-
1
-
-
0034564193
-
HIV-1 protease: Maturation, enzyme specificity, and drug resistance
-
Louis, J. M., Weber, I. T., Tozser, J., Clore, G. M. & Gronenborn, A. M. HIV-1 protease: maturation, enzyme specificity, and drug resistance. Adv. Pharmacol. 49, 111-146 (2000).
-
(2000)
Adv. Pharmacol
, vol.49
, pp. 111-146
-
-
Louis, J.M.1
Weber, I.T.2
Tozser, J.3
Clore, G.M.4
Gronenborn, A.M.5
-
2
-
-
34250336893
-
HIV-1 protease: Structure, dynamics and inhibition
-
Louis, J. M., Ishima, R., Torchia, D. A. & Weber, I. T. HIV-1 protease: structure, dynamics and inhibition. Adv. Pharmacol. 55, 261-298 (2007).
-
(2007)
Adv. Pharmacol
, vol.55
, pp. 261-298
-
-
Louis, J.M.1
Ishima, R.2
Torchia, D.A.3
Weber, I.T.4
-
3
-
-
0027218692
-
Structure-based inhibitors of HIV-1 protease
-
Wlodawer, A. & Erikson, J. Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62, 543-585 (1993).
-
(1993)
Annu. Rev. Biochem
, vol.62
, pp. 543-585
-
-
Wlodawer, A.1
Erikson, J.2
-
4
-
-
0031804609
-
Inhibitors of HIV-1 protease: A major success of structure-assisted drug design
-
Wlodawer, A. & Vondrasek, J. Inhibitors of HIV-1 protease: a major success of structure-assisted drug design. Annu. Rev. Biophys. Biomol. Struct. 27, 249-284 (1998).
-
(1998)
Annu. Rev. Biophys. Biomol. Struct
, vol.27
, pp. 249-284
-
-
Wlodawer, A.1
Vondrasek, J.2
-
5
-
-
0242353303
-
Solution structure of the mature HIV-1 protease monomer: Insight into the tertiary fold and stability of a precursor
-
Ishima, R., Torchia, D. A., Lynch, S. M., Gronenborn, A. M. & Louis, J. M. Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor. J. Biol. Chem. 278, 43311-43319 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 43311-43319
-
-
Ishima, R.1
Torchia, D.A.2
Lynch, S.M.3
Gronenborn, A.M.4
Louis, J.M.5
-
6
-
-
0024344021
-
Conserved folding in retroviral proteases: Crystal structure of a synthetic HIV-1 protease
-
Miller, M. et al. Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. Science 246, 1149-1152 (1989).
-
(1989)
Science
, vol.246
, pp. 1149-1152
-
-
Miller, M.1
-
7
-
-
0027936212
-
Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein
-
Louis, J. M., Nashed, N. T., Parris, K. D., Kimmel, A. R. & Jerina, D. M. Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein. Proc. Natl Acad. Sci. USA 91, 7970-7974 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7970-7974
-
-
Louis, J.M.1
Nashed, N.T.2
Parris, K.D.3
Kimmel, A.R.4
Jerina, D.M.5
-
8
-
-
0028345852
-
Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1
-
Co, E. et al. Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1. Biochemistry 33, 1248-1254 (1994).
-
(1994)
Biochemistry
, vol.33
, pp. 1248-1254
-
-
Co, E.1
-
9
-
-
0033551697
-
Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism
-
Louis, J. M., Wondrak, E. M., Kimmel, A. R., Wingfield, P. T. & Nashed, N. T. Proteolytic processing of HIV-1 protease precursor, kinetics and mechanism. J. Biol. Chem. 274, 23437-23442 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 23437-23442
-
-
Louis, J.M.1
Wondrak, E.M.2
Kimmel, A.R.3
Wingfield, P.T.4
Nashed, N.T.5
-
10
-
-
17444392445
-
Autoprocessing of HIV-1 protease is tightly coupled to protein folding
-
Louis, J. M., Clore, G. M. & Gronenborn, A. M. Autoprocessing of HIV-1 protease is tightly coupled to protein folding. Nature Struct. Biol. 6, 868-874 (1999).
