Identification of HIV-1 inhibitors targeting the nucleocapsid protein

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 4968-4977

  Breuer, Sebastian ^a   Chang, Max W ^a   Yuan, Jinyun ^a   Torbett, Bruce E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHOXY 2 METHOXY 4 (2 NITROPROP 1 EN 1 YL)BENZENE; 4 (BENZO[D][1,3]DIOXOL 5 YLMETHYLENE) 3 PHENYLISOXAZOL 5(4H) ONE; 4 AMINO 2 (2,3 DIMETHOXYBENZYLIDENE) 5 THIOXYHYDROTHIOPEN 3 (2H) ONE; 5 (2 NITROPROP 1 EN 1 YL)BENZO[D][1,3]DIOXOLE; 5 [5 NITRO 2 [[5 (TRIFLUOROMETHYL)PYRIDIN 2 YL]THIO]BENZYLIDENE] 2 THIOXOTHIAZOLIDIN 4 ONE; ANTIVIRUS AGENT; GAG PROTEIN; NUCLEOCAPSID PROTEIN; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOTOXICITY; DNA BINDING; DRUG IDENTIFICATION; DRUG SCREENING; DRUG TARGETING; EX VIVO STUDY; FLUORESCENCE POLARIZATION; FLUOROMETRY; HIGH THROUGHPUT SCREENING; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; PROTEIN DNA INTERACTION; VIRUS NUCLEOCAPSID;

ANTI-HIV AGENTS; BENZENE DERIVATIVES; BENZODIOXOLES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; DNA, VIRAL; FLUORESCENCE POLARIZATION; FLUOROMETRY; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HIV-1; HUMANS; ISOXAZOLES; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; RNA, VIRAL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; THIOPHENES;

EID: 84862291648     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201442t     Document Type: Article

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