Macrophage inflammatory protein 1α inhibits postentry steps of human immunodeficiency virus type 1 infection via suppression of intracellular cyclic AMP

Journal of Virology

Volumn 79, Issue 9, 2005, Pages 5625-5631

  Amella, Carol Ann ^a   Sherry, Barbara ^a   Shepp, David H ^b,d   Schmidtmayerova, Helena ^a,c  

^a Ctr for Immunology and Inflammation   (United States)

^b NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^c Institute for Medical Research at North Shore LIJ   (United States)

^d GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; VIRUS DNA;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION;

CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGE INFLAMMATORY PROTEIN-1; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 17444376444     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.9.5625-5631.2005     Document Type: Article

References (42)

1. Aandahl, E. M., P. Aukrust, B. S. Skalhegg, F. Muller, S. S. Froland, V. Hansson, and K. Tasken. 1998. Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients. FASEB J. 12:855-862.
2. Aukrust, P., E. M. Aandahl, B. S. Skalhegg, I. Nordoy, V. Hansson, K. Tasken, S. S. Froland, and F. Muller. 1999. Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency. J. Immunol. 162:1178-1185.
3. Blumer, K. J., and G. L. Johnson. 1994. Diversity in function and regulation of MAP kinase pathways. Trends Biochem. Sci. 19:236-240.
4. Buc, H. A., A. Moncion, M. Hamet, and J. L. Perignon. 1993. T-cell antigen receptor-mediated enhancement of the adenylate cyclase pathway depends on tyrosine protein kinases. Int. J. Immunopharmacol. 15:415-422.
5. Cartier, C., B. Hemonnot, B. Gay, M. Bardy, C. Sanchiz, C. Devaux, and L. Briant. 2003. Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein. J. Biol. Chem. 278:35211-35219.
6. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. La Rosa, W. Newman, N. Gerard, C. Gerard, and J. Sodroski. 1996. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135-1148.
7. Cocchi, F., A. L. De Vico, A. Garzino-Demo, S. K. Arya, R. C. Gallo, and P. Lusso. 1995. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270: 1811-1815.
8. Cole, S. W., B. D. Jamieson, and J. A. Zack. 1999. cAMP up-regulates cell surface expression of lymphocyte CXCR4: implications for chemotaxis and HIV-1 infection. J. Immunol. 162:1392-1400.
9. Cole, S. W., Y. D. Korin, J. L. Fahey, and J. A. Zack. 1998. Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production. J. Immunol. 161:610-616.
10. Cole, S. W., B. D. Naliboff, M. E. Kemeny, M. P. Griswold, J. L. Fahey, and J. A. Zack. 2001. Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity. Proc. Natl. Acad. Sci. USA 98:12695-12700.
11. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
12. Dragic, T., V. Litwin, G. P. Allaway, S. R. Martin, Y. Huang, K. A. Nagashima, C. Cayanan, P. J. Maddon, R. A. Koup, J. P. Moore, and W. A. Paxton. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-673.
13. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
14. Gilman, A. G. 1987. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56:615-649.
15. Gordon, C. J., M.A. Muesing, A. E. Proudfoot, C. A. Power, J. P. Moore, and A. Trkola. 1999. Enhancement of human immunodeficiency virus type 1 infection by the CC-chemokine Rantes is independent of the mechanism of virus-cell fusion. J. Virol. 73:684-694.
16. Haraguchi, S., R. A. Good, M. James-Yarish, G. J. Cianciolo, and N. K. Day. 1995. Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. Proc. Natl. Acad. Sci. USA 92:5568-5571.
17. Hayes, M. M., B. R. Lane, S. R. King, D. M. Markovitz, and M. J. Coffey. 2002. Prostaglandin E(2) inhibits replication of HIV-1 in macrophages through activation of protein kinase A. Cell. Immunol. 215:61-71.
18. Hofmann, B., P. Nishanian, T. Nguyen, P. Insixiengmay, and J. L. Fahey. 1993. Human immunodeficiency virus proteins induce the inhibitory cAMP/ protein kinase A pathway in normal lymphocytes. Proc. Natl. Acad. Sci. USA 90:6676-6680.
19. Hofmann, B., P. Nishanian, T. Nguyen, M. Liu, and J. L. Fahey. 1993. Restoration of T-cell function in HIV infection by reduction of intracellular cAMP levels with adenosine analogues. AIDS 7:659-664.
20. Holter, W., A. M. Spiegel, B. H. Howard, S. Weber, and M. R. Brann. 1991. Expression of GTP-binding proteins and prostaglandin E2 receptors during human T cell activation. Cell. Immunol. 134:287-295.