-
(1999)
Nature Struct. Biol
, vol.6
, pp. 868-874
-
-
Louis, J.M.1
Clore, G.M.2
Gronenborn, A.M.3
-
11
-
-
3543142335
-
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism
-
Pettit, S. C., Everitt, L. E., Choudhury, S., Dunn, B. M. & Kaplan, A. H. Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanism. J. Virol. 78, 8477-8485 (2004).
-
(2004)
J. Virol
, vol.78
, pp. 8477-8485
-
-
Pettit, S.C.1
Everitt, L.E.2
Choudhury, S.3
Dunn, B.M.4
Kaplan, A.H.5
-
12
-
-
34447133502
-
Mutational and structural studies aimed at characterizing the monomer of HIV-1 protease and its precursor
-
Ishima, R., Torchia, D. A. & Louis, J. M. Mutational and structural studies aimed at characterizing the monomer of HIV-1 protease and its precursor. J. Biol. Chem. 282, 17190-17199 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 17190-17199
-
-
Ishima, R.1
Torchia, D.A.2
Louis, J.M.3
-
13
-
-
33646356250
-
Detecting transient intermediates in macromolecular binding by paramagnetic NMR
-
Iwahara, J. & Clore, G. M. Detecting transient intermediates in macromolecular binding by paramagnetic NMR. Nature 440, 1227-1230 (2006).
-
(2006)
Nature
, vol.440
, pp. 1227-1230
-
-
Iwahara, J.1
Clore, G.M.2
-
14
-
-
33751086423
-
Visualization of transient encounter complexes in protein-protein association
-
Tang, C., Iwahara, J. & Clore, G. M. Visualization of transient encounter complexes in protein-protein association. Nature 444, 383-386 (2006).
-
(2006)
Nature
, vol.444
, pp. 383-386
-
-
Tang, C.1
Iwahara, J.2
Clore, G.M.3
-
15
-
-
34250838027
-
Solution structure and dynamics of the complex between cytochrome c and cytochrome c peroxidase determined by paramagnetic NMR
-
Volkov, A. N., Worall, J. A., Holtzmann, E. & Ubbink, M. Solution structure and dynamics of the complex between cytochrome c and cytochrome c peroxidase determined by paramagnetic NMR. Proc. Natl Acad. Sci. USA 103, 18945-18950 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18945-18950
-
-
Volkov, A.N.1
Worall, J.A.2
Holtzmann, E.3
Ubbink, M.4
-
16
-
-
35548976322
-
Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR
-
Tang, C., Schwieters, C. D. & Clore, G. M. Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR. Nature 449, 1078-1082 (2007).
-
(2007)
Nature
, vol.449
, pp. 1078-1082
-
-
Tang, C.1
Schwieters, C.D.2
Clore, G.M.3
-
17
-
-
2642680072
-
Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity
-
Tessmer, U. & Kräusslich, H.-G. Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity. J. Virol. 72, 3459-3463 (1998).
-
(1998)
J. Virol
, vol.72
, pp. 3459-3463
-
-
Tessmer, U.1
Kräusslich, H.-G.2
-
18
-
-
42449098891
-
Importance of protease cleavage sites within and flanking human immunodeficiency virus type 1 transframe protein p6* for spatiotemporal regulation of protease activation
-
Ludwig, C., Leiherer, A. & Wagner, G. Importance of protease cleavage sites within and flanking human immunodeficiency virus type 1 transframe protein p6* for spatiotemporal regulation of protease activation. J. Virol. 82, 4573-4584 (2008).
-
(2008)
J. Virol
, vol.82
, pp. 4573-4584
-
-
Ludwig, C.1
Leiherer, A.2
Wagner, G.3
-
19
-
-
0030066643
-
A transient precursor of the HIV-1 protease: Isolation, characterization and kinetics of maturation
-
Wondrak, E. M., Nashed, N. T., Haber, M. T., Jerina, D. M. & Louis, J. M. A transient precursor of the HIV-1 protease: isolation, characterization and kinetics of maturation. J. Biol. Chem. 271, 4477-4481 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 4477-4481
-
-
Wondrak, E.M.1
Nashed, N.T.2
Haber, M.T.3
Jerina, D.M.4
Louis, J.M.5
-
20
-
-
0032553427
-
Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins
-
Cherry, E. et al. Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins. J. Mol. Biol. 284, 43-56 (1998).
