-
1
-
-
67649407509
-
The cell biology of HIV-1 virion genesis
-
Bieniasz, P. D. (2009) The cell biology of HIV-1 virion genesis. Cell Host Microbe 5, 550-558
-
(2009)
Cell Host Microbe
, vol.5
, pp. 550-558
-
-
Bieniasz, P.D.1
-
2
-
-
80051767703
-
The role of cellular factors in promoting HIV budding
-
Weiss, E. R., and Göttlinger, H. (2011) The role of cellular factors in promoting HIV budding. J. Mol. Biol. 410, 525-533
-
(2011)
J. Mol. Biol.
, vol.410
, pp. 525-533
-
-
Weiss, E.R.1
Göttlinger, H.2
-
3
-
-
84880735062
-
HIV-1 Assembly, Budding, and Maturation
-
Sundquist, W. I., and Krausslich, H. G. (2012) HIV-1 Assembly, Budding, and Maturation. Cold Spring Harb. Perspect. Med. 2, a006924
-
(2012)
Cold Spring Harb. Perspect. Med.
, vol.2
-
-
Sundquist, W.I.1
Krausslich, H.G.2
-
4
-
-
84881193881
-
Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis
-
DOI 10.1016/j.chom.2008.10.013, PII S1931312808003673
-
Carlson, L. A., Briggs, J. A., Glass, B., Riches, J. D., Simon, M. N., Johnson, M. C., Müller, B., Grünewald, K., and Kräusslich, H. G. (2008) Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. Cell Host Microbe 4, 592-599 (Pubitemid 352762957)
-
(2008)
Cell Host and Microbe
, vol.4
, Issue.6
, pp. 592-599
-
-
Carlson, L.-A.1
Briggs, J.A.G.2
Glass, B.3
Riches, J.D.4
Simon, M.N.5
Johnson, M.C.6
Muller, B.7
Grunewald, K.8
Krausslich, H.-G.9
-
5
-
-
0025297912
-
Translational suppression in gene expression in retroviruses and retrotransposons
-
Jacks, T. (1990) Translational suppression in gene expression in retroviruses and retrotransposons. Curr. Top. Microbiol. Immunol. 157, 93-124
-
(1990)
Curr. Top. Microbiol. Immunol.
, vol.157
, pp. 93-124
-
-
Jacks, T.1
-
6
-
-
0004131381
-
-
Coffin, J. M., Hughes, S. H., and Varmus, H. E., ed Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
Swanstrom, R., and Wills, J. W. (1997) in Retroviruses (Coffin, J. M., Hughes, S. H., and Varmus, H. E., ed) pp. 263-334, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
-
(1997)
Retroviruses
, pp. 263-334
-
-
Swanstrom, R.1
Wills, J.W.2
-
7
-
-
3042642144
-
The stoichiometry of Gag protein in HIV-1
-
DOI 10.1038/nsmb785
-
Briggs, J. A., Simon, M. N., Gross, I., Kräusslich, H. G., Fuller, S. D., Vogt, V. M., and Johnson, M. C. (2004) The stoichiometry of Gag protein in HIV-1. Nat. Struct. Mol. Biol. 11, 672-675 (Pubitemid 38823535)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.7
, pp. 672-675
-
-
Briggs, J.A.G.1
Simon, M.N.2
Gross, I.3
Krausslich, H.-G.4
Fuller, S.D.5
Vogt, V.M.6
Johnson, M.C.7
-
8
-
-
33144463548
-
The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine
-
DOI 10.1128/JVI.80.5.2578-2581.2006
-
Ambrose, Z., Julias, J. G., Boyer, P. L., Kewalramani, V. N., and Hughes, S. H. (2006) The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudine. J. Virol. 80, 2578-2581 (Pubitemid 43271563)
-
(2006)
Journal of Virology
, vol.80
, Issue.5
, pp. 2578-2581
-
-
Ambrose, Z.1
Julias, J.G.2
Boyer, P.L.3
KewalRamani, V.N.4
Hughes, S.H.5
-
9
-
-
46049096485
-
Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
-
DOI 10.1038/nm1777, PII NM1777
-
Shen, L., Peterson, S., Sedaghat, A. R., McMahon, M. A., Callender, M., Zhang, H., Zhou, Y., Pitt, E., Anderson, K. S., Acosta, E. P., and Siliciano, R. F. (2008) Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nat. Med. 14, 762-766 (Pubitemid 351951518)
-
(2008)
Nature Medicine
, vol.14
, Issue.7
, pp. 762-766
-
-
Shen, L.1
Peterson, S.2
Sedaghat, A.R.3
McMahon, M.A.4
Callender, M.5
Zhang, H.6
Zhou, Y.7
Pitt, E.8
Anderson, K.S.9
Acosta, E.P.10
Siliciano, R.F.11
-
10
-
-
79956291343
-
Doseresponse curve slope is a missing dimension in the analysis of HIV-1 drug resistance
-
Sampah, M. E., Shen, L., Jilek, B. L., and Siliciano, R. F. (2011) Doseresponse curve slope is a missing dimension in the analysis of HIV-1 drug resistance. Proc. Natl. Acad. Sci. U.S.A. 108, 7613-7618
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 7613-7618
-
-
Sampah, M.E.1
Shen, L.2
Jilek, B.L.3
Siliciano, R.F.4
-
11
-
-
79960373686
-
A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs
-
Shen, L., Rabi, S. A., Sedaghat, A. R., Shan, L., Lai, J., Xing, S., and Siliciano, R. F. (2011) A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs. Sci. Transl. Med. 3, 91ra63
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Shen, L.1
Rabi, S.A.2
Sedaghat, A.R.3
Shan, L.4
Lai, J.5
Xing, S.6
Siliciano, R.F.7
-
12
-
-
0344334073
-
Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity
-
de la Carrière, L. C., Paulous, S., Clavel, F., and Mammano, F. (1999) Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity. J. Virol. 73, 3455-3459
-
(1999)
