Mutational anatomy of an HIV-1 protease variant conferring cross- resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity

Journal of Biological Chemistry

Volumn 271, Issue 50, 1996, Pages 31957-31963

  Schock, Hilary B ^a   Garsky, Victor M ^a   Kuo, Lawrence C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; INDINAVIR; MUTANT PROTEIN; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CROSS RESISTANCE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME SUBSTRATE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; VIRUS MUTATION;

CARBAMATES; CLINICAL TRIALS; FUSION PROTEINS, GAG-POL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; HYDROLYSIS; INDINAVIR; KINETICS; MUTAGENESIS; RITONAVIR; SULFONAMIDES;

FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0029731556     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.50.31957     Document Type: Article

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