-
(1998)
J. Mol. Biol
, vol.284
, pp. 43-56
-
-
Cherry, E.1
-
21
-
-
33846561471
-
1H transverse paramagnetic relaxation enhancement measurements on macromolecules
-
1H transverse paramagnetic relaxation enhancement measurements on macromolecules. J. Magn. Reson. 184, 185-195 (2007).
-
(2007)
J. Magn. Reson
, vol.184
, pp. 185-195
-
-
Iwahara, J.1
Tang, C.2
Clore, G.M.3
-
22
-
-
33645868288
-
Using Xplor-NIH for NMR molecular structure determination
-
Schwieters, C. D., Kuszewski, J. & Clore, G. M. Using Xplor-NIH for NMR molecular structure determination. Prog. Nucl. Magn. Reson. Spectrosc. 48, 47-62 (2006).
-
(2006)
Prog. Nucl. Magn. Reson. Spectrosc
, vol.48
, pp. 47-62
-
-
Schwieters, C.D.1
Kuszewski, J.2
Clore, G.M.3
-
23
-
-
2442433447
-
1H paramagnetic relaxation enhancement data arising from a flexible paramagnetic group attached to a macromolecule
-
1H paramagnetic relaxation enhancement data arising from a flexible paramagnetic group attached to a macromolecule. J. Am. Chem. Soc. 126, 5879-5896 (2004).
-
(2004)
J. Am. Chem. Soc
, vol.126
, pp. 5879-5896
-
-
Iwahara, J.1
Schwieters, C.D.2
Clore, G.M.3
-
24
-
-
0026344399
-
The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU
-
Spinelli, S., Liu, Q. Z., Alzari, P. M., Hirel, P. H. & Poljak, R. J. The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU. Biochimie 73, 1391-1396 (1991).
-
(1991)
Biochimie
, vol.73
, pp. 1391-1396
-
-
Spinelli, S.1
Liu, Q.Z.2
Alzari, P.M.3
Hirel, P.H.4
Poljak, R.J.5
-
25
-
-
0036367763
-
Reweighted atomic densities to represent ensembles of NMR structures
-
Schwieters, C. D. & Clore, G. M. Reweighted atomic densities to represent ensembles of NMR structures. J. Biomol. NMR 23, 221-225 (2002).
-
(2002)
J. Biomol. NMR
, vol.23
, pp. 221-225
-
-
Schwieters, C.D.1
Clore, G.M.2
-
26
-
-
0029833678
-
Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease
-
Wondrak, E. M. & Louis, J. M. Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease. Biochemistry 35, 12957-12962 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 12957-12962
-
-
Wondrak, E.M.1
Louis, J.M.2
-
27
-
-
2142642258
-
Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site
-
Mahalingam, B. et al. Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site. Eur. J. Biochem. 271, 1516-1524 (2004).
-
(2004)
Eur. J. Biochem
, vol.271
, pp. 1516-1524
-
-
Mahalingam, B.1
-
28
-
-
0028857598
-
Association of biomolecular systems via pulsed field gradient NMR self-diffusion measurements
-
Altieri, A. S., Hinton, D. P. & Byrd, R. A. Association of biomolecular systems via pulsed field gradient NMR self-diffusion measurements. J. Am. Chem. Soc. 117, 7566-7567 (1995).
-
(1995)
J. Am. Chem. Soc
, vol.117
, pp. 7566-7567
-
-
Altieri, A.S.1
Hinton, D.P.2
Byrd, R.A.3
-
29
-
-
3042767203
-
Characterization of phospholipid mixed micelles by translational diffusion
-
Chou, J. J., Baber, J. L. & Bax, A. Characterization of phospholipid mixed micelles by translational diffusion. J. Biomol. NMR 29, 299-308 (2004).
-
(2004)
J. Biomol. NMR
, vol.29
, pp. 299-308
-
-
Chou, J.J.1
Baber, J.L.2
Bax, A.3
-
30
-
-
0027787894
-
2O in protein NMR: Application to sensitivity enhancement and NOE measurements
-
2O in protein NMR: application to sensitivity enhancement and NOE measurements. J. Am. Chem. Soc. 115, 12593-12594 (1993).