J. Virol.
, vol.73
, pp. 3455-3459
-
-
De La Carrière, L.C.1
Paulous, S.2
Clavel, F.3
Mammano, F.4
-
13
-
-
84862915396
-
Interplay between single resistance-associated mutations in the HIV-1 protease and viral infectivity, protease activity, and inhibitor sensitivity
-
Henderson, G. J., Lee, S. K., Irlbeck, D. M., Harris, J., Kline, M., Pollom, E., Parkin, N., and Swanstrom, R. (2012) Interplay between single resistance-associated mutations in the HIV-1 protease and viral infectivity, protease activity, and inhibitor sensitivity. Antimicrob. Agents Chemother. 56, 623-633
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 623-633
-
-
Henderson, G.J.1
Lee, S.K.2
Irlbeck, D.M.3
Harris, J.4
Kline, M.5
Pollom, E.6
Parkin, N.7
Swanstrom, R.8
-
14
-
-
0035031936
-
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
-
DOI 10.1128/JVI.75.10.4832-4842.2001
-
Boyer, P. L., Sarafianos, S. G., Arnold, E., and Hughes, S. H. (2001) Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. J. Virol. 75, 4832-4842 (Pubitemid 32381526)
-
(2001)
Journal of Virology
, vol.75
, Issue.10
, pp. 4832-4842
-
-
Boyer, P.L.1
Sarafianos, S.G.2
Arnold, E.3
Hughes, S.H.4
-
15
-
-
0030987309
-
Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase
-
DOI 10.1021/bi962410z
-
Tong, W., Lu, C. D., Sharma, S. K., Matsuura, S., So, A. G., and Scott, W. A. (1997) Nucleotide-induced stable complex formation by HIV-1 reverse transcriptase. Biochemistry 36, 5749-5757 (Pubitemid 27214926)
-
(1997)
Biochemistry
, vol.36
, Issue.19
, pp. 5749-5757
-
-
Tong, W.1
Lu, C.-D.2
Sharma, S.K.3
Matsuura, S.4
So, A.G.5
Scott, W.A.6
-
16
-
-
0033165851
-
A mechanism of AZT resistance: An increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase
-
DOI 10.1016/S1097-2765(00)80185-9
-
Meyer, P. R., Matsuura, S. E., Mian, A. M., So, A. G., and Scott, W. A. (1999) A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase. Mol. Cell 4, 35-43 (Pubitemid 29386129)
-
(1999)
Molecular Cell
, vol.4
, Issue.1
, pp. 35-43
-
-
Meyer, P.R.1
Matsuura, S.E.2
Mohsin, M.A.3
So, A.G.4
Scott, W.A.5
-
17
-
-
73149122533
-
Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles
-
Jouvenet, N., Simon, S. M., and Bieniasz, P. D. (2009) Imaging the interaction of HIV-1 genomes and Gag during assembly of individual viral particles. Proc. Natl. Acad. Sci. U.S.A. 106, 19114-19119
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 19114-19119
-
-
Jouvenet, N.1
Simon, S.M.2
Bieniasz, P.D.3
-
18
-
-
73549091724
-
Dynamics of HIV-1 assembly and release
-
Ivanchenko, S., Godinez, W. J., Lampe, M., Kräusslich, H. G., Eils, R., Rohr, K., Bräuchle, C., Müller, B., and Lamb, D. C. (2009) Dynamics of HIV-1 assembly and release. PLoS Pathog. 5, e1000652
-
(2009)
PLoS Pathog.
, vol.5
-
-
Ivanchenko, S.1
Godinez, W.J.2
Lampe, M.3
Kräusslich, H.G.4
Eils, R.5
Rohr, K.6
Bräuchle, C.7
Müller, B.8
Lamb, D.C.9
-
19
-
-
79251506313
-
Analysis of the initiating events in HIV-1 particle assembly and genome packaging
-
Kutluay, S. B., and Bieniasz, P. D. (2010) Analysis of the initiating events in HIV-1 particle assembly and genome packaging. PLoS Pathog. 6, e1001200
-
(2010)
PLoS Pathog.
, vol.6
-
-
Kutluay, S.B.1
Bieniasz, P.D.2
-
20
-
-
84858214799
-
Assembly and architecture of HIV
-
Ganser-Pornillos, B. K., Yeager, M., and Pornillos, O. (2012) Assembly and architecture of HIV. Adv. Exp. Med. Biol. 726, 441-465
-
(2012)
Adv. Exp. Med. Biol.
, vol.726
, pp. 441-465
-
-
Ganser-Pornillos, B.K.1
Yeager, M.2
Pornillos, O.3
-
21
-
-
55049134097
-
Resilience to resistance of HIV-1 protease inhibitors: Profile of darunavir
-
Lefebvre, E., and Schiffer, C. A. (2008) Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir. AIDS Rev. 10, 131-142
-
(2008)
AIDS Rev.
, vol.10
, pp. 131-142
-
-
Lefebvre, E.1
Schiffer, C.A.2
-
22
-
-
84856710288
-
Terminal interface conformations modulate dimer stability prior to amino-terminal autoprocessing of HIV-1 protease
-
Agniswamy, J., Sayer, J. M., Weber, I. T., and Louis, J. M. (2012) Terminal interface conformations modulate dimer stability prior to amino-terminal autoprocessing of HIV-1 protease. Biochemistry 51, 1041-1050
-
(2012)
Biochemistry
, vol.51
, pp. 1041-1050
-
-
Agniswamy, J.1
Sayer, J.M.2
Weber, I.T.3
Louis, J.M.4
-
23
-
-
17444392445
-
Autoprocessing of HIV-1 protease is tightly coupled to protein folding
-
DOI 10.1038/12327
-
Louis, J. M., Clore, G. M., and Gronenborn, A. M. (1999) Autoprocessing of HIV-1 protease is tightly coupled to protein folding. Nat. Struct. Biol. 6, 868-875 (Pubitemid 29415180)
-
(1999)
Nature Structural Biology
, vol.6
, Issue.9
, pp. 868-875
-
-
Louis, J.M.1
Marius, C.G.2
Gronenborn, A.M.3
-
24
-
-
80053605302
-
Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions
-
Huang, L., Li, Y., and Chen, C. (2011) Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions. Retrovirology 8, 79
-
(2011)
Retrovirology
, vol.8
, pp. 79
-
-
Huang, L.1
Li, Y.2
Chen, C.3
-
25
-
-
53349152834
-
Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease
-
Tang, C., Louis, J. M., Aniana, A., Suh, J. Y., and Clore, G. M. (2008) Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease. Nature 455, 693-696
-
(2008)
Nature
, vol.455
, pp. 693-696
-
-
Tang, C.1
Louis, J.M.2
Aniana, A.3
Suh, J.Y.4
Clore, G.M.5
-
26
-
-
0037213627
-
The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of GagPol cleavage
-
DOI 10.1128/JVI.77.1.366-374.2003
-
Pettit, S. C., Gulnik, S., Everitt, L., and Kaplan, A. H. (2003) The dimer interfaces of protease and extra-protease domains influence the activation of protease and the specificity of Gag-Pol cleavage. J. Virol. 77, 366-374 (Pubitemid 36004976)
-
(2003)
Journal of Virology
, vol.77
, Issue.1
, pp. 366-374
-
-
Pettit, S.C.1
Gulnik, S.2
Everitt, L.3
Kaplan, A.H.4
-
27
-
-
42449098891
-
Importance of protease cleavage sites within and flanking human immunodeficiency virus type 1 transframe protein p6*for spatiotemporal regulation of protease activation
-
DOI 10.1128/JVI.02353-07
-
Ludwig, C., Leiherer, A., and Wagner, R. (2008) Importance of protease cleavage sites within and flanking human immunodeficiency virus type 1 transframe protein p6*for spatiotemporal regulation of protease activation. J. Virol. 82, 4573-4584 (Pubitemid 351563694)
-
(2008)
Journal of Virology
, vol.82
, Issue.9
, pp. 4573-4584
-
-
Ludwig, C.1
Leiherer, A.2
Wagner, R.3
-
28
-
-
3543142335
-
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism
-
DOI 10.1128/JVI.78.16.8477-8485.2004
