Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles

Journal of Biological Chemistry

Volumn 280, Issue 51, 2005, Pages 42149-42155

  Zhou, Jing ^a   Huang, Li ^a   Hachey, David L ^b   Chen, Chin Ho ^a   Aiken, Christopher ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE; IMMUNOLOGY; MUTAGENESIS; POLYMERS; PROTEINS; STOICHIOMETRY;

GAG POLYMER; HIV-1 PARTICLES; PROTEOLYTIC CLEAVAGE; VIRAL GAG PROTEIN;

VIRUSES;

3 O (3,3 DIMETHYLSUCCINYL)BETULIC ACID; BETULIC ACID; GAG PROTEIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STOICHIOMETRY; VIROGENESIS; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS REPLICATION;

CELL LINE; GENE PRODUCTS, GAG; HIV-1; HUMANS; VIRION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 28344449442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508951200     Document Type: Article

References (24)

1. Vogt, V. M. (1996) Curr. Top. Microbiol. Immunol. 214, 95-131
2. Erickson-Viitanen, S., Manfredi, J., Viitanen, P., Tribe, D. E., Tritch, R., Hutchison, C. A., III, Loeb, D. D., and Swantstrom, R. (1989) AIDS Res. Hum. Retroviruses 5, 577-591
3. Kaplan, A. H., and Swanstrom, R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4528-4532
4. Wiegers, K., Rutter, G., Kottler, H., Tessmer, U., Hohenberg, H., and Krausslich, H.-G. (1998) J. Virol. 72, 2846-2854
5. Zhou, J., Yuan, X., Dismuke, D., Forshey, B. M., Lundquist, C., Lee, K. H., Aiken, C, and Chen, C. H. (2004) J. Virol. 78, 922-929
6. Li, F., Goila-Gaur, R., Salzwedel, K., Kilgore, N. R., Reddick, M., Matallana, C., Castillo, A., Zoumplis, D., Martin, D. E., Orenstein, J. M., Allaway, G. P., Freed, E. O., and Wild, C. T. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13555-13560
7. Kanamoto, T., Kashiwada, Y., Kanbara, K., Gotoh, K., Yoshimori, M., Goto, T., Sano, K., and Nakashima, H. (2001) Antimicrob. Agents Chemother. 45, 1225-1230
8. Kashiwada, Y., Hashimoto, F., Cosentino, L. M., Chen, C. H., Garrett, P. E., and Lee, K. H. (1996) J. Med. Chem. 39, 1016-1017
9. Hashimoto, F., Kashiwada, Y., Cosentino, L. M., Chen, C. H., Garrett, P. E., and Lee, K. H. (1997) Bioorg. Med. Chem. 5, 2133-2143
10. Zhou, J., Chen, C. H., and Aiken, C. (2004) Retrovirology 1, 15
11. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A., and Martin, M. A. (1986) J. Virol. 59, 284-291
12. Chen, C., and Okayama, H. (1987) Mol. Cell. Biol. 7, 2745-2752
13. Gallay, P., Swingler, S., Aiken, C., and Trono, D. (1995) Cell 80, 379-388
14. Wyma, D. J., Kotov, A., and Aiken, C. (2000) J. Virol. 74, 9381-9387
15. Dong, X., Li, H., Derdowski, A., Ding, L., Burnett, A., Chen, X., Peters, T. R., Dermody, T. S., Woodruff, E., Wang, J. J., and Spearman, P. (2005) Cell 120, 663-674
16. Wehrly, K., and Chesebro, B. (1997) Methods 12, 288-293
17. Wyma, D. J., Jiang, J., Shi, J., Zhou, J., Lineberget, J. E., Miller, M. D., and Aiken, C. (2004) J. Virol. 78, 3429-3435
18. Fujioka, T., Kashiwada, Y., Kilkuskie, R. E., Cosentino, L. M., Ballas, L. M., Jiang, J. B., Janzen, W. P., Chen, I. S., and Lee, K. H. (1994) J. Nat Prod. 57, 243-247
19. Gheysen, D., Jacobs, E., de Forests, F., Thiriart, C., Francotte, M., Thines, D., and De Wilde, M. (1989) Cell 59, 103-112
20. Grant, R. A., Hiremath, C. N., Filman, D. J., Syed, R., Andries, K., and Hogle, J. M. (1994) Curr. Biol. 4, 784-797
21. Smith, T. J., Kremer, M. J., Luo, M., Vriend, G., Arnold, E., Kamer, G., Rossmann, M. G., McKinlay, M. A., Diana, G. D., and Otto, M. J. (1986) Science 233, 1286-1293
22. Briggs, J. A., Simon, M. N., Gross, I., Krausslich, H. G., Fuller, S. D., Vogt, V. M., and Johnson, M. C. (2004) Nat. Struct. Mol. Biol. 11, 672-675
23. Tang, C., Loeliger, E., Luncsford, P., Kinde, I., Beckett, D., and Summers, M. F. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 517-522
24. Aiken, C., and Chen, C. H. (2005) Trends Mol. Med. 11, 31-36