21. Irersen, A. K., L. Fugger, J. Eugen-Olsen, U. Balslev, T. Jensen, S. Wahl, J. Gerstoft, J. I. Mullins, and P. Skinhoj. 1998. Cervical human immunodeficiency virus type 1 shedding is associated with genital beta-chemokine secretion. J. Infect. Dis. 178:1334-1342.
22. Jennes, W., S. Sawadogo, S. Koblavi-Deme, B. Vuylsteke, C. Maurice, T. H. Roels, T. Chorba, J. N. Nkengasong, and L. Kestens. 2002. Positive association between beta-chemokine-producing T cells and HIV type 1 viral load in HIV-infected subjects in Abidjan, Cote d'Ivoire. AIDS Res. Hum. Retrovir. 18:171-177.
23. Johansson, C. C., T. Bryn, A. Yndestad, H. G. Eiken, V. Bjerkeli, S. S. Froland, P. Aukrust, and K. Tasken. 2004. Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP. AIDS 18:171-179.
24. Kinter, A., A. Catanzaro, J. Monaco, M. Ruiz, J. Justement, S. Moir, J. Arthos, A. Oliva, L. Ehler, S. Mizell, R. Jackson, M, Ostrowski, J. Hoxie, R. Offord, and A. S. Fauci. 1998. CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction. Proc. Natl. Acad. Sci. USA 95:11880-11885.
25. Ko, J., I. S. Kim, S. W. Jang, Y. H. Lee, S. Y. Shin, D. S. Min, and D. S. Na. 2002. Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells. FEBS Lett. 515:159-164.
26. Kopperud, R., C. Krakstad, F. Selheim, and S. O. Doskeland. 2003. cAMP effector mechanisms. Novel twists for an 'old' signaling system. FEBS Lett. 546:121-126.
27. Mack, M., B. Luckow, P. J. Nelson, J. Cihak, G. Simmons, P. R. Clapham, N. Signoret, M. Marsh, M. Stangassinger, F. Borlat, T. N. Wells, D. Schlondorff, and A. E. Proudfoot. 1998. Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J. Exp. Med. 187:1215-1224.
28. Masci, A. M., M. Galgani, S. Cassano, S. De Simone, A. Gallo, V. De Rosa, S. Zappacosta, and L. Racioppi. 2003. HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. J. Leukoc. Biol. 74:1117-1124.
29. Nokta, M., J. Belli, and R. Pollard. 1992. X-irradiation enhances in vitro human immunodeficiency virus replication correlation with cellular levels of cAMP. Proc. Soc. Exp. Biol. Med. 200:402-408.
30. Nokta, M., and R. Pollard. 1991. Human immunodeficiency virus infection: association with altered intracellular levels of cAMP and cGMP in MT-4 cells. Virology 181:211-217.
31. Nokta, M. A., and R. B. Pollard. 1992. Human immunodeficiency virus replication: modulation by cellular levels of cAMP. AIDS Res. Hum. Retrovir. 8:1255-1261.
32. Paxton, W. A., T. Dragic, R. A. Koup, and J. P. Moore. 1996. The beta-chemokines, HIV type 1 second receptors, and exposed uninfected persons. AIDS Res. Hum. Retrovir. 12:1203-1207.
33. Post, G. R., and J. H. Brown. 1996. G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J. 10:741-749.
34. Rich, T. C., and J. W. Karpen. 2002. Cyclic AMP sensors in living cells: what signals can they actually measure? Ann. Biomed. Eng. 30:1088-1099.
35. Schmidtmayerova, H., M. Alfano, G. Nuovo, and M. Bukrinsky. 1998. Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: replication is restricted at a postentry level. J. Virol. 72:4633-4642.
36. Shabb, J. B. 2001. Physiological substrates of cAMP-dependent protein kinase. Chem. Rev. 101:2381-2411.
37. Torgersen, K. M., T. Vang, H. Abrahamsen, S. Yaqub, and K. Tasken. 2002. Molecular mechanisms for protein kinase A-mediated modulation of immune function. Cell. Signal. 14:1-9.
38. Trkola, A., T. Dragic, J. Arthos, J. M. Binley, W. C. Olson, G. P. Allaway, C. Cheng-Mayer, J. Robinson, P. J. Maddon, and J. P. Moore. 1996. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 384:184-187.
39. Wu, L., N. P. Gerard, R. Wyatt, H. Choe, C. Parolin, N. Ruffing, A. Borsetti, A. A. Cardoso, E. Desjardin, W. Newman, C. Gerard, and J. Sodroski. 1996. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384:179-183.
40. Zack, J. A., A. M. Haislip, P. Krogstad, and I. S. Chen. 1992. Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle. J. Virol. 66:1717-1725.
41. Zaitseva, M., A. Blauvelt, S. Lee, C. K. Lapham, V. Klaus-Kovtun, H. Mostowski, J. Manischewitz, and H. Golding. 1997. Expression and function of CCR5 and CXCR4 on human langerhans cells and macrophages: implications for HIV primary infection. Nat. Med. 3:1369-1375.
42. Zhao, J., L. Ma, Y. L. Wu, P. Wang, W. Hu, and G. Pei. 1998. Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization. J. Cell. Biochem. 71:36-45.