-
Pettit, S. C., Everitt, L. E., Choudhury, S., Dunn, B. M., and Kaplan, A. H. (2004) Initial cleavage of the human immunodeficiency virus type 1 Gag-Pol precursor by its activated protease occurs by an intramolecular mechanism. J. Virol. 78, 8477-8485 (Pubitemid 39025113)
-
(2004)
Journal of Virology
, vol.78
, Issue.16
, pp. 8477-8485
-
-
Pettit, S.C.1
Everitt, L.E.2
Choudhury, S.3
Dunn, B.M.4
Kaplan, A.H.5
-
29
-
-
0024784403
-
Cleavage of HIV-1 gag polyprotein synthesized in vitro: sequential cleavage by the viral protease
-
Erickson-Viitanen, S., Manfredi, J., Viitanen, P., Tribe, D. E., Tritch, R., Hutchison, C. A., 3rd, Loeb, D. D., and Swanstrom, R. (1989) Cleavage of HIV-1 Gag polyprotein synthesized in vitro: sequential cleavage by the viral protease. AIDS Res. Hum. Retroviruses 5, 577-591 (Pubitemid 20055070)
-
(1989)
AIDS Research and Human Retroviruses
, vol.5
, Issue.6
, pp. 577-591
-
-
Erickson-Viitanen, S.1
Manfredi, J.2
Viitanen, P.3
Tribe, D.E.4
Tritch, R.5
Hutchison III, C.A.6
Loeb, D.D.7
Swanstrom, R.8
-
30
-
-
27744572130
-
Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates
-
Pettit, S. C., Lindquist, J. N., Kaplan, A. H., and Swanstrom, R. (2005) Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates. Retrovirology 2, 66
-
(2005)
Retrovirology
, vol.2
, pp. 66
-
-
Pettit, S.C.1
Lindquist, J.N.2
Kaplan, A.H.3
Swanstrom, R.4
-
31
-
-
0027971621
-
The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions
-
Pettit, S. C., Moody, M. D., Wehbie, R. S., Kaplan, A. H., Nantermet, P. V., Klein, C. A., and Swanstrom, R. (1994) The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions. J. Virol. 68, 8017-8027 (Pubitemid 24362690)
-
(1994)
Journal of Virology
, vol.68
, Issue.12
, pp. 8017-8027
-
-
Pettit, S.C.1
Moody, M.D.2
Wehbie, R.S.3
Kaplan, A.H.4
Nantermet, P.V.5
Klein, C.A.6
Swanstrom, R.7
-
32
-
-
0031925586
-
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites
-
Wiegers, K., Rutter, G., Kottler, H., Tessmer, U., Hohenberg, H., and Kräusslich, H. G. (1998) Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites. J. Virol. 72, 2846-2854 (Pubitemid 28175521)
-
(1998)
Journal of Virology
, vol.72
, Issue.4
, pp. 2846-2854
-
-
Wiegers, K.1
Rutter, G.2
Kottler, H.3
Tessmer, U.4
Hohenberg, H.5
Krausslich, H.-G.6
-
33
-
-
69249216636
-
A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
-
Lee, S. K., Harris, J., and Swanstrom, R. (2009) A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle. J. Virol. 83, 8536-8543
-
(2009)
J. Virol.
, vol.83
, pp. 8536-8543
-
-
Lee, S.K.1
Harris, J.2
Swanstrom, R.3
-
34
-
-
70350366737
-
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity
-
Müller, B., Anders, M., Akiyama, H., Welsch, S., Glass, B., Nikovics, K., Clavel, F., Tervo, H. M., Keppler, O. T., and Kräusslich, H. G. (2009) HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity. J. Biol. Chem. 284, 29692-29703
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 29692-29703
-
-
Müller, B.1
Anders, M.2
Akiyama, H.3
Welsch, S.4
Glass, B.5
Nikovics, K.6
Clavel, F.7
Tervo, H.M.8
Keppler, O.T.9
Kräusslich, H.G.10
-
35
-
-
0026086220
-
Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 Gag polyprotein
-
Tritch, R. J., Cheng, Y. E., Yin, F. H., and Erickson-Viitanen, S. (1991) Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 Gag polyprotein. J. Virol. 65, 922-930
-
(1991)
J. Virol.
, vol.65
, pp. 922-930
-
-
Tritch, R.J.1
Cheng, Y.E.2
Yin, F.H.3
Erickson-Viitanen, S.4
-
36
-
-
0026316549
-
Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid
-
Pettit, S. C., Simsic, J., Loeb, D. D., Everitt, L., Hutchison, C. A., 3rd, and Swanstrom, R. (1991) Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acid. J. Biol. Chem. 266, 14539-14547 (Pubitemid 21907537)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.22
, pp. 14539-14547
-
-
Pettit, S.C.1
Simsic, J.2
Loeb, D.D.3
Everitt, L.4
Hutchison III, C.A.5
Swanstrom, R.6
-
37
-
-
0036121219
-
Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
-
DOI 10.1016/S0969-2126(02)00720-7, PII S0969212602007207
-
Prabu-Jeyabalan, M., Nalivaika, E., and Schiffer, C. A. (2002) Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. Structure 10, 369-381 (Pubitemid 34230624)
-
(2002)
Structure
, vol.10
, Issue.3
, pp. 369-381
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
38
-
-
80051739212
-
Dynamics of preferential substrate recognition in HIV-1 protease: Redefining the substrate envelope
-
Ozen, A., Haliloǧlu, T., and Schiffer, C. A. (2011) Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope. J. Mol. Biol. 410, 726-744
-
(2011)
J. Mol. Biol.
, vol.410
, pp. 726-744
-
-
Ozen, A.1
Haliloǧlu, T.2
Schiffer, C.A.3
-
39
-
-
47049130164
-
Imaging the biogenesis of individual HIV-1 virions in live cells
-
DOI 10.1038/nature06998, PII NATURE06998
-
Jouvenet, N., Bieniasz, P. D., and Simon, S. M. (2008) Imaging the biogenesis of individual HIV-1 virions in live cells. Nature 454, 236-240 (Pubitemid 351969887)
-
(2008)
Nature
, vol.454
, Issue.7201
, pp. 236-240
-
-
Jouvenet, N.1
Bieniasz, P.D.2
Simon, S.M.3
-
40
-
-
0026322839
-
Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity
-
Kräusslich, H. G. (1991) Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc. Natl. Acad. Sci. U.S.A. 88, 3213-3217
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 3213-3217
-
-
Kräusslich, H.G.1
-
41
-
-
67650925011
-
The nucleocapsid region of human immunodeficiency virus type 1 Gag assists in the coordination of assembly and Gag processing: Role for RNA-Gag binding in the early stages of assembly
-
Ott, D. E., Coren, L. V., and Shatzer, T. (2009) The nucleocapsid region of human immunodeficiency virus type 1 Gag assists in the coordination of assembly and Gag processing: role for RNA-Gag binding in the early stages of assembly. J. Virol. 83, 7718-7727
-
(2009)
J. Virol.
, vol.83
, pp. 7718-7727
-
-
Ott, D.E.1
Coren, L.V.2
Shatzer, T.3
-
42
-
-
0027932364
-
The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency
-
Kaplan, A. H., Manchester, M., and Swanstrom, R. (1994) The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency. J. Virol. 68, 6782-6786
-
(1994)
J. Virol.
, vol.68
, pp. 6782-6786
-
-
Kaplan, A.H.1
Manchester, M.2
Swanstrom, R.3
-
43
-
-
61549084714
-
Viral protease inhibitors
-
Anderson, J., Schiffer, C., Lee, S. K., and Swanstrom, R. (2009) Viral protease inhibitors. Handb. Exp. Pharmacol. 189, 85-110
-
(2009)
Handb. Exp. Pharmacol.
