of Molecular Endocrinology   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c Department of Medicine ^*  (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN; VIRUS PROTEIN; CD4 ANTIGEN; PROTEIN KINASE LCK;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CELL SELECTION; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; LYMPHOCYTOPENIA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; ORGANOGENESIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS; TRANSGENIC MOUSE; ANIMAL; CELL DIFFERENTIATION; CELL SEPARATION; CYTOLOGY; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOLOGY; METABOLISM; PATHOGENICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY;

ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SEPARATION; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; IMMUNOBLOTTING; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, TRANSGENIC; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 77958125069     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001064     Document Type: Article

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