-
(1993)
J. Am. Chem. Soc
, vol.115
, pp. 12593-12594
-
-
Grzesiek, S.1
Bax, A.2
-
31
-
-
0025757134
-
Two-, three- and four-dimensional NMR methods for obtaining larger and more precise three-dimensional structures of proteins in solution
-
Clore, G. M. & Gronenborn, A. M. Two-, three- and four-dimensional NMR methods for obtaining larger and more precise three-dimensional structures of proteins in solution. Annu. Rev. Biophys. Biophys. Chem. 20, 29-63 (1991).
-
(1991)
Annu. Rev. Biophys. Biophys. Chem
, vol.20
, pp. 29-63
-
-
Clore, G.M.1
Gronenborn, A.M.2
-
32
-
-
0028674451
-
Multidimensional heteronuclear nuclear magnetic resonance of proteins
-
Clore, G. M. & Gronenborn, A. M. Multidimensional heteronuclear nuclear magnetic resonance of proteins. Methods Enzymol. 239, 349-363 (1994).
-
(1994)
Methods Enzymol
, vol.239
, pp. 349-363
-
-
Clore, G.M.1
Gronenborn, A.M.2
-
33
-
-
0029795040
-
The CD4 determinant of downregulation by HIV-1 Nef directly binds to Nef: Mapping of the Nef binding surface by NMR
-
Grzesiek, S., Stahl, S. J., Wingfield, P. T. & Bax, A. The CD4 determinant of downregulation by HIV-1 Nef directly binds to Nef: mapping of the Nef binding surface by NMR. Biochemistry 35, 10256-10261 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 10256-10261
-
-
Grzesiek, S.1
Stahl, S.J.2
Wingfield, P.T.3
Bax, A.4
-
35
-
-
42449146665
-
Consistent blind protein structure generation from NMR chemical shift data
-
Shen, Y. et al. Consistent blind protein structure generation from NMR chemical shift data. Proc. Natl Acad. Sci. USA 105, 4685-4690 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 4685-4690
-
-
Shen, Y.1
-
36
-
-
0037634016
-
A solution NMR study of the binding kinetics and internal dynamics of an HIV-1 protease-substrate complex
-
Katoh, E. et al. A solution NMR study of the binding kinetics and internal dynamics of an HIV-1 protease-substrate complex. Protein Sci. 12, 1376-1385 (2003).
-
(2003)
Protein Sci
, vol.12
, pp. 1376-1385
-
-
Katoh, E.1
-
37
-
-
0037181376
-
1 rotamer populations and angles of mobile surface side chains are accurately predicted by a torsion angle database potential of mean force
-
1 rotamer populations and angles of mobile surface side chains are accurately predicted by a torsion angle database potential of mean force. J. Am. Chem. Soc. 124, 2866-2867 (2002).
-
(2002)
J. Am. Chem. Soc
, vol.124
, pp. 2866-2867
-
-
Clore, G.M.1
Kuszewski, J.2
-
38
-
-
0033577269
-
Improving the packing and accuracy of NMR structures with a pseudopotential for the radius of gyration
-
Kuszewski, J., Gronenborn, A. M. & Clore, G. M. Improving the packing and accuracy of NMR structures with a pseudopotential for the radius of gyration. J. Am. Chem. Soc. 121, 2337-2338 (1999).
-
(1999)
J. Am. Chem. Soc
, vol.121
, pp. 2337-2338
-
-
Kuszewski, J.1
Gronenborn, A.M.2
Clore, G.M.3
-
39
-
-
41149167049
-
Visualization of transient ultra-weak protein self-association in solution using paramagnetic relaxation enhancement
-
Tang, C., Ghirlando, R. & Clore, G. M. Visualization of transient ultra-weak protein self-association in solution using paramagnetic relaxation enhancement. J. Am. Chem. Soc. 130, 4048-4056 (2008).
-
(2008)
J. Am. Chem. Soc
, vol.130
, pp. 4048-4056
-
-
Tang, C.1
Ghirlando, R.2
Clore, G.M.3
-
40
-
-
51349101286
-
Replica exchange simulations of transient encounter complexes in protein-protein association
-
Kim, Y. C., Tang, C., Clore, G. M. & Hummer, G. Replica exchange simulations of transient encounter complexes in protein-protein association. Proc. Natl Acad. Sci. USA 105, 12855-12860 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 12855-12860
-
-
Kim, Y.C.1
Tang, C.2
Clore, G.M.3
Hummer, G.4
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