, vol.189
, pp. 85-110
-
-
Anderson, J.1
Schiffer, C.2
Lee, S.K.3
Swanstrom, R.4
-
44
-
-
0141571239
-
Covariation of amino acid positions in HIV-1 protease
-
DOI 10.1016/S0042-6822(03)00484-7
-
Hoffman, N. G., Schiffer, C. A., and Swanstrom, R. (2003) Covariation of amino acid positions in HIV-1 protease. Virology 314, 536-548 (Pubitemid 37206360)
-
(2003)
Virology
, vol.314
, Issue.2
, pp. 536-548
-
-
Hoffman, N.G.1
Schiffer, C.A.2
Swanstrom, R.3
-
45
-
-
77957351212
-
HIV-1 protease mutations and protease inhibitor cross-resistance
-
Rhee, S. Y., Taylor, J., Fessel, W. J., Kaufman, D., Towner, W., Troia, P., Ruane, P., Hellinger, J., Shirvani, V., Zolopa, A., and Shafer, R. W. (2010) HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrob. Agents Chemother. 54, 4253-4261
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 4253-4261
-
-
Rhee, S.Y.1
Taylor, J.2
Fessel, W.J.3
Kaufman, D.4
Towner, W.5
Troia, P.6
Ruane, P.7
Hellinger, J.8
Shirvani, V.9
Zolopa, A.10
Shafer, R.W.11
-
46
-
-
0037310296
-
Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors
-
DOI 10.1128/AAC.47.2.759-769.2003
-
Watkins, T., Resch, W., Irlbeck, D., and Swanstrom, R. (2003) Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors. Antimicrob. Agents Chemother. 47, 759-769 (Pubitemid 36158112)
-
(2003)
Antimicrobial Agents and Chemotherapy
, vol.47
, Issue.2
, pp. 759-769
-
-
Watkins, T.1
Resch, W.2
Irlbeck, D.3
Swanstrom, R.4
-
47
-
-
27444444039
-
Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression: 48-Week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK study)
-
DOI 10.1097/01.qai.0000180077.59159.f4
-
Arribas, J. R., Pulido, F., Delgado, R., Lorenzo, A., Miralles, P., Arranz, A., González-García, J. J., Cepeda, C., Hervás, R., Paño, J. R., Gaya, F., Carcas, A., Montes, M. L., Costa, J. R., and Peña, J. M. (2005) Lopinavir/ritonavir as single-drug therapy for maintenance of HIV-1 viral suppression: 48-week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK Study). J. Acquir. Immune Defic. Syndr. 40, 280-287 (Pubitemid 41533067)
-
(2005)
Journal of Acquired Immune Deficiency Syndromes
, vol.40
, Issue.3
, pp. 280-287
-
-
Arribas, J.R.1
Pulido, F.2
Delgado, R.3
Lorenzo, A.4
Miralles, P.5
Arranz, A.6
Gonzalez-Garcia, J.J.7
Cepeda, C.8
Hervas, R.9
Pano, J.R.10
Gaya, F.11
Carcas, A.12
Montes, M.L.13
Costa, J.R.14
Pena, J.M.15
-
48
-
-
77957230936
-
Efficacy of darunavir/ritonavir maintenance monotherapy in patients with HIV-1 viral suppression: A randomized open-label, noninferiority trial, MONOI-ANRS 136
-
Katlama, C., Valantin, M. A., Algarte-Genin, M., Duvivier, C., Lambert-Niclot, S., Girard, P. M., Molina, J. M., Hoen, B., Pakianather, S., Peytavin, G., Marcelin, A. G., and Flandre, P. (2010) Efficacy of darunavir/ritonavir maintenance monotherapy in patients with HIV-1 viral suppression: a randomized open-label, noninferiority trial, MONOI-ANRS 136. AIDS 24, 2365-2374
-
(2010)
AIDS
, vol.24
, pp. 2365-2374
-
-
Katlama, C.1
Valantin, M.A.2
Algarte-Genin, M.3
Duvivier, C.4
Lambert-Niclot, S.5
Girard, P.M.6
Molina, J.M.7
Hoen, B.8
Pakianather, S.9
Peytavin, G.10
Marcelin, A.G.11
Flandre, P.12
-
49
-
-
84856966336
-
Long-term efficacy of darunavir/ritonavir monotherapy in patients with HIV-1 viral suppression: Week 96 results from the MONOIANRS 136 study
-
Valantin, M. A., Lambert-Niclot, S., Flandre, P., Morand-Joubert, L., Cabiè, A., Meynard, J. L., Ponscarme, D., Ajana, F., Slama, L., Curjol, A., Cuzin, L., Schneider, L., Taburet, A. M., Marcelin, A. G., and Katlama, C. (2012) Long-term efficacy of darunavir/ritonavir monotherapy in patients with HIV-1 viral suppression: week 96 results from the MONOIANRS 136 study. J. Antimicrob. Chemother. 67, 691-695
-
(2012)
J. Antimicrob. Chemother.
, vol.67
, pp. 691-695
-
-
Valantin, M.A.1
Lambert-Niclot, S.2
Flandre, P.3
Morand-Joubert, L.4
Cabiè, A.5
Meynard, J.L.6
Ponscarme, D.7
Ajana, F.8
Slama, L.9
Curjol, A.10
Cuzin, L.11
Schneider, L.12
Taburet, A.M.13
Marcelin, A.G.14
Katlama, C.15
-
50
-
-
0029151345
-
Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
-
Gulnik, S. V., Suvorov, L. I., Liu, B., Yu, B., Anderson, B., Mitsuya, H., and Erickson, J. W. (1995) Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry 34, 9282-9287
-
(1995)
Biochemistry
, vol.34
, pp. 9282-9287
-
-
Gulnik, S.V.1
Suvorov, L.I.2
Liu, B.3
Yu, B.4
Anderson, B.5
Mitsuya, H.6
Erickson, J.W.7
-
51
-
-
0032804864
-
Increased fitness of drug-resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
-
Nijhuis, M., Schuurman, R., de Jong, D., Erickson, J., Gustchina, E., Albert, J., Schipper, P., Gulnik, S., and Boucher, C. A. (1999) Increased fitness of drug-resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy. AIDS 13, 2349-2359
-
(1999)
AIDS
, vol.13
, pp. 2349-2359
-
-
Nijhuis, M.1
Schuurman, R.2
De Jong, D.3
Erickson, J.4
Gustchina, E.5
Albert, J.6
Schipper, P.7
Gulnik, S.8
Boucher, C.A.9
-
52
-
-
0029092503
-
In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease
-
Partaledis, J. A., Yamaguchi, K., Tisdale, M., Blair, E. E., Falcione, C., Maschera, B., Myers, R. E., Pazhanisamy, S., Futer, O., and Cullinan, A. B. (1995) In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease. J. Virol. 69, 5228-5235
-
(1995)
J. Virol.
, vol.69
, pp. 5228-5235
-
-
Partaledis, J.A.1
Yamaguchi, K.2
Tisdale, M.3
Blair, E.E.4
Falcione, C.5
Maschera, B.6
Myers, R.E.7
Pazhanisamy, S.8
Futer, O.9
Cullinan, A.B.10
-
53
-
-
0029896360
-
Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants
-
DOI 10.1074/jbc.271.30.17979
-
Pazhanisamy, S., Stuver, C. M., Cullinan, A. B., Margolin, N., Rao, B. G., and Livingston, D. J. (1996) Kinetic characterization of human immunodeficiency virus type 1 protease-resistant variants. J. Biol. Chem. 271, 17979-17985 (Pubitemid 26250782)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.30
, pp. 17979-17985
-
-
Pazhanisamy, S.1
Stuver, C.M.2
Cullinan, A.B.3
Margolin, N.4
Rao, B.G.5
Livingston, D.J.6
-
54
-
-
0029731556
-
Mutational anatomy of an HIV-1 protease variant conferring cross- resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity
-
DOI 10.1074/jbc.271.50.31957
-
Schock, H. B., Garsky, V. M., and Kuo, L. C. (1996) Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity. J. Biol. Chem. 271, 31957-31963 (Pubitemid 26422220)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.50
, pp. 31957-31963
-
-
Schock, H.B.1
Garsky, V.M.2
Kuo, L.C.3
-
55
-
-
7644230388
-
Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
-
DOI 10.1128/JVI.78.22.12446-12454.2004
-
Prabu-Jeyabalan, M., Nalivaika, E. A., King, N. M., and Schiffer, C. A. (2004) Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease. J. Virol. 78, 12446-12454 (Pubitemid 39458763)
-
(2004)
Journal of Virology
, vol.78
, Issue.22
, pp. 12446-12454
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.A.2
King, N.M.3
Schiffer, C.A.4
-
56
-
-
0031015475
-
Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors
-
Croteau, G., Doyon, L., Thibeault, D., McKercher, G., Pilote, L., and Lamarre, D. (1997) Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J. Virol. 71, 1089-1096 (Pubitemid 27030280)
-
(1997)
Journal of Virology
, vol.71
, Issue.2
, pp. 1089-1096
-
-
Croteau, G.1
Doyon, L.2
Thibeault, D.3
Mckercher, G.4
Pilote, L.5
Lamarre, D.6
-
57
-
-
0036337934
-
Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly
-
DOI 10.1128/JVI.76.17.8659-8666.2002
-
Resch, W., Ziermann, R., Parkin, N., Gamarnik, A., and Swanstrom, R. (2002) Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly. J. Virol. 76, 8659-8666 (Pubitemid 34864060)
-
(2002)
Journal of Virology
, vol.76
, Issue.17
, pp. 8659-8666
-
-
Resch, W.1
Ziermann, R.2
Parkin, N.3
Gamarnik, A.4
Swanstrom, R.5
-
58
-
-
0031946007
-
Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo
-
Zennou, V., Mammano, F., Paulous, S., Mathez, D., and Clavel, F. (1998) Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo. J. Virol. 72, 3300-3306 (Pubitemid 28175575)
-
(1998)
Journal of Virology
, vol.72
, Issue.4
, pp. 3300-3306
-
-
Zennou, V.1
Mammano, F.2
Paulous, S.3
Mathez, D.4
Clavel, F.5
-
59
-
-
0029131607
-
Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials
-
Chen, Z., Li, Y., Schock, H. B., Hall, D., Chen, E., and Kuo, L. C. (1995) Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials. J. Biol. Chem. 270, 21433-21436
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21433-21436
-
-
Chen, Z.1
Li, Y.2
Schock, H.B.3
Hall, D.4
Chen, E.5
Kuo, L.C.6
-
60
-
-
0028014288
-
2-symmetric protease inhibitor
-
Ho, D. D., Toyoshima, T., Mo, H., Kempf, D. J., Norbeck, D., Chen, C. M., Wideburg, N. E., Burt, S. K., Erickson, J. W., and Singh, M. K. (1994) Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor. J. Virol. 68, 2016-2020 (Pubitemid 24065777)
-
(1994)
Journal of Virology
, vol.68
, Issue.3
, pp. 2016-2020
-
-
Ho, D.D.1
Toyoshima, T.2
Mo, H.3
Kempf, D.J.4
Norbeck, D.5
Chen, C.-M.6
Wideburg, N.E.7
Burt, S.K.8
Erickson, J.W.9
Singh, M.K.10
-
61
-
-
0028286025
-
Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease
-
DOI 10.1073/pnas.91.12.5597
-
Kaplan, A. H., Michael, S. F., Wehbie, R. S., Knigge, M. F., Paul, D. A., Everitt, L., Kempf, D. J., Norbeck, D. W., Erickson, J. W., and Swanstrom, R. (1994) Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc. Natl. Acad. Sci. U.S.A. 91, 5597-5601 (Pubitemid 24174375)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.12
, pp. 5597-5601
-
-
Kaplan, A.H.1
Michael, S.F.2
Wehbie, R.S.3
Knigge, M.F.4
Paul, D.A.5
Everitt, L.6
Kempf, D.J.7
Norbeck, D.W.8
Erickson, J.W.9
Swanstrom, R.10
-
62
-
-
0033863985
-
Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: Virus fitness in the absence and in the presence of drug
-
DOI 10.1128/JVI.74.18.8524-8531.2000
-
Mammano, F., Trouplin, V., Zennou, V., and Clavel, F. (2000) Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug. J. Virol. 74, 8524-8531 (Pubitemid 30666703)
-
(2000)
Journal of Virology
, vol.74
, Issue.18
, pp. 8524-8531
-
-
Mammano, F.1
Trouplin, V.2
Zennou, V.3
Clavel, F.4
-
63
-
-
0028854676
-
Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
-
Markowitz, M., Mo, H., Kempf, D. J., Norbeck, D. W., Bhat, T. N., Erickson, J. W., and Ho, D. D. (1995) Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69, 701-706
-
(1995)
J. Virol.
, vol.69
, pp. 701-706
-
-
Markowitz, M.1
Mo, H.2
Kempf, D.J.3
Norbeck, D.W.4
Bhat, T.N.5
Erickson, J.W.6
Ho, D.D.7
-
64
-
-
0032928065
-
Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
-
Martinez-Picado, J., Savara, A. V., Sutton, L., and D'Aquila, R. T. (1999) Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J. Virol. 73, 3744-3752 (Pubitemid 29189817)
-
(1999)
Journal of Virology
, vol.73
, Issue.5
, pp. 3744-3752
-
-
Martinez-Picado, J.1
Savara, A.V.2
Sutton, L.3
D'Aquila, R.T.4
-
65
-
-
80051749007
-
Accessory mutations maintain stability in drug-resistant HIV-1 protease
-
Chang, M. W., and Torbett, B. E. (2011) Accessory mutations maintain stability in drug-resistant HIV-1 protease. J. Mol. Biol. 410, 756-760
-
(2011)
J. Mol. Biol.
, vol.410
, pp. 756-760
-
-
Chang, M.W.1
Torbett, B.E.2
-
66
-
-
0034284897
-
Polymorphism of HIV type 1 Gag p7/p1 and p1/p6 cleavage sites: Clinical significance and implications for resistance to protease inhibitors
-
Bally, F., Martinez, R., Peters, S., Sudre, P., and Telenti, A. (2000) Polymorphism of HIV type 1 Gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors. AIDS Res. Hum. Retroviruses 16, 1209-1213
-
(2000)
AIDS Res. Hum. Retroviruses
, vol.16
, pp. 1209-1213
-
-
Bally, F.1
Martinez, R.2
Peters, S.3
Sudre, P.4
Telenti, A.5
-
67
-
-
0029899093
-
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
-
Doyon, L., Croteau, G., Thibeault, D., Poulin, F., Pilote, L., and Lamarre, D. (1996) Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors. J. Virol. 70, 3763-3769 (Pubitemid 26161824)
-
(1996)
Journal of Virology
, vol.70
, Issue.6
, pp. 3763-3769
-
-
Doyon, L.1
Croteau, G.2
Thibeault, D.3
Poulin, F.4
Pilote, L.5
Lamarre, D.6
-
68
-
-
0035831126
-
Mutations in HIV-1 gag cleavage sites and their association with protease mutations
-
DOI 10.1097/00002030-200103090-00013
-
Koch, N., Yahi, N., Fantini, J., and Tamalet, C. (2001) Mutations in HIV-1 Gag cleavage sites and their association with protease mutations. AIDS 15, 526-528 (Pubitemid 32207574)
-
(2001)
AIDS
, vol.15
, Issue.4
, pp. 526-528
-
-
Koch, N.1
Yahi, N.2
Fantini, J.3
Tamalet, C.4
-
69
-
-
0031846317
-
Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
-
Mammano, F., Petit, C., and Clavel, F. (1998) Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and Gag coevolution in protease inhibitor-treated patients. J. Virol. 72, 7632-7637 (Pubitemid 28377901)
-
(1998)
Journal of Virology
, vol.72
, Issue.9
, pp. 7632-7637
-
-
Mammano, F.1
Petit, C.2
Clavel, F.3
-
70
-
-
0030769354
-
Drug resistance during Indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites
-
Zhang, Y. M., Imamichi, H., Imamichi, T., Lane, H. C., Falloon, J., Vasudevachari, M. B., and Salzman, N. P. (1997) Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites. J. Virol. 71, 6662-6670 (Pubitemid 27355324)
-
(1997)
Journal of Virology
, vol.71
, Issue.9
, pp. 6662-6670
-
-
Zhang, Y.-M.1
Imamichi, H.2
Imamichi, T.3
Lane, H.C.4
Falloon, J.5
Vasudevachari, M.B.6
Salzman, N.P.7
-
71
-
-
69449097224
-
Gag determinants of fitness and drug susceptibility in protease inhibitor-resistant human immunodeficiency virus type 1
-
Parry, C. M., Kohli, A., Boinett, C. J., Towers, G. J., McCormick, A. L., and Pillay, D. (2009) Gag determinants of fitness and drug susceptibility in protease inhibitor-resistant human immunodeficiency virus type 1. J. Virol. 83, 9094-9101
-
(2009)
J. Virol.
, vol.83
, pp. 9094-9101
-
-
Parry, C.M.1
Kohli, A.2
Boinett, C.J.3
Towers, G.J.4
McCormick, A.L.5
Pillay, D.6
-
72
-
-
0036468120
-
+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
-
+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy. J. Infect. Dis. 185, 315-323
-
(2002)
J. Infect. Dis.
, vol.185
, pp. 315-323
-
-
Deeks, S.G.1
Hoh, R.2
Grant, R.M.3
Wrin, T.4
Barbour, J.D.5
Narvaez, A.6
Cesar, D.7
Abe, K.8
Hanley, M.B.9
Hellmann, N.S.10
Petropoulos, C.J.11
McCune, J.M.12
Hellerstein, M.K.13
-
73
-
-
4644301808
-
High-resolution structure of a retrovial capsid hexameric amino-terminal domain
-
DOI 10.1038/nature02915
-
Mortuza, G. B., Haire, L. F., Stevens, A., Smerdon, S. J., Stoye, J. P., and Taylor, I. A. (2004) High-resolution structure of a retroviral capsid hexameric amino-terminal domain. Nature 431, 481-485 (Pubitemid 39329590)
-
(2004)
Nature
, vol.431
, Issue.7007
, pp. 481-485
-
-
Mortuza, G.B.1
Haire, L.F.2
Stevens, A.3
Smerdon, S.J.4
Stoye, J.P.5
Taylor, I.A.6
-
74
-
-
0032536896
-
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly
-
DOI 10.1093/emboj/17.6.1555
-
von Schwedler, U. K., Stemmler, T. L., Klishko, V. Y., Li, S., Albertine, K. H., Davis, D. R., and Sundquist, W. I. (1998) Proteolytic refolding of the HIV-1 capsid protein amino terminus facilitates viral core assembly. EMBO J. 17, 1555-1568 (Pubitemid 28119109)
-
(1998)
EMBO Journal
, vol.17
, Issue.6
, pp. 1555-1568
-
-
Von Schwedler, U.K.1
Stemmler, T.L.2
Klishko, V.Y.3
Li, S.4
Albertine, K.H.5
Davis, D.R.6
Sundquist, W.I.7
-
75
-
-
0034699383
-
Image reconstructions of helical assemblies of the HIV-1 CA protein
-
Li, S., Hill, C. P., Sundquist, W. I., and Finch, J. T. (2000) Image reconstructions of helical assemblies of the HIV-1 CA protein. Nature 407, 409-413
-
(2000)
Nature
, vol.407
, pp. 409-413
-
-
Li, S.1
Hill, C.P.2
Sundquist, W.I.3
Finch, J.T.4
-
76
-
-
26944457382
-
A peptide inhibitor of HIV-1 assembly in vitro
-
DOI 10.1038/nsmb964, PII NSMB964
-
Sticht, J., Humbert, M., Findlow, S., Bodem, J., Müller, B., Dietrich, U., Werner, J., and Kräusslich, H. G. (2005) A peptide inhibitor of HIV-1 assembly in vitro. Nat. Struct. Mol. Biol. 12, 671-677 (Pubitemid 43086272)
-
(2005)
Nature Structural and Molecular Biology
, vol.12
, Issue.8
, pp. 671-677
-
-
Sticht, J.1
Humbert, M.2
Findlow, S.3
Bodern, J.4
Muller, B.5
Dietrich, U.6
Werner, J.7
Krausslich, H.-G.8
-
77
-
-
26944455601
-
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor
-
DOI 10.1038/nsmb967, PII NSMB967
-
Ternois, F., Sticht, J., Duquerroy, S., Kräusslich, H. G., and Rey, F. A. (2005) The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor. Nat. Struct. Mol. Biol. 12, 678-682 (Pubitemid 43086273)
-
(2005)
Nature Structural and Molecular Biology
, vol.12
, Issue.8
, pp. 678-682
-
-
Ternois, F.1
Sticht, J.2
Duquerroy, S.3
Krausslich, H.-G.4
Rey, F.A.5
-
78
-
-
34548844198
-
Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein
-
DOI 10.1016/j.jmb.2007.07.070, PII S0022283607010492
-
Kelly, B. N., Kyere, S., Kinde, I., Tang, C., Howard, B. R., Robinson, H., Sundquist, W. I., Summers, M. F., and Hill, C. P. (2007) Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J. Mol. Biol. 373, 355-366 (Pubitemid 47445574)
-
(2007)
Journal of Molecular Biology
, vol.373
, Issue.2
, pp. 355-366
-
-
Kelly, B.N.1
Kyere, S.2
Kinde, I.3
Tang, C.4
Howard, B.R.5
Robinson, H.6
Sundquist, W.I.7
Summers, M.F.8
Hill, C.P.9
-
79
-
-
0037432551
-
Antiviral Inhibition of the HIV-1 capsid protein
-
DOI 10.1016/S0022-2836(03)00289-4
-
Tang, C., Loeliger, E., Kinde, I., Kyere, S., Mayo, K., Barklis, E., Sun, Y., Huang, M., and Summers, M. F. (2003) Antiviral inhibition of the HIV-1 capsid protein. J. Mol. Biol. 327, 1013-1020 (Pubitemid 36363708)
-
(2003)
Journal of Molecular Biology
, vol.327
, Issue.5
, pp. 1013-1020
-
-
Tang, C.1
Loeliger, E.2
Kinde, I.3
Kyere, S.4
Mayo, K.5
Barklis, E.6
Sun, Y.7
Huang, M.8
Summers, M.F.9
-
80
-
-
78650042418
-
HIV capsid is a tractable target for small molecule therapeutic intervention
-
Blair, W. S., Pickford, C., Irving, S. L., Brown, D. G., Anderson, M., Bazin, R., Cao, J., Ciaramella, G., Isaacson, J., Jackson, L., Hunt, R., Kjerrstrom, A., Nieman, J. A., Patick, A. K., Perros, M., Scott, A. D., Whitby, K., Wu, H., and Butler, S. L. (2010) HIV capsid is a tractable target for small molecule therapeutic intervention. PLoS Pathog. 6, e1001220
-
(2010)
PLoS Pathog.
, vol.6
-
-
Blair, W.S.1
Pickford, C.2
Irving, S.L.3
Brown, D.G.4
Anderson, M.5
Bazin, R.6
Cao, J.7
Ciaramella, G.8
Isaacson, J.9
Jackson, L.10
Hunt, R.11
Kjerrstrom, A.12
Nieman, J.A.13
Patick, A.K.14
Perros, M.15
Scott, A.D.16
Whitby, K.17
Wu, H.18
Butler, S.L.19
-
81
-
-
78650064115
-
Smallmolecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization
-
Shi, J., Zhou, J., Shah, V. B., Aiken, C., and Whitby, K. (2011) Smallmolecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. J. Virol. 85, 542-549
-
(2011)
J. Virol.
, vol.85
, pp. 542-549
-
-
Shi, J.1
Zhou, J.2
Shah, V.B.3
Aiken, C.4
Whitby, K.5
-
82
-
-
84864007910
-
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein
-
Lemke, C. T., Titolo, S., von Schwedler, U., Goudreau, N., Mercier, J. F., Wardrop, E., Faucher, A. M., Coulombe, R., Banik, S. S., Fader, L., Gagnon, A., Kawai, S. H., Rancourt, J., Tremblay, M., Yoakim, C., Simoneau, B., Archambault, J., Sundquist, W. I., and Mason, S. W. (2012) Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein. J. Virol. 86, 6643-6655
-
(2012)
J. Virol.
, vol.86
, pp. 6643-6655
-
-
Lemke, C.T.1
Titolo, S.2
Von Schwedler, U.3
Goudreau, N.4
Mercier, J.F.5
Wardrop, E.6
Faucher, A.M.7
Coulombe, R.8
Banik, S.S.9
Fader, L.10
Gagnon, A.11
Kawai, S.H.12
Rancourt, J.13
Tremblay, M.14
Yoakim, C.15
Simoneau, B.16
Archambault, J.17
Sundquist, W.I.18
Mason, S.W.19
-
83
-
-
0036784575
-
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
-
Pettit, S. C., Henderson, G. J., Schiffer, C. A., and Swanstrom, R. (2002) Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease. J. Virol. 76, 10226-10233
-
(2002)
J. Virol.
, vol.76
, pp. 10226-10233
-
-
Pettit, S.C.1
Henderson, G.J.2
Schiffer, C.A.3
Swanstrom, R.4
-
84
-
-
35348911923
-
Mutational analysis of the C-terminal Gag cleavage sites in human immunodeficiency virus type 1
-
DOI 10.1128/JVI.02496-06
-
Coren, L. V., Thomas, J. A., Chertova, E., Sowder, R. C., 2nd, Gagliardi, T. D., Gorelick, R. J., and Ott, D. E. (2007) Mutational analysis of the C-terminal Gag cleavage sites in human immunodeficiency virus type 1. J. Virol. 81, 10047-10054 (Pubitemid 350067708)
-
(2007)
Journal of Virology
, vol.81
, Issue.18
, pp. 10047-10054
-
-
Coren, L.V.1
Thomas, J.A.2
Chertova, E.3
Sowder II, R.C.4
Gagliardi, T.D.5
Gorelick, R.J.6
Ott, D.E.7
-
85
-
-
0345686713
-
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing
-
DOI 10.1073/pnas.2234683100
-
Li, F., Goila-Gaur, R., Salzwedel, K., Kilgore, N. R., Reddick, M., Matallana, C., Castillo, A., Zoumplis, D., Martin, D. E., Orenstein, J. M., Allaway, G. P., Freed, E. O., and Wild, C. T. (2003) PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc. Natl. Acad. Sci. U.S.A. 100, 13555-13560 (Pubitemid 37444780)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.23
, pp. 13555-13560
-
-
Li, F.1
Goila-Gaur, R.2
Salzwedel, K.3
Kilgore, N.R.4
Reddick, M.5
Matallana, C.6
Castillo, A.7
Zoumplis, D.8
Martin, D.E.9
Orenstein, J.M.10
Allaway, G.P.11
Freed, E.O.12
Wild, C.T.13
-
86
-
-
0346688636
-
Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation
-
DOI 10.1128/JVI.78.2.922-929.2004
-
Zhou, J., Yuan, X., Dismuke, D., Forshey, B. M., Lundquist, C., Lee, K. H., Aiken, C., and Chen, C. H. (2004) Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J. Virol. 78, 922-929 (Pubitemid 38067613)
-
(2004)
Journal of Virology
, vol.78
, Issue.2
, pp. 922-929
-
-
Zhou, J.1
Yuan, X.2
Dismuke, D.3
Forshey, B.M.4
Lundquist, C.5
Lee, K.-H.6
Aiken, C.7
Chen, C.H.8
-
87
-
-
78951488338
-
HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
-
Keller, P. W., Adamson, C. S., Heymann, J. B., Freed, E. O., and Steven, A. C. (2011) HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice. J. Virol. 85, 1420-1428
-
(2011)
J. Virol.
, vol.85
, pp. 1420-1428
-
-
Keller, P.W.1
Adamson, C.S.2
Heymann, J.B.3
Freed, E.O.4
Steven, A.C.5
-
88
-
-
28344449442
-
Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles
-
DOI 10.1074/jbc.M508951200
-
Zhou, J., Huang, L., Hachey, D. L., Chen, C. H., and Aiken, C. (2005) Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. J. Biol. Chem. 280, 42149-42155 (Pubitemid 43023184)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.51
, pp. 42149-42155
-
-
Zhou, J.1
Huang, L.2
Hachey, D.L.3
Chen, C.H.4
Aiken, C.5
-
89
-
-
82755190460
-
The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles
-
Nguyen, A. T., Feasley, C. L., Jackson, K. W., Nitz, T. J., Salzwedel, K., Air, G. M., and Sakalian, M. (2011) The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles. Retrovirology 8, 101
-
(2011)
Retrovirology
, vol.8
, pp. 101
-
-
Nguyen, A.T.1
Feasley, C.L.2
Jackson, K.W.3
Nitz, T.J.4
Salzwedel, K.5
Air, G.M.6
Sakalian, M.7
-
90
-
-
77649179193
-
The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation
-
Checkley, M. A., Luttge, B. G., Soheilian, F., Nagashima, K., and Freed, E. O. (2010) The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation. Virology 400, 137-144
-
(2010)
Virology
, vol.400
, pp. 137-144
-
-
Checkley, M.A.1
Luttge, B.G.2
Soheilian, F.3
Nagashima, K.4
Freed, E.O.5
-
91
-
-
33646021013
-
Mutant murine leukemia virus Gag proteins lacking proline at the N terminus of the capsid domain block infectivity in virions containing wild-type Gag
-
Rulli, S. J., Jr., Muriaux, D., Nagashima, K., Mirro, J., Oshima, M., Baumann, J. G., and Rein, A. (2006) Mutant murine leukemia virus Gag proteins lacking proline at the N terminus of the capsid domain block infectivity in virions containing wild-type Gag. Virology 347, 364-371
-
(2006)
Virology
, vol.347
, pp. 364-371
-
-
Rulli Jr., S.J.1
Muriaux, D.2
Nagashima, K.3
Mirro, J.4
Oshima, M.5
Baumann, J.G.6
Rein, A.7
-
92
-
-
0028338652
-
Characterization of human immunodeficiency virus type 1 dimeric RNA from wild-type and protease-defective virions
-
Fu, W., Gorelick, R. J., and Rein, A. (1994) Characterization of human immunodeficiency virus type 1 dimeric RNA from wild-type and protease-defective virions. J. Virol. 68, 5013-5018 (Pubitemid 24226568)
-
(1994)
Journal of Virology
, vol.68
, Issue.8
, pp. 5013-5018
-
-
Fu, W.1
Gorelick, R.J.2
Rein, A.3
-
93
-
-
0034856077
-
Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation
-
DOI 10.1128/JVI.75.19.9156-9164.2001
-
Shehu-Xhilaga, M., Kraeusslich, H. G., Pettit, S., Swanstrom, R., Lee, J. Y., Marshall, J. A., Crowe, S. M., and Mak, J. (2001) Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation. J. Virol. 75, 9156-9164 (Pubitemid 32851920)
-
(2001)
Journal of Virology
, vol.75
, Issue.19
, pp. 9156-9164
-
-
Shehu-Xhilaga, M.1
Kraeusslich, H.G.2
Pettit, S.3
Swanstrom, R.4
Lee, J.Y.5
Marshall, J.A.6
Crowe, S.M.7
Mak, J.8
-
94
-
-
43049089699
-
Nucleocapsid protein function in early infection processes
-
Thomas, J. A., and Gorelick, R. J. (2008) Nucleocapsid protein function in early infection processes. Virus Res. 134, 39-63
-
(2008)
Virus Res.
, vol.134
, pp. 39-63
-
-
Thomas, J.A.1
Gorelick, R.J.2
-
95
-
-
0028133360
-
Cleavage of p15 protein in vitro by human immunodeficiency virus type 1 protease is RNA dependent
-
Sheng, N., and Erickson-Viitanen, S. (1994) Cleavage of p15 protein in vitro by human immunodeficiency virus type 1 protease is RNA-dependent. J. Virol. 68, 6207-6214 (Pubitemid 24294870)
-
(1994)
Journal of Virology
, vol.68
, Issue.10
, pp. 6207-6214
-
-
Sheng, N.1
Erickson-Viitanen, S.2
-
96
-
-
0030738085
-
Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease
-
Sheng, N., Pettit, S. C., Tritch, R. J., Ozturk, D. H., Rayner, M. M., Swanstrom, R., and Erickson-Viitanen, S. (1997) Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease. J. Virol. 71, 5723-5732 (Pubitemid 27304905)
-
(1997)
Journal of Virology
, vol.71
, Issue.8
, pp. 5723-5732
-
-
Sheng, N.1
Pettit, S.C.2
Tritch, R.J.3
Ozturk, D.H.4
Rayner, M.M.5
Swanstrom, R.6
Erickson-Viitanen, S.7
-
97
-
-
84862291648
-
Identification of HIV-1 inhibitors targeting the nucleocapsid protein
-
Breuer, S., Chang, M. W., Yuan, J., and Torbett, B. E. (2012) Identification of HIV-1 inhibitors targeting the nucleocapsid protein. J. Med. Chem. 55, 4968-4977
-
(2012)
J. Med. Chem.
, vol.55
, pp. 4968-4977
-
-
Breuer, S.1
Chang, M.W.2
Yuan, J.3
Torbett, B.E.4
-
98
-
-
79956196738
-
A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease
-
Breuer, S., Sepulveda, H., Chen, Y., Trotter, J., and Torbett, B. E. (2011) A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease. Biochemistry 50, 4371-4381
-
(2011)
Biochemistry
, vol.50
, pp. 4371-4381
-
-
Breuer, S.1
Sepulveda, H.2
Chen, Y.3
Trotter, J.4
Torbett, B.E.5
-
99
-
-
77950927781
-
A simple fluorescence based assay for quantification of human immunodeficiency virus particle release
-
Hermle, J., Anders, M., Heuser, A. M., and Müller, B. (2010) A simple fluorescence based assay for quantification of human immunodeficiency virus particle release. BMC Biotechnol. 10, 32
-
(2010)
BMC Biotechnol.
, vol.10
, pp. 32
-
-
Hermle, J.1
Anders, M.2
Heuser, A.M.3
Müller, B.4
-
100
-
-
2942750655
-
Identification of a large polypeptide precursor of avian oncornavirus proteins
-
Vogt, V. M., and Eisenman, R. (1973) Identification of a large polypeptide precursor of avian oncornavirus proteins. Proc. Natl. Acad. Sci. U.S.A. 70, 1734-1738
-
(1973)
Proc. Natl. Acad. Sci. U.S.A.
, vol.70
, pp. 1734-1738
-
-
Vogt, V.M.1
Eisenman, R.2
-
101
-
-
5444247213
-
Combating susceptibility to drug resistance: Lessons from HIV-1 protease
-
DOI 10.1016/j.chembiol.2004.08.010, PII S1074552104002431
-
King, N. M., Prabu-Jeyabalan, M., Nalivaika, E. A., and Schiffer, C. (2004) Combating susceptibility to drug resistance: lessons from HIV-1 protease. Chem. Biol. 11, 1333-1338 (Pubitemid 39351371)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.10
, pp. 1333-1338
-
-
King, N.M.1
Prabu-Jeyabalan, M.2
Nalivaika, E.A.3
Schiffer, C.A.4
|